From sarcomeric mutations to heart disease: understanding familial hypertrophic cardiomyopathy.

PubWeight™: 0.84‹?›

🔗 View Article (PMID 12858566)

Published in Cold Spring Harb Symp Quant Biol on January 01, 2002

Authors

A Maass1, J P Konhilas, B L Stauffer, L A Leinwand

Author Affiliations

1: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA.

Articles by these authors

(truncated to the top 100)

Using mini-prep plasmid DNA for sequencing double stranded templates with Sequenase. Biotechniques (1988) 10.14

Myosin heavy chain isoform expression in the failing and nonfailing human heart. Circ Res (2000) 3.08

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix. Proc Natl Acad Sci U S A (1984) 2.64

Myosin heavy chain gene expression in human heart failure. J Clin Invest (1997) 2.39

Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse. J Appl Physiol (1985) (2001) 2.24

Human cardiac myosin heavy chain genes and their linkage in the genome. Nucleic Acids Res (1987) 2.22

The mammalian myosin heavy chain gene family. Annu Rev Cell Dev Biol (1996) 2.20

Conserved protein domains in a myosin heavy chain gene from Dictyostelium discoideum. Proc Natl Acad Sci U S A (1986) 2.05

Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on Heart Failure Research. Circulation (1997) 2.00

Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J Clin Invest (1999) 1.95

Functional analysis of human cardiac gap junction channel mutants. Proc Natl Acad Sci U S A (1991) 1.94

Echocardiographic assessment of left ventricular mass and systolic function in mice. Circ Res (1995) 1.91

The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Ther (1994) 1.82

Molecular characterization and functional expression of the human cardiac gap junction channel. J Cell Biol (1990) 1.81

A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J Clin Invest (1998) 1.77

Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction. J Biol Chem (1994) 1.77

Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome. Science (1983) 1.74

Isolation and characterization of human myosin heavy chain genes. Proc Natl Acad Sci U S A (1983) 1.72

Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci U S A (1993) 1.72

Cloning and characterization of a nonmuscle myosin heavy chain cDNA. Proc Natl Acad Sci U S A (1985) 1.69

Endothelial progenitor cell number and colony-forming capacity in overweight and obese adults. Int J Obes (Lond) (2008) 1.66

Expression of the beta (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects. Am J Physiol Heart Circ Physiol (2000) 1.60

Contractile protein mutations and heart disease. Curr Opin Cell Biol (1996) 1.58

Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy. Mol Med (1996) 1.54

Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction. J Physiol (2001) 1.52

A 29 residue region of the sarcomeric myosin rod is necessary for filament formation. J Mol Biol (1997) 1.52

Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. J Mol Biol (1999) 1.52

Full-length rat alpha and beta cardiac myosin heavy chain sequences. Comparisons suggest a molecular basis for functional differences. J Mol Biol (1989) 1.46

Hypertrophy, pathology, and molecular markers of cardiac pathogenesis. Circ Res (1998) 1.44

Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle. Dev Biol (1993) 1.40

Different pathways regulate expression of the skeletal myosin heavy chain genes. J Biol Chem (2001) 1.38

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J Clin Invest (2001) 1.37

Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T. Am J Physiol Heart Circ Physiol (2001) 1.36

Mapping class I gene sequences in the major histocompatibility complex. Nature (1982) 1.35

Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle. Nucleic Acids Res (1986) 1.34

Hormonal modulation of a gene injected into rat heart in vivo. Proc Natl Acad Sci U S A (1991) 1.31

Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation. Proc Natl Acad Sci U S A (1990) 1.30

Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions. J Physiol (2001) 1.20

Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization. J Mol Cell Cardiol (1989) 1.18

Mutation of the IIB myosin heavy chain gene results in muscle fiber loss and compensatory hypertrophy. Am J Physiol Cell Physiol (2001) 1.18

Sarcomeric gene expression and contractility in myofibroblasts. J Cell Biol (1997) 1.15

Myosin heavy chains IIa and IId are functionally distinct in the mouse. J Cell Biol (1998) 1.14

Thyroid hormone regulates expression of a transfected human alpha-myosin heavy-chain fusion gene in fetal rat heart cells. Proc Natl Acad Sci U S A (1990) 1.14

Cardiac adaptations to chronic exercise in mice. Am J Physiol (1994) 1.13

Alterations in gene expression in the rat heart after chronic pathological and physiological loads. J Mol Cell Cardiol (1994) 1.12

Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids. Biochem Genet (1979) 1.12

Expression in Escherichia coli of a functional Dictyostelium myosin tail fragment. J Cell Biol (1987) 1.11

Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene. Am J Physiol Heart Circ Physiol (2001) 1.10

Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium. Nucleic Acids Res (1987) 1.09

Behavior of genes directly injected into the rat heart in vivo. Circ Res (1992) 1.08

Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains. Dev Biol (2001) 1.08

Regulation of growth and differentiation of a rat hepatoma cell line by the synergistic interactions of hormones and collagenous substrata. J Cell Biol (1983) 1.07

Suppression of nonsense mutations in cell culture and mice by multimerized suppressor tRNA genes. Mol Cell Biol (2000) 1.07

Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development. Dev Biol (1999) 1.07

Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice. J Appl Physiol (1985) (2002) 1.05

Distinct behavior of cardiac myosin heavy chain gene constructs in vivo. Discordance with in vitro results. Circ Res (1993) 1.04

Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy. Biophys J (1998) 1.04

The human connexin gene family of gap junction proteins: distinct chromosomal locations but similar structures. Genomics (1991) 1.03

Skeletal muscle adaptations to microgravity exposure in the mouse. J Appl Physiol (1985) (2003) 1.03

Modulation of myosin filament organization by C-protein family members. Mol Biol Cell (1996) 1.02

Expression and DNA sequence analysis of a human embryonic skeletal muscle myosin heavy chain gene. Nucleic Acids Res (1989) 1.02

Fast myosin heavy chains expressed in secondary mammalian muscle fibers at the time of their inception. J Cell Sci (1994) 1.01

Myofibroblasts: molecular crossdressers. Curr Top Dev Biol (2001) 1.01

Expression of connexin43 in the developing rat heart. Circ Res (1991) 1.00

Regulation of scallop myosin by mutant regulatory light chains. J Mol Biol (1990) 1.00

Animal models of hypertrophic cardiomyopathy. Curr Opin Cardiol (2000) 0.98

A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol (1988) 0.97

Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain. J Cell Biol (1989) 0.96

Cardiomyopathy in transgenic myf5 mice. Circ Res (1996) 0.95

Inactivation of myosin heavy chain genes in the mouse: diverse and unexpected phenotypes. Microsc Res Tech (2000) 0.94

Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A (1994) 0.93

Small RNA molecules related to the Alu family of repetitive DNA sequences. Mol Cell Biol (1982) 0.93

Identification of a cis-acting regulatory element conferring inducibility of the atrial natriuretic factor gene in acute pressure overload. J Clin Invest (1997) 0.93

Sarcomeric myosin heavy chain expressed in nonmuscle cells forms thick filaments in the presence of substoichiometric amounts of light chains. Cell Motil Cytoskeleton (1993) 0.91

Assignment of the genes for triose phosphate isomerase to chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by somatic cell hybridization. Somatic Cell Genet (1978) 0.91

Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol (2001) 0.91

Complete nucleotide sequence of full length cDNA for rat alpha cardiac myosin heavy chain. Nucleic Acids Res (1989) 0.91

Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension. Nucleic Acids Res (1989) 0.90

Coexpression and assembly of myosin heavy chain and myosin light chain in Escherichia coli. Proc Natl Acad Sci U S A (1988) 0.90

Direct gene transfer into the mouse heart. J Mol Cell Cardiol (1997) 0.89

Identification of sequences necessary for the association of cardiac myosin subunits. J Cell Biol (1991) 0.88

Post-transcriptional regulation of rat alpha cardiac myosin heavy chain gene expression. J Biol Chem (1994) 0.87

Generation of a full-length human perinatal myosin heavy-chain-encoding cDNA. Gene (1990) 0.87

Gated magnetic resonance imaging of normal and hypertrophied murine hearts. Am J Physiol (1997) 0.87

Potential limitations of transcription terminators used as transgene insulators in adenoviral vectors. Gene Ther (2002) 0.86

Complete nucleotide sequence of full length cDNA for rat beta cardiac myosin heavy chain. Nucleic Acids Res (1989) 0.86

Cloning and characterization of the scallop essential and regulatory myosin light chain cDNAs. J Biol Chem (1987) 0.85

Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice. Am J Physiol (1999) 0.85

Rat liver fat-storing cell lines express sarcomeric myosin heavy chain mRNA and protein. Cell Motil Cytoskeleton (1993) 0.85

Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension. Nucleic Acids Res (1990) 0.84

Discordance between gene regulation in vitro and in vivo. Gene Expr (1992) 0.84

Prehypertension and endothelial progenitor cell function. J Hum Hypertens (2010) 0.83

Low sequence variation in the gene encoding the human beta-myosin heavy chain. Genomics (2001) 0.81

Enhanced detection of tRNA isoacceptors by combinatorial oligonucleotide hybridization. RNA (2000) 0.81

Sequence organization of variant mouse 4.5 S RNA genes and pseudogenes. Genomics (1992) 0.80

Functional analysis of a cardiac myosin rod in Dictyostelium discoideum. Cell Motil Cytoskeleton (1994) 0.80

Myoblast therapy. Science (1992) 0.79

A murine model for hypertrophic cardiomyopathy. Z Kardiol (1995) 0.79

Repetitive nucleotide sequence insertions into a novel calmodulin-related gene and its processed pseudogene. Gene (1988) 0.78

The vertebrate myosin heavy chain: genetics and assembly properties. Cell Struct Funct (1997) 0.78