Nigel D F Grindley

Author PubWeight™ 26.99‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 An open letter to Elias Zerhouni. Science 2005 2.19
2 Fingers-closing and other rapid conformational changes in DNA polymerase I (Klenow fragment) and their role in nucleotide selectivity. Biochemistry 2008 2.14
3 Conformational transitions in DNA polymerase I revealed by single-molecule FRET. Proc Natl Acad Sci U S A 2009 2.10
4 Use of 2-aminopurine fluorescence to examine conformational changes during nucleotide incorporation by DNA polymerase I (Klenow fragment). Biochemistry 2003 2.02
5 Structure of a synaptic gammadelta resolvase tetramer covalently linked to two cleaved DNAs. Science 2005 1.73
6 Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase. Proc Natl Acad Sci U S A 2011 1.52
7 An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a 'steric gate' residue for discrimination against ribonucleotides. Nucleic Acids Res 2003 1.44
8 The mutational specificity of the Dbh lesion bypass polymerase and its implications. J Biol Chem 2002 1.23
9 DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics. Biochemistry 2006 1.23
10 Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination. Proc Natl Acad Sci U S A 2006 1.17
11 Discrimination against purine-pyrimidine mispairs in the polymerase active site of DNA polymerase I: a structural explanation. Proc Natl Acad Sci U S A 2002 1.13
12 The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases. J Biol Chem 2006 1.09
13 Distinct roles of the active-site Mg2+ ligands, Asp882 and Asp705, of DNA polymerase I (Klenow fragment) during the prechemistry conformational transitions. J Biol Chem 2010 1.08
14 Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion. Nat Commun 2013 1.06
15 Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end. Proc Natl Acad Sci U S A 2012 1.04
16 Conformational changes during normal and error-prone incorporation of nucleotides by a Y-family DNA polymerase detected by 2-aminopurine fluorescence. Biochemistry 2007 1.04
17 Interaction of DNA polymerase I (Klenow fragment) with the single-stranded template beyond the site of synthesis. Biochemistry 2003 0.95
18 Cryptic plasmids of Mycobacterium avium: Tn552 to the rescue. Mol Microbiol 2002 0.88
19 The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates. Mol Cell 2003 0.84
20 Prechemistry nucleotide selection checkpoints in the reaction pathway of DNA polymerase I and roles of glu710 and tyr766. Biochemistry 2013 0.80
21 The left end of IS2: a compromise between transpositional activity and an essential promoter function that regulates the transposition pathway. J Bacteriol 2004 0.78
22 Chemical shift mapping of gammadelta resolvase dimer and activated tetramer: mechanistic implications for DNA strand exchange. Biochim Biophys Acta 2008 0.75