Published in Cell Mol Life Sci on July 01, 2003
Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nat Mater (2009) 2.87
Polyamines: essential factors for growth and survival. Planta (2008) 2.52
Mammalian polyamine metabolism and function. IUBMB Life (2009) 2.33
Polyamines: molecules with regulatory functions in plant abiotic stress tolerance. Planta (2010) 2.32
Interhelical spacing in liquid crystalline spermine and spermidine-DNA precipitates. Biophys J (2004) 1.52
Putrescine is involved in Arabidopsis freezing tolerance and cold acclimation by regulating abscisic acid levels in response to low temperature. Plant Physiol (2008) 1.52
Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog. Proc Natl Acad Sci U S A (2007) 1.41
Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis. Exp Dermatol (2013) 1.39
Current status of the polyamine research field. Methods Mol Biol (2011) 1.33
Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. EMBO J (2004) 1.32
The mechanisms by which polyamines accelerate tumor spread. J Exp Clin Cancer Res (2011) 1.30
The roles of polyamines during the lifespan of plants: from development to stress. Planta (2014) 1.26
The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation. J Biol Chem (2010) 1.15
Physiological polyamines: simple primordial stress molecules. J Cell Mol Med (2007) 1.07
Strong physical constraints on sequence-specific target location by proteins on DNA molecules. Nucleic Acids Res (2006) 1.06
Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Clin Cancer Res (2009) 1.01
Putrescine biosynthesis in mammalian tissues. Biochem J (2004) 0.99
Functional genomics of physiological plasticity and local adaptation in killifish. J Hered (2010) 0.99
RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis. Eukaryot Cell (2009) 0.98
Genetic and epigenetic underpinnings of sex differences in the brain and in neurological and psychiatric disease susceptibility. Prog Brain Res (2010) 0.97
Immunization with polyamine transport protein PotD protects mice against systemic infection with Streptococcus pneumoniae. Infect Immun (2006) 0.96
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. Eukaryot Cell (2004) 0.95
Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Proc Natl Acad Sci U S A (2007) 0.94
Functional characterization of seven γ-Glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and β-Alanine utilization in Pseudomonas aeruginosa PAO1. J Bacteriol (2011) 0.94
Physiological and molecular implications of plant polyamine metabolism during biotic interactions. Front Plant Sci (2014) 0.92
Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS One (2010) 0.89
Amino acids regulate expression of antizyme-1 to modulate ornithine decarboxylase activity. J Biol Chem (2011) 0.89
Probing tRNA interaction with biogenic polyamines. RNA (2010) 0.89
Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma. Front Oncol (2012) 0.89
Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. Antimicrob Agents Chemother (2006) 0.89
Consistency of polyamine profiles and expression of arginine decarboxylase in mitosis during zygotic embryogenesis of Scots pine. Plant Physiol (2006) 0.89
Biogenic and synthetic polyamines bind bovine serum albumin. Biomacromolecules (2010) 0.87
Regulation of apoptosis signal-regulating kinase 1 (ASK1) by polyamine levels via protein phosphatase 5. J Biol Chem (2005) 0.87
Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. PLoS One (2011) 0.86
Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme. J Biol Chem (2013) 0.85
The photoprotective role of spermidine in tomato seedlings under salinity-alkalinity stress. PLoS One (2014) 0.85
Polyamine analogues bind human serum albumin. Biomacromolecules (2007) 0.85
Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha. J Cell Physiol (2005) 0.85
Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells. J Biol Chem (2008) 0.85
Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines. Cancer Growth Metastasis (2015) 0.84
Minimal antizyme peptide fully functioning in the binding and inhibition of ornithine decarboxylase and antizyme inhibitor. PLoS One (2011) 0.83
Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference. FASEB J (2009) 0.82
Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production. Proteins (2011) 0.82
Involvement of polyamine binding protein D (PotD) of Synechocystis sp. PCC 6803 in spermidine uptake and excretion. Curr Microbiol (2014) 0.81
Binding of the biogenic polyamines to deoxyribonucleic acids of varying base composition: base specificity and the associated energetics of the interaction. PLoS One (2013) 0.81
Immunocytochemical demonstration of polyamines in nucleoli and nuclei. Histochem Cell Biol (2008) 0.81
Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase. J Biol Chem (2010) 0.81
Determinants of the differential antizyme-binding affinity of ornithine decarboxylase. PLoS One (2011) 0.81
A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells. Oxid Med Cell Longev (2012) 0.80
Agp2p, the plasma membrane transregulator of polyamine uptake, regulates the antifungal activities of the plant defensin NaD1 and other cationic peptides. Antimicrob Agents Chemother (2014) 0.80
Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area. PLoS One (2013) 0.79
Time-dependent DNA condensation induced by amyloid beta-peptide. Biophys J (2006) 0.78
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis. Cancer Biol Ther (2012) 0.77
MtnBD is a multifunctional fusion enzyme in the methionine salvage pathway of Tetrahymena thermophila. PLoS One (2013) 0.76
Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress. Biol Sex Differ (2016) 0.76
Polyamine-independent Expression of Caenorhabditis elegans Antizyme. J Biol Chem (2015) 0.75
Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. Cancer Res (2015) 0.75
The polyamine N-acetyltransferase-like enzyme PmvE plays a role in the virulence of Enterococcus faecalis. Infect Immun (2014) 0.75
Anaplerotic Accumulation of Tricarboxylic Acid Cycle Intermediates as Well as Changes in Other Key Metabolites During Heterotopic Ossification. J Cell Biochem (2015) 0.75
A rationally designed peptide enhances homologous recombination in vitro and resistance to DNA damaging agents in vivo. Nucleic Acids Res (2010) 0.75
Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei. FASEB J (2017) 0.75
Functional Changes in the Gut Microbiome Contribute to Transforming Growth Factor β-Deficient Colon Cancer. mSystems (2017) 0.75
Serum levels of polyamine synthesis enzymes increase in diabetic patients with breast cancer. Endocr Connect (2017) 0.75
Ancillary Activity: Beyond Core Metabolism in Immune Cells. Cell Metab (2017) 0.75
Improving cartilage phenotype from differentiated pericytes in tunable peptide hydrogels. Sci Rep (2017) 0.75
A pqr2 mutant encodes a defective polyamine transporter and is negatively affected by ABA for paraquat resistance in Arabidopsis thaliana. J Plant Res (2016) 0.75
Induced thermal resistance in HeLa cells. Nature (1975) 2.54
Development of difluoromethylornithine (DFMO) as a chemoprevention agent. Clin Cancer Res (1999) 2.08
Efflux of the natural polyamine spermidine facilitated by the Bacillus subtilis multidrug transporter Blt. J Biol Chem (1997) 1.46
Heat shock proteins in thermotolerance and other cellular processes. Cancer Res (1987) 1.44
Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention. J Natl Cancer Inst (1998) 1.37
Effects of cycloheximide on thermotolerance expression, heat shock protein synthesis, and heat shock protein mRNA accumulation in rat fibroblasts. Mol Cell Biol (1986) 1.36
Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. Nutr Cancer (1998) 1.34
Polyamine biosynthesis and accumulation during the G1 to S phase transition. J Cell Physiol (1977) 1.26
Dose de-escalation chemoprevention trial of alpha-difluoromethylornithine in patients with colon polyps. J Natl Cancer Inst (1994) 1.23
Cell cycle-specific activity of type I and type II cyclic adenosine 3':5'-monophosphate-dependent protein kinases in Chinese hamster ovary cells. J Biol Chem (1976) 1.17
APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse. Carcinogenesis (1999) 1.15
Hypusine formation in protein by a two-step process in cell lysates. J Biol Chem (1987) 1.11
Spermidine mediates degradation of ornithine decarboxylase by a non-lysosomal, ubiquitin-independent mechanism. J Cell Physiol (1987) 1.10
A transient thermotolerant survival response produced by single thermal doses in HeLa cells. Cancer Res (1976) 1.07
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells. Biochem J (1986) 1.07
Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine. Cancer Epidemiol Biomarkers Prev (2000) 1.05
Heat shock stimulates polyamine oxidation by two distinct mechanisms in mammalian cell cultures. Int J Radiat Oncol Biol Phys (1989) 1.03
The relationship between polyamine accumulation and DNA replication in synchronized Chinese hamster ovary cells after heat shock. Cancer Res (1977) 1.01
Spermidine acetylation in response to a variety of stresses in Escherichia coli. J Biol Chem (1991) 0.99
Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis. Biochem J (1997) 0.98
Characterization of a diamine exporter in Chinese hamster ovary cells and identification of specific polyamine substrates. J Biol Chem (1997) 0.97
Characterization of a novel spermidine/spermine acetyltransferase, BltD, from Bacillus subtilis. Biochem J (1999) 0.96
Clinical hyperthermia: results of a phase I trial employing hyperthermia alone or in combination with external beam or interstitial radiotherapy. Cancer (1982) 0.96
Ornithine decarboxylase and polyamines in colorectal neoplasia and mucosa. Cancer Epidemiol Biomarkers Prev (1993) 0.94
Membranes of animal cells. V. Biosynthesis of the surface membrane during the cell cycle. J Cell Physiol (1970) 0.94
The cell-cycle phase synthesis of non-histone proteins in mammalian cells. Biochim Biophys Acta (1973) 0.93
Prospects for hyperthermia in human cancer therapy. Part II: implications of biological and physical data for applications of hyperthermia to man. Radiology (1977) 0.93
Ornithine decarboxylase and polyamine levels in columnar upper gastrointestinal mucosae in patients with Barrett's esophagus. Cancer Res (1988) 0.93
Surrogate end-point biomarkers as measures of colon cancer risk and their use in cancer chemoprevention trials. Cancer Epidemiol Biomarkers Prev (1997) 0.93
Effects of diethyldithiocarbamate and endogenous polyamine content on cellular responses to hydrogen peroxide cytotoxicity. Biochem J (1989) 0.93
Ross' syndrome (tonic pupil plus). Br J Ophthalmol (1975) 0.92
Accumulation of heat shock protein 70 RNA and its relationship to protein synthesis after heat shock in mammalian cells. Exp Cell Res (1987) 0.92
Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane- and dimethylhydrazine-treated rats. Mol Carcinog (1997) 0.91
Sensitization of Chinese hamster ovary cells to heat shock by alpha-difluoromethylornithine. Cancer Res (1987) 0.91
Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis. Biol Signals (1997) 0.90
Cholesterol levels inversely reflect the thermal sensitivity of mammalian cells in culture. Nature (1980) 0.89
Non-histone protein synthesis during G1 phase and its relation to DNA replication. J Cell Physiol (1976) 0.89
Polyamine regulation of heat-shock-induced spermidine N1-acetyltransferase activity. Biochem J (1990) 0.89
Polyamine-mediated turnover of ornithine decarboxylase in Chinese-hamster ovary cells. Biochem J (1986) 0.89
Heat shock-induced shedding of cell surface integrins in A549 human lung tumor cells in culture. Exp Cell Res (1994) 0.89
Survival and cell kinetics effects of adriamycin on mammalian cells. Cancer Res (1973) 0.88
Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells. J Cell Physiol (1994) 0.88
Loss of intracellular putrescine pool-size regulation induces apoptosis. Exp Cell Res (1997) 0.88
Rate of heating as a determinant of hyperthermic cytotoxicity. Cancer Res (1981) 0.88
Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial. J Natl Cancer Inst (2001) 0.87
Regulation of DNA replication by serum and the transforming function in cultured rat fibroblasts transformed by Rous sarcoma virus. J Cell Physiol (1979) 0.86
Cyclic AMP levels and types I and II cyclic AMP-dependent protein kinase activity in synchronized cells and in quiescent cultures stimulated to proliferate. Biochim Biophys Acta (1978) 0.86
Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer. J Cell Biochem Suppl (1995) 0.86
Effect of heating on lethality due to hyperthermia and selected chemotherapeutic drugs. J Natl Cancer Inst (1982) 0.85
Expression of the human spermidine/spermine N1-acetyltransferase in spermidine acetylation-deficient Escherichia coli. Biochem J (1996) 0.85
Growth arrest- and polyamine-dependent expression of spermidine/spermine N1-acetyltransferase in human tumor cells. Cell Growth Differ (1996) 0.84
Polyamines and polyamine biosynthesis in cells exposed to hyperthermia. Radiat Res (1983) 0.84
Increased thioredoxin-1 inhibits SSAT expression in MCF-7 human breast cancer cells. Biochem Biophys Res Commun (2003) 0.83
Floppy eyelid with hyperglycinemia. Am J Ophthalmol (1984) 0.83
Restoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation. Eur J Biochem (1986) 0.83
Polyamine contents in rectal and buccal mucosae in humans treated with oral difluoromethylornithine. Cancer Epidemiol Biomarkers Prev (1993) 0.83
Phosphorylation of a high molecular weight DNA polymerase alpha. Proc Natl Acad Sci U S A (1987) 0.83
Sources of variability in estimating ornithine decarboxylase activity and polyamine contents in human colorectal mucosa. Cancer Epidemiol Biomarkers Prev (1994) 0.82
Enhancement of hyperthermia-induced cytotoxicity by polyamines. Cancer Res (1980) 0.82
Role of dietary polyamines in a phase III clinical trial of difluoromethylornithine (DFMO) and sulindac for prevention of sporadic colorectal adenomas. Br J Cancer (2013) 0.82
Hydroxyurea treatment affects the G1 phase in next generation CHO cells. Exp Cell Res (1977) 0.82
Ornithine decarboxylase production in vitro by using mouse cDNA. Biochem J (1987) 0.81
Reactive nitrogen species in colon carcinogenesis. Antioxid Redox Signal (1999) 0.81
Dissociation of 68,000 Mr heat shock protein synthesis from thermotolerance expression in rat fibroblasts. Radiat Res (1984) 0.81
Polyamine catabolism in rodent and human cells in culture. Biochem J (1991) 0.81
Separation of normal human bone marrow cells by counterflow centrifugal elutriation. I. Morphological analysis and subfractionation of neutrophilic granulocytes. Exp Hematol (1979) 0.81
G1 specific increases in cyclic AMP levels and protein kinase activity in Chinese hamster ovary cells. Biochim Biophys Acta (1976) 0.81
DNA replication kinetics in X-irradiated chinese hamster ovary cells. Radiat Res (1977) 0.81
Delayed sensitization to heat by inhibitors of polyamine-biosynthetic enzymes. Cancer Res (1982) 0.81
Correlation between amounts of cellular membrane components and sensitivity to hyperthermia in a variety of mammalian cell lines in culture. Cancer Res (1982) 0.81
Changes in the carbohydrate content of the KB cell during the growth cycle. J Cell Physiol (1971) 0.80
Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Res (2000) 0.80
Polyamines as modifiers of genetic risk factors in human intestinal cancers. Biochem Soc Trans (2003) 0.80
Cyclophosphamide inhibition of experimental allergic encephalomyelitis in Wistar rats. Proc Soc Exp Biol Med (1967) 0.79
Increased susceptibility of cells to inducible apoptosis during growth from early to late log phase: an important caveat for in vitro apoptosis research. Toxicol Lett (2000) 0.79
Factors regulating membrane permeability alter thermal resistance. Ann N Y Acad Sci (1980) 0.79
Influence of growth state on several thermal responses of EMT6/Az tumor cells in vitro. Cancer Res (1979) 0.79
Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs. Biochem J (1996) 0.79
Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation. Anticancer Res (2001) 0.79
Altered polyamine metabolism in Chinese hamster cells growing in a defined medium. J Cell Physiol (1986) 0.79
Combining polyamine depletion with radiation therapy for rapidly dividing head and neck tumors: strategies for improved locoregional control. Int J Radiat Oncol Biol Phys (1994) 0.78
Collateral sensitivity to methotrexate in cells resistant to adriamycin. Cancer Res (1979) 0.78
Polyamine biosynthesis inhibitors combined with systemic hyperthermia in cancer therapy. Int J Radiat Oncol Biol Phys (1990) 0.78
Ornithine decarboxylase induction in cells stimulated to proliferate differs from that in continuously dividing cells. Biochem J (1980) 0.78
Polyamines: a dual role in the modulation of cellular sensitivity to heat. Radiat Res (1982) 0.78
Hydroxyurea inhibits ODC induction, but not the G1 to S phase transition. Biochem Biophys Res Commun (1979) 0.78
Delta-type DNA polymerase characterized from Drosophila melanogaster embryos. Nucleic Acids Res (1992) 0.78
Aldose reductase inhibitors in clinical practice. Preliminary studies on diabetic neuropathy and retinopathy. Drugs (1986) 0.78
Cytoplasmic and nuclear protein kinases during the cell cycle. Biochim Biophys Acta (1977) 0.77
Enteraction of hyperthermia with radiations of different linerar energy transfer. Int J Radiat Biol Relat Stud Phys Chem Med (1977) 0.77
Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide. Life Sci (1993) 0.77
Clinical experience with sorbinil--an aldose reductase inhibitor. Metabolism (1986) 0.77
Hypusine biosynthesis in protein and its biological consequences. Adv Exp Med Biol (1988) 0.77
Amifostine: a tonic or toxin to myeloid progenitors. Leuk Res (2000) 0.77
Reversal of resistance to methotrexate by hyperthermia in Chinese hamster ovary cells. Cancer Res (1981) 0.76
Polyamine-dependent expression of the matrix metalloproteinase matrilysin in a human colon cancer-derived cell line. Mol Carcinog (1994) 0.76
Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines. Cancer Res (1986) 0.76
The potential of localized heating as a adjunct to radiation therapy. Radiology (1975) 0.76
Hyperthermic potentiation: biological aspects and applications to radiation therapy. Cancer (1977) 0.76
The pharmaceutical industry--to whom is it accountable? N Engl J Med (2000) 0.75