Published in Nat Rev Immunol on September 01, 2003
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Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants. Pediatrics (2009) 1.98
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Scaffold proteins and immune-cell signalling. Nat Rev Immunol (2009) 1.84
TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest (2009) 1.76
A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Am J Hum Genet (2004) 1.76
Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J Clin Invest (2010) 1.75
CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci (2011) 1.75
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Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. J Biol Chem (2008) 1.67
Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. EMBO J (2007) 1.65
Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. Cancer Res (2008) 1.63
Fas death receptor signalling: roles of Bid and XIAP. Cell Death Differ (2011) 1.63
Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Mol Cell Biol (2005) 1.61
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection. J Exp Med (2011) 1.60
Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol Sin (2008) 1.60
Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Proc Natl Acad Sci U S A (2007) 1.58
Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter. EMBO J (2004) 1.53
Cellular FLICE-inhibitory protein is required for T cell survival and cycling. J Exp Med (2005) 1.52
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J Clin Invest (2010) 1.50
Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4. Mol Cell Biol (2005) 1.50
MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer. Cancer Res (2013) 1.48
Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat Immunol (2011) 1.46
Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr (2010) 1.44
Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. Cancer Res (2009) 1.43
Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. Chem Biol (2008) 1.42
Tumour necrosis factor-α inhibition can stabilize disease in progressive vitiligo. Br J Dermatol (2015) 1.42
Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. Circ Res (2010) 1.42
Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray. PLoS Med (2005) 1.42
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The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness. Immunity (2012) 1.39
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Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood. Eur J Immunol (2010) 1.37
Two sides of a cellular coin: CD4(+)CD3- cells regulate memory responses and lymph-node organization. Nat Rev Immunol (2005) 1.35
Modulation of tumor necrosis factor by microbial pathogens. PLoS Pathog (2006) 1.34
Oxidative stress in Fanconi anemia hematopoiesis and disease progression. Antioxid Redox Signal (2008) 1.33
Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling. EMBO J (2007) 1.32
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell (2007) 1.30
Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role. Blood (2012) 1.30
A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol (2009) 1.28
Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors. J Exp Med (2011) 1.27
NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling. Cell Death Differ (2009) 1.27
Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice. J Immunol (2007) 1.27
Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell (2014) 1.27
Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics (Sao Paulo) (2008) 1.26
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci U S A (2008) 1.26
Innate but not adaptive immune responses contribute to behavioral seizures following viral infection. Epilepsia (2009) 1.26
Calpains, mitochondria, and apoptosis. Cardiovasc Res (2012) 1.25
A long-term, open-label trial of the safety and efficacy of etanercept (Enbrel) in patients with rheumatoid arthritis not treated with other disease-modifying antirheumatic drugs. Ann Rheum Dis (2006) 1.24
Tumor necrosis factor blockade and the risk of viral infection. Nat Rev Rheumatol (2010) 1.24
Retracted Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. J Biol Chem (2010) 1.24
Retracted Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. J Biol Chem (2010) 1.24
Interaction of staphylococci with bone. Int J Med Microbiol (2009) 1.23
NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell (2010) 1.22
Safety of biologic therapy in rheumatoid arthritis. Nat Rev Rheumatol (2011) 1.22
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A (2006) 1.22
Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. Apoptosis (2008) 1.21
Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarization. BMC Immunol (2009) 1.21
Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br J Pharmacol (2013) 1.21
The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol (2013) 1.21
Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. J Clin Invest (2006) 1.20
TNF superfamily: a growing saga of kidney injury modulators. Mediators Inflamm (2010) 1.20
Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response. Proc Natl Acad Sci U S A (2013) 1.19
Role for tumor necrosis factor alpha in murine cytomegalovirus transcriptional reactivation in latently infected lungs. J Virol (2005) 1.18
Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infection. Am J Pathol (2011) 1.16
Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression. Mol Cancer (2011) 1.16
Fold change of nuclear NF-κB determines TNF-induced transcription in single cells. Mol Cell (2014) 1.16