Published in J Neurosci on June 15, 2003
Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers. FASEB J (2007) 1.89
Morphine-like opiates selectively antagonize receptor-arrestin interactions. J Biol Chem (2010) 1.45
Opioid-receptor-heteromer-specific trafficking and pharmacology. Curr Opin Pharmacol (2009) 1.36
How to design an opioid drug that causes reduced tolerance and dependence. Ann Neurol (2010) 1.09
Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia. Neuroscience (2007) 1.09
Augmentation of morphine-induced sensitization but reduction in morphine tolerance and reward in delta-opioid receptor knockout mice. Neuropsychopharmacology (2008) 1.06
Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents. Neuroscience (2009) 1.03
Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide. ACS Chem Biol (2011) 1.03
Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli. J Neurosci (2011) 1.02
Coexpression of alpha 2A-adrenergic and delta-opioid receptors in substance P-containing terminals in rat dorsal horn. J Comp Neurol (2009) 1.02
Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches. Behav Pharmacol (2011) 1.02
Opioid receptor heteromers in analgesia. Expert Rev Mol Med (2012) 0.94
Hormonal regulation of delta opioid receptor immunoreactivity in interneurons and pyramidal cells in the rat hippocampus. Neurobiol Learn Mem (2011) 0.93
An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans. Neuropsychopharmacology (2013) 0.92
Trafficking of central opioid receptors and descending pain inhibition. Mol Pain (2007) 0.92
Comparing analgesia and mu-opioid receptor internalization produced by intrathecal enkephalin: requirement for peptidase inhibition. Neuropharmacology (2007) 0.91
In vivo trafficking of endogenous opioid receptors. Life Sci (2008) 0.91
Recent advances on the δ opioid receptor: from trafficking to function. Br J Pharmacol (2014) 0.90
Functional relevance of μ-δ opioid receptor heteromerization: a role in novel signaling and implications for the treatment of addiction disorders: from a symposium on new concepts in mu-opioid pharmacology. Drug Alcohol Depend (2011) 0.85
Pharmacological traits of delta opioid receptors: pitfalls or opportunities? Psychopharmacology (Berl) (2013) 0.84
Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance. Mol Pain (2007) 0.84
Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur J Neurosci (2010) 0.83
Peripheral δ-opioid receptors attenuate the exercise pressor reflex. Am J Physiol Heart Circ Physiol (2013) 0.82
Spinal μ and δ opioids inhibit both thermal and mechanical pain in rats. J Neurosci (2013) 0.82
Antibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and function. Front Pharmacol (2014) 0.82
Accelerated kindling development in mu-opioid receptor deficient mice. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.81
Behavioral consequences of delta-opioid receptor activation in the periaqueductal gray of morphine tolerant rats. Neural Plast (2009) 0.81
Analgesic synergy between opioid and α2 -adrenoceptors. Br J Pharmacol (2014) 0.81
In vivo opioid receptor heteromerization: where do we stand? Br J Pharmacol (2014) 0.80
Molecular Pharmacology of δ-Opioid Receptors. Pharmacol Rev (2016) 0.80
The role of δ-opioid receptors in learning and memory underlying the development of addiction. Br J Pharmacol (2014) 0.79
Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking. Br J Pharmacol (2014) 0.79
Molecular Perspectives for mu/delta Opioid Receptor Heteromers as Distinct, Functional Receptors. Cells (2014) 0.79
Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn. Mol Pain (2010) 0.79
Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5. Br J Pharmacol (2015) 0.78
Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors. Br J Pharmacol (2014) 0.77
Modulation of delta opioid agonist-induced antinociception by repeated morphine pretreatment in rhesus monkeys. Life Sci (2010) 0.76
Antinociceptive effects of two deltorphins analogs in the tail-immersion test in rats. Peptides (2012) 0.76
Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain. Eur J Neurosci (2015) 0.76
Impact of chronic morphine on delta opioid receptor-expressing neurons in the mouse hippocampus. Neuroscience (2015) 0.75
The delta opioid receptor tool box. Neuroscience (2016) 0.75
In vivo techniques to investigate the internalization profile of opioid receptors. Methods Mol Biol (2015) 0.75
Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell (2009) 3.61
Deficit in attachment behavior in mice lacking the mu-opioid receptor gene. Science (2004) 2.76
Reward processing by the opioid system in the brain. Physiol Rev (2009) 2.46
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis. Nat Neurosci (2013) 2.37
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem (2002) 2.00
Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A (2006) 1.95
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain (2011) 1.90
Increased abundance of opioid receptor heteromers after chronic morphine administration. Sci Signal (2010) 1.90
Neuropathic pain: a practical guide for the clinician. CMAJ (2006) 1.79
Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells. Hum Mol Genet (2005) 1.72
In vivo delta opioid receptor internalization controls behavioral effects of agonists. PLoS One (2009) 1.70
TNF-alpha and neuropathic pain--a review. J Neuroinflammation (2010) 1.68
Sex and gender reporting in health research: why Canada should be a leader. Can J Public Health (2012) 1.67
The delta opioid receptor: an evolving target for the treatment of brain disorders. Trends Pharmacol Sci (2011) 1.60
Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. J Neurosci (2003) 1.59
Deletion of mu- and kappa-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior. J Invest Dermatol (2006) 1.54
Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases. Pharmacol Ther (2007) 1.54
Mu opioid receptor: a gateway to drug addiction. Curr Opin Neurobiol (2004) 1.53
Morphine and pain-related stimuli enhance cell surface availability of somatic delta-opioid receptors in rat dorsal root ganglia. J Neurosci (2006) 1.43
Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation. J Clin Invest (2003) 1.40
The cognitive and neurophysiological basis of emotion dysregulation in bipolar disorder. J Affect Disord (2007) 1.38
Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice. J Neurosci (2002) 1.32
Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence. J Pharmacol Exp Ther (2003) 1.32
Opioid receptors: distinct roles in mood disorders. Trends Neurosci (2012) 1.31
Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl. RNA (2007) 1.24
Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors. J Neurosci (2002) 1.24
The global alliance for chronic diseases. Science (2009) 1.23
Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance. J Neurosci (2010) 1.21
Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1. J Biol Chem (2010) 1.20
Identification of a novel family of G protein-coupled receptor associated sorting proteins. J Neurochem (2004) 1.20
RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A (2006) 1.19
The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice. Eur J Neurosci (2004) 1.19
Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice. Alcohol Clin Exp Res (2005) 1.17
Phylogenetic changes in the expression of delta opioid receptors in spinal cord and dorsal root ganglia. J Comp Neurol (2003) 1.15
Inflammatory pain is enhanced in delta opioid receptor-knockout mice. Eur J Neurosci (2008) 1.14
Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine. Biol Psychiatry (2010) 1.14
Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation. Nat Struct Biol (2003) 1.13
Ligand-directed signalling within the opioid receptor family. Br J Pharmacol (2012) 1.13
Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene". Diabetes (2005) 1.12
Neuropathic pain is enhanced in delta-opioid receptor knockout mice. Eur J Neurosci (2006) 1.12
Interactions with PDZ domain proteins PIST/GOPC and PDZK1 regulate intracellular sorting of the somatostatin receptor subtype 5. J Biol Chem (2005) 1.11
Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system. J Comp Neurol (2003) 1.10
Spinal administration of a delta opioid receptor agonist attenuates hyperalgesia and allodynia in a rat model of neuropathic pain. Eur J Pain (2006) 1.10
Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice. Brain Res (2002) 1.10
Deletion of the δ opioid receptor gene impairs place conditioning but preserves morphine reinforcement. Biol Psychiatry (2010) 1.09
Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. J Neurochem (2002) 1.08
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. Nat Neurosci (2011) 1.08
Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats. Mol Pain (2010) 1.08
Generation and characterization of Rgs4 mutant mice. Mol Cell Biol (2005) 1.08
Dehydration-induced cross-regulation of apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neurons. Endocrinology (2004) 1.03
Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus. J Neurosci (2008) 1.03
Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord. J Neurosci (2004) 1.02
Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons. Mol Pharmacol (2005) 1.01
Mu and delta opioid receptors oppositely regulate motor impulsivity in the signaled nose poke task. PLoS One (2009) 1.01
Mu-opioid receptor knockout prevents changes in delta-opioid receptor trafficking induced by chronic inflammatory pain. Pain (2004) 1.01
Decreased motivation to eat in mu-opioid receptor-deficient mice. Eur J Neurosci (2007) 1.01
Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice. Eur J Pharmacol (2002) 1.00
A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Struct Funct (2014) 1.00
The multiple facets of opioid receptor function: implications for addiction. Curr Opin Neurobiol (2013) 0.99
Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease. Biochem Soc Trans (2008) 0.99
Mutational inactivation of two distinct negative RNA elements in the human papillomavirus type 16 L2 coding region induces production of high levels of L2 in human cells. J Virol (2003) 0.98
Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones. Eur J Neurosci (2003) 0.98
Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity. Neuropharmacology (2007) 0.98
15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse. Neuropharmacology (2013) 0.97
Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms. Neurobiol Learn Mem (2009) 0.97
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine. Eur J Pharmacol (2007) 0.97
Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system. J Comp Neurol (2003) 0.97
Presynaptic delta opioid receptors regulate ethanol actions in central amygdala. J Pharmacol Exp Ther (2006) 0.96
Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology. Recent Dev Alcohol (2003) 0.95
Agonist- and antagonist-induced sequestration/internalization of neuropeptide Y Y1 receptors in HEK293 cells. Br J Pharmacol (2003) 0.95
Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice. Neuropsychopharmacology (2005) 0.95
Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice. Eur J Neurosci (2003) 0.95
The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen. J Neural Transm (Vienna) (2011) 0.94
The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression. Parkinsons Dis (2012) 0.94
Chronobiological characteristics of painful diabetic neuropathy and postherpetic neuralgia: diurnal pain variation and effects of analgesic therapy. Pain (2005) 0.94
Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor. J Neurochem (2006) 0.94
Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking. J Biol Chem (2004) 0.92
"Getting physical": the management of neuropsychiatric disorders using novel physical treatments. Neuropsychiatr Dis Treat (2006) 0.92
The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference. Neuropharmacology (2007) 0.92
Executive functioning and theory of mind in euthymic bipolar disorder. Bipolar Disord (2005) 0.92
Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening. BMC Pharmacol (2003) 0.92
The acute box cis-element in human heavy ferritin mRNA 5'-untranslated region is a unique translation enhancer that binds poly(C)-binding proteins. J Biol Chem (2005) 0.92
Prolonged morphine treatment selectively increases membrane recruitment of delta-opioid receptors in mouse basal ganglia. J Mol Neurosci (2005) 0.92
Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation. J Biol Chem (2003) 0.92
Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia. Biol Psychiatry (2007) 0.92
δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization. J Pharmacol Exp Ther (2012) 0.91
Delta opioid receptors in brain function and diseases. Pharmacol Ther (2013) 0.91
Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors. J Neurosci (2005) 0.91
Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells. Int J Biochem Cell Biol (2004) 0.91
Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network. Addict Biol (2011) 0.91
Mu-opioid receptors are involved in the tolerance to nicotine antinociception. J Neurochem (2006) 0.90
Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2. Mol Pharmacol (2004) 0.90
The second extracellular loop: a damper for G protein-coupled receptors? Nat Struct Mol Biol (2005) 0.90
Remodelling of spinal nociceptive mechanisms in an animal model of monoarthritis. Eur J Neurosci (2005) 0.90
Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist. J Med Chem (2002) 0.90