Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: implications for gene therapy.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 12923569)

Published in Gene Ther on September 01, 2003

Authors

M Themis1, D May, C Coutelle, R F Newbold

Author Affiliations

1: Division of Cell and Molecular Biology, Imperial College, London, UK.

Articles by these authors

(truncated to the top 100)

The sequence of the human genome. Science (2001) 101.55

SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome. Nat Genet (1998) 3.79

Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat Med (1995) 3.61

Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev (2001) 3.43

The spread of multiply resistant Streptococcus pneumoniae at a day care center in Ohio. J Infect Dis (1992) 3.04

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene. Nature (1983) 2.77

An athymic nude mutation in the rat. Nature (1978) 2.54

Threshold of fragmentation for ultrasonic contrast agents. J Biomed Opt (2001) 2.39

Isolation and partial sequence of recombinant plasmids containing human alpha-, beta- and gamma-globin cDNA fragments. Nature (1978) 1.83

Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells. J Natl Cancer Inst (1999) 1.73

An RGD-oligolysine peptide: a prototype construct for integrin-mediated gene delivery. Hum Gene Ther (1998) 1.73

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification. Nature (1980) 1.71

Polymorphism of alcohol dehydrogenase, alcohol and aldehyde dehydrogenase activities: implication in alcoholic cirrhosis in white patients. The French Group for Research on Alcohol and Liver. Hepatology (1992) 1.68

First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying. Gut (1998) 1.68

Error rates in cervical cytological screening tests. Br J Cancer (1974) 1.61

Same-day, first-trimester antenatal diagnosis for cystic fibrosis by gene amplification. Lancet (1988) 1.58

Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res (2001) 1.54

Evolution and diversity of subduction zones controlled by slab width. Nature (2007) 1.54

The life-space diary: a measure of mobility in old people at home. Int Rehabil Med (1985) 1.54

Acceptability of carrier screening for cystic fibrosis during pregnancy in a German population. Hum Genet (1994) 1.48

Successful expression of beta-galactosidase and factor IX transgenes in fetal and neonatal sheep after ultrasound-guided percutaneous adenovirus vector administration into the umbilical vein. Gene Ther (1999) 1.43

Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology (2000) 1.41

Exceptional mutagenicity of a benzo(a)pyrene diol epoxide in cultured mammalian cells. Nature (1976) 1.40

On the structure of transcriptional unit in mammalian cells. Biochim Biophys Acta (1972) 1.38

Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli. EMBO J (2001) 1.35

Posterior lumbar interbody fusion with cages: an independent review of 71 cases. J Neurosurg (1999) 1.34

Haemoglobin interferes with the ex vivo luciferase luminescence assay: consequence for detection of luciferase reporter gene expression in vivo. Gene Ther (2000) 1.33

An araC-controlled bacterial cre expression system to produce DNA minicircle vectors for nuclear and mitochondrial gene therapy. J Biol Chem (2001) 1.30

Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens. Nature (1982) 1.26

Cell binding and internalization by filamentous phage displaying a cyclic Arg-Gly-Asp-containing peptide. J Biol Chem (1994) 1.23

Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am J Physiol (1986) 1.23

A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13. Am J Hum Genet (2001) 1.22

Construction and characterization of a highly stable human: rodent monochromosomal hybrid panel for genetic complementation and genome mapping studies. Cytogenet Cell Genet (1995) 1.21

The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters. BMC Cancer (2009) 1.20

Introduction of plasmid DNA into isolated mitochondria by electroporation. A novel approach toward gene correction for mitochondrial disorders. J Biol Chem (1997) 1.20

Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity. Cancer Res (2001) 1.18

WNT5A expression in human breast cancer. Anticancer Res (2005) 1.18

Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector. Hum Gene Ther (1998) 1.16

Globin mRNA contains a sequence complementary to double-stranded region of nuclear pre-mRNA. Nucleic Acids Res (1976) 1.15

Intra-amniotic delivery of CFTR-expressing adenovirus does not reverse cystic fibrosis phenotype in inbred CFTR-knockout mice. Mol Ther (2008) 1.14

hTERT mRNA expression correlates with telomerase activity in human breast cancer. Eur J Surg Oncol (2003) 1.13

Isolation of a conserved sequence deleted in Duchenne muscular dystrophy patients. Nucleic Acids Res (1987) 1.12

Lupus-like autoimmune disease induced by interferon therapy for myeloproliferative disorders. Clin Immunol Immunopathol (1992) 1.12

Linkage disequilibrium between RFLP haplotype 2 and the affected PAH allele in PKU families from the Berlin area of the German Democratic Republic. Hum Genet (1988) 1.11

Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Ther (2006) 1.10

Cutaneous manifestations in inflammatory bowel disease. Z Gastroenterol (2001) 1.08

Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice. Gene Ther (2003) 1.06

In utero gene therapy: the case for. Nat Med (1999) 1.06

Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector. Gene Ther (2008) 1.05

hTERT expression in human breast cancer and non-cancerous breast tissue: correlation with tumour stage and c-Myc expression. Breast Cancer Res Treat (2003) 1.04

Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Int J Cancer (2000) 1.03

Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes. Oncogene (1997) 1.02

Recombinant HMG1 protein produced in Pichia pastoris: a nonviral gene delivery agent. Biotechniques (1997) 1.02

Lentiviral transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific transgene expression. Gene Ther (2008) 1.02

Pleural effusion and a pelvic mass. Postgrad Med J (1998) 1.00

Phase I study of recombinant human tumor necrosis factor alpha in advanced malignant disease. Cancer Immunol Immunother (1989) 0.99

Atypical fibroxanthoma of the skin with metastasis. Cancer (1986) 0.98

Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line. J Natl Cancer Inst (2001) 0.98

Crossovers in two German cystic fibrosis families determine probe order for MET, 7C22 and XV-2c/CS.7. Hum Genet (1987) 0.97

Trypsin suppression of pancreatic enzyme secretion. Differential effect on cholecystokinin release and the enteropancreatic reflex. Gastroenterology (1986) 0.96

Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens. Carcinogenesis (1995) 0.96

Good and bad patients: a review of the literature and a theoretical critique. J Adv Nurs (1982) 0.96

An open-label trial of tomoxetine in pediatric attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol (2001) 0.96

Enhanced in vitro and in vivo gene delivery using cationic agent complexed retrovirus vectors. Gene Ther (1998) 0.94

In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE. Gene Ther (1995) 0.94

The association between telomerase, histopathological parameters, and KI-67 expression in breast cancer. Am J Surg (1999) 0.93

Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage. Gene Ther (2010) 0.93

DNA amplification of a further exon of Duchenne muscular dystrophy locus increase possibilities for deletion screening. Nucleic Acids Res (1989) 0.92

Typing of families with classical phenylketonuria using three alleles of the Hindiii linked restriction fragment polymorphism, detectable with a phenylalanine hydroxylase cDNA probe. Family typing for PKU by linked HindIII RFLP. Clin Genet (1986) 0.92

Telomerase activity and lymphovascular invasion in breast cancer. Eur J Surg Oncol (2000) 0.92

Glutathione S-transferase class mu in French alcoholic cirrhotic patients. Hum Genet (1991) 0.92

Mormon demographic history I. Nuptiality and fertility of once-married couples. Popul Stud (Camb) (1978) 0.91

Fetal and neonatal gene therapy: benefits and pitfalls. Gene Ther (2004) 0.91

[Fatty acids and monoglycerides from homogenates of frog ova and tadpoles as inhibitors of the respiratory chain]. Acta Biol Med Ger (1970) 0.90

LN-2 (CD74). A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. Cancer (1997) 0.89

Foetal gene delivery in mice by intra-amniotic administration of retroviral producer cells and adenovirus. Gene Ther (1997) 0.89

Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA. Gene Ther (2002) 0.88

Calcium ions as efficient cofactor of polycation-mediated gene transfer. Biochim Biophys Acta (1999) 0.87

PGP9.5: a marker for cellular neurothekeoma. Am J Surg Pathol (1999) 0.87

A novel peptide, PLAEIDGIELTY, for the targeting of alpha9beta1-integrins. FEBS Lett (1998) 0.87

Telomerase activity in melanoma and non-melanoma skin cancer. Br J Cancer (1999) 0.87

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells. Oncogene (2012) 0.87

Cell-mediated mutagenesis in cultured Chinese hamster cells by carcinogenic polycyclic hydrocarbons: nature and extent of the associated hydrocarbon-DNA reaction. Mutat Res (1977) 0.86

Benzo(a)pyrene metabolism and DNA adduct formation in serially cultivated strains of human epidermal keratinocytes. Int J Cancer (1980) 0.86

Meloidogyne incognita Resistance Characteristics in Tomato Genotypes Developed for Processing. J Nematol (1986) 0.86

Evidence of a tumour suppressive function of E2F1 gene in human breast cancer. Anticancer Res (2008) 0.86

Telomere-dependent senescence. Nat Biotechnol (1999) 0.86

Widespread and efficient marker gene expression in the airway epithelia of fetal sheep after minimally invasive tracheal application of recombinant adenovirus in utero. Gene Ther (2004) 0.86

A novel peptide, THALWHT, for the targeting of human airway epithelia. FEBS Lett (2001) 0.86

Analysis of ribosomal and alphoid repetitive DNA by fiber-FISH. Cytogenet Cell Genet (1997) 0.86

Biomechanical comparison of ankle arthrodesis techniques: crossed screws vs. blade plate. Foot Ankle Int (2001) 0.85

Contiguous arrays of satellites 1, 3, and beta form a 1.5-Mb domain on chromosome 22p. Genomics (1997) 0.85

Nucleic acid fixation to cyanuric chloride-activated paper. Use for nucleic acid transfer and affinity binding. Biochim Biophys Acta (1981) 0.85

The cytotoxic, mutagenic and clastogenic effects of chromium-containing compounds on mammalian cells in culture. Mutat Res (1979) 0.85

Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin. Eur J Biochem (1999) 0.84

Inhibition of metabolic cooperation between mammalian cells in culture by tumor promoters. Carcinogenesis (1981) 0.84

Carp preproinsulin cDNA sequence and evolution of insulin genes. Nucleic Acids Res (1983) 0.84

Use of cyanuric chloride-activated paper for detection of subpicogram quantities of specific DNA sequences and its application to linked restriction fragment length polymorphism analysis in a Duchenne muscular dystrophy affected family. Anal Biochem (1987) 0.84

Stimulation of pepsinogen release from isolated gastric glands by cholecystokininlike peptides. Am J Physiol (1983) 0.84

Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16INK4A). Carcinogenesis (1996) 0.84