Published in J Cereb Blood Flow Metab on May 01, 1992
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci U S A (1998) 3.17
Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes (2007) 2.91
Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest (2001) 2.68
The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. J Neurosci (2010) 2.42
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proc Natl Acad Sci U S A (1997) 2.12
Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field. Proc Natl Acad Sci U S A (2002) 1.85
Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR. Proc Natl Acad Sci U S A (1996) 1.74
Localized in vivo 13C NMR spectroscopy of the brain. NMR Biomed (2003) 1.55
1H-[13C] NMR measurements of [4-13C]glutamate turnover in human brain. Proc Natl Acad Sci U S A (1992) 1.47
Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR. Proc Natl Acad Sci U S A (2000) 1.44
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics. Philos Trans R Soc Lond B Biol Sci (1999) 1.32
Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivo. Proc Natl Acad Sci U S A (2004) 1.32
Kinetic analysis of dynamic 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts. Biophys J (1995) 1.30
Reduced glutamate neurotransmission in patients with Alzheimer's disease -- an in vivo (13)C magnetic resonance spectroscopy study. MAGMA (2003) 1.26
State of the art direct 13C and indirect 1H-[13C] NMR spectroscopy in vivo. A practical guide. NMR Biomed (2011) 1.19
Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMR. J Cereb Blood Flow Metab (2010) 1.14
Dynamic or inert metabolism? Turnover of N-acetyl aspartate and glutathione from D-[1-13C]glucose in the rat brain in vivo. J Neurochem (2004) 1.08
In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance. J Cereb Blood Flow Metab (2012) 1.07
Imaging brain activation: simple pictures of complex biology. Ann N Y Acad Sci (2008) 1.02
Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proc Natl Acad Sci U S A (1993) 1.00
Quantitative fMRI and oxidative neuroenergetics. Neuroimage (2012) 0.98
Unraveling the complex metabolic nature of astrocytes. Front Cell Neurosci (2013) 0.97
Increased brain uptake and oxidation of acetate in heavy drinkers. J Clin Invest (2013) 0.95
Measurement of cerebral oxidative glucose consumption in patients with type 1 diabetes mellitus and hypoglycemia unawareness using (13)C nuclear magnetic resonance spectroscopy. Metabolism (2009) 0.94
Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP. Magn Reson Imaging (2010) 0.92
A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and C-labeled glucose. Front Neuroenergetics (2011) 0.90
Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis. Proc Natl Acad Sci U S A (2009) 0.90
Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine. J Cereb Blood Flow Metab (2010) 0.89
Exchange-mediated dilution of brain lactate specific activity: implications for the origin of glutamate dilution and the contributions of glutamine dilution and other pathways. J Neurochem (2009) 0.89
Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain. Biomolecules (2016) 0.86
Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells. PLoS One (2012) 0.86
Fast isotopic exchange between mitochondria and cytosol in brain revealed by relayed 13C magnetization transfer spectroscopy. J Cereb Blood Flow Metab (2009) 0.85
Metabolic Flux and Compartmentation Analysis in the Brain In vivo. Front Endocrinol (Lausanne) (2013) 0.85
(13)C NMR spectroscopy applications to brain energy metabolism. Front Neuroenergetics (2013) 0.85
Effects of hypoglycaemia on neuronal metabolism in the adult brain: role of alternative substrates to glucose. J Inherit Metab Dis (2012) 0.84
Computational approaches for understanding energy metabolism. Wiley Interdiscip Rev Syst Biol Med (2013) 0.83
Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism. Int J Mol Sci (2015) 0.82
Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. J Biol Chem (2015) 0.81
A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivo. J Cereb Blood Flow Metab (2014) 0.78
(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism. Front Oncol (2016) 0.78
Studying Enzymes by In Vivo C Magnetic Resonance Spectroscopy. Prog Nucl Magn Reson Spectrosc (2009) 0.77
13C NMR metabolomic evaluation of immediate and delayed mild hypothermia in cerebrocortical slices after oxygen-glucose deprivation. Anesthesiology (2013) 0.76
Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain. J Neurochem (2014) 0.76
Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: an integrated study using (1)H- and (13)C-NMR spectroscopy. J Cereb Blood Flow Metab (2015) 0.76
Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods. Biochim Biophys Acta (2015) 0.76
Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-(13)C2]Glucose Metabolism in Anesthetized Rats. Neurochem Res (2016) 0.75
Genome-Scale Reconstruction of the Human Astrocyte Metabolic Network. Front Aging Neurosci (2017) 0.75
Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biol Psychiatry (2016) 0.75
How Energy Metabolism Supports Cerebral Function: Insights from (13)C Magnetic Resonance Studies In vivo. Front Neurosci (2017) 0.75
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N Engl J Med (1999) 8.32
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia (1999) 8.17
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med (1990) 7.13
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest (1999) 6.73
Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest (1996) 6.50
Energy on demand. Science (1999) 3.80
Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J Clin Invest (1992) 3.55
The molecular mechanism of thermal unfolding of Escherichia coli formylmethionine transfer RNA. J Mol Biol (1974) 3.25
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci U S A (1998) 3.17
Cellular applications of 31P and 13C nuclear magnetic resonance. Science (1979) 3.14
Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med (1996) 2.92
Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science (1991) 2.92
Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry (1999) 2.78
Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proc Natl Acad Sci U S A (1993) 2.77
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proc Natl Acad Sci U S A (1999) 2.76
High resolution 31P nuclear magnetic resonance studies of intact yeast cells. Proc Natl Acad Sci U S A (1975) 2.72
Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest (2001) 2.68
Phosphorus-31 nuclear magnetic resonance studies of wild-type and glycolytic pathway mutants of Saccharomyces cerevisiae. Biochemistry (1979) 2.67
High-resolution 31P nuclear magnetic resonance studies of metabolism in aerobic Escherichia coli cells. Proc Natl Acad Sci U S A (1977) 2.58
31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest (1992) 2.52
Spatially localized 1H NMR spectra of metabolites in the human brain. Proc Natl Acad Sci U S A (1988) 2.44
Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol Psychiatry (2008) 2.42
High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo. Proc Natl Acad Sci U S A (1983) 2.40
Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magn Reson Med (1994) 2.39
The absence of "heme-heme" interactions in hemoglobin. Science (1969) 2.26
Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1995) 2.25
13C/31P NMR studies on the mechanism of insulin resistance in obesity. Diabetes (1998) 2.21
13C NMR studies of gluconeogenesis in rat liver cells: utilization of labeled glycerol by cells from euthyroid and hyperthyroid rats. Proc Natl Acad Sci U S A (1979) 2.19
Phosphorus-31 nuclear magnetic resonance studies of the effect of oxygen upon glycolysis in yeast. Biochemistry (1981) 2.17
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proc Natl Acad Sci U S A (1997) 2.12
Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab (1995) 1.98
High resolution nuclear magnetic resonance studies of hydrogen bonded protons of tRNA in water. Nature (1971) 1.97
31P nuclear magnetic resonance studies of Ehrlich ascites tumor cells. Proc Natl Acad Sci U S A (1977) 1.97
Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging. Proc Natl Acad Sci U S A (1992) 1.92
Improvements on an in vivo automatic shimming method [FASTERMAP]. Magn Reson Med (1997) 1.92
31P nuclear magnetic resonance studies of bioenergetics and glycolysis in anaerobic Escherichia coli cells. Proc Natl Acad Sci U S A (1978) 1.92
31P magnetic resonance of tRNA. Proc Natl Acad Sci U S A (1975) 1.88
Allosteric interpretation of haemoglobin properties. Q Rev Biophys (1975) 1.88
31P nuclear magnetic resonance measurements of ATPase kinetics in aerobic Escherichia coli cells. Proc Natl Acad Sci U S A (1977) 1.86
Determination of the iron-sulfur distances in rubredoxin by x-ray absorption spectroscopy. Proc Natl Acad Sci U S A (1975) 1.85
31P NMR studies of intracellular pH and phosphate metabolism during cell division cycle of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1981) 1.84
An allosteric model of hemoglobin. I. Kinetics. J Mol Biol (1971) 1.84
Electronic structure of cyanide complexes of hemes and heme proteins. J Mol Biol (1971) 1.79
High-resolution 13C nuclear magnetic resonance studies of glucose metabolism in Escherichia coli. Proc Natl Acad Sci U S A (1978) 1.79
Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task. Proc Natl Acad Sci U S A (1994) 1.79
Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo. Proc Natl Acad Sci U S A (1984) 1.76
Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest (1998) 1.75
Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging. Proc Natl Acad Sci U S A (2001) 1.74
Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR. Proc Natl Acad Sci U S A (1996) 1.74
The flux from glucose to glutamate in the rat brain in vivo as determined by 1H-observed, 13C-edited NMR spectroscopy. J Cereb Blood Flow Metab (1990) 1.74
13C NMR study of transamination during acetate utilization by Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1981) 1.70
Determination of secondary and tertiary structural features of transfer RNA molecules in solution by nuclear magnetic resonance. Proc Natl Acad Sci U S A (1973) 1.70
Cerebral metabolic studies in vivo by 31P NMR. Proc Natl Acad Sci U S A (1983) 1.69
Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR Biomed (2001) 1.69
Electron spin resonance of irradiated DNA. J Chem Phys (1963) 1.65
Dynamic shim updating: a new approach towards optimized whole brain shimming. Magn Reson Med (1996) 1.65
In vivo carbon-13 nuclear magnetic resonance studies of mammals. Science (1981) 1.61
FMRI of the prefrontal cortex during overt verbal fluency. Neuroreport (1997) 1.61
Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures. Neurology (2001) 1.60
Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proc Natl Acad Sci U S A (1993) 1.60
Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose. J Neurochem (1994) 1.60
13C NMR of intermediary metabolism: implications for systemic physiology. Annu Rev Physiol (2001) 1.59
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. J Clin Invest (1996) 1.58
Liver glycogen turnover in fed and fasted humans. Am J Physiol (1994) 1.57
Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest (1996) 1.57
13C nuclear magnetic resonance studies of anaerobic glycolysis in suspensions of yeast cells. Proc Natl Acad Sci U S A (1979) 1.55
In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during. J Neurochem (2001) 1.55
Ring-current shifts in the 300 MHz nuclear magnetic resonance spectra of six purified transfer RNA molecules. J Mol Biol (1973) 1.52
Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T). Proc Natl Acad Sci U S A (1984) 1.51
Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magn Reson Med (1992) 1.51