Published in Curr Med Chem on August 01, 2003
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol (2007) 3.51
Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene (2006) 2.96
Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy. Semin Cancer Biol (2008) 2.93
Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen. J Bioenerg Biomembr (2007) 2.47
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer Res (2008) 2.16
Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS One (2008) 1.87
Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr (2008) 1.73
Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition. Mol Cell (2014) 1.73
Mitochondrial ion channels. Annu Rev Physiol (2007) 1.70
On the role of VDAC in apoptosis: fact and fiction. J Bioenerg Biomembr (2005) 1.68
Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinases I and II. Mol Cell Biol (2007) 1.65
Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell (2009) 1.58
Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress. Kidney Int (2011) 1.58
18F-FDG uptake in lung, breast, and colon cancers: molecular biology correlates and disease characterization. J Nucl Med (2009) 1.52
MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. Mol Cell Biol (2006) 1.48
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology. Front Oncol (2013) 1.42
Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling. BMC Syst Biol (2010) 1.36
Uncovering the role of VDAC in the regulation of cell life and death. J Bioenerg Biomembr (2008) 1.34
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. Physiol Rev (2015) 1.31
3-Bromopyruvate: targets and outcomes. J Bioenerg Biomembr (2012) 1.27
Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr (2009) 1.20
Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury. Circ Res (2010) 1.20
Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy. Cell Death Differ (2014) 1.11
Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc Res (2009) 1.09
Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes. J Biol Chem (2013) 1.07
The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death. J Biol Chem (2007) 1.07
Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production. EMBO Mol Med (2012) 1.07
Probing the outer mitochondrial membrane in cardiac mitochondria with nanoparticles. Biophys J (2006) 1.04
Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol (2015) 1.03
Two-color STED microscopy reveals different degrees of colocalization between hexokinase-I and the three human VDAC isoforms. PMC Biophys (2010) 1.01
Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes. Biophys J (2006) 0.99
Is cancer a metabolic disease? Am J Pathol (2013) 0.99
Mitochondrial hexokinase and cardioprotection of the intact heart. J Bioenerg Biomembr (2009) 0.98
Myc, mondo, and metabolism. Genes Cancer (2010) 0.97
How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions? Oncogene (2014) 0.93
Regulation and cytoprotective role of hexokinase III. PLoS One (2010) 0.92
Voltage-dependant anion channels: novel insights into isoform function through genetic models. Biochim Biophys Acta (2011) 0.90
Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow. J Biol Chem (2007) 0.90
FDG PET in Prostate Cancer. PET Clin (2009) 0.89
Clotrimazole induces a late G1 cell cycle arrest and sensitizes glioblastoma cells to radiation in vitro. Anticancer Drugs (2010) 0.88
Emerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy. Evid Based Complement Alternat Med (2012) 0.84
Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase. J Bioenerg Biomembr (2012) 0.84
The role of hexokinase in cardioprotection - mechanism and potential for translation. Br J Pharmacol (2014) 0.84
Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals. J Mol Cell Cardiol (2016) 0.84
Mitochondrial Ca(2+) and regulation of the permeability transition pore. J Bioenerg Biomembr (2016) 0.84
Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumors via HIF-1α activation. Oncotarget (2016) 0.83
The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria. J Biol Chem (2015) 0.83
Mitochondrial and nuclear genes of mitochondrial components in cancer. Curr Genomics (2009) 0.82
Approaching the structure of human VDAC1, a key molecule in mitochondrial cross-talk. J Bioenerg Biomembr (2008) 0.82
The regulation of apoptosis by the downstream regulatory element antagonist modulator/potassium channel interacting protein 3 (DREAM/KChIP3) through interactions with hexokinase I. Biochem Biophys Res Commun (2013) 0.81
TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. J Cell Biol (2016) 0.80
Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target. Cancer Biol Ther (2010) 0.80
Mitochondrial VDAC and hexokinase together modulate plant programmed cell death. Protoplasma (2012) 0.79
Exploiting unique structural and functional properties of malarial glycolytic enzymes for antimalarial drug development. Malar Res Treat (2014) 0.79
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma. Int J Clin Exp Pathol (2015) 0.79
Ouabain targets the unfolded protein response for selective killing of HepG2 cells during glucose deprivation. Cancer Biother Radiopharm (2012) 0.78
Non-classical gluconeogenesis-dependent glucose metabolism in Rhipicephalus microplus embryonic cell line BME26. Int J Mol Sci (2015) 0.78
VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology. Front Oncol (2016) 0.75
Prognostic Significance of the Metabolic Marker Hexokinase-2 in Various Solid Tumors: A Meta-Analysis. PLoS One (2016) 0.75
VDAC-Tubulin, an Anti-Warburg Pro-Oxidant Switch. Front Oncol (2017) 0.75
Yeast mitochondrial interactosome model: metabolon membrane proteins complex involved in the channeling of ADP/ATP. Int J Mol Sci (2012) 0.75
Mitochondria in relation to cancer metastasis: introduction to a mini-review series. J Bioenerg Biomembr (2012) 0.75
Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus Hürthle Cell Neoplasms: A Retrospective Analysis. Dis Markers (2017) 0.75
Mammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases. Inflammopharmacology (2017) 0.75
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J Cell Biol (2004) 5.02
Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem (2001) 3.33
Untangling the wires: a strategy to trace functional interactions in signaling and gene networks. Proc Natl Acad Sci U S A (2002) 3.18
Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res (2005) 2.64
Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses. Mol Syst Biol (2007) 2.56
Metformin and the fate of fat. Gastroenterology (2006) 2.18
Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. Mol Syst Biol (2009) 1.77
Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops. J Biol Chem (2006) 1.75
Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr (2008) 1.73
Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades. Mol Syst Biol (2006) 1.49
Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity. Biophys J (2005) 1.44
Modular response analysis of cellular regulatory networks. J Theor Biol (2002) 1.43
Temperature dependence of the epidermal growth factor receptor signaling network can be accounted for by a kinetic model. Biochemistry (2002) 1.38
Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains. Biosystems (2005) 1.26
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst Biol (2012) 1.25
Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. Cell Signal (2011) 1.21
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells. Cell Signal (2010) 1.18
Adenine nucleotide changes in the remnant liver: An early signal for regeneration after partial hepatectomy. Hepatology (2008) 1.14
Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat. BMC Genomics (2008) 1.07
TGF-beta1 calcium signaling in osteoblasts. J Cell Biochem (2007) 1.06
Cell signaling. Mitochondrial longevity pathways. Science (2007) 1.04
Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization. Alcohol Clin Exp Res (2005) 1.02
TNF-alpha-induced cell death in ethanol-exposed cells depends on p38 MAPK signaling but is independent of Bid and caspase-8. Am J Physiol Gastrointest Liver Physiol (2003) 0.99
Multistrip Western blotting to increase quantitative data output. Electrophoresis (2007) 0.97
Chronic ethanol feeding alters miRNA expression dynamics during liver regeneration. Alcohol Clin Exp Res (2012) 0.93
Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats. Pflugers Arch (2012) 0.91
Advancing alcohol biomarkers research. Alcohol Clin Exp Res (2010) 0.91
Mechanisms of alcohol-induced tissue injury. Alcohol Clin Exp Res (2003) 0.91
Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin. J Biol Chem (2014) 0.89
Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations. J Biol Chem (2003) 0.88
TGF-beta1 calcium signaling increases alpha5 integrin expression in osteoblasts. J Orthop Res (2002) 0.87
Acetate causes alcohol hangover headache in rats. PLoS One (2010) 0.87
Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats. Am J Physiol Gastrointest Liver Physiol (2012) 0.85
Elevated PTEN levels account for the increased sensitivity of ethanol-exposed cells to tumor necrosis factor-induced cytotoxicity. J Biol Chem (2004) 0.84
Chronic alcohol exposure alters transcription broadly in a key integrative brain nucleus for homeostasis: the nucleus tractus solitarius. Physiol Genomics (2005) 0.84
Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei. J Neuroinflammation (2012) 0.84
Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes. Hepatology (2002) 0.81
Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. Alcohol Clin Exp Res (2005) 0.79
Adiponectin fine-tuning of liver regeneration dynamics revealed through cellular network modelling. J Physiol (2015) 0.79
Rapid temporal changes in the expression of a set of neuromodulatory genes during alcohol withdrawal in the dorsal vagal complex: molecular evidence of homeostatic disturbance. Alcohol Clin Exp Res (2012) 0.78
RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death. Alcohol Clin Exp Res (2005) 0.78
Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions. Am J Respir Cell Mol Biol (2014) 0.78
TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression. Ann N Y Acad Sci (2002) 0.78
Computational Modeling of Spatiotemporal Ca(2+) Signal Propagation Along Hepatocyte Cords. IEEE Trans Biomed Eng (2016) 0.75
Alcohol and breast cancer: reconciling epidemiological and molecular data. Adv Exp Med Biol (2015) 0.75
Farewell to Drs. Ivan Diamond and T.-K. Li. Alcohol Clin Exp Res (2014) 0.75
Multistrip Western blotting: a tool for comparative quantitative analysis of multiple proteins. Methods Mol Biol (2015) 0.75
Inhibition of insulin-like growth factor I receptor tyrosine kinase by ethanol. Biochem Pharmacol (2004) 0.75