Published in J Med Chem on July 31, 2003
Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog. BMC Vet Res (2013) 0.81
Pharmacophore elucidation and molecular docking studies on 5-phenyl-1-(3-pyridyl)-1h-1,2,4-triazole-3-carboxylic acid derivatives as COX-2 inhibitors. Sci Pharm (2010) 0.80
QSAR and classification models of a novel series of COX-2 selective inhibitors: 1,5-diarylimidazoles based on support vector machines. J Comput Aided Mol Des (2004) 0.80
Synthesis and evaluation of antiinflammatory, analgesic and ulcerogenic potential of NSAIDs bearing 1,3,4-oxadiazole scaffold. Indian J Pharm Sci (2011) 0.79
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. J Med Chem (2013) 0.78
Anti-inflammatory agents of the carbamoylmethyl ester class: synthesis, characterization, and pharmacological evaluation. J Inflamm Res (2013) 0.75
Erratum to: Acute Neuroinflammation Promotes Cell Responses to 1800 MHz GSM Electromagnetic Fields in the rat Cerebral Cortex. Neurotox Res (2017) 0.75
Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.75
Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. J Biol Chem (2008) 1.95
Preoperative hemoglobin levels and the need for transfusion after prosthetic hip and knee surgery: analysis of predictive factors. J Bone Joint Surg Am (2002) 1.67
Genetic predisposition to early recurrence in clinically localized prostate cancer. BJU Int (2012) 1.50
Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J Med Chem (2012) 1.43
Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation. Endocrinology (2005) 1.42
Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation. Diabetes (2006) 1.32
Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. A review of pharmacological profile and clinical management of allergic rhinitis. Drugs Today (Barc) (2003) 1.04
Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment. Toxicol Appl Pharmacol (2010) 1.00
A practical demonstration of water disinfection using TiO2 films and sunlight. Water Res (2006) 0.97
Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A. Hepatology (2009) 0.94
Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy. J Lipid Res (2002) 0.93
PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells. Biochim Biophys Acta (2010) 0.93
Thermal degradation of allicin in garlic extracts and its implication on the inhibition of the in-vitro growth of Helicobacter pylori. Biotechnol Prog (2004) 0.90
Sigma 1 receptor: a new therapeutic target for pain. Eur J Pharmacol (2013) 0.89
Allyl-thiosulfinates, the bacteriostatic compounds of garlic against Helicobacter pylori. Biotechnol Prog (2004) 0.89
The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. Inflamm Bowel Dis (2003) 0.88
Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells. Biochim Biophys Acta (2005) 0.88
Shoelace technique for gradual closure of fasciotomy wounds. J Trauma (2005) 0.88
Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations. Biochem Biophys Res Commun (2010) 0.86
Down-regulation of acyl-CoA oxidase gene expression in heart of troglitazone-treated mice through a mechanism involving chicken ovalbumin upstream promoter transcription factor II. Mol Pharmacol (2003) 0.86
Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective σ1 receptor ligands. J Med Chem (2013) 0.85
Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages. Biochim Biophys Acta (2011) 0.84
PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice. J Gerontol A Biol Sci Med Sci (2006) 0.84
(R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria. Pharmacol Res (2010) 0.84
Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy. J Gerontol A Biol Sci Med Sci (2007) 0.84
Is the H4 receptor a new drug target for allergies and asthma? Front Biosci (Elite Ed) (2013) 0.83
A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats. Br J Pharmacol (2006) 0.83
Investigational sigma-1 receptor antagonists for the treatment of pain. Expert Opin Investig Drugs (2015) 0.83
Modulation of peripheral μ-opioid analgesia by σ1 receptors. J Pharmacol Exp Ther (2013) 0.82
Evaluation of responsive gene expression as a sensitive and specific biomarker in patients with ulcerative colitis. Inflamm Bowel Dis (2013) 0.82
UR-1505, a new salicylate, blocks T cell activation through nuclear factor of activated T cells. Mol Pharmacol (2007) 0.82
Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study. Clin Ther (2007) 0.82
Antihistaminic effects of rupatadine and PKPD modelling. Eur J Drug Metab Pharmacokinet (2008) 0.81
Low serum zinc level as a predictive factor of delayed wound healing in total hip replacement. Wound Repair Regen (2006) 0.81
σ1 receptors are involved in the visceral pain induced by intracolonic administration of capsaicin in mice. Anesthesiology (2013) 0.80
S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. Behav Pharmacol (2014) 0.80
The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control. Antioxid Redox Signal (2015) 0.80
Allosteric regulation of PKCθ: understanding multistep phosphorylation and priming by ligands in AGC kinases. Proteins (2011) 0.80
Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects. Eur J Pharmacol (2013) 0.79
Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting. PLoS One (2013) 0.78
The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease. PPAR Res (2010) 0.78
Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study. Clin Ther (2008) 0.78
Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli. Biochim Biophys Acta (2007) 0.78
Optimization of Allium sativum solvent extraction for the inhibition of in vitro growth of Helicobacter pylori. Biotechnol Prog (2002) 0.78
Inhibition of cardiac hypertrophy by triflusal (4-trifluoromethyl derivative of salicylate) and its active metabolite. Mol Pharmacol (2006) 0.78
Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats. J Neurochem (2014) 0.78
Intravenous and subcutaneous injection of mercury: an unusual self-injury. J Trauma (2009) 0.77
The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition. Biochem Pharmacol (2007) 0.77
UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis. Inflamm Bowel Dis (2008) 0.77
Dextran causes aggregation of mitochondria and influences their oxidoreductase activities and light scattering. Arch Biochem Biophys (2003) 0.77
A fast method for the determination of fractional contributions to solvation in proteins. Protein Sci (2006) 0.77
Evaluation of formalin-induced pain behavior and glutamate release in the spinal dorsal horn using in vivo microdialysis in conscious rats. J Pharmacol Sci (2012) 0.77
Comparative bioavailability study of triflusal oral solution vs. triflusal capsules in healthy subjects. A single, randomized, two-way cross-over, open-label phase I study. Arzneimittelforschung (2010) 0.76
The new salicylate derivative UR-1505 modulates the Th2/humoral response in a dextran sodium sulphate model of colitis that resembles ulcerative colitis. J Pharmacol Sci (2009) 0.76
Metabolic alterations and increased liver mTOR expression precede the development of autoimmune disease in a murine model of lupus erythematosus. PLoS One (2012) 0.76
Molecular modelling. Mol Biosyst (2006) 0.75
Prevention of stroke in patients with ischemic stroke or transient ischemic attack. Stroke (2006) 0.75
New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs. J Med Chem (2004) 0.75
DFFR: A NEW METHOD FOR HIGH-THROUGHPUT RECALIBRATION OF AUTOMATIC FORCE-FIELDS FOR DRUGS. J Chem Theory Comput (2020) 0.75