Published in Blood on July 17, 2003
Successful treatment of canine hemophilia by continuous expression of canine FVIIa. Blood (2008) 2.01
Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide. Blood (2011) 1.14
A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia. Nat Biotechnol (2011) 1.12
Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro. Blood (2010) 1.00
Exposure to acrolein by inhalation causes platelet activation. Toxicol Appl Pharmacol (2010) 0.97
Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin. Br J Haematol (2010) 0.85
A soluble tissue factor-annexin V chimeric protein has both procoagulant and anticoagulant properties. Blood (2005) 0.84
Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma. Thromb Res (2011) 0.83
Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo. Blood (2011) 0.81
Disulfide locked variants of factor VIIa with a restricted beta-strand conformation have enhanced enzymatic activity. Protein Sci (2005) 0.80
Repeated autologous intraarticular blood injections as an animal model for joint pain in haemophilic arthropathy. Arthritis Res Ther (2013) 0.78
Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa. Thromb Haemost (2015) 0.77
Preclinical trauma studies of recombinant factor VIIa. Crit Care (2005) 0.76
Long-term expression of canine FVIIa in hemophilic dogs. Thromb Res (2010) 0.75
Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding. Pharm Res (2016) 0.75
Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheeze. J Allergy Clin Immunol (2008) 1.63
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest (2014) 1.61
Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy. Cancer Res (2010) 1.59
Canine specific ELISA for coagulation factor VII. Vet J (2011) 1.46
Whole blood coagulation in children with thrombocytopenia and the response to platelet replacement, recombinant factor VIIa, and a potent factor VIIa analogue. Br J Haematol (2008) 1.41
The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem (2010) 1.24
Characterization of recombinant murine factor VIIa and recombinant murine tissue factor: a human-murine species compatibility study. Thromb Res (2004) 1.18
Quantification of surgical blood loss. Vet Surg (2006) 1.16
Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria. Antimicrob Agents Chemother (2008) 1.10
The glucagon-like peptide-1 receptor--or not? Endocrinology (2013) 1.10
[Lack of clarity about asthma and allergies in children]. Ugeskr Laeger (2013) 1.08
Validation of human recombinant tissue factor-activated thromboelastography on citrated whole blood from clinically healthy dogs. Vet Clin Pathol (2005) 1.05
Multimodality functional imaging of spontaneous canine tumors using 64Cu-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT. Radiother Oncol (2011) 1.04
Seasonal variation of maternally derived respiratory syncytial virus antibodies and association with infant hospitalizations for respiratory syncytial virus. J Pediatr (2009) 1.03
A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J Pharmacol Exp Ther (2007) 1.00
Tissue factor activated thromboelastography correlates to clinical signs of bleeding in dogs. Vet J (2007) 0.99
Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain. Endocrinology (2015) 0.98
The influence of platelets, plasma and red blood cells on functional haemostatic assays. Blood Coagul Fibrinolysis (2011) 0.97
Evaluation of a commercially available human C-reactive protein (CRP) turbidometric immunoassay for determination of canine serum CRP concentration. Vet Clin Pathol (2003) 0.95
(64)Cu-ATSM and (18)FDG PET uptake and (64)Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry. Radiat Oncol (2012) 0.94
Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange. J Biol Chem (2006) 0.94
A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia. Arterioscler Thromb Vasc Biol (2007) 0.94
Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor. Eur J Biochem (2003) 0.92
A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models. Blood (2013) 0.92
Atopic disposition, wheezing, and subsequent respiratory syncytial virus hospitalization in Danish children younger than 18 months: a nested case-control study. Pediatrics (2006) 0.91
Mast cell tumours and other skin neoplasia in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand (2010) 0.90
FDG PET/CT imaging in canine cancer patients. Vet Radiol Ultrasound (2010) 0.90
Thromboelastography results on citrated whole blood from clinically healthy cats depend on modes of activation. Acta Vet Scand (2010) 0.89
Contrast-enhanced ultrasonography in normal canine liver. Evaluation of imaging and safety parameters. Vet Radiol Ultrasound (2005) 0.89
Hemostatic biomarkers in dogs with chronic congestive heart failure. J Vet Intern Med (2007) 0.88
Use of serum C-reactive protein as an early marker of inflammatory activity in canine type II immune-mediated polyarthritis: case report. Acta Vet Scand (2006) 0.88
Study on biological variation of haemostatic parameters in clinically healthy dogs. Vet J (2006) 0.88
The use of sequential organ failure assessment parameters in an awake porcine model of severe Staphylococcus aureus sepsis. APMIS (2012) 0.87
Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study. Radiat Oncol (2013) 0.86
The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry. J Biol Chem (2008) 0.85
A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation. Protein Sci (2007) 0.85
Acute neurological signs as the predominant clinical manifestation in four dogs with Angiostrongylus vasorum infections in Denmark. Acta Vet Scand (2011) 0.85
Evaluation of a nine-point body condition scoring system in physically inactive pet cats. Am J Vet Res (2011) 0.85
Factor VIIa analogue (V158D/E296V/M298Q-FVIIa) normalises clot formation in whole blood from patients with severe haemophilia A. Br J Haematol (2007) 0.85
Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin. Br J Haematol (2010) 0.85
Impairment of the hemostatic potential of platelets during storage as evaluated by flow cytometry, thrombin generation, and thrombelastography under conditions promoting formation of coated platelets. Transfusion (2007) 0.84
Monocyte chemotactic protein-1 and other inflammatory parameters in Bernese Mountain dogs with disseminated histiocytic sarcoma. Vet J (2013) 0.84
Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model. J Clin Pharmacol (2008) 0.84
Evaluation of platelet aggregometry in dogs using the Multiplate platelet analyzer: impact of anticoagulant choice and assay duration. J Vet Emerg Crit Care (San Antonio) (2012) 0.83
Extensive small-angle X-ray scattering studies of blood coagulation factor VIIa reveal interdomain flexibility. Biochemistry (2010) 0.82
Animal models of DIC and their relevance to human DIC: a systematic review. Thromb Res (2011) 0.82
Haemostatic alterations in a group of canine cancer patients are associated with cancer type and disease progression. Acta Vet Scand (2012) 0.82
Haematological and biochemical changes in dogs naturally infected with Angiostrongylus vasorum before and after treatment. Vet J (2007) 0.82
Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound. Eur J Pharm Biopharm (2007) 0.81
Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity. J Biol Chem (2008) 0.81
Recombinant factor VIIa reduces bleeding in severely thrombocytopenic rabbits. Thromb Res (2003) 0.81
Internal quality control of a turbidimetric immunoassay for canine serum C-reactive protein based on pooled patient samples. Vet Clin Pathol (2004) 0.81
Comparison of B-mode and Doppler ultrasonographic findings with histologic features of benign and malignant mammary tumors in dogs. Am J Vet Res (2006) 0.81
Effects of physiologic agonists on canine whole blood flow cytometry assays of leukocyte-platelet aggregation and platelet activation. Vet Immunol Immunopathol (2008) 0.80
Risk Factors for Hospitalization for Respiratory Syncytial Virus Infection: A Population-based Cohort Study of Danish Children. Pediatr Infect Dis J (2016) 0.80
Activity, folding, misfolding, and aggregation in vitro of the naturally occurring human tissue factor mutant R200W. Biochemistry (2005) 0.79
Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers. Eur J Clin Pharmacol (2007) 0.79
Intratesticular and subcutaneous lidocaine alters the intraoperative haemodynamic responses and heart rate variability in male cats undergoing castration. Vet Anaesth Analg (2012) 0.79
Decreased platelet function in Cavalier King Charles Spaniels with mitral valve regurgitation. J Vet Intern Med (2003) 0.79
Diagnosis and treatment of platelet hyperactivity in relation to thrombosis in dogs and cats. J Vet Emerg Crit Care (San Antonio) (2012) 0.79
Thromboelastography in veterinary medicine. Semin Thromb Hemost (2010) 0.79
Comparative analysis of haematological, haemostatic, and inflammatory parameters in canine venous and arterial blood samples. Vet J (2006) 0.79
Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand (2009) 0.78
Prevention of beta strand movement into a zymogen-like position does not confer higher activity to coagulation factor VIIa. Biochemistry (2004) 0.78
Dogs with heart diseases causing turbulent high-velocity blood flow have changes in platelet function and von Willebrand factor multimer distribution. J Vet Intern Med (2005) 0.78
Diagnosis coding in The Danish National Patient Registry for respiratory syncytial virus infections. Scand J Infect Dis (2005) 0.78
Characterization of canine superficial tumors using gray-scale B mode, color flow mapping, and spectral doppler ultrasonography--a multivariate study. Vet Radiol Ultrasound (2006) 0.78
Cellular localization, binding sites, and pharmacologic effects of TFF3 in experimental colitis in mice. Dig Dis Sci (2007) 0.78
Breed-specific variation of hematologic and biochemical analytes in healthy adult Bernese Mountain dogs. Vet Clin Pathol (2009) 0.78
A loop of coagulation factor VIIa influencing macromolecular substrate specificity. FEBS Lett (2006) 0.78
Decreased plasma concentration of nitric oxide metabolites in dogs with untreated mitral regurgitation. J Vet Intern Med (2003) 0.78
Activation peptides prolong the murine plasma half-life of human factor VII. Blood (2011) 0.77
[Tubercular meningitis with severe hyponatraemia caused by cerebral salt wasting]. Ugeskr Laeger (2011) 0.77
Effects on the conformation of FVIIa by sTF and Ca²⁺ binding: studies of fluorescence resonance energy transfer and quenching. Biochem Biophys Res Commun (2011) 0.77
Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers. Eur J Clin Pharmacol (2007) 0.77
Mortality in virulent canine babesiosis is associated with a consumptive coagulopathy. Vet J (2012) 0.77
Transition state analysis of the complex between coagulation factor VIIa and tissue factor: suggesting a sequential domain-binding pathway. Biochem Biophys Res Commun (2005) 0.77
A review of the sonographic assessment of tumor metastases in liver and superficial lymph nodes. Vet Radiol Ultrasound (2004) 0.77
Antibody-induced enhancement of factor VIIa activity through distinct allosteric pathways. J Biol Chem (2012) 0.77
Fibrin gel structure obtained with a FVIIa analogue with enhanced FX-activating potential in haemophilia. Thromb Haemost (2009) 0.77
Endogenous fibrinolytic potential in tissue-plasminogen activator-modified thromboelastography analysis is significantly decreased in dogs suffering from diseases predisposing to thrombosis. Vet Clin Pathol (2013) 0.76
Injectable Colloidal Gold for Use in Intrafractional 2D Image-Guided Radiation Therapy. Adv Healthc Mater (2015) 0.76
Hemostatic response to surgical neutering via ovariectomy and ovariohysterectomy in dogs. Am J Vet Res (2012) 0.76
Sequential coagulation factor VIIa domain binding to tissue factor. Biochem Biophys Res Commun (2005) 0.76
Endotoxin activity in whole blood measured by neutrophil chemiluminescence is applicable to canine whole blood. Comp Immunol Microbiol Infect Dis (2007) 0.76
Thrombin-activatable fibrinolysis inhibitor activity in healthy and diseased dogs. Vet Clin Pathol (2010) 0.76
GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation. Inflamm Bowel Dis (2016) 0.75
Comparative aspects of blood coagulation--the road to new investigative fields within veterinary haemostasis. Vet J (2004) 0.75
Breed predisposition to canine gastric carcinoma--a study based on the Norwegian canine cancer register. Acta Vet Scand (2013) 0.75
The use of the rapid osmotic fragility test as an additional test to diagnose canine immune-mediated haemolytic anaemia. Acta Vet Scand (2013) 0.75
Artificial contact pathway activation masks the haemostatic potential of rFVIIa and NN1731 in thrombocytopenic whole blood. Br J Haematol (2010) 0.75
Exercise induced hypercoagulability, increased von Willebrand factor and decreased thyroid hormone concentrations in sled dogs. Acta Vet Scand (2014) 0.75
[Necroticing fasciitis in children]. Ugeskr Laeger (2009) 0.75
Evaluation of inflammatory and hemostatic surgical stress responses in male cats after castration under general anesthesia with or without local anesthesia. Am J Vet Res (2012) 0.75
Comparable risk of childhood asthma after vaginal delivery and emergency caesarean section. Dan Med J (2017) 0.75
Comparison of manual and automated methods for determining platelet counts in dogs with macrothrombocytopenia. J Vet Diagn Invest (2004) 0.75
Site-directed fluorescence probing to dissect the calcium-dependent association between soluble tissue factor and factor VIIa domains. Biochim Biophys Acta (2003) 0.75