Published in Clin Pharmacokinet on January 01, 2003
Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci U S A (2005) 3.24
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res (2004) 3.03
The influence of polymer topology on pharmacokinetics: differences between cyclic and linear PEGylated poly(acrylic acid) comb polymers. J Control Release (2009) 1.62
Multifunctional micellar nanomedicine for cancer therapy. Exp Biol Med (Maywood) (2008) 1.33
Enabling individualized therapy through nanotechnology. Pharmacol Res (2010) 1.28
Polymeric nanomedicine for cancer MR imaging and drug delivery. Chem Commun (Camb) (2009) 1.24
Cancer therapies utilizing the camptothecins: a review of the in vivo literature. Mol Pharm (2010) 1.17
Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancer. Br J Cancer (2008) 1.14
Mathematical model for radial expansion and conflation of intratumoral infectious centers predicts curative oncolytic virotherapy parameters. PLoS One (2013) 1.08
Inflammation responsive logic gate nanoparticles for the delivery of proteins. Bioconjug Chem (2011) 1.04
Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer-drug conjugate. Int J Nanomedicine (2006) 1.00
Stealth properties to improve therapeutic efficacy of drug nanocarriers. J Drug Deliv (2013) 0.99
Polymeric nanogel formulations of nucleoside analogs. Expert Opin Drug Deliv (2007) 0.98
Silk-elastinlike protein polymer hydrogels for localized adenoviral gene therapy of head and neck tumors. Biomacromolecules (2009) 0.98
Stimuli-responsive nanomaterials for biomedical applications. J Am Chem Soc (2015) 0.97
Nanopharmaceuticals (part 1): products on the market. Int J Nanomedicine (2014) 0.95
Block Ionomer Complex Micelles with Cross-Linked Cores for Drug Delivery. Polym Sci Ser A Chem Phys (2009) 0.90
Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles. Chem Commun (Camb) (2009) 0.88
Immunotoxins and anticancer drug conjugate assemblies: the role of the linkage between components. Toxins (Basel) (2011) 0.87
The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells. Biomaterials (2009) 0.87
Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release (2011) 0.84
Drug-Free Macromolecular Therapeutics--A New Paradigm in Polymeric Nanomedicines. Biomater Sci (2015) 0.82
Recent advances in dendrimer-based nanovectors for tumor-targeted drug and gene delivery. Drug Discov Today (2014) 0.82
A novel role for raloxifene nanomicelles in management of castrate resistant prostate cancer. Biomed Res Int (2014) 0.81
Phase 2 trial of paclitaxel polyglumex with capecitabine for metastatic breast cancer. Am J Clin Oncol (2014) 0.81
A versatile technique for the in vivo imaging of human tumor xenografts using near-infrared fluorochrome-conjugated macromolecule probes. PLoS One (2013) 0.80
Cold instability of aponeocarzinostatin and its stabilization by labile chromophore. Biophys J (2005) 0.80
Synthesis and evaluation of poly(styrene-co-maleic acid) micellar nanocarriers for the delivery of tanespimycin. Int J Pharm (2011) 0.79
Procoagulant inhibitory properties of paclitaxel poliglumex. Int J Gen Med (2010) 0.75
Current status of nanomedicine and nanosurgery. Anesth Essays Res (2015) 0.75
The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate. Int J Nanomedicine (2016) 0.75
The potential of polymeric micelles in the context of glioblastoma therapy. Front Pharmacol (2013) 0.75
Styrene maleic acid encapsulated raloxifene micelles for management of inflammatory bowel disease. Clin Transl Med (2017) 0.75
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Genome sequencing and analysis of Aspergillus oryzae. Nature (2005) 5.47
The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev (2010) 5.26
Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov Today (2006) 4.35
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv Drug Deliv Rev (2012) 2.99
Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Res (2013) 2.98
Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications. Int Immunopharmacol (2003) 2.47
Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin Invest (2009) 1.83
Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice. Environ Health Perspect (2012) 1.73
Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev (2009) 1.68
Antibacterial effect of bactericide immobilized in resin matrix. Dent Mater (2008) 1.51
Ischemia postconditioning and mesenchymal stem cells engraftment synergistically attenuate ischemia reperfusion-induced lung injury in rats. J Surg Res (2012) 1.50
Highly divergent methyltransferases catalyze a conserved reaction in tocopherol and plastoquinone synthesis in cyanobacteria and photosynthetic eukaryotes. Plant Cell (2003) 1.47
Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities. Infect Immun (2002) 1.39
DWARF AND LOW-TILLERING, a new member of the GRAS family, plays positive roles in brassinosteroid signaling in rice. Plant J (2009) 1.38
Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin. Int J Cancer (2004) 1.35
In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor. Cancer Res (2003) 1.31
Oryza sativa dicer-like4 reveals a key role for small interfering RNA silencing in plant development. Plant Cell (2007) 1.30
Tumor necrosis factor-alpha gene (TNF-alpha) -1031/-863, -857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese. J Clin Periodontol (2003) 1.26
Factors and mechanism of "EPR" effect and the enhanced antitumor effects of macromolecular drugs including SMANCS. Adv Exp Med Biol (2003) 1.26
NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. Proc Natl Acad Sci U S A (2004) 1.25
KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood (2009) 1.21
How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum. Immunol Res (2009) 1.13
alpha-Tocopherol plays a role in photosynthesis and macronutrient homeostasis of the cyanobacterium Synechocystis sp. PCC 6803 that is independent of its antioxidant function. Plant Physiol (2006) 1.11
Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. Gene (2004) 1.10
Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization. J Clin Invest (2003) 1.08
SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours. J Control Release (2004) 1.07
Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention effect in solid tumors. Cancer Sci (2012) 1.07
8-nitroguanosine formation in viral pneumonia and its implication for pathogenesis. Proc Natl Acad Sci U S A (2003) 1.07
The fungal hydrophobin RolA recruits polyesterase and laterally moves on hydrophobic surfaces. Mol Microbiol (2005) 1.06
Total bacterial counts on oral mucosa after using a commercial saliva substitute in patients undergoing hematopoietic cell transplantation. Support Care Cancer (2009) 1.05
Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouse. J Neurosci Res (2003) 1.05
Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application. Cancer Sci (2009) 1.03
A built-in strategy for containment of transgenic plants: creation of selectively terminable transgenic rice. PLoS One (2008) 1.03
Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72. J Biol Chem (2002) 1.02
Distribution of Archaea in Japanese patients with periodontitis and humoral immune response to the components. FEMS Microbiol Lett (2008) 1.02
HIV gp120-induced interaction between CD4 and CCR5 requires cholesterol-rich microenvironments revealed by live cell fluorescence resonance energy transfer imaging. J Biol Chem (2006) 1.01
Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors. Jpn J Clin Oncol (2009) 1.00
Isolation, identification, and structure of a potent alkyl-peroxyl radical scavenger in crude canola oil, canolol. Biosci Biotechnol Biochem (2005) 1.00
Rice DENSE AND ERECT PANICLE 2 is essential for determining panicle outgrowth and elongation. Cell Res (2010) 0.99
The small subunit of snapdragon geranyl diphosphate synthase modifies the chain length specificity of tobacco geranylgeranyl diphosphate synthase in planta. Plant Cell (2009) 0.97
Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies. Clin Cancer Res (2005) 0.97
Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients. Clin Chem Lab Med (2014) 0.97
Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide. Cancer Res (2002) 0.97
Clinical, pathological and genetic evaluations of Chinese patients with autosomal-dominant hypophosphatasia. Arch Oral Biol (2010) 0.96
The histone methyltransferase SDG724 mediates H3K36me2/3 deposition at MADS50 and RFT1 and promotes flowering in rice. Plant Cell (2012) 0.95
An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface. J Biol Chem (2004) 0.95
[A cross sectional study of passive smoking of non-smoking women and analysis of influence factors on women passive smoking]. Wei Sheng Yan Jiu (2006) 0.95
Copoly(styrene-maleic acid)-pirarubicin micelles: high tumor-targeting efficiency with little toxicity. Bioconjug Chem (2005) 0.95
Transplantation with survivin-engineered mesenchymal stem cells results in better prognosis in a rat model of myocardial infarction. Eur J Heart Fail (2009) 0.95
An alternative pathway contributes to phenylalanine biosynthesis in plants via a cytosolic tyrosine:phenylpyruvate aminotransferase. Nat Commun (2013) 0.94
Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation. Support Care Cancer (2010) 0.94
Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation. J Drug Target (2007) 0.94
4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils. Int J Cancer (2008) 0.94
Novel hydrophobic surface binding protein, HsbA, produced by Aspergillus oryzae. Appl Environ Microbiol (2006) 0.94
Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase. Int J Cancer (2008) 0.94
Identification of bradykinin receptors in clinical cancer specimens and murine tumor tissues. Int J Cancer (2002) 0.93
Molecular analysis of rice plants harboring a multi-functional T-DNA tagging system. J Genet Genomics (2009) 0.93
Multidrug resistance protein 2 implicates anticancer drug-resistance to sorafenib. Biol Pharm Bull (2011) 0.92
Effects of dietary L-lysine intake on the intestinal mucosa and expression of CAT genes in weaned piglets. Amino Acids (2013) 0.92
Nitric oxide as an endogenous mutagen for Sendai virus without antiviral activity. J Virol (2004) 0.92
Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity. BMC Cancer (2014) 0.91
ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice. Plant Mol Biol (2010) 0.90
Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase (Streptococcus pyrogenic exotoxin B). Infect Immun (2004) 0.90
Dietary L-glutamine supplementation improves pregnancy outcome in mice infected with type-2 porcine circovirus. Amino Acids (2011) 0.89
Immunostimulation-Mediated Anti-tumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained Under 'Vigorous' Condition. Evid Based Complement Alternat Med (2008) 0.89
Cyclic mechanical stretch augments hyaluronan production in cultured human uterine cervical fibroblast cells. Mol Hum Reprod (2005) 0.89
Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury. J Neuroinflammation (2012) 0.89
Molecular cloning and characterization of a novel gamma-CGTase from alkalophilic Bacillus sp. Appl Microbiol Biotechnol (2005) 0.89
High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor. Biomaterials (2006) 0.89
Cancer preventive effect of Kumaizasa bamboo leaf extracts administered prior to carcinogenesis or cancer inoculation. Anticancer Res (2010) 0.89
Regulatory T cells contribute to rosuvastatin-induced cardioprotection against ischemia-reperfusion injury. Coron Artery Dis (2013) 0.89
Transcriptional activation by MEIS1A in response to protein kinase A signaling requires the transducers of regulated CREB family of CREB co-activators. J Biol Chem (2009) 0.89
Expression of POTE protein in human testis detected by novel monoclonal antibodies. Biochem Biophys Res Commun (2007) 0.89
Tryptophan metabolism in animals: important roles in nutrition and health. Front Biosci (Schol Ed) (2011) 0.88
Clinical profiles and long-term outcomes of patients with pancreatic ductal adenocarcinoma and diabetes mellitus. Diabetes Metab Res Rev (2012) 0.88
Oligodendrocyte progenitor cell susceptibility to injury in multiple sclerosis. Am J Pathol (2013) 0.88
In vitro and in vivo evaluation of tumor targeting styrene-maleic acid copolymer-pirarubicin micelles: Survival improvement and inhibition of liver metastases. Cancer Sci (2010) 0.88
A highly sulfated chondroitin sulfate preparation, CS-E, prevents excitatory amino acid-induced neuronal cell death. J Neurochem (2007) 0.87
Electrospinning collagen/chitosan/poly(L-lactic acid-co-ε-caprolactone) to form a vascular graft: mechanical and biological characterization. J Biomed Mater Res A (2012) 0.87
A first implementation of an automated reel-to-reel fluidic self-assembly machine. Adv Mater (2014) 0.87
Protective effect of canolol from oxidative stress-induced cell damage in ARPE-19 cells via an ERK mediated antioxidative pathway. Mol Vis (2011) 0.87
[Effect of glucocorticoid on CD4+CD25+ T regulatory cells in asthmatic mice]. Zhongguo Dang Dai Er Ke Za Zhi (2008) 0.87
The influence of health-promoting lifestyles on the quality of life of retired workers in a medium-sized city of Northeastern China. Environ Health Prev Med (2013) 0.86
Prognostic value of the microRNA-29 family in patients with primary osteosarcomas. Med Oncol (2014) 0.86
Ectopic thyroid mass in the left lateral neck and anterior mediastinum: a case report. J Med Case Rep (2014) 0.86
Retracted Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via downregulation of MMP7 and MMP13. Tumour Biol (2014) 0.86
Preparation and evaluation of GAC-based iron-containing adsorbents for arsenic removal. Environ Sci Technol (2005) 0.86
Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice. J Vet Sci (2013) 0.86