Published in Dev Biol on September 01, 2003
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Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67
Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol (2011) 3.25
Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med (2010) 3.02
Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol (2010) 2.37
The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci U S A (2004) 2.34
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Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression. Mol Cancer (2006) 1.44
Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells. J Leukoc Biol (2007) 1.39
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Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood (2009) 1.37
A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development (2011) 1.31
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Vascular Robo4 restricts proangiogenic VEGF signaling in breast. Proc Natl Acad Sci U S A (2010) 1.15
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Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol (2008) 0.99
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Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm. Curr Opin Hematol (2011) 0.97
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Silencing of directional migration in roundabout4 knockdown endothelial cells. BMC Cell Biol (2008) 0.96
Expression of Slit and Robo genes in the developing mouse heart. Dev Dyn (2010) 0.93
Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability. PLoS Pathog (2012) 0.92
MR angiogenesis imaging with Robo4- vs. alphaVbeta3-targeted nanoparticles in a B16/F10 mouse melanoma model. FASEB J (2010) 0.91
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Expression of Robo4 in the fibrovascular membranes from patients with proliferative diabetic retinopathy and its role in RF/6A and RPE cells. Mol Vis (2009) 0.90
Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol (2010) 0.90
Quantification of SLIT-ROBO transcripts in hepatocellular carcinoma reveals two groups of genes with coordinate expression. BMC Cancer (2008) 0.89
Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia. Exp Neurol (2007) 0.89
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RabGDI controls axonal midline crossing by regulating Robo1 surface expression. Neural Dev (2012) 0.88
Activation of endothelial roundabout receptor 4 reduces the severity of virus-induced keratitis. J Immunol (2011) 0.87
Robo4 regulates the radial migration of newborn neurons in developing neocortex. Cereb Cortex (2011) 0.87
Upregulated genes in sporadic, idiopathic pulmonary arterial hypertension. Respir Res (2006) 0.87
Characterization of the interaction between Robo1 and heparin and other glycosaminoglycans. Biochimie (2013) 0.87
SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. J Mol Cell Cardiol (2013) 0.87
Life is a pattern: vascular assembly within the embryo. Front Biosci (Elite Ed) (2012) 0.86
The role of Robo3 in the development of cortical interneurons. Cereb Cortex (2009) 0.86
Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Dis Model Mech (2011) 0.85
Retargeting of gene expression using endothelium specific hexon modified adenoviral vector. Virology (2013) 0.85
Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish. J Biol Chem (2011) 0.84
ROBO4-mediated vascular integrity regulates the directionality of hematopoietic stem cell trafficking. Stem Cell Reports (2015) 0.84
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Slit2N/Robo1 inhibit HIV-gp120-induced migration and podosome formation in immature dendritic cells by sequestering LSP1 and WASp. PLoS One (2012) 0.82
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Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. Mol Hum Reprod (2010) 0.82
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Alternatively spliced Robo2 isoforms in zebrafish and rat. Dev Genes Evol (2006) 0.80
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Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish development. Gene Expr (2007) 0.79
Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy. J Clin Invest (2016) 0.79
Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway. Cell Commun Signal (2014) 0.79
Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis. PLoS One (2015) 0.79
Role of ROBO4 signalling in developmental and pathological angiogenesis. Biomed Res Int (2014) 0.79
Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1). Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.79
Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique? J Transl Med (2015) 0.77
Clinical and prognostic implications of Roundabout 4 (robo4) in adult patients with acute myeloid leukemia. PLoS One (2015) 0.77
Transcriptional targeting of primary and metastatic tumor neovasculature by an adenoviral type 5 roundabout4 vector in mice. PLoS One (2013) 0.77
The role of epigenetics in the endothelial cell shear stress response and atherosclerosis. Int J Biochem Cell Biol (2015) 0.77
NG2 glia are required for vessel network formation during embryonic development. Elife (2015) 0.77
Human placental multipotent mesenchymal stromal cells modulate placenta angiogenesis through Slit2-Robo signaling. Cell Adh Migr (2016) 0.76
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Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol (2015) 0.76
Slit2-Robo signaling in inflammation and kidney injury. Pediatr Nephrol (2014) 0.76
Slit2/Robo4 Signaling: Potential Role of a VEGF-Antagonist Pathway to Regulate Luteal Permeability. Geburtshilfe Frauenheilkd (2017) 0.75
Endo-MitoEGFP mice: a novel transgenic mouse with fluorescently marked mitochondria in microvascular endothelial cells. PLoS One (2013) 0.75
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis. Mol Oncol (2015) 0.75
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. Nat Commun (2016) 0.75
The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers. BMC Cancer (2015) 0.75
Potential Role of Axonal Chemorepellent Slit2 in Modulating Adventitial Inflammation in a Rat Carotid Artery Balloon Injury Model. J Cardiovasc Pharmacol (2016) 0.75
Lethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression. Biol Open (2016) 0.75
The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. PLoS One (2017) 0.75
VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels. Development (2017) 0.75
Neurovascular patterning cues and implications for central and peripheral neurological disease. Surg Neurol Int (2017) 0.75
The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs. Dev Dyn (2007) 8.86
China's research culture. Science (2010) 5.08
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature (2012) 3.81
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67
Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators. Cell (2005) 3.42
Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell (2003) 3.14
The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol (2006) 3.11
The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med (2009) 3.05
Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med (2010) 3.02
Magnitude and time course of changes induced by continuous-flow left ventricular assist device unloading in chronic heart failure: insights into cardiac recovery. J Am Coll Cardiol (2013) 2.92
Netrins promote developmental and therapeutic angiogenesis. Science (2006) 2.83
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis. J Neurosci (2010) 2.73
A subset of octopaminergic neurons are important for Drosophila aggression. Nat Neurosci (2008) 2.64
In vivo imaging reveals dendritic targeting of laminated afferents by zebrafish retinal ganglion cells. Neuron (2006) 2.54
A critical role for elastin signaling in vascular morphogenesis and disease. Development (2003) 2.47
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci (2004) 2.41
A Drosophila model for TDP-43 proteinopathy. Proc Natl Acad Sci U S A (2010) 2.36
Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations. Development (2004) 2.35
The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci U S A (2004) 2.34
New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron (2010) 2.12
Signalling mechanisms mediating neuronal responses to guidance cues. Nat Rev Neurosci (2003) 2.11
Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. Am J Physiol Heart Circ Physiol (2005) 2.06
Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest (2003) 2.05
Axon tracking in serial block-face scanning electron microscopy. Med Image Anal (2008) 2.05
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Medical tourism: globalization of the healthcare marketplace. MedGenMed (2007) 1.95
Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila. Nat Neurosci (2011) 1.90
Polarization and orientation of retinal ganglion cells in vivo. Neural Dev (2006) 1.89
Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci (2004) 1.89
Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet (2007) 1.85
Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet (2010) 1.83
Risk factors predictive of right ventricular failure after left ventricular assist device implantation. Am J Cardiol (2010) 1.81
Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. Curr Opin Genet Dev (2002) 1.77
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol (2009) 1.73
Slit protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells. J Biol Chem (2003) 1.73
Pathfinding in a large vertebrate axon tract: isotypic interactions guide retinotectal axons at multiple choice points. Development (2008) 1.73
Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A (2008) 1.70
Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nat Neurosci (2002) 1.69
roundabout4 is essential for angiogenesis in vivo. Proc Natl Acad Sci U S A (2005) 1.69
A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A (2003) 1.60
Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher. PLoS Genet (2008) 1.59
DSCAM functions as a netrin receptor in commissural axon pathfinding. Proc Natl Acad Sci U S A (2009) 1.58
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity. Nat Struct Mol Biol (2011) 1.58
Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer). Neuron (2004) 1.56
Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels. Cancer Cell (2012) 1.56
The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development (2008) 1.50
An interactive visualization tool for multi-channel confocal microscopy data in neurobiology research. IEEE Trans Vis Comput Graph (2009) 1.42
Synaptic activity and activity-dependent competition regulates axon arbor maturation, growth arrest, and territory in the retinotectal projection. J Neurosci (2010) 1.41
Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling. Nat Neurosci (2007) 1.37
Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration. Proc Natl Acad Sci U S A (2005) 1.37
Prior human leukocyte antigen-allosensitization and left ventricular assist device type affect degree of post-implantation human leukocyte antigen-allosensitization. J Heart Lung Transplant (2009) 1.37
Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest (2011) 1.36
Highly conserved gene order and numerous novel repetitive elements in genomic regions linked to wing pattern variation in Heliconius butterflies. BMC Genomics (2008) 1.36
Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor. Dev Biol (2003) 1.36
Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses. J Immunol (2003) 1.35
Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart. J Am Coll Cardiol (2010) 1.34
New insights into elastin and vascular disease. Trends Cardiovasc Med (2003) 1.32
Pre-mRNA splicing and retinitis pigmentosa. Mol Vis (2006) 1.32
Domain-specific regulation of foxP2 CNS expression by lef1. BMC Dev Biol (2008) 1.31
When sugars guide axons: insights from heparan sulphate proteoglycan mutants. Nat Rev Genet (2004) 1.30
Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5. Proc Natl Acad Sci U S A (2008) 1.28
Elastin haploinsufficiency induces alternative aging processes in the aorta. Rejuvenation Res (2008) 1.26
Slit1a inhibits retinal ganglion cell arborization and synaptogenesis via Robo2-dependent and -independent pathways. Neuron (2007) 1.26
HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification. PLoS Genet (2008) 1.25
Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells. J Cell Biol (2003) 1.24
A complex choreography of cell movements shapes the vertebrate eye. Development (2012) 1.22
Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature (2011) 1.22
Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing. J Biol Chem (2006) 1.22
Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. J Biol Chem (2003) 1.22
Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain. Development (2005) 1.21
Probing symmetry properties of few-layer MoS2 and h-BN by optical second-harmonic generation. Nano Lett (2013) 1.20
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Pulsatility and the risk of nonsurgical bleeding in patients supported with the continuous-flow left ventricular assist device HeartMate II. Circ Heart Fail (2013) 1.19
Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Mol Cell Neurosci (2005) 1.17
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Vascular Robo4 restricts proangiogenic VEGF signaling in breast. Proc Natl Acad Sci U S A (2010) 1.15
Transient decrease in F-actin may be necessary for translocation of proteins into dendritic spines. Eur J Neurosci (2005) 1.15
Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation. Blood (2007) 1.14
p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci (2007) 1.14
Morbidity and mortality in heart transplant candidates supported with mechanical circulatory support: is reappraisal of the current United network for organ sharing thoracic organ allocation policy justified? Circulation (2012) 1.14
Netrin/DCC signaling controls contralateral dendrites of octavolateralis efferent neurons. J Neurosci (2006) 1.13