Metal-binding sites in proteins.

Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries. Proc Natl Acad Sci U S A (1993) 1.14

Modeling Structural Coordination and Ligand Binding in Zinc Proteins with a Polarizable Potential. J Chem Theory Comput (2012) 1.01

Zinc-binding cysteines: diverse functions and structural motifs. Biomolecules (2014) 1.00

Metalloprotein and metallo-DNA/RNAzyme design: current approaches, success measures, and future challenges. Inorg Chem (2006) 0.98

Emerging critical roles of Fe-S clusters in DNA replication and repair. Biochim Biophys Acta (2015) 0.96

The roles of metal ions in regulation by riboswitches. Met Ions Life Sci (2011) 0.92

Immunohistowax processing, a new fixation and embedding method for light microscopy, which preserves antigen immunoreactivity and morphological structures: visualisation of dendritic cells in peripheral organs. J Clin Pathol (2000) 0.91

Redox biology: computational approaches to the investigation of functional cysteine residues. Antioxid Redox Signal (2011) 0.89

Prediction of metal ion-binding sites in proteins using the fragment transformation method. PLoS One (2012) 0.88

Detection of metals and metalloproteins in the plasma of stroke patients by mass spectrometry methods. Metallomics (2012) 0.81

Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.80

Biochemical and biophysical characterization of the selenium-binding and reducing site in Arabidopsis thaliana homologue to mammals selenium-binding protein 1. J Biol Chem (2014) 0.78

X-ray fluorescence microscopy for investigation of archival tissues. Health Phys (2012) 0.77

Different reactive oxygen species lead to distinct changes of cellular metal ions in the eukaryotic model organism Saccharomyces cerevisiae. Int J Mol Sci (2011) 0.76

Identification of 2-oxohistidine Interacting Proteins Using E. coli Proteome Chips. Mol Cell Proteomics (2016) 0.76

Microbial Metalloproteomics. Proteomes (2015) 0.75

G-LoSA: An efficient computational tool for local structure-centric biological studies and drug design. Protein Sci (2016) 0.75

Recognizing metal and acid radical ion-binding sites by integrating ab initio modeling with template-based transferals. Bioinformatics (2016) 0.75

Tuned by metals: the TET peptidase activity is controlled by 3 metal binding sites. Sci Rep (2016) 0.75

PIXE-electrophoresis shows starving collembolan reallocates protein-bound metals. Ecotoxicology (2015) 0.75

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science (1993) 5.78

Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system. Proteins (1988) 4.82

Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase. J Mol Biol (1982) 4.11

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature (1984) 4.05

Structure of the fibre-forming protein pilin at 2.6 A resolution. Nature (1995) 3.70

Protein docking using continuum electrostatics and geometric fit. Protein Eng (2001) 3.48

Structure of a protein photocycle intermediate by millisecond time-resolved crystallography. Science (1997) 3.25

1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore. Biochemistry (1995) 3.15

Structure at 0.85 A resolution of an early protein photocycle intermediate. Nature (1998) 2.98

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science (1998) 2.75

The beta bulge: a common small unit of nonrepetitive protein structure. Proc Natl Acad Sci U S A (1978) 2.72

Electrostatic recognition between superoxide and copper, zinc superoxide dismutase. Nature (1984) 2.36

Photoactive yellow protein: a structural prototype for the three-dimensional fold of the PAS domain superfamily. Proc Natl Acad Sci U S A (1998) 2.26

The structure of nitric oxide synthase oxygenase domain and inhibitor complexes. Science (1997) 2.18

Structure of the I1 early intermediate of photoactive yellow protein by FTIR spectroscopy. Nat Struct Biol (2001) 2.14

Structure and mechanism of copper, zinc superoxide dismutase. Nature (1984) 2.06

Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. Proc Natl Acad Sci U S A (1985) 1.97

Complete chemical structure of photoactive yellow protein: novel thioester-linked 4-hydroxycinnamyl chromophore and photocycle chemistry. Biochemistry (1994) 1.93

Chemistry of antibody binding to a protein. Science (1987) 1.82

Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins. J Biol Chem (1994) 1.60

Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein. Biochemistry (1997) 1.59

Mechanisms of antibody binding to a protein. Science (1987) 1.55

Structural basis for the root effect in haemoglobin. Nat Struct Biol (1996) 1.55

The structural biochemistry of the superoxide dismutases. Biochim Biophys Acta (2009) 1.50

Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions. Science (1995) 1.49

Crystallographic structure of a photoreceptor protein at 2.4 A resolution. Proc Natl Acad Sci U S A (1989) 1.45

The atomic mobility component of protein antigenicity. Annu Rev Immunol (1985) 1.40

The interdependence of protein surface topography and bound water molecules revealed by surface accessibility and fractal density measures. J Mol Biol (1992) 1.39

Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium. Proc Natl Acad Sci U S A (1995) 1.37

Genetically engineered polymers of human CuZn superoxide dismutase. Biochemistry and serum half-lives. J Biol Chem (1989) 1.32

Primary structure of phage mu transposase: homology to mu repressor. Proc Natl Acad Sci U S A (1985) 1.30

Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies. Infect Immun (1996) 1.29

Metalloantibodies. Science (1990) 1.27

Screening a peptidyl database for potential ligands to proteins with side-chain flexibility. Proteins (1998) 1.25

The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysis. Proteins (1994) 1.23

Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket. Proc Natl Acad Sci U S A (1990) 1.20

The relationship between structure and function for the sulfite reductases. Curr Opin Struct Biol (1996) 1.14

Optical studies of a bacterial photoreceptor protein, photoactive yellow protein, in single crystals. Biochemistry (1995) 1.13

Structural characterization of histone H2A variants. Cold Spring Harb Symp Quant Biol (2004) 1.13

Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine. J Biol Chem (1990) 1.12

Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins. Biochemistry (2000) 1.12

New insights into the photocycle of Ectothiorhodospira halophila photoactive yellow protein: photorecovery of the long-lived photobleached intermediate in the Met100Ala mutant. Biochemistry (1998) 1.09

Crystallographic characterization of recombinant human CuZn superoxide dismutase. J Biol Chem (1986) 1.05

A structural model for the prostate disease marker, human prostate-specific antigen. Protein Sci (1994) 1.05

N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization. EMBO J (1999) 1.05

Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase. Proc Natl Acad Sci U S A (1996) 1.04

Atomic and residue hydrophilicity in the context of folded protein structures. Proteins (1995) 1.04

Biochemical purification and crystallographic characterization of the fiber-forming protein pilin from Neisseria gonorrhoeae. J Biol Chem (1990) 1.03

Active conformation of an insect neuropeptide family. Proc Natl Acad Sci U S A (1991) 1.03

Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction. EMBO J (1999) 1.01

Protonation states and pH titration in the photocycle of photoactive yellow protein. Biochemistry (2000) 1.01

Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen. J Exp Med (1992) 1.01

Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism. Proc Natl Acad Sci U S A (1989) 1.01

Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition. J Biol Chem (1999) 1.00

Protein metal-binding sites. Curr Opin Biotechnol (1992) 1.00

Site-specific mutations provide new insights into the origin of pH effects and alternative spectral forms in the photoactive yellow protein from Halorhodospira halophila. Biochemistry (2003) 0.99

Recognition and interactions controlling the assemblies of beta barrel domains. Biophys J (1986) 0.99

Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c. J Biol Chem (1991) 0.98

Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines. Biochem Biophys Res Commun (1991) 0.96

Structural basis for the binding of an anti-cytochrome c antibody to its antigen: crystal structures of FabE8-cytochrome c complex to 1.8 A resolution and FabE8 to 2.26 A resolution. J Mol Biol (1998) 0.96

Crystallographic characterization of a photoactive yellow protein with photochemistry similar to sensory rhodopsin. J Biol Chem (1986) 0.96

Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization. J Mol Biol (1994) 0.96

Biological sensors: More than one way to sense oxygen. Curr Biol (1999) 0.95

Site-directed mutagenesis of a catalytic antibody: an arginine and a histidine residue play key roles. Biochemistry (1994) 0.95

Predicting molecular interactions and inducible complementarity: fragment docking of Fab-peptide complexes. Proteins (1994) 0.94

Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface. J Mol Biol (2000) 0.93

Structural basis for amide hydrolysis catalyzed by the 43C9 antibody. J Mol Biol (1999) 0.92

Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange. Biochemistry (1997) 0.92

Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein. Biochemistry (2000) 0.92

Kinetic studies of reduction of a 1:1 cytochrome c-flavodoxin complex by free flavin semiquinones and rubredoxin. Biochemistry (1986) 0.92

Altering the antigenicity of proteins. Proc Natl Acad Sci U S A (1992) 0.91

Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products. Biochemistry (1997) 0.89

Preparation and properties of a 3,4-dihydroxycinnamic acid chromophore variant of the photoactive yellow protein. Arch Biochem Biophys (1997) 0.89

Function of the Greek key connection analysed using circular permutants of superoxide dismutase. EMBO J (1997) 0.89

Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase. Proteins (1997) 0.88

Three-dimensional model of coagulation factor Va bound to activated protein C. Thromb Haemost (2000) 0.87

Complex formation between Azotobacter vinelandii ferredoxin I and its physiological electron donor NADPH-ferredoxin reductase. J Biol Chem (1999) 0.87

Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. EMBO J (1995) 0.86

Kinetics of electron transfer between cytochromes c' and the semiquinones of free flavin and clostridial flavodoxin. Biochemistry (1986) 0.86

Homology models of the C domains of blood coagulation factors V and VIII: a proposed membrane binding mode for FV and FVIII C2 domains. Blood Cells Mol Dis (1998) 0.86

Monoclonal antibody-based ELISAs for part-per-billion determination of polycyclic aromatic hydrocarbons: effects of haptens and formats on sensitivity and specificity. Anal Chem (1999) 0.86

Harmful somatic mutations: lessons from the dark side. Immunol Rev (1998) 0.85

Humanization and molecular modeling of the anti-CD4 monoclonal antibody, OKT4A. J Immunol (1996) 0.85

Crystallographic characterization of a Cu,Zn superoxide dismutase from Photobacterium leiognathi. J Mol Biol (1990) 0.84

Determining phases and anomalous-scattering models from the multiwavelength anomalous diffraction of native protein metal clusters. improved MAD phase error estimates and anomalous-scatterer positions. Acta Crystallogr D Biol Crystallogr (1997) 0.82

Biochemical implications from the variable gene sequences of an anti-cytochrome c antibody and crystallographic characterization of its antigen-binding fragment in free and antigen-complexed forms. J Mol Biol (1991) 0.82

Unraveling the effect of changes in conformation and compactness at the antibody V(L)-V(H) interface upon antigen binding. J Mol Recognit (2000) 0.82

Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. Biochemistry (2001) 0.82

Dual photoactive species in Glu46Asp and Glu46Ala mutants of photoactive yellow protein: a pH-driven color transition. Biochemistry (1999) 0.82

Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase. J Biol Chem (1999) 0.81

A nonpeptidal peptidomimetic agonist of the insect FLRFamide myosuppressin family. Peptides (1996) 0.80

Transient kinetics of reduction of blue copper proteins by free flavin and flavodoxin semiquinones. Biochemistry (1986) 0.80

Pseudodipeptide analogs of the pyrokinin/PBAN (FXPRLa) insect neuropeptide family containing carbocyclic Pro-mimetic conformational components. Regul Pept (1995) 0.80

Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII. Thromb Haemost (2000) 0.80