PubRank

H Tschesche

Author PubWeight™ 139.00‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997 4.31
2 Unusual solution properties of proline and its interaction with proteins. Biochim Biophys Acta 1978 1.94
3 Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J Biol Chem 1997 1.82
4 Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor. EMBO J 1998 1.79
5 The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J 1994 1.68
6 The effect of nisin on murein synthesis. Arch Microbiol 1980 1.53
7 Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol 1996 1.52
8 A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase. FEBS Lett 1992 1.51
9 Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain. Biochem J 1993 1.49
10 Structural properties of matrix metalloproteinases. Cell Mol Life Sci 1999 1.43
11 Fragmentation of human polymorphonuclear-leucocyte collagenase. Biochem J 1993 1.32
12 The expression of angiogenin in tissue samples of different brain tumours and cultured glioma cells. Anticancer Res 2000 1.32
13 Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study. FEBS Lett 1994 1.32
14 Oxygen radicals as effectors of cartilage destruction. Direct degradative effect on matrix components and indirect action via activation of latent collagenase from polymorphonuclear leukocytes. Arthritis Rheum 1986 1.28
15 Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII. J Biol Chem 2000 1.24
16 Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases. Chem Biol 2000 1.21
17 Activation of type IV procollagenases by human tumor-associated trypsin-2. J Biol Chem 1997 1.19
18 Insights into MMP-TIMP interactions. Ann N Y Acad Sci 1999 1.18
19 Latent and active human polymorphonuclear leukocyte collagenases. Isolation, purification and characterisation. Eur J Biochem 1983 1.18
20 X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. Eur J Biochem 1995 1.15
21 Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells. FEBS Lett 1995 1.14
22 Interleukin-8 synthesis and the onset of labor. Obstet Gynecol 1995 1.12
23 Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2. J Biol Chem 2000 1.11
24 Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan. Biochem J 1994 1.09
25 Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure. J Mol Biol 2001 1.08
26 Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2. J Mol Biol 2006 1.07
27 The primary structure of porcine glandular kallikreins. Adv Exp Med Biol 1979 1.06
28 Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms. Eur J Biochem 1990 1.05
29 Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase. J Clin Chem Clin Biochem 1989 1.05
30 Design and synthesis of heterotrimeric collagen peptides with a built-in cystine-knot. Models for collagen catabolism by matrix-metalloproteases. FEBS Lett 1996 1.04
31 Assay of matrix metalloproteases types 8 and 9 by ELISA in human breast cancer. Br J Cancer 1995 1.03
32 A new principle of regulation of enzymic activity. Activation and regulation of human polymorphonuclear leukocyte collagenase via disulfide-thiol exchange as catalysed by the glutathione cycle in a peroxidase-coupled reaction to glucose metabolism. Eur J Biochem 1981 1.03
33 Direct activation of human neutrophil procollagenase by recombinant stromelysin. Biochem J 1993 1.03
34 Origin of cervical collagenase during parturition. Am J Obstet Gynecol 1992 1.02
35 Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor. Biochemistry 1995 1.01
36 Cellular source, activation and inhibition of dental plaque collagenase. J Clin Periodontol 1995 1.00
37 The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin. J Mol Biol 1999 0.99
38 The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor. Eur J Biochem 1984 0.99
39 Inactivation of human plasma alpha 1-proteinase inhibitor by human PMN leucocyte collagenase. FEBS Lett 1990 0.98
40 The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2. FEBS Lett 1996 0.97
41 Degradation of kinins, angiotensins and substance P by polymorphonuclear matrix metalloproteinases MMP 8 and MMP 9. Braz J Med Biol Res 1994 0.96
42 Lantent collagenase from human polymorphonuclear leucocytes and activation to collagenase by removal of a inhibitor. FEBS Lett 1980 0.96
43 Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan. Biochem J 1998 0.94
44 C-terminal-sequence determination by carboxypeptidase C from orange levels. Eur J Biochem 1972 0.92
45 The collagenase inhibitor from human polymorphonuclear leukocytes. Isolation, purification and characterisation. Eur J Biochem 1983 0.92
46 Carbon-13 nuclear magnetic resonance studies of the selectively isotope-labeled reactive site peptide bond of the basic pancreatic trypsin inhibitor in the complexes with trypsin, trypsinogen, and anhydrotrypsin. Biochemistry 1980 0.92
47 The recombinant catalytic domain of human neutrophil collagenase lacks type I collagen substrate specificity. Biochem Biophys Res Commun 1993 0.92
48 Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis. FEBS Lett 1997 0.92
49 [Properties of the trypsin-like (acrosin) from boar spermatozoa]. Hoppe Seylers Z Physiol Chem 1972 0.90
50 Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts. Mol Carcinog 1998 0.90
51 Stability studies on derivatives of the bovine pancreatic trypsin inhibitor. Biochemistry 1987 0.90
52 Mercurial activation of human polymorphonuclear leucocyte procollagenase. Eur J Biochem 1991 0.90
53 Transforming growth factor beta 1 regulates tissue inhibitor of metalloproteinases-1 expression in differentiated human articular chondrocytes. Arthritis Rheum 1994 0.89
54 Biochemical events in cervical ripening dilatation during pregnancy and parturition. J Obstet Gynaecol (Tokyo 1995) 1995 0.89
55 Characterisation of beta 1-anticollagenase from human plasma and its reaction with polymorphonuclear leukocyte collagenase by disulfide/thiol interchange. Eur J Biochem 1983 0.89
56 Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma. J Biol Chem 1999 0.89
57 Isolation and characterization of an oligosaccharide- and glycoprotein-specific sialidase from human leucocytes. Hoppe Seylers Z Physiol Chem 1984 0.88
58 Cloning and expression in Pichia pastoris of metalloprotease domain of ADAM 9 catalytically active against fibronectin. Protein Expr Purif 2001 0.87
59 Proteases and their inhibitors are indicative in gestational disease. Eur J Obstet Gynecol Reprod Biol 1996 0.87
60 Kind of sample as preanalytical determinant of matrix metalloproteinase 2 and 9 and tissue inhibitor of metalloproteinase 2 in blood. Clin Chem 1998 0.86
61 Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. FEBS Lett 1992 0.86
62 Preparation and characterization of the active derivative bovine trypsin-kallikrein inhibitor (Kunitz) with the reactive site lysine-15 -- alanine-16 hydrolyzed. Eur J Biochem 1976 0.86
63 Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1. FEBS Lett 1992 0.86
64 Hydrolysis-resynthesis equilibrium of the lysine-15--alanine-16 peptide bond in bovine trypsin inhibitor (Kunitz). Hoppe Seylers Z Physiol Chem 1976 0.84
65 Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. Hum Reprod 1999 0.84
66 N-Acetylalanine aminopeptidase, a new enzyme from human erythrocytes. Hoppe Seylers Z Physiol Chem 1981 0.84
67 A highly sensitive immunoenzymometric assay for the determination of angiogenin. Eur J Clin Chem Clin Biochem 1993 0.83
68 Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. Eur Respir J 1997 0.83
69 Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas. Acta Otolaryngol 1996 0.83
70 Porcine glandular kallikreins. Methods Enzymol 1981 0.83
71 Semisynthetic engineering of proteinase inhibitor homologues. Biochim Biophys Acta 1987 0.83
72 In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. Clin Exp Immunol 1994 0.83
73 Activation of human neutrophil procollagenase by stromelysin 2. Eur J Biochem 1996 0.83
74 Determination of arginine in the reactive site of proteinase inhibitors by selective and reversible derivatization of the arginine side chain. Hoppe Seylers Z Physiol Chem 1976 0.83
75 Inactivation of human plasma C1-inhibitor by human PMN leucocyte matrix metalloproteinases. FEBS Lett 1991 0.83
76 A sandwich enzyme immunoassay for the determination of neutrophil lipocalin in body fluids. Clin Chim Acta 1995 0.82
77 Release of proteinases from stimulated polymorphonuclear leukocytes. Evidence for subclasses of the main granule types and their association with cytoskeletal components. Eur J Biochem 1991 0.82
78 Stopped-flow kinetics of the resynthesis of the reactive site peptile bond in kallikrein inhibitor (Kunitz) by beta-trypsin. Biochemistry 1978 0.82
79 Separation of granule subpopulations in human polymorphonuclear leukocytes. Biol Chem Hoppe Seyler 1990 0.82
80 Characterization of C-terminally truncated human tissue inhibitor of metalloproteinases-4 expressed in Pichia pastoris. Biol Chem 2001 0.82
81 MMP-TIMP interaction depends on residue 2 in TIMP-4. FEBS Lett 2001 0.82
82 Collagenolysis in the lower uterine segment during parturition at term: correlations with stage of cervical dilatation and duration of labor. Am J Obstet Gynecol 1999 0.82
83 1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile. Eur J Biochem 1997 0.82
84 Determination of metalloproteinases, plasminogen-activators and their inhibitors in the synovial fluids of patients with rheumatoid arthritis during chemical synoviorthesis. Clin Chim Acta 1996 0.81
85 Recombinant aprotinin homologue with new inhibitory specificity for cathepsin G. Eur J Biochem 1991 0.81
86 Partial amino acid sequence of human PMN leukocyte procollagenase. Biol Chem Hoppe Seyler 1990 0.81
87 Characterization and sequence determination of six aprotinin homologues from bovine lungs. Biol Chem Hoppe Seyler 1988 0.81
88 Preparation of chemically 'mutated' aprotinin homologues by semisynthesis. P1 substitutions change inhibitory specificity. Eur J Biochem 1988 0.81
89 Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. J Med Chem 2000 0.80
90 Trypsin-kallikrein inhibitors from snails (Helix pomatia). Methods Enzymol 1976 0.80
91 Isolation and structural characterization of fucosylated gangliosides with linear poly-N-acetyllactosaminyl chains from human granulocytes. Glycobiology 1996 0.80
92 The influence of localized chemical modifications of the basic pancreatic trypsin inhibitor on static and dynamic aspects of the molecular conformation in solution. Eur J Biochem 1979 0.80
93 Pregnancy-associated plasma protein-E (PAPP-E). Biochim Biophys Acta 2000 0.80
94 The proteolytic activity of the recombinant cryptic human fibronectin type IV collagenase from E. coli expression. J Protein Chem 2000 0.80
95 Tissue inhibitor of metalloproteinase 1, collagenolytic and gelatinolytic activity in loose hip endoprostheses. J Rheumatol 1995 0.80
96 A 1H nuclear-magnetic-resonance study of the solution conformation of the isoinhibitor K from Helix pomatia. Eur J Biochem 1978 0.80
97 Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. J Med Chem 2001 0.80
98 Mercurial activation of human PMN leucocyte type IV procollagenase (gelatinase). FEBS Lett 1992 0.80
99 Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Purification and tissue distribution in the rat. Eur J Biochem 1995 0.79
100 Expression of human membrane type 1 matrix metalloproteinase in Pichia pastoris. Protein Expr Purif 2000 0.79
101 Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and -13 and of TIMP-1. Biol Chem 2000 0.79
102 Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. Antimicrob Agents Chemother 1994 0.79
103 Preparation of active recombinant TIMP-1 from Escherichia coli inclusion bodies and complex formation with the recombinant catalytic domain of PMNL-collagenase. Biochemistry 1993 0.79
104 Kinetics of the interaction of alpha-chymotrypsin with trypsin kallikrein inhibitor (Kunitz) in which the reactive-site peptide bond Lys-15--Ala-16 is split. Eur J Biochem 1978 0.79
105 Expression, purification, characterization, and X-ray analysis of selenomethionine 215 variant of leukocyte collagenase. J Protein Chem 1997 0.79
106 A 1H nuclear-magnetic-resonance study of the conformation and the molecular dynamics of the glycoprotein cow-colostrum trypsin inhibitor. Eur J Biochem 1978 0.79
107 Replacement of lysine by arginine, phenylalanine and tryptophan in the reactive site of the bovine trypsin-kallikrein inhibitor (Kunitz) and change of the inhibitory properties. Eur J Biochem 1976 0.79
108 The proteolytic activity and cleavage specificity of fibronectin-gelatinase and fibronectin-lamininase. J Protein Chem 1999 0.79
109 BPTI backbone variants and implications for inhibitory activity. Int J Pept Protein Res 1994 0.79
110 The pH dependence of the equilibrium constant KHyd for the hydrolysis of the Lys15-Ala16 reactive-site peptide bond in bovine pancreatic trypsin inhibitor (aprotinin). J Protein Chem 1988 0.79
111 Interaction of beta 1-anticollagenase from human plasma with collagenases from various tissues and competition with alpha 2-macroglobulin. Eur J Biochem 1983 0.78
112 Evidence for the tissue inhibitor of metalloproteinases-1 (TIMP-1) in human polymorphonuclear leukocytes. Eur J Biochem 1995 0.78
113 [Measuring the concentration of various plasma and placenta extract proteolytic and vascular factors in pregnant patients with HELLP syndrome, pre-/eclampsia and highly pathologic Doppler flow values]. Gynakol Geburtshilfliche Rundsch 1995 0.78
114 Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome. J Biol Chem 2000 0.78
115 Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation. Am J Physiol 1995 0.78
116 Synthesis and analytical use of 3-carboxypropionyl-alanyl-alanyl-valine-4-nitroanilide: a specific substrate for human leukocyte elastase. Hoppe Seylers Z Physiol Chem 1980 0.78
117 [Characterization of a trypsin-like proteinase (acrosin) from boar spermatozoa by inhibition with different protein proteinase inhibitors. 3. Inhibitors from pancreas glands]. Hoppe Seylers Z Physiol Chem 1972 0.78
118 Carboxypeptidase C. Methods Enzymol 1977 0.77
119 The primary structure of pig pancreatic kallikrein B. Adv Exp Med Biol 1976 0.77
120 The effect of cleaving the reactive-site peptide bond Lys-15--Ala-16 on the conformation of bovine trypsin-kallikrein inhibitor (K unitz) as revealed by solvent-perturbation spectra, circular dichroism and fluorescence. Eur J Biochem 1975 0.77
121 The structure of the porcine pancreatic secretory trypsin inhibitor. I. A sequence determination by Edman degradation and mass spectral identification of the p-bromophenyl-thiohydantoins. Eur J Biochem 1970 0.77
122 The N-terminus of collagenase MMP-8 determines superactivity and inhibition: a relation of structure and function analyzed by biomolecular interaction analysis. Biochemistry 1999 0.77
123 Cloning, expression and activation of a truncated 92-kDa gelatinase minienzyme. Gene 1997 0.77
124 A new inhibitor of elastase from the sea anemone (Anemonia sulcata). Biol Chem Hoppe Seyler 1987 0.77
125 Proteinase inhibitors from boar seminal plasma. Methods Enzymol 1976 0.77
126 Isolation, characterization and radioimmunoassay of corticosteroid-binding globulin (CBG) in human serum -- clinical significance and comparison to thyroxine-binding globulin (TBG). Acta Endocrinol (Copenh) 1979 0.77
127 Cleavage of peptide-4-nitroanilide substrates with varying chain length by human leukocyte elastase. Hoppe Seylers Z Physiol Chem 1981 0.77
128 Separation of the human leucocyte enzymes alanine aminopeptidase, cathepsin G, collagenase, elastase and myeloperoxidase. Hoppe Seylers Z Physiol Chem 1982 0.77
129 [Principles of physiologic and drug-induced cervix ripening--recent morphologic and biochemical findings]. Geburtshilfe Frauenheilkd 1990 0.77
130 Cathepsin D from human leukocytes. Purification by affinity chromatography and properties of the enzyme. Biol Chem Hoppe Seyler 1988 0.77
131 Peptide/protein inhibitors of trypsin and kallikrein - primary structural requirements. Adv Exp Med Biol 1983 0.77
132 A new acrosin inhibitor from boar spermatozoa. Eur J Biochem 1982 0.77
133 Angiogenin plasma levels during pregnancy. Am J Obstet Gynecol 1997 0.77
134 Collagenase in Sjögren's syndrome. Ann Rheum Dis 1994 0.76
135 Different binding capacities of influenza A and Sendai viruses to gangliosides from human granulocytes. Glycoconj J 1993 0.76
136 Recombinant cryptic human fibronectinase cleaves actin and myosin: substrate specificity and possible role in muscular dystrophy. Biol Chem 2001 0.76
137 On the teratogenesis of round-headed spermatozoa: investigations with antibodies against acrosin, an intraacrosomally located acrosin-inhibitor, and the outer acrosomal membrane. Andrologia 1985 0.76
138 Inhibition of degranulation of human polymorphonuclear leukocytes by complement factor D. FEBS Lett 1995 0.76
139 Placebo-controlled study of the effects of three-month lymecycline treatment on serum matrix metalloproteinases in reactive arthritis. Ann N Y Acad Sci 1994 0.76
140 Aminopeptidases from human leucocytes. Hoppe Seylers Z Physiol Chem 1984 0.76
141 Pyroglutamyl-aprotinin, a new aprotinin homologue from bovine lungs--isolation, properties, sequence analysis and characterization using 1H nuclear magnetic resonance in solution. Biol Chem Hoppe Seyler 1987 0.76
142 Activation of the human leukocyte proteinases elastase and cathepsin G by various surfactants. Biol Chem Hoppe Seyler 1990 0.76
143 Occurrence of multiple forms of bull and ram acrosin during proenzyme activation and inhibition of activation by p-nitrophenyl p'-guanidinobenzoate. Hoppe Seylers Z Physiol Chem 1976 0.76
144 Migration of polymorphonuclear leukocytes through human amnion membrane--a scanning electron microscopic study. Biol Chem Hoppe Seyler 1992 0.76
145 Biochemistry of natural proteinase inhibitors. Angew Chem Int Ed Engl 1974 0.76
146 [Human acrosin: inhibition by protein-proteinase inhibitors]. Hoppe Seylers Z Physiol Chem 1972 0.76
147 On the carbohydrate composition of bovine colostrum trypsin inhibitor. Hoppe Seylers Z Physiol Chem 1975 0.76
148 The carbohydrate linkage site of cow colostrum trypsin inhibitor. Hoppe Seylers Z Physiol Chem 1978 0.76
149 Synthesis of the active derivative of bovine trypsin-kallikrein inhibitor (Kunitz) with open peptide bond in the reactive site. Angew Chem Int Ed Engl 1974 0.75
150 Matrix degrading proteinases from human granulocytes: type I, II, III collagenase, gelatinase and type IV, V-collagenase. A survey of recent findings and inhibition by gamma-anticollagenase. Folia Histochem Cytobiol 1986 0.75
151 Replacement of lysine by arginine, phenylalanine, and tryptophan in the reactive site of the trypsin-kallikrein inhibitor (Kunitz). Angew Chem Int Ed Engl 1974 0.75
152 Strong crossreaction of human anti-aprotinin antibodies from heart transplant patient with [Arg15]aprotinin. Immunopharmacology 1997 0.75
153 Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases. FEBS Lett 1998 0.75
154 Granulocyte chemotaxis measured in a Boyden chamber assay by quantification of neutrophil elastase. Eur J Clin Chem Clin Biochem 1993 0.75
155 Inactivation of the trypsin-kallikrein inhibitor (Kunitz) by cleavage of the dipeptide Ala 16--Arg 17 in the reactive site. Angew Chem Int Ed Engl 1974 0.75
156 Semisynthetic aprotinin derivatives with specific alterations at the reactive-site peptide bond can be used to study structure-function relationships. Biochim Biophys Acta 1989 0.75
157 Amino acid micro determination with a standard single-column analyzer. J Chromatogr 1969 0.75
158 The specific trypsin inhibitor from pig pancreas. Angew Chem Int Ed Engl 1969 0.75
159 Albumin gland inhibitor from snails (Helix pomatia). Methods Enzymol 1976 0.75
160 [On modification of the specific trypsin inhibitor from porcine pancreas during inhibition by trypsin]. Hoppe Seylers Z Physiol Chem 1967 0.75
161 Structure and function of natural inhibitors as antagonists of proteinase activities. Adv Exp Med Biol 1984 0.75
162 Chemical semisynthesis of aprotinin homologues and derivatives mutated in P' positions. J Protein Chem 1991 0.75
163 Activation of chymotrypsinogen by boar acrosin and its prevention by antiboar acrosin rabbit gamma-globulins. Hoppe Seylers Z Physiol Chem 1976 0.75
164 Proteinase catalyzed resynthesis of the peptide bond Lys 15--Ala 16 in the derivative of trypsin-kallikrein inhibitor (Kunitz) with this peptide bond hydrolyzed. Angew Chem Int Ed Engl 1974 0.75
165 Neutrophil procollagenase can be activated by stromelysin-2. Ann N Y Acad Sci 1994 0.75
166 Kinetics of binding of bovine trypsin-killikrein inhibitor (K unitz) in which the reactive-site peptide bond Lys-15--Ala-16 is cleaved, to alpha-chymotrypsin and beta-trypsin. Eur J Biochem 1975 0.75
167 The activation of human neutrophil gelatinase. Acta Biochim Pol 1990 0.75
168 Structure and function of natural proteinase inhibitors. Angew Chem Int Ed Engl 1973 0.75
169 Enzymatic semisynthesis of aprotinin homologues mutated in P' positions. J Protein Chem 1991 0.75
170 Inhibition of tryptase TL2 from human T4+ lymphocytes and inhibition of HIV-1 replication in H9 cells by recombinant aprotinin and bikunin homologues. J Protein Chem 1997 0.75
171 The metal ion requirement for activation of latent collagenase from human polymorphonuclear leucocytes. Hoppe Seylers Z Physiol Chem 1981 0.75
172 Semisynthetic inhibitors of human leukocyte elastase and their protective effect on lung elastin degradation in vitro. Adv Exp Med Biol 1988 0.75
173 Semisynthesis of Arg15, Glu15, Met15, and Nle15-aprotinin involving enzymatic peptide bond resynthesis. J Protein Chem 1989 0.75
174 Trypsin-kallikrein inhibitors from cuttlefish (Loligo vulgaris). Methods Enzymol 1976 0.75
175 Quantification of hemostatic proteins and activation products in synovial fluids from arthritic joints prior to and after induction of chemical synoviorthesis. Haemostasis 1996 0.75
176 Aprotinin derivatives with chromophoric leaving groups can be used as highly selective active-site titrants for serine proteinases and permit the determination of kinetic constants of enzyme-inhibitor complexes. Biochim Biophys Acta 1988 0.75
177 [Trypsin inhibitors. V. Isolation of a des-thr-ser-pro-gln-arg-trypsin inhibitor with full biological activity from the pig]. Hoppe Seylers Z Physiol Chem 1969 0.75
178 [Identification of organs of snails (Helix pomatia) synthetizing protease inhibitors]. Hoppe Seylers Z Physiol Chem 1972 0.75
179 Trypsin-kallikrein isoinhibitor K (type Kunitz) from snails (Helix pomatia). Purification and characterization. Eur J Biochem 1975 0.75
180 The amino-acid sequence of isoinhibitor K form snails (Helix pomatia). A sequence determination by automated Edman degradation and mass-spectral identification of the phenylthiohydantoins. Eur J Biochem 1975 0.75
181 [On trypsin inhibitors. 3. Modification and inhibotory behavior of the specific trypsin inhibitor from porcine pancreas--a tryptic hydrolysis catalyzable in acid]. Hoppe Seylers Z Physiol Chem 1968 0.75
182 The in vivo effect of doxycycline treatment on matrix metalloproteinases in reactive arthritis. Ann N Y Acad Sci 1994 0.75
183 [Trypsin inhibitors. VII. Primary structure of the specific trypsin inhibitor II (Kazal-type) from porcine pancreas. Sequence analysis with mass spectrometry identification of the p-bromophenylthio-hydantoins from the Edman degradation]. Hoppe Seylers Z Physiol Chem 1970 0.75
184 [2,2,2-Trifluoro-1-(2-ureido-ethanesulfonyl)-N-benzoylethylamine, a reagent for blocking lysine residues in proteins against tryptic hydrolysis]. Hoppe Seylers Z Physiol Chem 1969 0.75
185 Partial amino-acid sequence of human PMN leukocyte procollagenase. Biol Chem Hoppe Seyler 1990 0.75
186 Effect of immunosuppressive drugs on the release of metalloproteinases from human polymorphonuclear leukocytes. Transpl Int 1991 0.75
187 Serum collagenase levels during pregnancy and parturition. Eur J Obstet Gynecol Reprod Biol 1994 0.75
188 Structural characterization by nuclear magnetic resonance of a reactive-site 13carbon-labelled basic pancreatic trypsin inhibitor with the peptide bond Arg-39--Ala-40 cleaved and Arg-39 removed. Eur J Biochem 1979 0.75
189 [Isolation and purification of the pancreatic secretory trypsin inhibitor of the cat]. Hoppe Seylers Z Physiol Chem 1971 0.75
190 [Trypsin inhibitors. IV. 2 specific trypsin inhibitors from porcine pancreas]. Hoppe Seylers Z Physiol Chem 1969 0.75
191 The degradation of collagen by a metalloproteinase from human leucocytes. Adv Exp Med Biol 1988 0.75
192 1H Nmr studies at 360 MHz of the methyl groups in native and chemically modified basic pancreatic trypsin inhibitor (BPTI). Biophys Struct Mech 1977 0.75
193 Methoxymethyl isocyanate as a new agent for reversible protection of SH groups in protein and peptide chemistry. Angew Chem Int Ed Engl 1973 0.75
194 Quantitative mass spectral identification of p-bromophenylthiohydantoins from Edman degradations by tetradeuterated internal standards. Hoppe Seylers Z Physiol Chem 1976 0.75
195 [On the distribution of proteinase inhibitors of broad specificity in the organs of cuttle fish (Loligo vulgaris) (author's transl)]. Hoppe Seylers Z Physiol Chem 1975 0.75
196 Influence of boar acrosin antibodies produced in rabbit and sheep on chymotrypsinogen activation catalyzed by acrosin from boar, bull, ram, rabbkt and human. Hoppe Seylers Z Physiol Chem 1976 0.75
197 Gas chromatographic identification of the thiohydantoins of degradation products of peptides and proteins. Angew Chem Int Ed Engl 1970 0.75
198 Isolation of porcine urinary kallikrein. Adv Exp Med Biol 1976 0.75
199 Some properties of latent collagenase from human synovial fluid. Acta Biochim Pol 1990 0.75
200 [On trypsin inhibitors. II. On the characterization of the specific trypsin inhibitor from porcine pancreas]. Hoppe Seylers Z Physiol Chem 1967 0.75
201 [Proteinase isoinhibitors with broad specificity for trypsin, chymotrypsin, plasmin and kallikrein from cuttlefish (Loligo vulgaris)]. Hoppe Seylers Z Physiol Chem 1975 0.75
202 Enzymatic resynthesis of the "reactive site" bond in the modified aprotinin derivatives [seco-15/16]aprotinin and [Di-seco-15/16,39/40]aprotinin. Biol Chem Hoppe Seyler 1988 0.75
203 Enzymatic cleavage of the N-epsilon-acetyl protecing group from lysine in proteins (Klunitz trypsin-kallikrein inhibitor) in vitro and in vivo. Hoppe Seylers Z Physiol Chem 1974 0.75
204 [Disulfide bridges of the secretory trypsin inhibitor from procine pancreas and the degradation of covalent structure during the temporary inhibition]. Hoppe Seylers Z Physiol Chem 1972 0.75
205 Submicro-determination of amino acids by a single-column analysis in a 4-hour run using automated buffer gradient mixing. J Chromatogr 1973 0.75
206 Leukocyte proteinase release during storage of red cell concentrates. Eur J Clin Chem Clin Biochem 1994 0.75
207 Complex formation of guanidinated bovine trypsin inhibitor (Kunitz) with trypsin, chymotrypsin and trypsinogen as studied by the spin-label technique. FEBS Lett 1982 0.75
208 Novel heterocyclic inhibitors of matrix metalloproteinases: three 6H-1,3,4-thiadiazines. Acta Crystallogr C 2001 0.75
209 Design of an aprotinin variant with inhibitory activity against chymotrypsin and cathepsin G by recombinant DNA technology. Biol Chem Hoppe Seyler 1990 0.75
210 [New polyvalent protease inhibitors for trypsin, chymotrypsin, plasmin and kallikreins from snails (Helix pomatia)]. Hoppe Seylers Z Physiol Chem 1972 0.75
211 Broad-specificity protease-isoinhibitors for trypsin, chymotrypsin, plasmin and kallikrein from snails (Helix pomatia). Isolation, inhibition characteristics and amino-acid composition. Eur J Biochem 1972 0.75
212 [The disulfide bridges of the trypsin-kallikrein inhibitor K from snails (Helix pomatia). Thermal inactivation and proteolysis by thermolysin (author's transl)]. Hoppe Seylers Z Physiol Chem 1976 0.75
213 Formation of a covalent Hg-Cys-bond during mercurial activation of PMNL procollagenase gives evidence of a cysteine-switch mechanism. FEBS Lett 1992 0.75