PubRank

Laurence D Hurst

Author PubWeight™ 155.02‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Clustering of housekeeping genes provides a unified model of gene order in the human genome. Nat Genet 2002 6.89
2 Dosage sensitivity and the evolution of gene families in yeast. Nature 2003 6.77
3 Hearing silence: non-neutral evolution at synonymous sites in mammals. Nat Rev Genet 2006 5.97
4 Comparisons of dN/dS are time dependent for closely related bacterial genomes. J Theor Biol 2005 5.20
5 Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature 2004 4.06
6 Stratus not altocumulus: a new view of the yeast protein interaction network. PLoS Biol 2006 3.44
7 Human SNP variability and mutation rate are higher in regions of high recombination. Trends Genet 2002 3.11
8 Positively charged residues are the major determinants of ribosomal velocity. PLoS Biol 2013 3.11
9 Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes. Genome Res 2003 3.10
10 Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals. Genome Biol 2005 2.94
11 Evidence for purifying selection against synonymous mutations in mammalian exonic splicing enhancers. Mol Biol Evol 2005 2.85
12 The signature of selection mediated by expression on human genes. Genome Res 2003 2.56
13 Evolution of chromosome organization driven by selection for reduced gene expression noise. Nat Genet 2007 2.55
14 Chance and necessity in the evolution of minimal metabolic networks. Nature 2006 2.48
15 Genomic function: Rate of evolution and gene dispensability. Nature 2003 2.40
16 Evolutionary and physiological importance of hub proteins. PLoS Comput Biol 2006 2.34
17 Splicing and the evolution of proteins in mammals. PLoS Biol 2007 2.32
18 Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts. Trends Genet 2005 2.04
19 Evidence for co-evolution of gene order and recombination rate. Nat Genet 2003 1.84
20 Still stratus not altocumulus: further evidence against the date/party hub distinction. PLoS Biol 2007 1.84
21 Metabolic trade-offs and the maintenance of the fittest and the flattest. Nature 2011 1.82
22 A unification of mosaic structures in the human genome. Hum Mol Genet 2003 1.79
23 How do synonymous mutations affect fitness? Bioessays 2007 1.63
24 Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving. Mol Biol Evol 2013 1.61
25 Similar rates but different modes of sequence evolution in introns and at exonic silent sites in rodents: evidence for selectively driven codon usage. Mol Biol Evol 2004 1.55
26 Chromatin remodelling is a major source of coexpression of linked genes in yeast. Trends Genet 2007 1.55
27 Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature 2011 1.52
28 Evolution of cis-regulatory elements in duplicated genes of yeast. Trends Genet 2003 1.49
29 Exonic splicing regulatory elements skew synonymous codon usage near intron-exon boundaries in mammals. Mol Biol Evol 2007 1.43
30 GroEL dependency affects codon usage--support for a critical role of misfolding in gene evolution. Mol Syst Biol 2010 1.43
31 Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genet 2008 1.41
32 Evidence against the selfish operon theory. Trends Genet 2004 1.38
33 Evidence for a preferential targeting of 3'-UTRs by cis-encoded natural antisense transcripts. Nucleic Acids Res 2005 1.37
34 Evidence for a trade-off between translational efficiency and splicing regulation in determining synonymous codon usage in Drosophila melanogaster. Mol Biol Evol 2007 1.36
35 Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcriptionand organismic complexity. Genome Res 2006 1.35
36 Human antisense genes have unusually short introns: evidence for selection for rapid transcription. Trends Genet 2005 1.35
37 The impact of the nucleosome code on protein-coding sequence evolution in yeast. PLoS Genet 2008 1.34
38 Biased codon usage near intron-exon junctions: selection on splicing enhancers, splice-site recognition or something else? Trends Genet 2005 1.33
39 Evidence that the human X chromosome is enriched for male-specific but not female-specific genes. Mol Biol Evol 2003 1.32
40 The evolution of isochores: evidence from SNP frequency distributions. Genetics 2002 1.29
41 A mixture of "cheats" and "co-operators" can enable maximal group benefit. PLoS Biol 2010 1.27
42 Predicting the virulence of MRSA from its genome sequence. Genome Res 2014 1.23
43 How biologically relevant are interaction-based modules in protein networks? Genome Biol 2004 1.22
44 Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction. PLoS Genet 2005 1.20
45 Imprinted chromosomal regions of the human genome have unusually high recombination rates. Genetics 2003 1.15
46 Maternally-inherited Grb10 reduces placental size and efficiency. Dev Biol 2009 1.14
47 The price of silent mutations. Sci Am 2009 1.14
48 Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile. Genome Res 2004 1.14
49 Direct and indirect consequences of meiotic recombination: implications for genome evolution. Trends Genet 2011 1.13
50 Transcriptional coupling of neighboring genes and gene expression noise: evidence that gene orientation and noncoding transcripts are modulators of noise. Genome Biol Evol 2011 1.12
51 Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay. BMC Biol 2009 1.11
52 Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. Hum Mol Genet 2005 1.10
53 How common are intragene windows with KA > KS owing to purifying selection on synonymous mutations? J Mol Evol 2007 1.09
54 Stochasticity in protein levels drives colinearity of gene order in metabolic operons of Escherichia coli. PLoS Biol 2009 1.08
55 Is the synonymous substitution rate in mammals gene-specific? Mol Biol Evol 2002 1.08
56 Support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation. Genome Biol 2011 1.07
57 The determinants of gene order conservation in yeasts. Genome Biol 2007 1.05
58 Great majority of recombination events in Arabidopsis are gene conversion events. Proc Natl Acad Sci U S A 2012 1.05
59 Co-expressed yeast genes cluster over a long range but are not regularly spaced. J Mol Biol 2006 1.02
60 Timing of replication is a determinant of neutral substitution rates but does not explain slow Y chromosome evolution in rodents. Mol Biol Evol 2009 1.02
61 Why there is more to protein evolution than protein function: splicing, nucleosomes and dual-coding sequence. Biochem Soc Trans 2009 1.01
62 Is optimal gene order impossible? Trends Genet 2006 0.98
63 Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution. Nucleic Acids Res 2012 0.98
64 Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals. Genome Biol 2009 0.97
65 Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes. Genome Biol 2008 0.96
66 Do Alu repeats drive the evolution of the primate transcriptome? Genome Biol 2008 0.96
67 Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes. Genome Biol 2008 0.94
68 Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses. PLoS Genet 2013 0.93
69 Molecular genetics: The sound of silence. Nature 2011 0.92
70 The evolution, impact and properties of exonic splice enhancers. Genome Biol 2013 0.92
71 Understanding the limits to generalizability of experimental evolutionary models. Nature 2008 0.91
72 Atypical at skew in Firmicute genomes results from selection and not from mutation. PLoS Genet 2011 0.91
73 Late-replicating domains have higher divergence and diversity in Drosophila melanogaster. Mol Biol Evol 2011 0.91
74 The form of a trade-off determines the response to competition. Ecol Lett 2013 0.90
75 The small introns of antisense genes are better explained by selection for rapid transcription than by "genomic design". Genetics 2005 0.90
76 Clustering of tissue-specific genes underlies much of the similarity in rates of protein evolution of linked genes. J Mol Evol 2002 0.90
77 Error prevention and mitigation as forces in the evolution of genes and genomes. Nat Rev Genet 2011 0.89
78 Do Wolbachia-associated incompatibilities promote polyandry? Evolution 2007 0.89
79 Monoallelic expression and tissue specificity are associated with high crossover rates. Trends Genet 2009 0.89
80 Birt Hogg-Dubé syndrome-associated FLCN mutations disrupt protein stability. Hum Mutat 2011 0.89
81 Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates. Genome Biol Evol 2009 0.88
82 Can mutation or fixation biases explain the allele frequency distribution of human single nucleotide polymorphisms (SNPs)? Gene 2002 0.87
83 Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos. J Anat 2010 0.87
84 Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation. Mol Syst Biol 2010 0.86
85 Positive charge loading at protein termini is due to membrane protein topology, not a translational ramp. Mol Biol Evol 2013 0.86
86 Competition between transposable elements and mutator genes in bacteria. Mol Biol Evol 2012 0.85
87 Causes and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee. Genome Biol 2015 0.84
88 A test of the null model for 5' UTR evolution based on GC content. Mol Biol Evol 2008 0.83
89 Human genetics: mystery of the mutagenic male. Nature 2002 0.83
90 Evolutionary genomics: A positive becomes a negative. Nature 2009 0.81
91 Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. J Bone Miner Res 2005 0.81
92 Dissecting dispensability. Nat Genet 2005 0.80
93 A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators. Genome Biol 2014 0.80
94 Protein rates of evolution are predicted by double-strand break events, independent of crossing-over rates. Genome Biol Evol 2009 0.80
95 Does negative auto-regulation increase gene duplicability? BMC Evol Biol 2009 0.79
96 Evidence for a priming effect on maternal resource allocation: implications for interbrood competition. Proc Biol Sci 2003 0.79
97 Intronic AT skew is a defendable proxy for germline transcription but does not predict crossing-over or protein evolution rates in Drosophila melanogaster. J Mol Evol 2010 0.79
98 Late replicating domains are highly recombining in females but have low male recombination rates: implications for isochore evolution. PLoS One 2011 0.78
99 Evolution encoded. Sci Am 2004 0.77
100 Genes that Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving. Mol Biol Evol 2015 0.77
101 Unique cost dynamics elucidate the role of frameshifting errors in promoting translational robustness. Genome Biol Evol 2010 0.77
102 Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study. Sci Rep 2013 0.77
103 Evidence for deep phylogenetic conservation of exonic splice-related constraints: splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans. Genome Biol Evol 2013 0.77
104 Parasitic sex puppeteers. Sci Am 2002 0.75