Published in Oncogene on September 04, 2003
Synergistic control of cell adhesion by integrins and syndecans. Nat Rev Mol Cell Biol (2007) 3.21
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol (2010) 2.65
Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. Mol Cell Biol (2004) 1.88
Chlamydial entry involves TARP binding of guanine nucleotide exchange factors. PLoS Pathog (2008) 1.63
Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol (2007) 1.37
Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death. Mol Biol Cell (2007) 1.28
Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency. Stem Cells (2012) 1.09
Endogenous RhoG is rapidly activated after epidermal growth factor stimulation through multiple guanine-nucleotide exchange factors. Mol Biol Cell (2010) 1.08
Adhesive F-actin waves: a novel integrin-mediated adhesion complex coupled to ventral actin polymerization. PLoS One (2011) 1.07
ERBB4 confers metastatic capacity in Ewing sarcoma. EMBO Mol Med (2013) 1.05
Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas. Mol Med (2007) 1.04
Epithelial membrane protein-1 is a biomarker of gefitinib resistance. Proc Natl Acad Sci U S A (2005) 0.98
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2. Cell Commun Signal (2011) 0.95
Integrin α6β4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation. Am J Physiol Cell Physiol (2011) 0.94
Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J Neurochem (2005) 0.91
β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells. Mol Biol Cell (2011) 0.90
EGFR/HER-targeted therapeutics in ovarian cancer. Future Med Chem (2012) 0.90
Characterization of primary cilia in human airway smooth muscle cells. Chest (2009) 0.88
Therapeutic IMC-C225 antibody inhibits breast cancer cell invasiveness via Vav2-dependent activation of RhoA GTPase. Clin Cancer Res (2008) 0.86
Involvement of 14-3-3 proteins in the second epidermal growth factor-induced wave of Rac1 activation in the process of cell migration. J Biol Chem (2011) 0.84
Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor model. PLoS One (2013) 0.84
Entry of Neisseria meningitidis into mammalian cells requires the Src family protein tyrosine kinases. Infect Immun (2010) 0.83
Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation. J Biol Chem (2010) 0.83
An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand. Cell Commun Signal (2006) 0.81
Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration. Mol Biol Cell (2013) 0.78
Thyroid cancer: EphB3 stimulates cell migration and metastasis in a kinase-dependent manner through Vav2-Rho GTPase Axis. J Biol Chem (2016) 0.75
Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells. Mol Biol Cell (2017) 0.75
High expression of integrin β6 in association with the Rho-Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers. Cancer Med (2016) 0.75
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat Cell Biol (2005) 2.99
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J Cell Sci (2002) 2.91
GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol (2007) 2.80
Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol (2003) 2.47
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat Struct Biol (2002) 2.11
The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo. Proc Natl Acad Sci U S A (2008) 1.85
The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol Cancer Ther (2007) 1.62
Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res (2006) 1.37
Integrin signaling in cancer cell survival and chemoresistance. Chemother Res Pract (2012) 1.26
Negative regulation of FAK signaling by SOCS proteins. EMBO J (2003) 1.26
Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells. Cancer Res (2007) 1.22
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. J Clin Invest (2011) 1.20
Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. EMBO J (2002) 1.15
Regulation of Bcl-2 proteins during anoikis and amorphosis. Biochim Biophys Acta (2004) 1.11
p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration. J Biol Chem (2003) 1.10
Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.08
Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J Biol Chem (2010) 1.04
The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle. J Biol Chem (2005) 1.03
In vitro guanine nucleotide exchange activity of DHR-2/DOCKER/CZH2 domains. Methods Enzymol (2006) 1.01
Critical role for caspase-8 in epidermal growth factor signaling. Cancer Res (2009) 1.00
SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. J Biol Chem (2004) 0.98
Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas. Cell Signal (2003) 0.94
Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines. ACS Chem Biol (2010) 0.94
Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation. Hypertension (2003) 0.93
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP. Bioorg Med Chem Lett (2011) 0.91
Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis. Mol Cell Biol (2004) 0.90
Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors. J Med Chem (2007) 0.89
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. ACS Chem Biol (2013) 0.89
EGF receptor activity is essential for adhesion-induced stress fiber formation and cofilin phosphorylation. Cell Signal (2005) 0.87
Molecular basis for regulation of Src by the docking protein p130Cas. J Mol Recognit (2005) 0.84
Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras. Org Lett (2009) 0.84
Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex. FEBS Lett (2005) 0.84
Abl functions as a negative regulator of Met-induced cell motility via phosphorylation of the adapter protein CrkII. Cell Signal (2007) 0.83
Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. Mol Cancer Ther (2013) 0.83
Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis. PLoS One (2010) 0.83
The docking protein p130Cas regulates cell sensitivity to proteasome inhibition. BMC Biol (2011) 0.82
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. Bioorg Med Chem Lett (2013) 0.80
A scalable method for molecular network reconstruction identifies properties of targets and mutations in acute myeloid leukemia. J Comput Biol (2015) 0.78
Caspase-8 as a potential mediator of pro-tumorigenic signals. Cell Cycle (2009) 0.78
Cell biology. Two lipids that give direction. Science (2009) 0.78
Organization of functional domains in the docking protein p130Cas. Biochem Biophys Res Commun (2004) 0.77
Modulation of Ah receptor and CYP1A1 expression by alpha-naphthoflavone in rainbow trout hepatocytes. Comp Biochem Physiol C Toxicol Pharmacol (2005) 0.76
Crystallization of the SH2-binding site of p130Cas in complex with Lck, a Src-family kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.76