Published in J Clin Invest on May 01, 1959
The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles. Proc Natl Acad Sci U S A (1976) 3.91
Measurement of intracellular pH of skeletal muscle with pH-sensitive glass microelectrodes. J Clin Invest (1967) 3.62
INTRACELLULAR ACID-BASE REGULATION. I. THE RESPONSE OF MUSCLE CELLS TO CHANGES IN CO2 TENSION OR EXTRACELLULAR BICARBONATE CONCENTRATION. J Clin Invest (1965) 2.77
Transport of pyruvate nad lactate into human erythrocytes. Evidence for the involvement of the chloride carrier and a chloride-independent carrier. Biochem J (1976) 2.19
Vacuolar pH Measurement in Higher Plant Cells : I. EVALUATION OF THE METHYLAMINE METHOD. Plant Physiol (1981) 2.17
Direct intracellular pH measurement in rat and crab muscle. J Physiol (1972) 2.01
Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci U S A (1997) 1.83
Intracellular pH and distribution of weak acids across cell membranes. A study of D- and L-lactate and of DMO in rat diaphragm. J Physiol (1975) 1.62
Bioenergetic properties and viability of alkalophilic Bacillus firmus RAB as a function of pH and Na+ contents of the incubation medium. J Bacteriol (1982) 1.62
Reduction of membrane potential, an immediate effect of colicin K. Proc Natl Acad Sci U S A (1978) 1.57
Protons make tumor cells move like clockwork. Pflugers Arch (2009) 1.48
Dynamics of interstitial and intracellular pH in evolving brain infarct. Am J Physiol (1991) 1.43
Net uptake of potassium in Neurospora. Exchange for sodium and hydrogen ions. J Gen Physiol (1968) 1.40
The in vivo pH of the extravascular space of the lung. J Clin Invest (1969) 1.36
Intracellular pH, H ion flux and H ion permeability coefficient in bullfrog toe muscle. J Physiol (1972) 1.34
Quantitative measurements of the proton-motive force and its relation to steady state lactose accumulation in Escherichia coli. Biochem J (1981) 1.33
Effects of ouabain and diphenylhydantoin on transmembrane potentials, intracellular electrolytes, and cell pH of rat muscle and liver in vivo. J Physiol (1971) 1.32
Mode of action of colicin Ia: effect of colicin on the Escherichia coli proton electrochemical gradient. Proc Natl Acad Sci U S A (1978) 1.31
Energetics of sucrose transport into protoplasts from developing soybean cotyledons. Plant Physiol (1985) 1.28
Stimulation of Na:H exchange by insulin. Biophys J (1981) 1.28
INTRACELLULAR ACID-BASE RELATIONS OF DOG BRAIN WITH REFERENCE TO THE BRAIN EXTRACELLULAR VOLUME. J Clin Invest (1964) 1.27
Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH. J Cell Biol (1986) 1.24
Quantitative analysis of proton-linked transport systems. Glutamate transport in Staphylococcus aureus. Biochem J (1979) 1.23
The effect of insulin on plasma-membrane and mitochondrial-membrane potentials in isolated fat-cells. Biochem J (1981) 1.19
Determination of extracellular space and intracellular electrolytes in rat liver in vivo. J Physiol (1971) 1.18
Ionic responses rapidly elicited by activation of protein kinase C in quiescent Swiss 3T3 cells. Proc Natl Acad Sci U S A (1985) 1.15
Intracellular pH of sea urchin eggs measured by the dimethyloxazolidinedione (DMO) method. J Cell Biol (1981) 1.14
Intracellular pH in rat isolated superior cervical ganglia in relation to nicotine-depolarization and nicotine-uptake. Br J Pharmacol (1972) 1.13
Carrier-Mediated Uptake of Abscisic Acid by Suspension-Cultured Amaranthus tricolor Cells. Plant Physiol (1991) 1.09
Acid-base relations in epithelium of turtle bladder: site of active step in acidification and role of metabolic CO2. J Clin Invest (1969) 1.09
Mechanism of excitation of Aplysia neurons by carbon dioxide. J Gen Physiol (1970) 1.06
Renal bicarbonate wasting during phosphate depletion. A possible cause of altered acid-base homeostasis in hyperparathyroidism. J Clin Invest (1973) 1.06
Extracellular Na+ and initiation of DNA synthesis: role of intracellular pH and K+. J Cell Biol (1984) 1.05
Stimulation of Weak Acid Uptake and Increase in Cell Sap pH as Evidence for Fusicoccin- and K-Induced Cytosol Alkalinization. Plant Physiol (1986) 1.04
The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets. Biochem J (1979) 1.02
Effect of glucose on the intracellular pH of pancreatic islet cells. Biochem J (1984) 1.00
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion. Front Pharmacol (2014) 1.00
The mechanism of inhibition by acidosis of gluconeogenesis from lactate in rat liver. Biochem J (1977) 1.00
Evidence for a plasmalemma redox system in sugarcane. Plant Physiol (1985) 0.99
On the localization of organic acids in Acid-induced ATP synthesis. Plant Physiol (1967) 0.96
Characterization of transmembrane movement of glucose and glucose analogs in Streptococcus mutants Ingbritt. J Bacteriol (1990) 0.96
Inhibition of the bicarbonate exit step in urinary acidification by a disulfonic stilbene. J Clin Invest (1978) 0.96
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets. J Clin Invest (1978) 0.96
Phosphate transport in rat liver mitochondria. Kinetics, inhibitor sensitivity, energy requirements, and labeled components. Mol Cell Biochem (1975) 0.95
The simultaneous determination of muscle cell pH using a weak acid and weak base. J Clin Invest (1972) 0.95
Ionic responses rapidly elicited by porcine platelet-derived growth factor in Swiss 3T3 cells. EMBO J (1984) 0.95
Vacuoles from Sugarcane Suspension Cultures : III. PROTONMOTIVE POTENTIAL DIFFERENCE. Plant Physiol (1982) 0.94
Mechanism of the stimulation of serine and alanine transport into isolated rat liver cells by bicarbonate ions. Biochem J (1979) 0.93
Patterns of electrochemical proton gradient formation by membrane vesicles from an obligately acidophilic bacterium. J Bacteriol (1984) 0.93
Control of active proton transport in turtle urinary bladder by cell pH. J Gen Physiol (1980) 0.89
Effects of increasing extracellular pH on protein synthesis and protein degradation in the perfused working rat heart. Biochem J (1989) 0.89
Intracellular pH in hibernation and respiratory acidosis in the European hamster. J Comp Physiol B (1985) 0.87
Intracellular pH and the distribution of weak acids and bases in isolated rat superior cervical ganglia. J Physiol (1979) 0.86
Characterization of Alkaloid Uptake by Catharanthus roseus (L.) G. Don Protoplasts. Plant Physiol (1988) 0.86
Intracellular pH of single crustacean muscle fibres by the DMO and electrode methods during acid and alkaline conditions. J Physiol (1976) 0.86
Bioenergetic properties of alkalophilic Bacillus sp. strain C-59 on an alkaline medium containing K2CO3. J Bacteriol (1987) 0.86
The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells. Br J Cancer (1999) 0.86
The role of pH, PCO2, and bicarbonate in regulating rat diaphragm citrate content. J Clin Invest (1970) 0.86
In vivo myocardial cell pH in the dog. Response to ischemia and infusion of alkali. J Clin Invest (1975) 0.86
The intracellular pH of the human platelet. J Clin Invest (1966) 0.86
Nicotine uptake by isolated rat ganglia. Br J Pharmacol (1969) 0.85
Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient. Br J Cancer (1998) 0.85
pH-dependent stimulation by Ca2+ of prostacyclin synthesis in rat aortic rings: effects of drugs and inorganic ions. Br J Pharmacol (1987) 0.84
Effect of intracellular alkalinization on pancreatic islet calcium uptake and insulin secretion. Biochem J (1986) 0.84
Changes in bone sodium and carbonate in metabolic acidosis and alkalosis in the dog. J Clin Invest (1971) 0.83
Effects of carbonic anhydrase inhibitors on contraction, intracellular pH and energy-rich phosphates of rat skeletal muscle. J Physiol (1990) 0.83
Effect of volume expansion on renal citrate and ammonia metabolism in KCl-deficient rats. J Clin Invest (1975) 0.82
Drug displacement from protein binding: source of the sulphadoxine liberated by phenylbutazone. Br J Pharmacol (1971) 0.81
Deficiency of carbonic anhydrase in the vasculature of rabbit kidneys. J Clin Invest (1983) 0.81
Intracellular pH during daily torpor in Peromyscus maniculatus. J Comp Physiol B (1990) 0.81
The re-establishment of retinotectal projections after uncrossing the optic chiasma in Xenopus laevis with one compound eye. J Physiol (1970) 0.80
Pancreatic acinar cell function: measurement of intracellular ions and pH and their relation to secretion. J Physiol (1981) 0.80
Intracellular pH during calcification. A study of the avian shell gland. Biochem J (1969) 0.80
Effects of CO2 on transmembrane potentials of rat liver and muscle in vivo. J Physiol (1971) 0.79
In vivo measurement of regional brain and tumor pH using [14C]dimethyloxazolidinedione and quantitative autoradiography. II: Characterization of the extracellular fluid compartment using pH-sensitive microelectrodes and [14C]sucrose. J Cereb Blood Flow Metab (1986) 0.78
The sensitivity of a malignant cell line to hyperthermia (42 degrees C) at low intracellular pH. Br J Cancer (1976) 0.78
pH-dependency of iodothyronine metabolism in isolated perfused rat liver. Biochem J (1982) 0.77
Growth inhibition of putrefactive anaerobe 3679 caused by stringent-type response induced by protonophoric activity of sorbic acid. Appl Environ Microbiol (1987) 0.77
Down with plasma. Intracellular chemical pathology studied by analysis of cells of solid tissues, erythrocytes, and leukocytes. Proc R Soc Med (1969) 0.77
Effects of monensin on metabolism of isolated rat islets of Langerhans. Biochem J (1984) 0.76
Proceedings: The uptake of weak acids and bases into isolated rat superior cervical ganglia in relation to intracellular pH. Br J Pharmacol (1976) 0.76
Physiological conditions affecting Staphylococcus aureus susceptibility to staphylococcin 1580. Antimicrob Agents Chemother (1978) 0.75
Effectiveness of oral litholysis therapy for improving glucose intolerance and malnutrition in patients with poor results following endoscopic therapy and extracorporeal shock wave lithotripsy for calcified pancreatic stones. Clin J Gastroenterol (2015) 0.75
The relationship between tissue and arterial pH in hypercarbic rabbits. Arch Gynecol (1978) 0.75
The intracellular pH and the buffer capacity of the heart. Basic Res Cardiol (1977) 0.75
Chloride transport pathways and their bioenergetic implications in the obligate acidophile Bacillus coagulans. J Bacteriol (1990) 0.75
Influence of fusicoccin on the control of cell division by auxins. Plant Physiol (1979) 0.75
Effects of electrostimulation on glycogenolysis in cultured rat myotubes. Pflugers Arch (2003) 0.75
Nature and significance of concentration relations of potassium and sodium ions in skeletal muscle. Physiol Rev (1957) 9.70
Water and electrolyte metabolism. Physiol Rev (1954) 4.76
The acid-labile CO(2) in mammalian muscle and the pH of the muscle fibre. J Physiol (1944) 3.69
Neutralization of infused acid by nephrectomized dogs. J Clin Invest (1955) 2.77
The acute effects in man of rapid intravenous infusion of hypertonic sodium bicarbonate solution. I. Changes in acid-base balance and distribution of the excess buffer base. Medicine (Baltimore) (1955) 2.67
pH values of the yeast cell. Biochem J (1950) 2.27
The influence of the external medium on the internal pH of muscle. Proc R Soc Lond B Biol Sci (1955) 2.07
The distribution and excretion of phenobarbital. J Clin Invest (1957) 1.84
The internal distribution of hydrogen ions with varying degrees of metabolic acidosis. J Clin Invest (1957) 1.69
Plasma, extracellular and muscle electrolyte responses to acute metabolic acidosis. Am J Physiol (1956) 1.52
Distribution of sodium bicarbonate infused into nephrectomized dogs. J Clin Invest (1955) 1.45
Quantitative studies of the demethylation of trimethadione (tridione). J Pharmacol Exp Ther (1953) 1.27
Renal excretion of 5,5-dimethyl-2-4-oxazolidinedione (product of demethylation of trimethadione. Proc Soc Exp Biol Med (1957) 1.14
The apparent first dissociation constant, pK1, of carbonic acid in the human erythrocyte. J Biol Chem (1957) 1.12
Metabolic demethylation of 3, 5, 5-trimethyl-2, 4-oxazolidinedione (trimethadione, tridione). Proc Soc Exp Biol Med (1952) 1.10
Serial changes in tissue carbon dioxide content during acute respiratory acidosis. J Clin Invest (1958) 1.08
A simple ultraviolet spectrophotometric method for the determination of protein. J Lab Clin Med (1956) 9.66
Reduction of carbon tetrachloride in vivo and reduction of carbon tetrachloride and chloroform in vitro by tissues and tissue constituents. J Pharmacol Exp Ther (1961) 2.53
The distribution and excretion of phenobarbital. J Clin Invest (1957) 1.84
Phenobarbital: studies of elimination, accumulation, tolerance, and dosage schedules. J Pharmacol Exp Ther (1954) 1.54
Metabolic demethylation of 3-methyl-5-ethyl-5-phenyl hydantoin (Mesantoin). J Pharmacol Exp Ther (1952) 1.48
Intracellular pH of isolated perfused turtle heart. Am J Physiol (1960) 1.47
Quantitative studies of the demethylation of trimethadione (tridione). J Pharmacol Exp Ther (1953) 1.27
N-methylated derivatives of barbituric acid, hydantoin and oxazolidinedione used in the treatment of epilepsy. Neurology (1958) 1.16
Renal excretion of 5,5-dimethyl-2-4-oxazolidinedione (product of demethylation of trimethadione. Proc Soc Exp Biol Med (1957) 1.14
Theories of general anesthesia. J Pharmacol Exp Ther (1950) 1.12
Metabolic demethylation of 3, 5, 5-trimethyl-2, 4-oxazolidinedione (trimethadione, tridione). Proc Soc Exp Biol Med (1952) 1.10
The metabolic conversion of 5, 5-diphenyl hydantoin to 5-(p-hydroxyphenyl)-5-phenyl hydantoin. J Pharmacol Exp Ther (1957) 1.07
The rate of penetration of barbituric acid derivatives into the brain. J Pharmacol Exp Ther (1950) 1.05
The metabolic hydroxylation of phenobarbital. J Pharmacol Exp Ther (1956) 0.92
Metabolic transformations of trichlorethylene. J Pharmacol Exp Ther (1949) 0.91
Metabolic conversion of primidone (mysoline) to phenobarbital. Proc Soc Exp Biol Med (1956) 0.90
Lysis of dog erythrocytes in mildly alkaline isotonic media. Am J Physiol (1956) 0.89
Introduction; termination of drug action by elimination of unchanged drug. Fed Proc (1958) 0.87
The role of the liver in the demethylation of N-methyl derivatives of hydantoin and of 2,4-oxazolidinedione. J Pharmacol Exp Ther (1954) 0.85
The effects of N-methylation in 5,5-disubstituted derivatives of barbituric acid, hydantoin, and 2-4-oxazolidinedione. J Am Pharm Assoc Am Pharm Assoc (1955) 0.83
THE METABOLIC FATE OF 5-ALLYL-5-(1-METHYLBUTYL)BARBITURIC ACID (SECOBARBITAL). J Pharmacol Exp Ther (1965) 0.83
Quantitative studies of the metabolic fate of mephobarbital (N-methyl phenobarbital). J Pharmacol Exp Ther (1952) 0.82
The metabolic fate of 5-(1-cyclohexen-1-yl)-1, 5-dimethyl barbituric acid (hexobarbital, evipal) and of 5-(1-cyclohexen-1-yl)-5-methyl barbituric acid ("nor-evipal"). J Pharmacol Exp Ther (1953) 0.81
Demethylation of N-methyl derivatives of barbituric acid, hydantoin, and 2,4-oxazolidinedione by rat liver microsomes. Life Sci (1963) 0.80
Quantitative studies of the demethylation of N-methyl barbital (metharbital, gemonil). J Pharmacol Exp Ther (1953) 0.78
A SIMPLE, RAPID METHOD FOR PAPER CHROMATOGRAPHY OF BARBITURATES. Clin Chem (1965) 0.78
The metabolic fate of chloral hydrate. J Pharmacol Exp Ther (1948) 0.78
A STUDY OF THE PRODUCT OF DEMETHYLATION OF TRIMETHADIONE IN THE CONTROL OF PETIT MAL EPILEPSY. Neurology (1965) 0.78
The role of the liver in the metabolic disposition of mephoparbital. J Pharmacol Exp Ther (1952) 0.77
Reduction and oxidation of chloral hydrate by isolated tissues in vitro. J Pharmacol Exp Ther (1949) 0.76
SYNTHESIS OF 5,5-DIMETHYL-2,4-OXAZOLIDINEDIONE-2-C14 (DMO-2-C14). J Pharm Sci (1963) 0.75
Metabolic deëathylation of 5,5-dimethyl-3-ethyl-2,4 oxazolidinedione (dimedion). Arch Int Pharmacodyn Ther (1957) 0.75
A case of toxic myocarditis due to the common cold with an unusual type of electrocardiogram. Med J Aust (1955) 0.75
Bromal hydrate and chloral hydrate; a pharmacological contrast and its chemical basis. J Pharmacol Exp Ther (1948) 0.75
Metabolic oxidation of phenobarbital to p-hydroxyphenobarbital. Science (1954) 0.75
Metabolic fate of thiobarbital. Fed Proc (1947) 0.75
A pharmacological comparison of the optical isomers of 5-ethyl-5-methyl-2,4-oxazolidinedione and of 3,5-dimethyl-5 ethyl-2,4-oxazolidinedione (paramethadione, paradione). J Pharmacol Exp Ther (1955) 0.75
Metabolic demethylation of 3,5-dimethyl-5-ethyl 2,4-oxazolidinedione (paramethadione, paradione). J Pharmacol Exp Ther (1955) 0.75
The metabolic fate of 5-ethyl-1-methyl-5-phenyl hydantoin (1-methylnirvanol) and that of 3,5-diethyl-5-phenyl hydantoin (3-ethylnirvanol). J Pharmacol Exp Ther (1959) 0.75
Quantitative studies of the physiological disposition of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin) and 5-ethyl-5-phenyl hydantoin (nirvanol). J Pharmacol Exp Ther (1953) 0.75
The treatment of epilepsy. Bull Johns Hopkins Hosp (1948) 0.75
Further studies of metabolic removal of alkyl groups from nitrogen in barbituric acid derivatives. Proc Soc Exp Biol Med (1953) 0.75
A pharmacological comparison of the optical isomers of 5-ethyl-5-phenyl hydantoin (nirvanol) and of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin). J Pharmacol Exp Ther (1954) 0.75
The metabolic conversion of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin) and of 5-ethyl-5-phenyl hydantoin (nirvanol) to 5 - ethyl -5- (p-hydroxyphenyl) hydantoin. J Pharmacol Exp Ther (1956) 0.75
THE METABOLIC FATE OF CARBROMAL (2-BROMO-2-ETHYLBUTYRYLUREA). J Pharmacol Exp Ther (1964) 0.75
A case of temporal arteritis. Med J Aust (1949) 0.75
SUBSTRATE INDUCTION OF TRYPTOPHAN PYRROLASE IN CHICKEN LIVERS. Guys Hosp Rep (1965) 0.75
Metabolic demethylation of 1,3-dimethyl-5-ethyl-5-phenyl hydantoin (dimethylnirvanol). J Pharmacol Exp Ther (1961) 0.75