Inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, expression, and functional properties.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 3295240)

Published in Biochim Biophys Acta on July 30, 2003

Authors

Mitchell Ho1, Mariangela Segre

Author Affiliations

1: Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.

Articles cited by this

Towards a network theory of the immune system. Ann Immunol (Paris) (1974) 16.43

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science (2001) 5.39

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J Exp Med (1998) 2.39

Idiotypic networks and other preconceived ideas. Immunol Rev (1984) 2.31

Improving antibody affinity by mimicking somatic hypermutation in vitro. Nat Biotechnol (1999) 1.85

Anti-alprenolol anti-idiotypic antibodies bind to beta-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase. Proc Natl Acad Sci U S A (1980) 1.80

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci U S A (1992) 1.79

Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol Pharmacol (1992) 1.76

WAM: an improved algorithm for modelling antibodies on the WEB. Protein Eng (2000) 1.67

Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. J Biol Chem (1994) 1.51

Molecular basis of antigen mimicry by an anti-idiotope. Nature (1995) 1.32

Somatic insertions and deletions shape the human antibody repertoire. J Mol Biol (1999) 1.28

Cocaine enhances monocyte migration across the blood-brain barrier. Cocaine's connection to AIDS dementia and vasculitis? Adv Exp Med Biol (1998) 1.27

Peptides crossing the blood-brain barrier: some unusual observations. Brain Res (1999) 0.95

Idiotypic mimicry and the assembly of a supramolecular structure: an anti-idiotypic antibody that mimics taxol in its tubulin-microtubule interactions. Proc Natl Acad Sci U S A (1994) 0.91

Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions. Mol Pharmacol (2000) 0.91

Internal image concept revisited. Proc Soc Exp Biol Med (1996) 0.89

The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain. J Biol Chem (1996) 0.88

Exploring the feasibility of an anti-idiotypic cocaine vaccine: analysis of the specificity of anticocaine antibodies (Ab1) capable of inducing Ab2beta anti-idiotypic antibodies. Immunology (2000) 0.86

[125I]RTI-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain. J Neurochem (1993) 0.84

Measurement of antibody affinity for cell surface antigens using an enzyme-linked immunosorbent assay. J Immunol Methods (1989) 0.83

[3H]GBR 12935 binding to dopamine uptake sites in the human brain. J Neurochem (1989) 0.82

Expression and regulation of the human dopamine transporter in a neuronal cell line. Brain Res Mol Brain Res (1998) 0.82

Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists. Life Sci (1993) 0.81

Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine. Brain Res (2000) 0.81

Rabbit anti-idiotypic antibodies raised against monoclonal anti-morphine IgG block mu & delta opiate receptor sites. Life Sci (1985) 0.80

Transport of cationized anti-tetanus Fab'2 fragments across an in vitro blood-brain barrier model: involvement of the transcytosis pathway. J Neurochem (1999) 0.78

Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library. Synapse (1999) 0.78

Characterization of a monoclonal anti-idiotypic antibody that mimics cyclosporine A in a single binding system. J Immunol (1991) 0.77