Published in Proteins on October 01, 2003
Uronate isomerase: a nonhydrolytic member of the amidohydrolase superfamily with an ambivalent requirement for a divalent metal ion. Biochemistry (2006) 1.07
TrzN from Arthrobacter aurescens TC1 Is a zinc amidohydrolase. J Bacteriol (2006) 1.03
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics (2006) 43.68
Genome-wide insertional mutagenesis of Arabidopsis thaliana. Science (2003) 39.19
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med (2005) 16.59
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science (2008) 11.74
Empirical analysis of transcriptional activity in the Arabidopsis genome. Science (2003) 11.62
Antibody recognition of a highly conserved influenza virus epitope. Science (2009) 11.26
Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature (2011) 11.07
Synchrony, waves, and spatial hierarchies in the spread of influenza. Science (2006) 10.43
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (2010) 10.30
Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med (2011) 10.29
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science (2006) 10.04
HIV vaccine design and the neutralizing antibody problem. Nat Immunol (2004) 9.48
Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines. J Synchrotron Radiat (2002) 9.48
Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis (2003) 9.44
Severe respiratory disease concurrent with the circulation of H1N1 influenza. N Engl J Med (2009) 8.99
Impact of influenza vaccination on seasonal mortality in the US elderly population. Arch Intern Med (2005) 8.46
Protein tyrosine phosphatases in the human genome. Cell (2004) 8.09
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120. J Virol (2002) 7.82
Structure of a V3-containing HIV-1 gp120 core. Science (2005) 7.69
How TCRs bind MHCs, peptides, and coreceptors. Annu Rev Immunol (2006) 7.57
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Proc Natl Acad Sci U S A (2004) 7.55
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature (2011) 7.20
Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus. Science (2004) 6.70
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science (2003) 6.68
The importance of alignment accuracy for molecular replacement. Acta Crystallogr D Biol Crystallogr (2004) 6.49
Structure of an agonist-bound human A2A adenosine receptor. Science (2011) 6.21
Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities. J Mol Biol (2005) 6.17
Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus. Science (2010) 6.10
A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure (2008) 6.01
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Mortality benefits of influenza vaccination in elderly people: an ongoing controversy. Lancet Infect Dis (2007) 5.91
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A (2009) 5.86
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86
A highly conserved neutralizing epitope on group 2 influenza A viruses. Science (2011) 5.66
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120. J Virol (2003) 5.59
Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science (2013) 5.53
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol (2006) 5.51
Tolerating some redundancy significantly speeds up clustering of large protein databases. Bioinformatics (2002) 5.46
Flexible structure alignment by chaining aligned fragment pairs allowing twists. Bioinformatics (2003) 5.46
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science (2011) 5.44
Influenza and the winter increase in mortality in the United States, 1959-1999. Am J Epidemiol (2004) 5.26
Structure of the human κ-opioid receptor in complex with JDTic. Nature (2012) 5.18
FFAS03: a server for profile--profile sequence alignments. Nucleic Acids Res (2005) 4.99
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Multinational impact of the 1968 Hong Kong influenza pandemic: evidence for a smoldering pandemic. J Infect Dis (2005) 4.75
A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. J Virol (2005) 4.71
Single mimivirus particles intercepted and imaged with an X-ray laser. Nature (2011) 4.63
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Science (2013) 4.61
Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science (2011) 4.42
A primer on metagenomics. PLoS Comput Biol (2010) 4.40
Community cyberinfrastructure for Advanced Microbial Ecology Research and Analysis: the CAMERA resource. Nucleic Acids Res (2010) 4.39
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science (2007) 4.35
Transmissibility and mortality impact of epidemic and pandemic influenza, with emphasis on the unusually deadly 1951 epidemic. Vaccine (2006) 4.28
Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. Immunity (2005) 4.26
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science (2009) 4.25
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies. PLoS Pathog (2013) 4.23
New world bats harbor diverse influenza A viruses. PLoS Pathog (2013) 4.10
Seasonality of influenza in Brazil: a traveling wave from the Amazon to the subtropics. Am J Epidemiol (2007) 4.06
The Genomic Standards Consortium. PLoS Biol (2011) 3.99
Protein production and purification. Nat Methods (2008) 3.97
A rare-cell detector for cancer. Proc Natl Acad Sci U S A (2004) 3.95
Structure-function of the G protein-coupled receptor superfamily. Annu Rev Pharmacol Toxicol (2012) 3.83
Stochastic processes are key determinants of short-term evolution in influenza a virus. PLoS Pathog (2006) 3.82
Crystal structure of a lipid G protein-coupled receptor. Science (2012) 3.78
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science (2005) 3.72
Serial femtosecond crystallography of G protein-coupled receptors. Science (2013) 3.58
Antibody vs. HIV in a clash of evolutionary titans. Proc Natl Acad Sci U S A (2005) 3.57