Published in J Lipid Res on July 01, 2003
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins. Proc Natl Acad Sci U S A (2007) 4.05
Apolipoprotein E but not B is required for the formation of infectious hepatitis C virus particles. J Virol (2009) 2.00
Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution. Biochemistry (2007) 1.94
Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci U S A (2006) 1.79
Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. PLoS Pathog (2007) 1.56
Multiple functions of microsomal triglyceride transfer protein. Nutr Metab (Lond) (2012) 1.47
Secretion of hepatitis C virus envelope glycoproteins depends on assembly of apolipoprotein B positive lipoproteins. PLoS One (2009) 1.31
New approaches to target microsomal triglyceride transfer protein. Curr Opin Lipidol (2008) 1.18
Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia. J Lipid Res (2009) 1.13
Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. J Biol Chem (2012) 1.11
Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition. J Biol Chem (2008) 1.05
The role of the carbohydrate response element-binding protein in male fructose-fed rats. Endocrinology (2012) 1.00
JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs. BMC Cardiovasc Disord (2005) 0.98
Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice. Am J Physiol Heart Circ Physiol (2008) 0.98
Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST. J Biol Chem (2013) 0.97
Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Mol Cell Biol (2009) 0.97
The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species. J Lipid Res (2011) 0.95
Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP). Nutr Metab (Lond) (2010) 0.94
Targeting host factors: a novel rationale for the management of hepatitis C virus. World J Gastroenterol (2009) 0.93
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci U S A (2016) 0.91
New treatments for chronic hepatitis C. Korean J Hepatol (2010) 0.89
Quantifying apoprotein synthesis in rodents: coupling LC-MS/MS analyses with the administration of labeled water. J Lipid Res (2012) 0.88
Hepatitis C virus: a new class of virus associated with particles derived from very low-density lipoproteins. Arterioscler Thromb Vasc Biol (2012) 0.85
Acute suppression of apo B secretion by insulin occurs independently of MTP. Biochem Biophys Res Commun (2011) 0.84
Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes. PLoS One (2015) 0.83
Pharmacologic inhibition of phospholipid transfer protein activity reduces apolipoprotein-B secretion from hepatocytes. J Pharmacol Exp Ther (2009) 0.81
Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing. J Lipid Res (2012) 0.81
Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity. Mol Endocrinol (2015) 0.81
Postprandial changes in high density lipoproteins in rats subjected to gavage administration of virgin olive oil. PLoS One (2013) 0.80
ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5). Lipids (2011) 0.79
Does inhibition of apolipoprotein B synthesis produce foie gras? J Lipid Res (2009) 0.76
The Serum Very-Low-Density Lipoprotein Serves as a Restriction Factor against Hepatitis C Virus Infection. J Virol (2015) 0.76
Identification and characterization of dual inhibitors for phospholipid transfer protein and microsomal triglyceride transfer protein. J Pharmacol Exp Ther (2010) 0.76
The Constitutive Lipid Droplet Protein Plin2 Regulates Autophagy in Liver. Autophagy (2017) 0.75
Dirlotapide, a U.S. Food and Drug Administration-approved first-in-class obesity drug for dogs-will humans be next? J Diabetes Sci Technol (2007) 0.75
Camphene, a Plant Derived Monoterpene, Exerts Its Hypolipidemic Action by Affecting SREBP-1 and MTP Expression. PLoS One (2016) 0.75
Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med (2010) 14.43
Contribution of SHANK3 mutations to autism spectrum disorder. Am J Hum Genet (2007) 5.04
Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J Am Coll Cardiol (2005) 3.53
Safety and efficacy of eplerenone in patients at high risk for hyperkalemia and/or worsening renal function: analyses of the EMPHASIS-HF study subgroups (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure). J Am Coll Cardiol (2013) 1.83
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore. Proc Natl Acad Sci U S A (2009) 1.82
Acetyl-coenzyme A carboxylases: versatile targets for drug discovery. J Cell Biochem (2006) 1.77
Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study. J Am Coll Cardiol (2012) 1.71
Old world nonhuman primate models of type 2 diabetes mellitus. ILAR J (2006) 1.70
Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther (2008) 1.17
AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res (2010) 1.10
Eplerenone in patients with systolic heart failure and mild symptoms: analysis of repeat hospitalizations. Circulation (2012) 1.06
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. J Med Chem (2010) 1.05
Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS-HF). Eur J Heart Fail (2010) 1.02
Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg Med Chem Lett (2007) 1.01
Association of obesity and survival in systolic heart failure after acute myocardial infarction: potential confounding by age. Eur J Heart Fail (2010) 0.99
Species independence in brain tissue binding using brain homogenates. Drug Metab Dispos (2011) 0.97
A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys. J Pharmacol Exp Ther (2010) 0.91
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design. Eur J Med Chem (2012) 0.90
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos (2006) 0.89
Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state. Expert Opin Drug Metab Toxicol (2010) 0.88
Self-expandable metal stents (SEMS) can serve as a bridge to surgery or as a definitive therapy in patients with an advanced stage of cancer: clinical experience of a tertiary cancer center. Dig Dis Sci (2010) 0.88
Salvage surgery for locally recurrent prostate cancer after radiation therapy: tricks of the trade. Urol Oncol (2007) 0.88
Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage. Hum Mol Genet (2010) 0.86
Extraction of tacit knowledge from large ADME data sets via pairwise analysis. Bioorg Med Chem (2011) 0.86
5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization. Bioorg Med Chem Lett (2005) 0.85
Pharmacokinetics of 18F-labeled trovafloxacin in normal and Escherichia coli-infected rats and rabbits studied with positron emission tomography. Clin Microbiol Infect (1997) 0.85
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg Med Chem Lett (2009) 0.85
Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion. Drug Metab Dispos (2012) 0.85
The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet (2010) 0.84
Influence of range of motion in resistance training in women: early phase adaptations. J Strength Cond Res (2005) 0.82
Microsomal triglyceride transfer protein (MTP) inhibitors: discovery of clinically active inhibitors using high-throughput screening and parallel synthesis paradigms. Curr Opin Drug Discov Devel (2002) 0.82
Eplerenone and new-onset diabetes in patients with mild heart failure: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF). Eur J Heart Fail (2012) 0.82
Pharmacologic inhibition of phospholipid transfer protein activity reduces apolipoprotein-B secretion from hepatocytes. J Pharmacol Exp Ther (2009) 0.81
Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation. J Neurosci Methods (2007) 0.81
Timing of eplerenone initiation and outcomes in patients with heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction: insights from the EPHESUS trial. Eur J Heart Fail (2009) 0.81
A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys. J Pharmacol Exp Ther (2010) 0.81
Impact of an integrated intervention program on atorvastatin adherence: a randomized controlled trial. Int J Gen Med (2013) 0.79
In vitro-in vivo correlation and translation to the clinical outcome for CJ-13,610, a novel inhibitor of 5-lipoxygenase. Drug Metab Dispos (2010) 0.78
Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor. Am J Physiol Heart Circ Physiol (2003) 0.78
Assessment of in silico models for fraction of unbound drug in human liver microsomes. Expert Opin Drug Metab Toxicol (2010) 0.78
The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial. Eur Heart J (2013) 0.78
Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeys. Metabolism (2011) 0.77
Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase. J Lipid Res (2004) 0.76
Identification and characterization of dual inhibitors for phospholipid transfer protein and microsomal triglyceride transfer protein. J Pharmacol Exp Ther (2010) 0.76
Pharmacokinetics of 18F-labeled trovafloxacin in normal and Escherichia coli-infected rats and rabbits studied with positron emission tomography. Clin Microbiol Infect (1997) 0.76
An analysis of full range of motion vs. partial range of motion training in the development of strength in untrained men. J Strength Cond Res (2004) 0.76
Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy: analysis of the EMPHASIS-HF study. Circ Heart Fail (2013) 0.75
Homophobic and sexist yet uncontested: examining football fan postings on Internet message boards. J Homosex (2011) 0.75
Interview with John Vincent, Ph.D. Rejuvenation Res (2009) 0.75
Differential Allelic Expression of HTR1B in Suicide Victims: Genetic and Epigenetic Effect of the Cis-Acting Variants. Neuropsychobiology (2017) 0.75
An analysis of teaching and coaching behaviors of elite strength and conditioning coaches. J Strength Cond Res (2002) 0.75
A job analysis of major college female strength and conditioning coaches. J Strength Cond Res (2013) 0.75
Job analysis of college Division I-A football strength and conditioning coaches. J Strength Cond Res (2004) 0.75
Effects of food on a gastrically degraded drug: azithromycin fast-dissolving gelatin capsules and HPMC capsules. Pharm Res (2011) 0.75