Published in Clin Microbiol Rev on July 01, 2003
The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med (2008) 3.31
Analysis of core housekeeping and virulence genes reveals cryptic lineages of Clostridium perfringens that are associated with distinct disease presentations. Genetics (2006) 1.04
Rapid cytopathic effects of Clostridium perfringens beta-toxin on porcine endothelial cells. Infect Immun (2010) 0.94
Therapeutic plasma exchange as rescue therapy in severe sepsis and septic shock: retrospective observational single-centre study of 23 patients. BMC Anesthesiol (2014) 0.87
The cysteine protease α-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis. PLoS One (2011) 0.84
Pathology of fatal traumatic and nontraumatic clostridial gas gangrene: a histopathological, immunohistochemical, and ultrastructural study of six autopsy cases. Int J Legal Med (2007) 0.82
Vibrio vulnificus secretes a broad-specificity metalloprotease capable of interfering with blood homeostasis through prothrombin activation and fibrinolysis. J Bacteriol (2005) 0.82
The pore-forming α-toxin from clostridium septicum activates the MAPK pathway in a Ras-c-Raf-dependent and independent manner. Toxins (Basel) (2015) 0.81
Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors. PLoS Pathog (2015) 0.81
Clostridium perfringens α-Toxin Impairs Innate Immunity via Inhibition of Neutrophil Differentiation. Sci Rep (2016) 0.78
The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms. Infect Immun (2015) 0.77
Evasion and interactions of the humoral innate immune response in pathogen invasion, autoimmune disease, and cancer. Clin Immunol (2015) 0.75
Comparing culture and molecular methods for the identification of microorganisms involved in necrotizing soft tissue infections. BMC Infect Dis (2016) 0.75
Clostridium perfringens α-toxin impairs erythropoiesis by inhibition of erythroid differentiation. Sci Rep (2017) 0.75
The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58
Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med (2001) 27.70
Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A. N Engl J Med (1989) 8.01
Thrombotic microangiopathies. N Engl J Med (2002) 6.01
Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med (1984) 5.89
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA (2001) 5.86
Invasive group A streptococcus infections. Clin Infect Dis (1992) 4.82
Streptococcal infections of skin and soft tissues. N Engl J Med (1996) 4.78
Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med (2001) 4.10
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J Cell Biol (1992) 4.06
The histotoxic clostridial infections of man. Bacteriol Rev (1962) 4.06
Defining the group A streptococcal toxic shock syndrome. Rationale and consensus definition. The Working Group on Severe Streptococcal Infections. JAMA (1993) 3.70
Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen. Proc Natl Acad Sci U S A (1988) 3.25
Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci U S A (1999) 2.98
Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes. Proc Natl Acad Sci U S A (1993) 2.92
Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med (1990) 2.82
Receptor-mediated calcium entry in fura-2-loaded human platelets stimulated with ADP and thrombin. Dual-wavelengths studies with Mn2+. Biochem J (1989) 2.73
Mechanisms initiating platelet thrombus formation. Thromb Haemost (1997) 2.73
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature (1992) 2.48
Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection. J Clin Invest (1998) 2.47
Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen. J Cell Biol (1988) 2.28
Vascular-bed--specific hemostasis and hypercoagulable states. N Engl J Med (1999) 2.21
Antithrombin III in patients with severe sepsis. A randomized, placebo-controlled, double-blind multicenter trial plus a meta-analysis on all randomized, placebo-controlled, double-blind trials with antithrombin III in severe sepsis. Intensive Care Med (1998) 2.12
Molecular analysis of pyrogenic exotoxins from Streptococcus pyogenes isolates associated with toxic shock-like syndrome. J Clin Microbiol (1991) 2.07
Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem (1988) 2.04
Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock. J Clin Invest (1993) 2.00
Increased tissue thromboplastin activity in monocytes of patients with meningococcal infection: related to an unfavourable prognosis. Thromb Haemost (1983) 1.96
Platelet function in septic multiple organ dysfunction syndrome. Intensive Care Med (1997) 1.91
The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor. J Biol Chem (1988) 1.89
Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease. Blood (1998) 1.79
Identification of a specific receptor for plasmin on a group A streptococcus. Infect Immun (1987) 1.72
Staging of the baboon response to group A streptococci administered intramuscularly: a descriptive study of the clinical symptoms and clinical chemical response patterns. Clin Infect Dis (1999) 1.71
Genetic and phenotypic diversity among isolates of Streptococcus pyogenes from invasive infections. J Infect Dis (1996) 1.71
Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem (1996) 1.70
Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees. J Exp Med (1994) 1.64
Contact activation in shock caused by invasive group A Streptococcus pyogenes. Crit Care Med (2000) 1.60
Heparin inhibits ligand binding to the leukocyte integrin Mac-1 (CD11b/CD18). Circulation (1999) 1.58
The activity of tissue factor pathway inhibitor in experimental models of superantigen-induced shock and polymicrobial intra-abdominal sepsis. Crit Care Med (2001) 1.57
Tissue factor pathway inhibitor and the revised theory of coagulation. Annu Rev Med (1995) 1.54
Review: infectious diseases and coagulation disorders. J Infect Dis (1999) 1.50
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. J Clin Invest (1997) 1.49
Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system. J Immunol (1995) 1.48
Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. Circulation (1997) 1.47
Tissue factor is a major stimulus for vegetation formation in enterococcal endocarditis in rabbits. J Clin Invest (1984) 1.46
Regulation of endothelial cell coagulant properties. Modulation of tissue factor, plasminogen activator inhibitors, and thrombomodulin by phorbol 12-myristate 13-acetate and tumor necrosis factor. J Biol Chem (1989) 1.44
Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study. Crit Care Med (2001) 1.41
Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons. Am J Respir Crit Care Med (2001) 1.39
Lethal effects and cardiovascular effects of purified alpha- and theta-toxins from Clostridium perfringens. J Infect Dis (1988) 1.36
Influence of recombination and niche separation on the population genetic structure of the pathogen Streptococcus pyogenes. Infect Immun (2002) 1.31
The actin cytoskeleton in store-mediated calcium entry. J Physiol (2000) 1.29
Mediation of adherence of streptococci to human endothelial cells by complement S protein (vitronectin). Infect Immun (1988) 1.27
Chlamydia species infect human vascular endothelial cells and induce procoagulant activity. J Investig Med (1997) 1.27
Intracellular transport mechanisms of signal transducers. Annu Rev Physiol (2002) 1.26
Streptococcal cysteine protease augments lung injury induced by products of group A streptococci. Infect Immun (1996) 1.25
The effect of leukocyte elastase on tissue factor pathway inhibitor. Blood (1992) 1.22
Activation of human endothelial cells by viable or heat-killed gram-negative bacteria requires soluble CD14. Infect Immun (1995) 1.15
Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens. J Infect Dis (2000) 1.12
Clostridium perfringens invasiveness is enhanced by effects of theta toxin upon PMNL structure and function: the roles of leukocytotoxicity and expression of CD11/CD18 adherence glycoprotein. FEMS Immunol Med Microbiol (1993) 1.11
Group A streptococcal bacteremia: the role of tumor necrosis factor in shock and organ failure. J Infect Dis (1996) 1.10
Regulatory role of cytokines in disseminated intravascular coagulation. Semin Thromb Hemost (2001) 1.09
Antithrombin, heparin, and heparan sulfate. Crit Care Med (2002) 1.09
Circulating platelet-neutrophil complexes represent a subpopulation of activated neutrophils primed for adhesion, phagocytosis and intracellular killing. Br J Haematol (1999) 1.07
Clostridial gas gangrene. II. Phospholipase C-induced activation of platelet gpIIbIIIa mediates vascular occlusion and myonecrosis in Clostridium perfringens gas gangrene. J Infect Dis (2000) 1.07
Xa receptor EPR-1. FASEB J (1995) 1.06
Platelet activation. Blood Rev (1995) 1.06
Tumor necrosis factor infusions have a procoagulant effect on the hemostatic mechanism of humans. Blood (1989) 1.03
Recent advances in platelet-polymorphonuclear leukocyte interaction. Haemostasis (1999) 1.02
Recent developments in non-excitable cell calcium entry. Cell Calcium (2001) 1.02
Bacterial species- and strain-dependent induction of tissue factor in human vascular endothelial cells. Infect Immun (1999) 0.98
The TF:VIIa complex: clinical significance, structure-function relationships and its role in signaling and metastasis. Thromb Haemost (2001) 0.96
Antithrombin inhibits lipopolysaccharide-induced tissue factor and interleukin-6 production by mononuclear cells, human umbilical vein endothelial cells, and whole blood. Crit Care Med (2001) 0.96
Neutrophil depletion suppresses 111In-labeled platelet accumulation in infarcted myocardium. J Cardiovasc Pharmacol (1985) 0.95
Platelet Ca2+-activated, phospholipid-dependent protein kinase: evidence for proteolytic activation of the enzyme in cells treated with phospholipase C1. Biochem Biophys Res Commun (1984) 0.94
Analysis of plasmin(ogen) acquisition by clinical isolates of group A streptococci incubated in human plasma. J Infect Dis (1994) 0.94
Endothelium and disordered fibrin turnover in the injured lung: newly recognized pathways. Crit Care Med (2002) 0.93
IL-10 regulates thrombus-induced vein wall inflammation and thrombosis. J Immunol (1998) 0.92
The tissue factor pathway in disseminated intravascular coagulation. Semin Thromb Hemost (2001) 0.92
The platelet glycoprotein IIb/IIIa complex is involved in the adhesion of activated platelets to leukocytes. Thromb Haemost (1993) 0.92
Modulation of human endothelial thrombomodulin by neutrophils and their release products. Am J Respir Crit Care Med (1997) 0.90
THE METHOD OF SPREAD OF GAS GANGRENE INTO LIVING MUSCLE. Br Med J (1917) 0.90
Quality of life effects of antithrombin III in sepsis survivors: results from the KyberSept trial [ISRCTN22931023]. Crit Care (2002) 0.89
Contact-induced neutrophil activation by platelets in human cell suspensions and whole blood. Blood (1992) 0.89
Activation of Mac-1 (CD11b/CD18)-bound factor X by released cathepsin G defines an alternative pathway of leucocyte initiation of coagulation. Biochem J (1996) 0.88
The hemopexin-type repeats of human vitronectin are recognized by Streptococcus pyogenes. Biochem Biophys Res Commun (1997) 0.87
M type 1 and 3 group A streptococci stimulate tissue factor-mediated procoagulant activity in human monocytes and endothelial cells. Infect Immun (2003) 0.86
Activation of platelet gpIIbIIIa by phospholipase C from Clostridium perfringens involves store-operated calcium entry. J Infect Dis (2003) 0.86
Transcellular metabolism of arachidonic acid: increased platelet thromboxane generation in the presence of activated polymorphonuclear leukocytes. Blood (1992) 0.85
Herpes simplex virus and atherosclerosis. Eur Heart J (1993) 0.84
Signaling by E-selectin and ICAM-1 induces endothelial tissue factor production via autocrine secretion of platelet-activating factor and tumor necrosis factor alpha. J Interferon Cytokine Res (1995) 0.84
Interleukin-4 counteracts pyrogen-induced downregulation of thrombomodulin in cultured human vascular endothelial cells. Blood (1991) 0.84
Kallikrein-kinin system activation in streptococcal toxic shock syndrome. Clin Infect Dis (2000) 0.83
Mononuclear phagocyte thromboplastin and endotoxin in patients with secondary bacterial peritonitis. Scand J Gastroenterol (1987) 0.83
Mechanism of tissue factor activation on cells. Blood Coagul Fibrinolysis (1998) 0.83
Inhibition of IL-1 induced tissue factor (TF) synthesis and procoagulant activity (PCA) in purified human monocytes by IL-4, IL-10 and IL-13. Cytokine (1996) 0.82
Experimental and emerging therapies for sepsis and septic shock. Expert Opin Investig Drugs (2001) 0.81
Variations among clinical isolates of Staphylococcus aureus to induce expression of E-selectin and ICAM-1 in human endothelial cells. FEMS Immunol Med Microbiol (2002) 0.80
Role of free protein S and C4b binding protein in regulating the coagulant response to Escherichia coli. Blood (1995) 0.80