PubRank

S M Hecht

Author PubWeight™ 121.24‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proc Natl Acad Sci U S A 1979 2.81
2 gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini. J Biol Chem 1983 2.41
3 Isolation and identification of four cytokinins from wheat germ transfer ribonucleic acid. Biochemistry 1970 2.30
4 Cytokinins: synthesis, mass spectra, and biological activity of compounds related to zeatin. Proc Natl Acad Sci U S A 1969 2.30
5 On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex. Biochemistry 1989 1.95
6 Cytokinin from soluble RNA of Escherichia coli: 6-(3-methyl-2-butenylamino)-2-methylthio-9-beta-D-ribofuranosylpurine. Science 1968 1.66
7 Ribonucleoside phosphates via phosphorimidazolidate intermediates. Synthesis of pseudoadenosine 5'-triphosphate. Biochemistry 1973 1.40
8 Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin. Biochemistry 1982 1.36
9 Cytokinins: development of a potent antagonist. Proc Natl Acad Sci U S A 1971 1.32
10 Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. J Med Chem 1991 1.28
11 CYTOKININS: SYNTHESIS OF 6-(3-METHYL-3-BUTENYLAMINO)-9-beta-D-RIBOFURANOSYLPURINE (3IPA), AND THE EFFECT OF SIDE-CHAIN UNSATURATION ON THE BIOLOGICAL ACTIVITY OF ISOPENTYLAMINOPURINES AND THEIR RIBOSIDES. Proc Natl Acad Sci U S A 1968 1.26
12 Analysis of products formed during bleomycin-mediated DNA degradation. Biochemistry 1985 1.22
13 The isolation and identification of two cytokinins from Escherichia coli transfer ribonucleic acids. Biochemistry 1969 1.22
14 Cytokinin of wheat germ transfer RNA: 6-(4-hydroxy-3-methyl-2-butenylamino)-2-methylthio-9-beta-D-ribofuranosylpurine. Science 1969 1.22
15 On the "activation" of cytokinins. J Biol Chem 1975 1.22
16 "Chemical aminoacylation" of tRNA's. J Biol Chem 1978 1.19
17 The effect of "cap" analogs on reovirus mRNA binding to wheat germ ribosomes. Evidence for enhancement of ribosomal binding via a preferred cap conformation. J Biol Chem 1978 1.18
18 Metal ion and substrate structure dependence of the processing of tRNA precursors by RNase P and M1 RNA. J Biol Chem 1990 1.17
19 Oligonucleotide N-alkylphosphoramidates: synthesis and binding to polynucleotides. Biochemistry 1988 1.16
20 Chemical transformations of 7,9-disubstituted purines and related heterocycles. Selective reduction of imines and immonium salts. J Org Chem 1976 1.16
21 T4 RNA ligase mediated preparation of novel "chemically misacylated" tRNAPheS. Biochemistry 1984 1.15
22 Site-specific cleavage of RNA by Fe(II).bleomycin. Proc Natl Acad Sci U S A 1990 1.13
23 DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs. Biochemistry 1986 1.12
24 N 6 -( 2 -Isopentenyl)adenosine: the regulatory effects of a cytokinin and modified nucleoside from tRNA on human lymphocytes. Biochim Biophys Acta 1972 1.11
25 Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG). Biochemistry 1988 1.09
26 Effects of release factor 1 on in vitro protein translation and the elaboration of proteins containing unnatural amino acids. Biochemistry 1999 1.02
27 Structural studies of of "active complex" of bleomycin: assignment of ligands to the ferrous ion in a ferrous-bleomycin-carbon monoxide complex. Proc Natl Acad Sci U S A 1979 1.01
28 Copper-dependent cleavage of DNA by bleomycin. Biochemistry 1987 1.00
29 Amino acid substitutions in protein biosynthesis. Poly(A)-directed polyphenylalanine synthesis. J Biol Chem 1980 1.00
30 A model for topoisomerase I-mediated insertions and deletions with duplex DNA substrates containing branches, nicks, and gaps. Biochemistry 1995 0.99
31 Use of COMPARE analysis to discover new natural product drugs: isolation of camptothecin and 9-methoxycamptothecin from a new source. J Nat Prod 2000 0.99
32 Chemical modifications of transfer RNA species. Desulfurization with Raney nickel. Proc Natl Acad Sci U S A 1971 0.99
33 A chemical synthesis of adenosine 5'-(gamma-32P)triphosphate. Biochim Biophys Acta 1973 0.98
34 Polynucleotide recognition and degradation by bleomycin. Prog Nucleic Acid Res Mol Biol 1994 0.98
35 Control of the position of RNase P-mediated transfer RNA precursor processing. J Biol Chem 1990 0.97
36 Isomeric phenylalanyl-tRNAs. Position of the aminoacyl moiety during protein biosynthesis. Proc Natl Acad Sci U S A 1974 0.97
37 , Occolowitz J, Burrows WJ, Armstrong DJ, Skoog F, Bock RM, Gillam I, Tener GM: Cytokinins: isolation identification of 6-(3-methyl-2-butenylamino)-9-beta-D-ribyfuranosylpurine (2iPA) from yeast cysteine tRNA. Biochem Biophys Res Commun 1969 0.95
38 A Mn2(+)-dependent ribozyme. Science 1990 0.94
39 Cytokinins. Activity and identification in Staphylococcus epidermidis transfer ribonucleic acid. J Biol Chem 1970 0.93
40 Characterization of iron (II).bleomycin-mediated RNA strand scission. Biochemistry 1993 0.93
41 DNA polymerase beta inhibitors from Sandoricum koetjape. J Nat Prod 1999 0.92
42 Chemical modifications of transfer RNA species. Transfer RNA's terminating in 2'- and 3'-O-methyladenosine. Biochem Biophys Res Commun 1973 0.91
43 Metallobleomycin-mediated cleavage of DNA not involving a threading-intercalation mechanism. J Am Chem Soc 2001 0.91
44 Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex. Biochemistry 1999 0.90
45 Chemical and structural characterization of the interaction of bleomycin A2 with d(CGCGAATTCGCG)2. efficient, double-strand DNA cleavage accessible without structural reorganization. J Am Chem Soc 2001 0.90
46 Dipeptide formation with misacylated tRNAPhes. J Biol Chem 1983 0.90
47 Proton nuclear magnetic resonance study of the structure of bleomycin and the zinc-bleomycin complex. Biochemistry 1979 0.90
48 A role for the metal binding domain in determining the DNA sequence selectivity of Fe-bleomycin. J Biol Chem 1990 0.89
49 Anticytokinin activity of substituted pyrrolo[2,3-d]pyrimidines. Proc Natl Acad Sci U S A 1975 0.89
50 Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site. J Biol Chem 1990 0.89
51 Competitive inhibition of beef heart cyclic AMP phosphodiesterase by cytokinins and related compounds. Proc Natl Acad Sci U S A 1974 0.89
52 Chemical modifications of transfer rna species. Heavy atom derivatization of aminoacyl tRNA. Biochem Biophys Res Commun 1972 0.88
53 On the chemical nature of DNA and RNA modification by a hemin model system. Biochemistry 1990 0.88
54 DNA damage and growth inhibition in cultured human cells by bleomycin congeners. Biochemistry 1985 0.88
55 Preparation of misacylated aminoacyl-tRNA(Phe)'s useful as probes of the ribosomal acceptor site. Biochemistry 1989 0.88
56 Position of uridine thiation: the identification of minor nucleosides from transfer RNA by mass spectrometry. Biochim Biophys Acta 1969 0.88
57 There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5H-pyrido[4,3-b]indoles. Proc Natl Acad Sci U S A 1980 0.88
58 Studies on the total synthesis of tallysomycin. Synthesis of the threonylbithiazole moiety containing a structurally unique glycosylcarbinolamide. Org Lett 2001 0.88
59 Metabolic activation of 1-methyl-3-amino-5H-pyrido[4,3-b]indole and several structurally related mutagens. Biochemistry 1981 0.88
60 Deglyco-bleomycin. Degradation of DNA and formation of a structurally unique Fe(II) . CO complex. J Biol Chem 1982 0.87
61 DNA strand scission by activated bleomycin group antibiotics. Fed Proc 1986 0.86
62 Plant anticancer agents, XXXIV. Cucurbitacins from Elaeocarpus dolichostylus. J Nat Prod 1985 0.86
63 Probing the S1/S1' substrate binding pocket geometry of HIV-1 protease with modified aspartic acid analogues. Biochemistry 2000 0.86
64 DNA damage induced by bleomycin in the presence of dibucaine is not predictive of cell growth inhibition. Biochemistry 1985 0.86
65 Inhibition of topoisomerase I function by nitidine and fagaronine. Chem Res Toxicol 1994 0.86
66 Fe.bleomycin as a probe of RNA conformation. Nucleic Acids Res 1996 0.84
67 Inhibition of topoisomerase I function by coralyne and 5,6-dihydrocoralyne. Chem Res Toxicol 1996 0.84
68 Position of aminoacylation of individual Escherichia coli and yeast tRNAs. Proc Natl Acad Sci U S A 1976 0.84
69 Mass spectra of nucleoside components of tRNA. Anal Biochem 1969 0.83
70 Initial position of aminoacylation of individual Escherichia coli, yeast, and calf liver transfer RNAs. Biochemistry 1977 0.83
71 DNA strand scission by bleomycin group antibiotics. J Nat Prod 1986 0.83
72 Iron(II)-bleomycin. Biochemical and spectral properties in the presence of radical scavengers. Biochem Biophys Res Commun 1982 0.83
73 Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon. J Nat Prod 2000 0.83
74 Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A(5). Org Lett 2000 0.83
75 Bleomycin congeners exhibiting altered DNA cleavage specificity. Chem Res Toxicol 1992 0.83
76 A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta. J Nat Prod 2000 0.82
77 Use of COMPARE analysis to discover functional analogues of bleomycin. J Nat Prod 2000 0.82
78 Fe.bleomycin cleaves a transfer RNA precursor and its "transfer DNA" analog at the same major site. J Biol Chem 1993 0.82
79 Both positional isomers of aminoacyl-tRNA's are bound by elongation factor Tu. J Biol Chem 1979 0.82
80 DNA polymerase beta inhibitors from Baeckea gunniana. J Nat Prod 1999 0.82
81 Ribosomal binding and dipeptide formation by misacylated tRNA(Phe),S. Biochemistry 1988 0.81
82 In vitro suppression as a tool for the investigation of translation initiation. Nucleic Acids Res 1997 0.81
83 Synthesis and DNA cleavage activity of a novel bleomycin A(5) glycoconjugate. Org Lett 2001 0.81
84 Ribonucleoside 3'-di- and -triphosphates. Synthesis of guanosine tetraphosphate (ppGpp). Biochemistry 1975 0.81
85 On the role of the bithiazole moiety in sequence-selective DNA cleavage by Fe.bleomycin. J Biol Chem 1994 0.81
86 Transfer RNA pyrophosphorolysis with CTP(ATP):tRNA nucleotidyltransferase. A direct route to tRNAs modified at the 3' terminus. J Biol Chem 1983 0.81
87 Facile characterization of translation initiation via nonsense codon suppression. Nucleic Acids Res 1999 0.81
88 Structurally altered substrates for DNA topoisomerase I. Effects of inclusion of a single 3'-deoxynucleotide within the scissile strand. Nucleosides Nucleotides 1998 0.81
89 Copper(I)-bleomycin: structurally unique complex that mediates oxidative DNA strand scission. Biochemistry 1985 0.81
90 Question of the ribosyl moiety in the promotion of callus growth by exogenously added cytokinins. Biochemistry 1971 0.81
91 Differential effects of camptothecin derivatives on topoisomerase I-mediated DNA structure modification. Biochemistry 1998 0.80
92 9-Octadecynoic acid: a novel DNA binding agent. Chem Res Toxicol 1992 0.80
93 Copper(I) . bleomycin. A structurally unique oxidation-reduction active complex. J Biol Chem 1981 0.80
94 Amplification of protein expression in a cell free system. Nucleic Acids Res 1992 0.80
95 Naturally occurring alkylresorcinols that mediate DNA damage and inhibit its repair. Biochemistry 2000 0.80
96 Interaction of glycyl-L-phenylalanine with Escherichia coli phenylalanyl-tRNA synthetase. Biochemistry 1974 0.80
97 A structurally modified yeast tRNAPhe with six nucleotides in the anticodon loop lacks significant phenylalanine acceptance. J Biol Chem 1982 0.80
98 DNA methylation diminishes bleomycin-mediated strand scission. Biochemistry 1985 0.80
99 High-field 1H-NMR spectral analysis of some cucurbitacins. J Nat Prod 1985 0.80
100 Copper(II) facilitates bleomycin-mediated unwinding of plasmid DNA. Biochemistry 1988 0.80
101 Specific cleavage of a DNA triple helix by FeII.bleomycin. Biochemistry 1995 0.80
102 Iron(II) bleomycin-mediated degradation of a DNA-RNA heteroduplex. Biochemistry 1994 0.79
103 Degradation of structurally modified DNAs by bleomycin group antibiotics. Biochemistry 1988 0.79
104 DNA polymerase beta inhibitors from Tetracera boiviniana. J Nat Prod 1999 0.79
105 Oxygen transfer from bleomycin-metal complexes. J Biol Chem 1982 0.79
106 Structural basis for the deoxyribonucleic acid affinity of bleomycins. Biochemistry 1982 0.79
107 A concise synthesis of substituted 4-alkylaminopyrazolo(3,40d)pyrimidines. J Chem Soc Perkin 1 1973 0.79
108 Ribosome-catalyzed formation of an abnormal peptide analogue. Biochemistry 1986 0.78
109 Characterisation of guanidino-containing antibiotics: field desorption mass spectrometry of bleomycin B2 and phleomycins D1 and E. Biochem Biophys Res Commun 1980 0.78
110 Phosphoryl migration during the chemical synthesis of RNA. Nucleic Acids Res 1995 0.78
111 Metal binding to modified bleomycins. Zinc and ferrous complexes with an acetylated bleomycin. Biochemistry 1980 0.78
112 On the chemistry of RNA degradation by Fe.bleomycin. Bioorg Med Chem 1997 0.78
113 Field desorption and fast atom bombardment mass spectrometry of bleomycins and their derivatives. Biochem Biophys Res Commun 1981 0.78
114 Analogues of bleomycin: synthesis of conformationally rigid methylvalerates. Org Lett 2001 0.78
115 Escherichia coli tryptophan synthase: synthesis of catalytically competent alpha subunit in a cell-free system containing preacylated tRNAs. Biochemistry 1987 0.78
116 Kinetics of DNA cleavage by Fe(II).bleomycins. J Am Chem Soc 2001 0.77
117 Isomeric aminoacyl-tRNAs are both bound by elongation factor Tu. Proc Natl Acad Sci U S A 1977 0.77
118 Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase beta. Bioorg Med Chem 2000 0.77
119 DNA topoisomerase I-mediated formation of structurally modified DNA duplexes. Effects of metal ions and topoisomerase I inhibitors. Biochemistry 1998 0.77
120 Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase. J Biol Chem 2001 0.77
121 bis-5-Alkylresorcinols from Panopsis rubescens that inhibit DNA polymerase beta. J Nat Prod 1999 0.77
122 Sequence-specific hydrolysis of yeast tRNA(Phe) mediated by metal-free bleomycin. Biochemistry 1995 0.76
123 Site-specific DNA cleavage by antisense oligonucleotides covalently linked to phenazine di-N-oxide. J Biol Chem 1991 0.76
124 A ribozyme model: site-specific cleavage of an RNA substrate by Mn2+. Adv Inorg Biochem 1994 0.76
125 Loss of positional specificity in the aminoacylation of Escherichia coli tRNAGly. J Biol Chem 1983 0.76
126 Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata. J Nat Prod 1999 0.76
127 Construction and processing of transfer RNA precursor models. J Biol Chem 1990 0.75
128 2'-Versus 3'-OH specificity in tRNA aminoacylation. Further support for the "secondary cognition" proposal. J Biol Chem 1978 0.75
129 Hydrolysis of ribonucleoside 3'-diphosphates by rye grass 3'-nucleotidase. Biochemistry 1975 0.75
130 Design and preparation of affinity columns for the purification of eukaryotic messenger ribonucleic acid cap binding protein. Biochemistry 1981 0.75
131 Preparation of tRNAs terminating in 2'- and 3'- deoxyadenosine. Methods Enzymol 1979 0.75
132 Cytokinin activity in tRNA-Phe. Biochem Biophys Res Commun 1970 0.75
133 Effects of camptothecin analogues on DNA transformations mediated by calf thymus and human DNA topoisomerases I. Chem Res Toxicol 1998 0.75
134 Photoactivated DNA cleavage by compounds structurally related to the bithiazole moiety of bleomycin. Bioorg Med Chem 2001 0.75
135 Mass spectra of some heterocycles related to N 6 -( 2 -isopentenyl)adenosine. Anal Biochem 1971 0.75
136 [Effect of the antitumor antibiotic bleomycin on nuclear structure: sedimentation studies]. Rev Esp Fisiol 1981 0.75
137 DNA duplexes containing 3'-deoxynucleotides as substrates for DNA topoisomerase I cleavage and ligation. J Biol Chem 1998 0.75
138 Mass spectra of some 6-substituted ureidopurines and N 6 -acyladenines. Anal Biochem 1972 0.75
139 Kinetics of the bleomycin A2 damage in vivo to the folded chromosome of Escherichia coli. Chem Biol Interact 1983 0.75
140 Studies toward the site specific incorporation of sugars into proteins: synthesis of glycosylated aminoacyl-tRNAs. Carbohydr Res 2001 0.75
141 Transfer RNA control of the activation of isomeric tRNATrp's. J Biol Chem 1979 0.75
142 Mass spectrometric identification of some prenylaminopurines. Biochim Biophys Acta 1970 0.75
143 Isoenergetic hydride transfer. A reversible tRNA modification with concomitant alteration of biochemical properties. J Biol Chem 1978 0.75
144 Stereochemistry of of nucleic acids and their constituents. XXVI. The crystal and molecular structure of a 1:1 adduct of ethanol and 3'-deoxy-3'-(dihydroxyphosphinylmethyl)adenosine, an analog of adenosine 3'-monophosphate. J Am Chem Soc 1972 0.75
145 STUDIES OF THE CYCLIZATIONS OF AN O-(alpha-METHYLALLYL)PHENOL AND THE CORRESPONDING METHYL ETHER INDUCED BY ELECTROPHILIC REAGENTS. Proc Natl Acad Sci U S A 1965 0.75
146 Substrate specificity of bleomycin hydrolase. Biochem Pharmacol 1989 0.75
147 Synthesis and biological activity of pyrazolo[3,4,-d]pyrimidine nucleosides and nucleotides related to tubercidin, toyocamycin, and sangivamycin. Biochemistry 1976 0.75
148 Mass spectra of ribonucleoside components of tRNA. II. Anal Biochem 1970 0.75
149 Bleomycin may be activated for DNA cleavage by NADPH-cytochrome P-450 reductase. Biochemistry 1984 0.75
150 Multiple pathways in the oxidation of cis-stilbene by iron-bleomycin. J Am Chem Soc 1986 0.75
151 Preparation of Escherichia coli tRNAs terminating of modified nucleosides by the use of CTP(ATP):tRNA nucleotidyltransferase and polynucleotide phosphorylase. Biochemistry 1977 0.75
152 Isoenergetic hydride transfer. A reversible, phase transition mediated tRNA modification. J Am Chem Soc 1977 0.75
153 5-Alkylresorcinols from Hakea amplexicaulis that cleave DNA. Chem Res Toxicol 1992 0.75
154 Chemical modifications of transfer RNA species. Metal ion binding to monoperphthalate-treated tRNA. Biochem Biophys Res Commun 1971 0.75
155 Structure and chemistry of alkali-labile product formed during Fe(II)-bleomycin-mediated DNA strand scission. Nucleic Acids Symp Ser 1986 0.75