Published in Am J Respir Crit Care Med on July 31, 2003
Airway Inflammation and Disease Burden in Asthmatic Smokers | NCT02833727
Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med (2007) 2.81
How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol (2009) 2.46
Asthma and panic in young adults: a 20-year prospective community study. Am J Respir Crit Care Med (2005) 2.42
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med (2004) 2.19
How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br J Pharmacol (2006) 2.14
The use of propensity scores and observational data to estimate randomized controlled trial generalizability bias. Stat Med (2013) 2.08
Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): current literature review. J Thorac Dis (2014) 1.95
Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med (2011) 1.76
External validity of randomised controlled trials in asthma: to whom do the results of the trials apply? Thorax (2006) 1.72
Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med (2008) 1.68
Management of severe asthma in children. Lancet (2010) 1.60
The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly. J Allergy (Cairo) (2011) 1.49
Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma. Thorax (2005) 1.44
A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease. Can Respir J (2007) 1.40
Reassessing the evidence hierarchy in asthma: evaluating comparative effectiveness. Curr Allergy Asthma Rep (2011) 1.28
Recurrent, severe wheezing is associated with morbidity and mortality in adults with sickle cell disease. Am J Hematol (2011) 1.24
Epigenetics and airways disease. Respir Res (2006) 1.16
Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma. Cochrane Database Syst Rev (2010) 1.16
Effect of smoking abstinence and reduction in asthmatic smokers switching to electronic cigarettes: evidence for harm reversal. Int J Environ Res Public Health (2014) 1.11
Guidelines for diagnosis and management of bronchial asthma: Joint ICS/NCCP (I) recommendations. Lung India (2015) 1.07
Persistence of oxidant and protease burden in the airways after smoking cessation. BMC Pulm Med (2009) 1.06
Airway biomarkers of the oxidant burden in asthma and chronic obstructive pulmonary disease: current and future perspectives. Int J Chron Obstruct Pulmon Dis (2008) 1.00
Effects of short-term treatment with atorvastatin in smokers with asthma--a randomized controlled trial. BMC Pulm Med (2011) 1.00
A call for action: Comparative effectiveness research in asthma. J Allergy Clin Immunol (2010) 0.97
Measurement of asthma control according to Global Initiative for Asthma guidelines: a comparison with the Asthma Control Questionnaire. Respir Res (2012) 0.95
Clinical characteristics of asthma combined with COPD feature. Yonsei Med J (2014) 0.94
The impact of smoking on clinical and therapeutic effects in asthmatics. J Korean Med Sci (2009) 0.93
Collaboration between Oregon's chronic disease programs and Medicaid to decrease smoking among Medicaid-insured Oregonians with asthma. Prev Chronic Dis (2005) 0.92
Non-eosinophilic asthma and the innate immune response. Thorax (2007) 0.92
One-year treatment with mometasone furoate in chronic obstructive pulmonary disease. Respir Res (2008) 0.89
Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study. Respir Res (2011) 0.87
Trigger recognition and management in poorly controlled asthmatics. Allergy Asthma Proc (2010) 0.87
Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc (2016) 0.87
How variability in clinical phenotypes should guide research into disease mechanisms in asthma. Ann Am Thorac Soc (2013) 0.86
Effects of smoking cessation on airflow obstruction and quality of life in asthmatic smokers. Allergy Asthma Immunol Res (2010) 0.85
The Effect of Cigarette Smoke-derived Oxidants on the Inflammatory Response of the Lung. Clin Appl Immunol Rev (2006) 0.83
Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines-an exploratory study. PLoS One (2013) 0.83
Importance of evidence grading for guideline implementation: the example of asthma. Ann Fam Med (2009) 0.83
Psychological factors in asthma. Allergy Asthma Clin Immunol (2008) 0.82
Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen. Am J Physiol Lung Cell Mol Physiol (2009) 0.81
Clinical and molecular aspects of glucocorticoid resistant asthma. Ther Clin Risk Manag (2007) 0.81
Recommendation for optimal management of severe refractory asthma. J Asthma Allergy (2010) 0.81
Prevalence, patterns and correlates of cigarette smoking in male adolescents in northern Jordan, and the influence of waterpipe use and asthma diagnosis: a descriptive cross-sectional study. Int J Environ Res Public Health (2014) 0.81
The glucocorticoid receptor: a revisited target for toxins. Toxins (Basel) (2010) 0.81
Inhaled steroid/tobacco smoke particle interactions: a new light on steroid resistance. Respir Res (2009) 0.81
Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical practice. Int J Chron Obstruct Pulmon Dis (2010) 0.81
Severe asthma in children. J Allergy Clin Immunol Pract (2014) 0.80
Management of asthma in the elderly patient. Clin Interv Aging (2013) 0.80
Results from a community-based program evaluating the effect of changing smoking status on asthma symptom control. BMC Public Health (2012) 0.80
Toll-like receptor-9 agonist inhibits airway inflammation, remodeling and hyperreactivity in mice exposed to chronic environmental tobacco smoke and allergen. Int Arch Allergy Immunol (2009) 0.80
Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics. BMC Pulm Med (2013) 0.79
Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers. PLoS One (2014) 0.79
Extrafine inhaled corticosteroid therapy in the control of asthma. J Asthma Allergy (2013) 0.78
Coughs and wheezes spread diseases: but what about the environment? Thorax (2006) 0.78
Role of individual-housing-based socioeconomic status measure in relation to smoking status among late adolescents with asthma. Ann Epidemiol (2016) 0.77
Nicotine mediates hypochlorous acid-induced nuclear protein damage in mammalian cells. Inflammation (2014) 0.76
Asthma treatment outcome in adults is associated with rs9910408 in TBX21 gene. Sci Rep (2013) 0.76
Association between cigarette smoking and interleukin-17A expression in nasal tissues of patients with chronic rhinosinusitis and asthma. Medicine (Baltimore) (2016) 0.75
Asthma control in primary care: the results of an observational cross-sectional study in Italy and Spain. World Allergy Organ J (2017) 0.75
Determinants of uncontrolled asthma in a Swedish asthma population: cross-sectional observational study. Eur Clin Respir J (2014) 0.75
Corticosteroid resistance in smokers with asthma. Am J Respir Crit Care Med (2004) 0.75
Smoking: a neglected cause of glucocorticoid resistance in asthma. Am J Respir Crit Care Med (2003) 0.75
Attitudes Toward Prohibiting Tobacco Sales in Pharmacy Stores Among U.S. Adults. Am J Prev Med (2016) 0.75
Obesity, low levels of physical activity and smoking present opportunities for primary care asthma interventions: an analysis of baseline data from The Asthma Tools Study. NPJ Prim Care Respir Med (2015) 0.75
Physician-prescribed Asthma Treatment Regimen does not differ Between Smoking and Non-smoking Patients With Asthma in Seoul and Gyunggi province of Korea. Allergy Asthma Immunol Res (2014) 0.75
Long lasting effects of smoking: breast cancer survivors' inflammatory responses to acute stress differ by smoking history. Psychoneuroendocrinology (2012) 0.75
The management of asthmatic smokers. Asthma Res Pract (2016) 0.75
Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet (2004) 7.90
Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet (2007) 6.57
Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med (2009) 4.83
Asthma control during the year after bronchial thermoplasty. N Engl J Med (2007) 4.79
Smoke-free legislation and hospitalizations for acute coronary syndrome. N Engl J Med (2008) 4.57
Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. J Hypertens (2010) 2.73
Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol (2006) 2.70
Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med (2007) 1.93
A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. J Immunol (2004) 1.88
Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma. Am J Med (2002) 1.87
Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease. Am J Respir Crit Care Med (2006) 1.86
Stepping down inhaled corticosteroids in asthma: randomised controlled trial. BMJ (2003) 1.76
Components of socioeconomic risk associated with head and neck cancer: a population-based case-control study in Scotland. Br J Oral Maxillofac Surg (2009) 1.60
Cyclophosphamide metabolism in children with non-Hodgkin's lymphoma. Clin Cancer Res (2004) 1.56
Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am J Respir Crit Care Med (2006) 1.46
Subtraction helical CT angiography of intra- and extracranial vessels: technical considerations and preliminary experience. AJNR Am J Neuroradiol (2003) 1.45
Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol (2013) 1.45
Budesonide and formoterol in a single inhaler improves asthma control compared with increasing the dose of corticosteroid in adults with mild-to-moderate asthma. Chest (2003) 1.42
TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells. J Immunol (2005) 1.41
Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin (2007) 1.24
Smoking and asthma: dangerous liaisons. Eur Respir J (2012) 1.24
Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am J Clin Nutr (2005) 1.17
Digital asthma self-management interventions: a systematic review. J Med Internet Res (2014) 1.16
Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS). Arterioscler Thromb Vasc Biol (2002) 1.12
The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. Am J Respir Crit Care Med (2014) 1.11
Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. J Allergy Clin Immunol (2004) 1.11
Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease. Arterioscler Thromb Vasc Biol (2004) 1.09
Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis. Eur J Immunol (2005) 1.08
Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. Atherosclerosis (2008) 1.06
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Atherosclerosis (2008) 1.02
Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. J Allergy Clin Immunol (2012) 1.01
Effects of short-term treatment with atorvastatin in smokers with asthma--a randomized controlled trial. BMC Pulm Med (2011) 1.00
Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries. Int J Cancer (2014) 0.99
Association of the factor XII 46C>T polymorphism with risk of coronary heart disease (CHD) in the WOSCOPS study. Atherosclerosis (2002) 0.99
IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin. J Allergy Clin Immunol (2012) 0.98
The scar on the face of Scotland: deprivation and alcohol-related facial injuries in Scotland. J Trauma (2010) 0.97
Validity of self-reported smoking status: Comparison of patients admitted to hospital with acute coronary syndrome and the general population. Nicotine Tob Res (2008) 0.97
A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. Eur Heart J (2003) 0.97
Macrovascular and microvascular outcomes after beginning of insulin versus additional oral glucose-lowering therapy in people with type 2 diabetes: an observational study. Pharmacoepidemiol Drug Saf (2012) 0.94
Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention. Epilepsia (2012) 0.92
Safety of bronchial thermoplasty in patients with severe refractory asthma. Ann Allergy Asthma Immunol (2013) 0.91
Comparison and relative utility of inequality measurements: as applied to Scotland's child dental health. PLoS One (2013) 0.91
The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease. Circulation (2004) 0.90
A randomised controlled trial of a smoking cessation intervention delivered by dental hygienists: a feasibility study. BMC Oral Health (2007) 0.90
Socioeconomic inequalities in incidence of lung and upper aero-digestive tract cancer by age, tumour subtype and sex: a population-based study in Scotland (2000-2007). Cancer Epidemiol (2012) 0.89
Facial injuries in Scotland 2001-2009: epidemiological and sociodemographic determinants. Br J Oral Maxillofac Surg (2012) 0.87
Comparative study of modified release alpha-blocker exposure in elderly patients with fractures. Pharmacoepidemiol Drug Saf (2007) 0.87
Prognostic factors associated with local recurrence, metastases, and tumor-related death in patients with synovial sarcoma. Am J Clin Oncol (2004) 0.86
Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax (2012) 0.86
Short and long-term effects of cigarette smoking independently influence exhaled nitric oxide concentration in asthma. J Allergy Clin Immunol (2005) 0.86
Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform. Biochem J (2003) 0.85
Impact of smoking on asthma therapy: a critical review of clinical evidence. Drugs (2005) 0.85
Glucocorticoid receptor alpha:beta ratio in blood mononuclear cells is reduced in cigarette smokers. J Allergy Clin Immunol (2004) 0.85
Predicting sleep disordered breathing in outpatients with suspected OSA. BMJ Open (2014) 0.84
Disconnect between sputum neutrophils and other measures of airway inflammation in asthma. Eur Respir J (2013) 0.84
Challenges of treating asthma in people who smoke. Expert Rev Clin Immunol (2010) 0.83
Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines-an exploratory study. PLoS One (2013) 0.83
A Randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial. Trials (2014) 0.82
House dust mite control measures in the treatment of asthma. Ther Clin Risk Manag (2006) 0.82
Smokers with asthma: what are the management options? Am J Respir Crit Care Med (2007) 0.81
(R)-salbutamol in the treatment of asthma and chronic obstructive airways disease. Expert Opin Pharmacother (2011) 0.81
A randomized, controlled trial of C0- Vs C2-guided therapeutic drug monitoring of cyclosporine in stable heart transplant patients. J Heart Lung Transplant (2005) 0.80
Obstructive sleep apnoea syndrome and weight loss: review. Sleep Disord (2012) 0.79
Predicting job loss in those off sick. Occup Med (Lond) (2008) 0.79
Treating patients with respiratory disease who smoke. Ther Adv Respir Dis (2008) 0.78
CCR2 and coronary artery disease: a woscops substudy. BMC Res Notes (2010) 0.78
A comparative study of clinical management strategies for vaginal discharge in family planning and genitourinary medicine settings. J Fam Plann Reprod Health Care (2005) 0.78
Assessment of the presence of occult myocardial infarction in chronic obstructive pulmonary disease using contrast-enhanced cardiac magnetic resonance imaging. Respiration (2009) 0.77
Randomised controlled trial of azithromycin in smokers with asthma. Eur Respir J (2013) 0.77
Bronchial nitric oxide flux (J'aw) is sensitive to oral corticosteroids in smokers with asthma. Respir Med (2011) 0.77
Observational study of the association of first insulin type in uncontrolled type 2 diabetes with macrovascular and microvascular disease. PLoS One (2012) 0.77
Characterization and validation of an isotope-dilution LC-MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum. Bioanalysis (2013) 0.77
Levosalbutamol for chronic obstructive pulmonary disease: a treatment evaluation. Expert Opin Pharmacother (2012) 0.76
Asthma guidelines and smokers: it's time to be inclusive. Chest (2012) 0.76
Response. Chest (2015) 0.75
Nerve growth factor in serum and lymphocyte culture in pigeon fanciers' acute hypersensitivity pneumonitis. Chest (2006) 0.75
Does the aldosterone:renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? A clinical trial protocol for RENALDO (RENin-ALDOsterone) study. BMC Cardiovasc Disord (2007) 0.75
Why is eosinophilic bronchitis not asthma? Am J Respir Crit Care Med (2004) 0.75
Socioeconomic factors influence selection and participation in a population-based case-control study of head and neck cancer in Scotland. J Clin Epidemiol (2008) 0.75
Asthma: ten myths debunked. Practitioner (2004) 0.75
Managing chronic obstructive pulmonary disease. Practitioner (2003) 0.75