PubRank

Gino Villetti

Author PubWeight™ 21.82‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. J Pharmacol Exp Ther 2007 1.29
2 Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J 2010 1.12
3 Conformation-sensitive antibodies against alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide. J Biol Chem 2007 1.08
4 Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. J Med Chem 2005 1.07
5 CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis 2010 0.96
6 Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. Thorax 2011 0.96
7 The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. J Alzheimers Dis 2011 0.95
8 Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice. BMC Neurosci 2013 0.92
9 In vivo imaging of transiently transgenized mice with a bovine interleukin 8 (CXCL8) promoter/luciferase reporter construct. PLoS One 2012 0.90
10 Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819). J Med Chem 2006 0.88
11 In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res 2007 0.87
12 Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist. Neuroreport 2002 0.86
13 Enlightened Mannhemia haemolytica lung inflammation in bovinized mice. Vet Res 2014 0.83
14 Ganstigmine and donepezil improve neurodegeneration in AD11 antinerve growth factor transgenic mice. Am J Alzheimers Dis Other Demen 2004 0.83
15 Evaluation of lung inflammation induced by intratracheal administration of LPS in mice: comparison between MRI and histology. MAGMA 2010 0.80
16 Formoterol and beclomethasone dipropionate interact positively in antagonising bronchoconstriction and inflammation in the lung. Pharmacol Res 2007 0.79
17 Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice. Am J Respir Cell Mol Biol 2012 0.79
18 Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie. Prion 2012 0.77
19 CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. Eur J Pharmacol 2005 0.77
20 Mechanisms of action of CHF3381 in the forebrain. Br J Pharmacol 2003 0.77
21 Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases. J Med Chem 2014 0.76
22 Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1). J Med Chem 2007 0.76
23 Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2). J Med Chem 2007 0.76
24 Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives. Bioorg Med Chem 2006 0.76
25 The protective effect of ganstigmine against amyloid beta 25-35 neurotoxicity on chicken cortical neurons is independent from the cholinesterase inhibition. Neurosci Lett 2003 0.75
26 Discovery and optimization of thiazolidinyl- and pyrrolidinyl- derivatives as inhaled PDE4 inhibitors for respiratory diseases. J Med Chem 2017 0.75
27 High throughput screening of beta-amyloid secretion inhibitors using homogenous time-resolved fluorescence. Comb Chem High Throughput Screen 2004 0.75