Published in Eur J Pharm Sci on August 01, 2003
Comparative cellular toxicity of hydrophilic and hydrophobic microcystins on Caco-2 cells. Toxins (Basel) (2012) 0.99
A framework to select clinically relevant cancer cell lines for investigation by establishing their molecular similarity with primary human cancers. Cancer Res (2011) 0.97
Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria. Drug Metab Dispos (2013) 0.96
Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines. BMC Cancer (2010) 0.95
The effect of complexation hydrogels on insulin transport in intestinal epithelial cell models. Acta Biomater (2009) 0.92
Assessment of poly(methacrylic acid-co-N-vinyl pyrrolidone) as a carrier for the oral delivery of therapeutic proteins using Caco-2 and HT29-MTX cell lines. J Biomed Mater Res A (2010) 0.88
Bovine Muc1 inhibits binding of enteric bacteria to Caco-2 cells. Glycoconj J (2010) 0.86
An investigation of the relationship between the anti-inflammatory activity, polyphenolic content, and antioxidant activities of cooked and in vitro digested culinary herbs. Oxid Med Cell Longev (2012) 0.84
MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2010) 0.83
Shape effect in the design of nanowire-coated microparticles as transepithelial drug delivery devices. ACS Nano (2012) 0.82
Evaluation of in vitro cytotoxicity and paracellular permeability of intact monolayers with mouse embryonic stem cells. Toxicol In Vitro (2008) 0.81
Transporter and ion channel gene expression after Caco-2 cell differentiation using 2 different microarray technologies. AAPS J (2004) 0.81
Orally bioavailable tubulin antagonists for paclitaxel-refractory cancer. Pharm Res (2012) 0.80
Nanoscale Delivery of Resveratrol towards Enhancement of Supplements and Nutraceuticals. Nutrients (2016) 0.79
Cytoplasmic actin is an extracellular insect immune factor which is secreted upon immune challenge and mediates phagocytosis and direct killing of bacteria, and is a Plasmodium Antagonist. PLoS Pathog (2015) 0.77
pH-responsive hydrogels containing PMMA nanoparticles: an analysis of controlled release of a chemotherapeutic conjugate and transport properties. J Biomater Sci Polym Ed (2012) 0.77
The effects of intralaboratory modifications to media composition and cell source on the expression of pharmaceutically relevant transporters and metabolizing genes in the Caco-2 cell line. J Pharm Sci (2012) 0.75
Hybrid responsive hydrogel carriers for oral delivery of low molecular weight therapeutic agents. J Drug Deliv Sci Technol (2015) 0.75
In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials (2003) 4.26
Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives. J Gene Med (2005) 2.71
Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv Drug Deliv Rev (2002) 2.27
Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. J Control Release (2003) 2.18
Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev (2009) 1.82
Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection. Biomaterials (2010) 1.77
Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system. Bioconjug Chem (2002) 1.55
Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes. Bioconjug Chem (2006) 1.55
The depolymerization of chitosan: effects on physicochemical and biological properties. Int J Pharm (2004) 1.35
Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm Res (2002) 1.34
PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. Bioconjug Chem (2005) 1.32
Integrin targeting using RGD-PEI conjugates for in vitro gene transfer. J Gene Med (2003) 1.30
Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres. Int J Pharm (2006) 1.27
Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings. Biomacromolecules (2005) 1.22
In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes. Toxicol Appl Pharmacol (2009) 1.21
Core-cross-linked polymeric micelles as paclitaxel carriers. Bioconjug Chem (2004) 1.20
Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments. Pharm Res (2002) 1.19
Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice. Eur J Pharm Biopharm (2004) 1.18
Poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) nanoparticles for local delivery of paclitaxel for restenosis treatment. J Control Release (2007) 1.13
Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance. Mol Pharm (2009) 1.12
In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure. Bioconjug Chem (2009) 1.12
Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance DNA condensation of low molecular weight polyethylenimines. Biomacromolecules (2002) 1.11
Biodegradable polymeric nanocarriers for pulmonary drug delivery. Expert Opin Drug Deliv (2008) 1.11
Characterization of a homologous series of D,L-lactic acid oligomers; a mechanistic study on the degradation kinetics in vitro. Biomaterials (2003) 1.10
Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applications. Mol Pharm (2010) 1.10
Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes. Bioconjug Chem (2002) 1.07
Galactose-PEI-DNA complexes for targeted gene delivery: degree of substitution affects complex size and transfection efficiency. J Control Release (2003) 1.07
The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-kappaB decoy in mice. Pharm Res (2002) 1.06
Crosslinked nanocarriers based upon poly(ethylene imine) for systemic plasmid delivery: in vitro characterization and in vivo studies in mice. J Control Release (2007) 1.05
Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity. Bioconjug Chem (2009) 1.03
Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells. Bioconjug Chem (2003) 1.03
Electrospun biodegradable nanofiber nonwovens for controlled release of proteins. J Control Release (2008) 1.03
Deposition of nanoparticles in the arterial vessel by porous balloon catheters: localization by confocal laser scanning microscopy and transmission electron microscopy. AAPS PharmSci (2002) 1.02
Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity. Mol Pharm (2010) 1.01
Nonviral pulmonary delivery of siRNA. Acc Chem Res (2011) 1.01
Synthesis, characterization and cytotoxicity of poly(ethylene glycol)-graft-trimethyl chitosan block copolymers. Biomaterials (2005) 1.00
Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin. J Pharm Sci (2006) 0.99
Paclitaxel releasing films consisting of poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) and their potential as biodegradable stent coatings. J Control Release (2006) 0.99
Effect of poly(ethylene imine) molecular weight and pegylation on organ distribution and pharmacokinetics of polyplexes with oligodeoxynucleotides in mice. Drug Metab Dispos (2004) 0.97
Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: establishment of structure-activity relationships in vitro. J Control Release (2007) 0.97
Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model. Int J Pharm (2008) 0.96
Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo. J Control Release (2007) 0.96
Novel magnetic iron oxide nanoparticles coated with poly(ethylene imine)-g-poly(ethylene glycol) for potential biomedical application: synthesis, stability, cytotoxicity and MR imaging. Int J Pharm (2011) 0.96
Computational insights into the interactions between DNA and siRNA with "rigid" and "flexible" triazine dendrimers. Biomacromolecules (2010) 0.95
Polycationic triazine-based dendrimers: effect of peripheral groups on transfection efficiency. New J Chem (2009) 0.95
Stabilized nanocarriers for plasmids based upon cross-linked poly(ethylene imine). Biomacromolecules (2006) 0.94
Hydrolytic degradation of poly(lactide-co-glycolide) films: effect of oligomers on degradation rate and crystallinity. Int J Pharm (2003) 0.93
In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers. Biomaterials (2011) 0.93
The potential of glycol chitosan nanoparticles as carrier for low water soluble drugs. Int J Pharm (2009) 0.92
Integrin alphaVbeta3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PEGylated poly(ethylene imine). Bioconjug Chem (2009) 0.92
Targeting the blind spot of polycationic nanocarrier-based siRNA delivery. ACS Nano (2012) 0.92
PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: structure-function relationships. Toxicol Appl Pharmacol (2009) 0.92
Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers. Biomaterials (2012) 0.92
Amine-modified hyperbranched polyesters as non-toxic, biodegradable gene delivery systems. Biomaterials (2009) 0.92
Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice. J Control Release (2011) 0.91
Physicochemical and biological characterization of polyethylenimine-graft-poly(ethylene glycol) block copolymers as a delivery system for oligonucleotides and ribozymes. Bioconjug Chem (2004) 0.91
Controlled release of gentamicin from calcium phosphate-poly(lactic acid-co-glycolic acid) composite bone cement. Biomaterials (2006) 0.91
Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy. J Control Release (2008) 0.91
Charged nanoparticles as protein delivery systems: a feasibility study using lysozyme as model protein. Eur J Pharm Biopharm (2007) 0.91
Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features. J Control Release (2003) 0.91
Peroral delivery of insulin using chitosan derivatives: a comparative study of polyelectrolyte nanocomplexes and nanoparticles. Int J Pharm (2007) 0.90
Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats. Eur J Pharm Biopharm (2008) 0.89
In vitro and in vivo correlation of buserelin release from biodegradable implants using statistical moment analysis. J Control Release (2004) 0.89
Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method. Eur J Pharm Biopharm (2007) 0.88
Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells. Pharm Res (2005) 0.88
Cellular uptake mechanism and knockdown activity of siRNA-loaded biodegradable DEAPA-PVA-g-PLGA nanoparticles. Eur J Pharm Biopharm (2011) 0.88
Effects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs. J Gene Med (2008) 0.88
Biophysical investigation of pulmonary surfactant surface properties upon contact with polymeric nanoparticles in vitro. Nanomedicine (2010) 0.88
Controlled pulmonary drug and gene delivery using polymeric nano-carriers. J Control Release (2011) 0.88
Bioreducible polymers with cell penetrating and endosome buffering functionality for gene delivery systems. J Control Release (2011) 0.88
DNA nano-carriers from biodegradable cationic branched polyesters are formed by a modified solvent displacement method. J Control Release (2006) 0.87
Trastuzumab-polyethylenimine-polyethylene glycol conjugates for targeting Her2-expressing tumors. Bioconjug Chem (2006) 0.87
Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems. Adv Drug Deliv Rev (2004) 0.87
Pulmonary gene delivery using polymeric nonviral vectors. Bioconjug Chem (2011) 0.86
Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin. J Pharm Sci (2004) 0.86
Preparation of nanoparticles by solvent displacement for drug delivery: a shift in the "ouzo region" upon drug loading. Eur J Pharm Sci (2010) 0.86
Influence of particle size and material properties on mucociliary clearance from the airways. J Aerosol Med Pulm Drug Deliv (2010) 0.86
Poly(diallyldimethylammonium chlorides) and their N-methyl-N-vinylacetamide copolymer-based DNA-polyplexes: role of molecular weight and charge density in complex formation, stability, and in vitro activity. Int J Pharm (2004) 0.86
Coating of poly(p-xylylene) by PLA-PEO-PLA triblock copolymers with excellent polymer-polymer adhesion for stent applications. Biomacromolecules (2006) 0.85
Amphiphilic and biodegradable hy-PEI-g-PCL-b-PEG copolymers efficiently mediate transgene expression depending on their graft density. Int J Pharm (2011) 0.85
Poly(ethylenimine-co-L-lactamide-co-succinamide): a biodegradable polyethylenimine derivative with an advantageous pH-dependent hydrolytic degradation for gene delivery. Bioconjug Chem (2002) 0.85
Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors. AAPS PharmSciTech (2011) 0.84
HER2 targeted polyplexes: the effect of polyplex composition and conjugation chemistry on in vitro and in vivo characteristics. Bioconjug Chem (2007) 0.84
Biophysical characterization of hyper-branched polyethylenimine-graft-polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy-PEI-PCL-mPEG) for siRNA delivery. J Control Release (2011) 0.84
In vitro cytotoxic and immunomodulatory profiling of low molecular weight polyethylenimines for pulmonary application. Toxicol In Vitro (2009) 0.84
Solubilization of sagopilone, a poorly water-soluble anticancer drug, using polymeric micelles for parenteral delivery. Int J Pharm (2010) 0.84
Efficiency of polyethylenimines and polyethylenimine-graft-poly (ethylene glycol) block copolymers to protect oligonucleotides against enzymatic degradation. Eur J Pharm Biopharm (2004) 0.84
Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery. J Control Release (2011) 0.84
Delivery of messenger RNA using poly(ethylene imine)-poly(ethylene glycol)-copolymer blends for polyplex formation: biophysical characterization and in vitro transfection properties. J Control Release (2010) 0.83
Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems. J Control Release (2011) 0.83
Effects of different application parameters on penetration characteristics and arterial vessel wall integrity after local nanoparticle delivery using a porous balloon catheter. Eur J Pharm Biopharm (2004) 0.83
The role of branched polyesters and their modifications in the development of modern drug delivery vehicles. J Control Release (2005) 0.82
Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and enoxaparin. Eur J Pharm Biopharm (2008) 0.82
Pharmaceutical care for patients with ischemic stroke: improving the patients quality of life. Pharm World Sci (2009) 0.82
Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant. J Nanosci Nanotechnol (2006) 0.82
Surfactant-free redispersible nanoparticles in fast-dissolving composite microcarriers for dry-powder inhalation. Eur J Pharm Biopharm (2010) 0.82
Amphiphilic biodegradable PEG-PCL-PEI triblock copolymers for FRET-capable in vitro and in vivo delivery of siRNA and quantum dots. Mol Pharm (2014) 0.81
Iloprost-containing liposomes for aerosol application in pulmonary arterial hypertension: formulation aspects and stability. Pharm Res (2006) 0.81
Design of amine-modified graft polyesters for effective gene delivery using DNA-loaded nanoparticles. Pharm Res (2004) 0.81