Published in Intensive Care Med on October 14, 2003
A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens. Crit Care Med (2007) 3.03
Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version. Ger Med Sci (2010) 1.30
Alcohol-use disorders in the critically ill patient. Chest (2010) 1.07
Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version. Ger Med Sci (2015) 0.94
Identification and management of alcohol withdrawal syndrome. Drugs (2015) 0.81
Is it prime time for alpha2-adrenocepter agonists in the treatment of withdrawal syndromes? J Med Toxicol (2014) 0.81
Care for hospitalized patients with unhealthy alcohol use: a narrative review. Addict Sci Clin Pract (2013) 0.76
The Sedative Effect of Propranolol on Critically Ill Patients: A Case Series. Front Med (Lausanne) (2017) 0.75
Alcohol withdrawal prevention: a randomized evaluation of lorazepam and ethanol--a pilot study. Am J Crit Care (2013) 0.75
Alcohol withdrawal syndrome in critically ill patients: protocolized versus nonprotocolized management. J Trauma Acute Care Surg (2014) 0.75
Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. Pharmacogenetics (2004) 2.37
Beta-trace protein, cystatin C, beta(2)-microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children. Clin Chem (2002) 2.17
Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. Clin Pharmacol Ther (2005) 1.96
Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled phase II study. Crit Care Med (2002) 1.94
The effect of computerized tailored brief advice on at-risk drinking in subcritically injured trauma patients. J Trauma (2006) 1.77
Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications. Int J Cancer (2004) 1.66
Effect of metabolic blockade on the psychoactive effects of dextromethorphan. Hum Psychopharmacol (2010) 1.59
New strategies to detect alcohol use disorders in the preoperative assessment clinic of a German university hospital. Anesthesiology (2008) 1.50
Inhibition of cytochromes P450 by antifungal imidazole derivatives. Drug Metab Dispos (2002) 1.47
Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. Hum Mutat (2008) 1.42
CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking. Cancer Epidemiol Biomarkers Prev (2006) 1.33
Renal replacement therapy with high-cutoff hemofilters: Impact of convection and diffusion on cytokine clearances and protein status. Am J Kidney Dis (2004) 1.30
Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking. Drug Alcohol Depend (2006) 1.23
Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. Ther Drug Monit (2002) 1.19
CYP2A6 genetic variation and potential consequences. Adv Drug Deliv Rev (2002) 1.17
Multicenter evaluation of an artificial neural network to increase the prostate cancer detection rate and reduce unnecessary biopsies. Clin Chem (2002) 1.13
Gender differences in the performance of a computerized version of the alcohol use disorders identification test in subcritically injured patients who are admitted to the emergency department. Alcohol Clin Exp Res (2004) 1.12
Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method. Pharmacogenet Genomics (2005) 1.10
Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients. Anesthesiology (2004) 1.09
New CYP2A6 gene deletion and conversion variants in a population of Black African descent. Pharmacogenomics (2010) 1.05
Postoperative analgesia after major spine surgery: patient-controlled epidural analgesia versus patient-controlled intravenous analgesia. Anesth Analg (2006) 1.04
Research design strategies to evaluate the impact of formulations on abuse liability. Drug Alcohol Depend (2006) 1.03
A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo. Pharmacogenomics J (2009) 1.03
Do formulation differences alter abuse liability of methylphenidate? A placebo-controlled, randomized, double-blind, crossover study in recreational drug users. J Clin Psychopharmacol (2007) 1.01
3alpha-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period. Gynecol Endocrinol (2005) 0.99
Antibiotic-mediated release of tumour necrosis factor alpha and norharman in patients with hospital-acquired pneumonia and septic encephalopathy. Intensive Care Med (2004) 0.99
N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report. Crit Care (2004) 0.98
Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochem Pharmacol (2002) 0.97
Emerging biomarkers: new directions and clinical applications. Alcohol Clin Exp Res (2005) 0.97
CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence. Pharmacogenetics (2003) 0.96
Predictors of loss to follow-up in young patients with minor trauma after screening and written intervention for alcohol in an urban emergency department. J Stud Alcohol Drugs (2007) 0.96
Assessment of pharmacokinetics and pharmacodynamic effects related to abuse potential of a unique oral osmotic-controlled extended-release methylphenidate formulation in humans. J Clin Pharmacol (2007) 0.95
Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations. Pain (2012) 0.95
A randomized, double-blind, placebo-controlled, crossover study to evaluate the subjective abuse potential and cognitive effects of nabiximols oromucosal spray in subjects with a history of recreational cannabis use. Hum Psychopharmacol (2011) 0.95
A practical concept for preoperative identification of patients with impaired primary hemostasis. Clin Appl Thromb Hemost (2004) 0.95
Comparison of protein expression profiles between monolayer and spheroid cell culture of HT-29 cells revealed fragmentation of CK18 in three-dimensional cell culture. Electrophoresis (2002) 0.95
The usefulness of direct ethanol metabolites in assessing alcohol intake in nonintoxicated male patients in an emergency room setting. Alcohol Clin Exp Res (2008) 0.94
Study of therapy resistance in cancer cells with functional proteome analysis. Clin Chem Lab Med (2002) 0.94
Renal elimination of troponin T and troponin I. Clin Chem (2003) 0.94
Evaluation of the abuse potential of extended release hydromorphone versus immediate release hydromorphone. J Clin Psychopharmacol (2010) 0.93
Abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered crushed oxycodone HCl abuse-deterrent controlled-release tablets in recreational opioid users. J Clin Pharmacol (2013) 0.93
Assessment of Pharmacokinetic and Pharmacodynamic Interactions Between Albumin-Fused Mutated Butyrylcholinesterase and Intravenously Administered Cocaine in Recreational Cocaine Users. J Clin Psychopharmacol (2015) 0.93
Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. Biochem Pharmacol (2002) 0.93
Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration. Mol Pharmacol (2003) 0.93
Predictors of pain behaviors in fibromyalgia syndrome. Arthritis Rheum (2005) 0.93
Postoperative epidural anesthesia preserves lymphocyte, but not monocyte, immune function after major spine surgery. Anesth Analg (2004) 0.92
Risk management and post-marketing surveillance for the abuse of medications acting on the central nervous system: expert panel report. Drug Alcohol Depend (2009) 0.92
Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon. Life Sci (2003) 0.92
Positive and negative subjective effects of extended-release oxymorphone versus controlled-release oxycodone in recreational opioid users. J Opioid Manag (2011) 0.91
Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism. J Pharmacol Exp Ther (2003) 0.91
Analysis of subforms of free prostate-specific antigen in serum by two-dimensional gel electrophoresis: potential to improve diagnosis of prostate cancer. Clin Chem (2004) 0.90
Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers. J Clin Pharmacol (2004) 0.90
Bone resorption parameters [carboxy-terminal telopeptide of type-I collagen (ICTP), amino-terminal collagen type-I telopeptide (NTx), and deoxypyridinoline (Dpd)] in MGUS and multiple myeloma. Eur J Haematol (2002) 0.89
Vitamin E as an antioxidant of the lung: mechanisms of vitamin E delivery to alveolar type II cells. Am J Respir Crit Care Med (2002) 0.89
Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. Drug Metab Dispos (2003) 0.88
Mild hypothermia after near drowning in twin toddlers. Crit Care (2004) 0.88
A proteomic investigation into etoposide chemo-resistance of neuroblastoma cell lines. Proteomics (2005) 0.88
Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics. Eur J Clin Pharmacol (2006) 0.87
Effects of dopexamine on the intestinal microvascular blood flow and leukocyte activation in a sepsis model in rats. Crit Care (2006) 0.87
HDL-holoparticle uptake by alveolar type II cells: effect of vitamin E status. Am J Respir Cell Mol Biol (2002) 0.87
High permeability haemofiltration improves peripheral blood mononuclear cell proliferation in septic patients with acute renal failure. Nephrol Dial Transplant (2003) 0.87
Different impact of biomarkers as mortality predictors among diabetic and nondiabetic patients undergoing hemodialysis. J Am Soc Nephrol (2003) 0.87
Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock. Crit Care (2004) 0.87
Hazardous alcohol consumption and sense of coherence in emergency department patients with minor trauma. Drug Alcohol Depend (2005) 0.87
Association between CYP3A4 genotype and risk of endometrial cancer following tamoxifen use. Carcinogenesis (2007) 0.86
Posttraumatic immune modulation in chronic alcoholics is associated with multiple organ dysfunction syndrome. J Trauma (2002) 0.86
From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists. Trends Pharmacol Sci (2013) 0.86
Human melanoma: drug resistance. Recent Results Cancer Res (2003) 0.86
Intermittent high-permeability hemofiltration modulates inflammatory response in septic patients with multiorgan failure. Nephron Clin Pract (2003) 0.85
Differences in the in vitro and in vivo pharmacokinetic profiles of once-daily modified-release methylphenidate formulations in Canada: examination of current bioequivalence criteria. Clin Ther (2012) 0.85
Brain Network Activation (BNA) reveals scopolamine-induced impairment of visual working memory. J Mol Neurosci (2014) 0.85
Increased interleukin-10 and cortisol in long-term alcoholics after cardiopulmonary bypass: a hint to the increased postoperative infection rate? Alcohol Clin Exp Res (2005) 0.84
Socioeconomic and drug use determinants of smoking status in an urban adult population of Black African descent. Nicotine Tob Res (2008) 0.83
Stress induced IL-10 does not seem to be essential for early monocyte deactivation following cardiac surgery. Cytokine (2003) 0.82
The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence. Pharmacogenomics (2002) 0.82
Intermittent high permeability hemofiltration in septic patients with acute renal failure. Intensive Care Med (2003) 0.81
Alcohol biomarker screening in medical and surgical settings. Alcohol Clin Exp Res (2006) 0.81
Lidocaine and octanol have different modes of action at tetrodotoxin-resistant Na(+) channels of peripheral nerves. Anesth Analg (2003) 0.80
Study of the development of thermoresistance in human pancreatic carcinoma cell lines using proteome analysis. Electrophoresis (2004) 0.80
Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia. BMC Neurosci (2004) 0.80
Low-dose prostacyclin preserves renal function in high-risk patients after coronary bypass surgery. Crit Care Med (2002) 0.80
Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker. Clin Pharmacol Ther (2002) 0.80
Effects of C1 esterase inhibitor administration on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation during experimental endotoxemia. Intensive Care Med (2003) 0.80
An artificial neural network considerably improves the diagnostic power of percent free prostate-specific antigen in prostate cancer diagnosis: results of a 5-year investigation. Int J Cancer (2002) 0.80
Isoelectric focusing in long immobilized pH gradient gels to improve protein separation in proteomic analysis. Electrophoresis (2003) 0.79
Myocardial ischemia and cytokine response are associated with subsequent onset of infections after noncardiac surgery. Anesth Analg (2002) 0.79
Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers. Epilepsy Behav (2010) 0.79
Unobserved heterogeneity in trauma patients' desire for autonomy in medical decision making in an emergency department. Med Sci Monit (2008) 0.79
Comparative abuse liability and pharmacological effects of meprobamate, triazolam, and butabarbital. J Clin Psychopharmacol (2003) 0.79
Effects of an Innovative Psychotherapy Program for Surgical Patients: Bridging Intervention in Anesthesiology--A Randomized Controlled Trial. Anesthesiology (2015) 0.79
The functional integrity of platelets in volume-reduced platelet concentrates. Anesth Analg (2005) 0.79
Randomized open-label drug-drug interaction trial of dextromethorphan/quinidine and paroxetine in healthy volunteers. Clin Drug Investig (2012) 0.79
The role of adverse events and related safety data in the pre-market evaluation of drug abuse potential. Drug Alcohol Depend (2010) 0.78
Reduced cognitive and psychomotor impairment with extended-release oxymorphone versus controlled-release oxycodone. Pain Physician (2010) 0.78
Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19. Drug Metab Dispos (2002) 0.78
EMD 281014, a specific and potent 5HT2 antagonist in humans: a dose-finding PET study. Psychopharmacology (Berl) (2004) 0.78
Effects of coagulation factor XIII on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation in experimental endotoxemia. Crit Care (2006) 0.78