Published in Br J Pharmacol on August 01, 2003
The Concise Guide to PHARMACOLOGY 2013/14: transporters. Br J Pharmacol (2013) 2.07
Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol (2006) 2.00
Molecular targets for antiepileptic drug development. Neurotherapeutics (2007) 1.78
Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics (2010) 1.60
SLC1 glutamate transporters. Pflugers Arch (2013) 0.83
Therapeutically targeting astrocytes with stem and progenitor cell transplantation following traumatic spinal cord injury. Brain Res (2014) 0.81
Neuroprotective Effects of the Glutamate Transporter Activator (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153) following Traumatic Brain Injury in the Adult Rat. J Neurotrauma (2015) 0.77
Biochemical and functional characterization of Parawixia bistriata spider venom with potential proteolytic and larvicidal activities. Biomed Res Int (2014) 0.76
Neuroprotective activity of parawixin 10, a compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae) in rats undergoing intrahippocampal NMDA microinjection. Pharmacogn Mag (2015) 0.75
Glutamate uptake. Prog Neurobiol (2001) 13.59
The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. J Anat (1962) 8.63
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron (1996) 7.20
Localization of neuronal and glial glutamate transporters. Neuron (1994) 5.14
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science (1997) 5.13
Flux coupling in a neuronal glutamate transporter. Nature (1996) 4.43
An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature (1995) 4.14
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med (1992) 3.71
Primary structure and functional characterization of a high-affinity glutamate transporter. Nature (1992) 3.69
Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci (1994) 3.34
Cloning and expression of a rat brain L-glutamate transporter. Nature (1992) 3.14
Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc Natl Acad Sci U S A (1997) 2.86
Diversity of Conus neuropeptides. Science (1990) 2.78
Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. Proc Natl Acad Sci U S A (1992) 2.59
Active transport of L-glutamate by membrane vesicles isolated from rat brain. Biochemistry (1978) 1.98
Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature (1990) 1.91
High affinity glutamate transporters: regulation of expression and activity. Mol Pharmacol (1997) 1.73
Excitatory amino acid transporters: keeping up with glutamate. Neurochem Int (2002) 1.61
Glutamate receptors and the induction of excitotoxic neuronal death. Prog Brain Res (1994) 1.57
Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. J Neurosci (2002) 1.54
Excitatory amino acid transporters: a family in flux. Annu Rev Pharmacol Toxicol (1999) 1.49
Differential expression of three glutamate transporter subtypes in the rat retina. Cell Tissue Res (1996) 1.37
Further evolution toward effective therapy for acute ischemic stroke. JAMA (1998) 1.33
Structure and pharmacology of spider venom neurotoxins. Biochimie (2000) 1.32
Pharmacology and biochemistry of spider venoms. Toxicon (2002) 1.31
Quantitation of ischemic damage in the rat retina. Exp Eye Res (1991) 1.22
The chemistry of phyletic dominance. Proc Natl Acad Sci U S A (1995) 1.18
A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system. Neuroscience (2002) 1.14
Spider toxins as tools for dissecting elements of excitatory amino acid transmission. Trends Neurosci (1988) 1.11
Differential modulation of human glutamate transporter subtypes by arachidonic acid. J Biol Chem (1995) 1.06
Phosphorylation and modulation of brain glutamate transporters by protein kinase C. J Biol Chem (1993) 1.03
Cellular distribution and kinetic properties of high-affinity glutamate transporters. Brain Res Bull (1998) 1.01
A pharmacological review of competitive inhibitors and substrates of high-affinity, sodium-dependent glutamate transport in the central nervous system. Curr Pharm Des (1999) 1.01
Glutamate release in experimental ischaemia of the retina: an approach using microdialysis. J Neurochem (1992) 1.00
Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. Invest Ophthalmol Vis Sci (1998) 0.99
The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. J Neurochem (2003) 0.97
Toxins affecting calcium channels in neurons. Toxicon (1997) 0.92
Histologic changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamate. Graefes Arch Clin Exp Ophthalmol (1985) 0.90
Characterization of glutamate, aspartate, and GABA release from ischemic rat cerebral cortex. Brain Res Bull (1994) 0.89
Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats. Brain Res Bull (2000) 0.89
Structure-activity relationships of philanthotoxin analogs and polyamines on N-methyl-D-aspartate and nicotinic acetylcholine receptors. J Pharmacol Exp Ther (1990) 0.87
Region-specific loss of glutamate innervation in Alzheimer's disease. Neurosci Lett (1987) 0.86
Localization and function of five glutamate transporters cloned from the salamander retina. Vision Res (1998) 0.82
PhTx4, a new class of toxins from Phoneutria nigriventer spider venom, inhibits the glutamate uptake in rat brain synaptosomes. Brain Res (1999) 0.81
Identification and preclinical testing of novel antiepileptic compounds. Epilepsia (1997) 0.80
The role of excitotoxicity and metabolic failure in the pathogenesis of neurological disorders. Neurobiology (Bp) (1998) 0.80
K(+)-Evoked [(3)H]D-aspartate release in rat spinal cord synaptosomes: modulation by neuropeptide Y and calcium channel antagonists. J Neurosci Res (2000) 0.79
Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids. Brain Res (1996) 0.79
Effects of the crude venom of the social wasp Agelaia vicina on gamma-aminobutyric acid and glutamate uptake in synaptosomes from rat cerebral cortex. J Biochem Mol Toxicol (2000) 0.79
Spider toxins affecting glutamate receptors: polyamines in therapeutic neurochemistry. Pharmacol Ther (1991) 0.79
Effect of amino acid ergot alkaloids on glutamate transport via human glutamate transporter hGluT-1. J Neurol Sci (1998) 0.78
Characterization of the pharmacology and regional distribution of (S)-[3H]-5-fluorowillardiine binding in rat brain. Br J Pharmacol (1995) 0.78
Purification and amino acid sequence of the insecticidal neurotoxin Tx4(6-1) from the venom of the 'armed' spider Phoneutria nigriventer (Keys). Toxicon (1995) 0.78
Inhibition of the glutamate uptake in the excitatory neuromuscular synapse of the locust by delta-philanthotoxin; a component of the venom of the solitary wasp Philanthus triangulum F. A high resolution autoradiographic study. Comp Biochem Physiol C (1984) 0.77
Arthropod toxins as leads for novel insecticides: an assessment of polyamine amides as glutamate antagonists. Toxicon (1992) 0.77
Presynaptic effects of spider toxins: increase of high affinity uptake in the arthropod peripheral glutamatergic system. Experientia (1989) 0.76
Paralizing activity of the Parawixia bistriata crude venom in termites: a new bioassay. Toxicon (2000) 0.76
Reduction of high affinity glutamate uptake in rat hippocampus by two polyamine-like toxins isolated from the venom of the predatory wasp Philanthus triangulum F. Experientia (1986) 0.76
Transport mechanism of glutamate by hypotonic-treated glial plasmalemmal vesicles from rat hippocampus. Effects of concentration gradients of Na+ and K+ and of ionophores. J Mol Neurosci (1993) 0.76
Is glutamate a trigger factor in epileptic hyperactivity? Epilepsia (1981) 0.76
A call for transparent reporting to optimize the predictive value of preclinical research. Nature (2012) 14.63
Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons. Nat Neurosci (2002) 2.45
Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venom. Mol Pharmacol (2007) 1.66
Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter. J Biol Chem (2008) 1.61
Glutamate and monoamine transporters: new visions of form and function. Curr Opin Neurobiol (2007) 1.57
Dynamic regulation of the dopamine transporter. Eur J Pharmacol (2003) 1.32
Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters. Mol Pharmacol (2004) 1.30
Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding. J Biol Chem (2010) 1.27
Structural rearrangements at the translocation pore of the human glutamate transporter, EAAT1. J Biol Chem (2006) 1.26
Cellular aspects of wound healing. An Bras Dermatol (2009) 1.15
Large collective motions regulate the functional properties of glutamate transporter trimers. Proc Natl Acad Sci U S A (2011) 1.15
The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. J Neurosci (2002) 1.15
Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter. Proc Natl Acad Sci U S A (2009) 1.09
A novel sorting motif in the glutamate transporter excitatory amino acid transporter 3 directs its targeting in Madin-Darby canine kidney cells and hippocampal neurons. J Neurosci (2002) 1.09
A hydrophobic domain in glutamate transporters forms an extracellular helix associated with the permeation pathway for substrates. J Biol Chem (2002) 1.03
New views of glutamate transporter structure and function: advances and challenges. Neuropharmacology (2010) 1.01
Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation. J Neurosci (2011) 1.00
Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transporters. J Neurochem (2006) 0.98
Genetic complementation screen identifies a mitogen-activated protein kinase phosphatase, MKP3, as a regulator of dopamine transporter trafficking. Mol Biol Cell (2008) 0.97
Convulsant activity and neurochemical alterations induced by a fraction obtained from fruit Averrhoa carambola (Oxalidaceae: Geraniales). Neurochem Int (2005) 0.95
Descriptive and functional neuroanatomy of locus coeruleus-noradrenaline-containing neurons involvement in bradykinin-induced antinociception on principal sensory trigeminal nucleus. J Chem Neuroanat (2006) 0.93
Biocompatibility of natural latex implanted into dental alveolus of rats. J Oral Sci (2006) 0.87
Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships. Cell Mol Neurobiol (2004) 0.87
Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB J (2013) 0.87
Inhibition of dopamine transporter activity by G protein βγ subunits. PLoS One (2013) 0.86
Serotonergic neurotransmission in the dorsal raphe nucleus recruits in situ 5-HT(2A/2C) receptors to modulate the post-ictal antinociception. Exp Neurol (2008) 0.84
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae). Epilepsy Behav (2011) 0.84
Neurotoxins from invertebrates as anticonvulsants: from basic research to therapeutic application. Pharmacol Ther (2007) 0.84
Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl termini. J Neurochem (2004) 0.84
Increased vascular permeability, angiogenesis and wound healing induced by the serum of natural latex of the rubber tree Hevea brasiliensis. Phytother Res (2010) 0.83
GABA(A) receptor blockade in dorsomedial and ventromedial nuclei of the hypothalamus evokes panic-like elaborated defensive behaviour followed by innate fear-induced antinociception. Brain Res (2009) 0.83
Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin. Eur J Pharmacol (2009) 0.83
The cholinergic stimulation of the central amygdala modifying the tonic immobility response and antinociception in guinea pigs depends on the ventrolateral periaqueductal gray. Brain Res Bull (2003) 0.83
Antinociception induced by acute oral administration of sweet substance in young and adult rodents: the role of endogenous opioid peptides chemical mediators and μ(1)-opioid receptors. Pharmacol Biochem Behav (2011) 0.83
Elucidating the neurotoxicity of the star fruit. Angew Chem Int Ed Engl (2013) 0.82
Renal toxicity caused by oral use of medicinal plants: the yacon example. J Ethnopharmacol (2010) 0.82
A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes. PLoS One (2012) 0.82
Neurochemical characterization of a neuroprotective compound from Parawixia bistriata spider venom that inhibits synaptosomal uptake of GABA and glycine. Mol Pharmacol (2006) 0.81
5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: role of dorsal raphe nucleus. Exp Neurol (2009) 0.81
Spider and wasp neurotoxins: pharmacological and biochemical aspects. Eur J Pharmacol (2004) 0.81
Close encounters of the oily kind: regulation of transporters by lipids. Mol Interv (2009) 0.81
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae). Brain Res (2006) 0.81
Cellular prion protein modulates defensive attention and innate fear-induced behaviour evoked in transgenic mice submitted to an agonistic encounter with the tropical coral snake Oxyrhopus guibei. Behav Brain Res (2008) 0.80
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae). Epilepsy Behav (2011) 0.80
Effects of acute and chronic fluoxetine and diazepam on freezing behavior induced by electrical stimulation of dorsolateral and lateral columns of the periaqueductal gray matter. Pharmacol Biochem Behav (2004) 0.80
Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus. Basic Clin Pharmacol Toxicol (2009) 0.80
Involvement of pre- and post-synaptic serotonergic receptors of dorsal raphe nucleus neural network in the control of the sweet-substance-induced analgesia in adult Rattus norvegicus (Rodentia, Muridae). Neurosci Lett (2005) 0.79
Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar rats. Life Sci (2006) 0.79
Fos-like immunoreactivity in the brain associated with freezing or escape induced by inhibition of either glutamic acid decarboxylase or GABAA receptors in the dorsal periaqueductal gray. Brain Res (2005) 0.79
Anticonvulsant effects of the wasp Polybia ignobilis venom on chemically induced seizures and action on GABA and glutamate receptors. Comp Biochem Physiol C Toxicol Pharmacol (2005) 0.79
Acid and alkaline phosphatase activities of a fraction isolated from Parawixia bistriata spider venom. Toxicon (2006) 0.79
Anticonvulsant and behavioural effects of the denatured venom of the social wasp Polybia occidentalis (Polistinae, Vespidae). Basic Clin Pharmacol Toxicol (2005) 0.79
Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm. Neuropsychopharmacology (2011) 0.79
Cellular prion protein regulates the motor behaviour performance and anxiety-induced responses in genetically modified mice. Behav Brain Res (2007) 0.79
Neuropathology and behavioral impairments after bilateral global ischemia surgery and exposure to static magnetic field: Evidence in the motor cortex, the hippocampal CA1 region and the neostriatum. Int J Radiat Biol (2013) 0.78
Morphological and morphometric analyses of crushed sciatic nerves after application of a purified protein from natural latex and hyaluronic acid hydrogel. Growth Factors (2014) 0.78
Effects of microinjections of neurotoxin AvTx8, isolated from the social wasp Agelaia vicina (Hymenoptera, Vespidae) venom, on GABAergic nigrotectal pathways. Brain Res (2005) 0.78
Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways. Neuropharmacology (2012) 0.78
Chemical neuroanatomical and psychopharmacological evidence that κ receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour. Eur J Pharmacol (2013) 0.78
Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: evidence in motor cortex, hippocampal CA1 region and the neostriatum. J Neurol Sci (2011) 0.77
Anxiogenic effect of median raphe nucleus lesion in stressed rats. Prog Neuropsychopharmacol Biol Psychiatry (2002) 0.77
Characterization of the actions of AvTx 7 isolated from Agelaia vicina (Hymenoptera: Vespidae) wasp venom on synaptosomal glutamate uptake and release. J Biochem Mol Toxicol (2004) 0.77
Influence of treadmill training on motor performance and organization of exploratory behavior in Meriones unguiculatus with unilateral ischemic stroke: histological correlates in hippocampal CA1 region and the neostriatum. Neurosci Lett (2007) 0.77
Rostral ventromedial medulla modulates nociception and tonic immobility behavior through connections with the A7 catecholaminergic region. Behav Brain Res (2012) 0.77
The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT₂A and 5-HT₂C serotonergic receptors in post-ictal antinociception. Synapse (2013) 0.77
Rostral ventromedial medulla connections in Cavia porcellus and their relation with tonic immobility defensive behavior: a biotinylated dextran amine neurotracing study. Neurosci Lett (2012) 0.77
Innate defensive behaviour and panic-like reactions evoked by rodents during aggressive encounters with Brazilian constrictor snakes in a complex labyrinth: behavioural validation of a new model to study affective and agonistic reactions in a prey versus predator paradigm. J Neurosci Methods (2007) 0.76
Acetylcholine-mediated neurotransmission within the nucleus raphe magnus exerts a key role in the organization of both interictal and postictal antinociception. Epilepsy Behav (2011) 0.76
Role of muscarinic and nicotinic cholinergic receptors in an experimental model of epilepsy-induced analgesia. Pharmacol Biochem Behav (2004) 0.76
Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol. Epilepsy Res (2004) 0.76
A anticonvulsive fraction from Scaptocosa raptoria (Araneae: Lycosidae) spider venom. Neurosci Lett (2004) 0.76
Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits μ1-opioid receptor to modulate post-ictal antinociception. Neuropeptides (2011) 0.76
[Morphological features of utilization intraperitoneal double-sided prostheses in inguinoplasty in dogs]. Rev Col Bras Cir (2009) 0.76
Dorsal raphe nucleus and locus coeruleus neural networks and the elaboration of the sweet-substance-induced antinociception. Neurosci Lett (2005) 0.76
Effects of Tityus serrulatus scorpion venom and its toxin TsTX-V on neurotransmitter uptake in vitro. Toxicol Appl Pharmacol (2006) 0.76
Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides μ1 receptor-mediated post-ictal antinociception. Nanomedicine (2011) 0.76
Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor. Int J Neuropsychopharmacol (2013) 0.76
The role of 5-HT1A receptors in the anti-aversive effects of cannabidiol on panic attack-like behaviors evoked in the presence of the wild snake Epicrates cenchria crassus (Reptilia, Boidae). J Psychopharmacol (2013) 0.76
Paradoxical effect of noradrenaline-mediated neurotransmission in the antinociceptive phenomenon that accompanies tonic-clonic seizures: role of locus coeruleus neurons and α(2)- and β-noradrenergic receptors. Epilepsy Behav (2011) 0.76
Application of a low-level laser therapy and the purified protein from natural latex (Hevea brasiliensis) in the controlled crush injury of the sciatic nerve of rats: a morphological, quantitative, and ultrastructural study. Biomed Res Int (2013) 0.76
Oral treatment with Hev b 13 prevents experimental arthritis in mice. Clin Exp Immunol (2012) 0.75
Chloride finds its place in the transport cycle. Nat Struct Mol Biol (2007) 0.75
Effects of the Paratemnus elongatus pseudoscorpion venom in the uptake and binding of the L-glutamate and GABA from rat cerebral cortex. J Biochem Mol Toxicol (2006) 0.75
Neuroanatomical and neuropharmacological approaches to postictal antinociception-related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors. Brain Behav (2013) 0.75