DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 3098567)

Published in Neurobiol Dis on November 01, 2003

Authors

S J Evans1, P V Choudary, M P Vawter, J Li, J H Meador-Woodruff, J F Lopez, S M Burke, R C Thompson, R M Myers, E G Jones, W E Bunney, S J Watson, H Akil

Author Affiliations

1: Pritzker Consortium for Severe Psychiatric Disorders, San Francisco, CA, USA. evanssi@umich.edu

Articles citing this

Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci U S A (2005) 2.38

Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum. PLoS One (2008) 2.22

Dysregulation of the fibroblast growth factor system in major depression. Proc Natl Acad Sci U S A (2004) 2.19

Aging and gene expression in the primate brain. PLoS Biol (2005) 1.76

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proc Natl Acad Sci U S A (2013) 1.63

Target identification for CNS diseases by transcriptional profiling. Neuropsychopharmacology (2008) 1.32

Gene expression profiling of neurochemically defined regions of the human brain by in situ hybridization-guided laser capture microdissection. J Neurosci Methods (2008) 1.02

Systematic analysis of gene expression in human brains before and after death. Genome Biol (2005) 0.98

Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability. Curr Genomics (2010) 0.97

Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner. Cereb Cortex (2009) 0.94

Biomarkers of HIV-1-associated neurocognitive disorders: challenges of proteomic approaches. Biomark Med (2009) 0.86

Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia. BMC Genomics (2013) 0.86

Microarrays and the microscope: balancing throughput with resolution. J Physiol (2006) 0.84

The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression. J Psychiatr Res (2016) 0.75

Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions. PLoS One (2014) 0.75

Post-mortem molecular profiling of three psychiatric disorders. Genome Med (2017) 0.75

Articles cited by this

Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47

Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex (1993) 7.13

Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci U S A (2000) 5.01

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. J Neurosci (1993) 4.90

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J Biol Chem (1995) 3.69

Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry (2001) 3.19

Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci (1995) 3.00

Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. J Neurosci (1997) 2.69

PAK3 mutation in nonsyndromic X-linked mental retardation. Nat Genet (1998) 2.52

Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes. Neuropsychopharmacology (2004) 2.48

Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry (1999) 2.45

Ca2+/calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum. J Biol Chem (1985) 2.26

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc Natl Acad Sci U S A (1993) 2.07

Transcriptional profiling reveals strict boundaries between hippocampal subregions. J Comp Neurol (2001) 1.98

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry (2001) 1.94

Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J Biol Chem (1995) 1.86

Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. Mol Cell Biol (1997) 1.75

Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei. Proc Natl Acad Sci U S A (2001) 1.67

New modulatory alpha subunits for mammalian Shab K+ channels. J Biol Chem (1997) 1.52

Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Serial Analysis of Gene Expression. Eur J Neurosci (2002) 1.27

Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain Res Mol Brain Res (1998) 1.26

Neurogranin: immunocytochemical localization of a brain-specific protein kinase C substrate. J Neurosci (1990) 1.19

Human brain factor 1, a new member of the fork head gene family. Genomics (1994) 1.16

A new view of specific and nonspecific thalamocortical connections. Adv Neurol (1998) 1.15

Cell- and lamina-specific expression and activity-dependent regulation of type II calcium/calmodulin-dependent protein kinase isoforms in monkey visual cortex. J Neurosci (1998) 1.14

Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA. Brain Res (1992) 1.13

A method for fixation of previously fresh-frozen human adult and fetal brains that preserves histological quality and immunoreactivity. J Neurosci Methods (1992) 1.07

N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. J Biol Chem (1998) 1.05

Isolation and characterization of a new member of the human Ly6 gene family (LY6H). Genomics (1998) 1.03

Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs. Biochem Biophys Res Commun (2002) 1.03

GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. Brain Res Mol Brain Res (1995) 0.97

Expression of serotonin 5-HT(2A) receptors in the human cerebellum and alterations in schizophrenia. Synapse (2001) 0.97

Mab21, the mouse homolog of a C. elegans cell-fate specification gene, participates in cerebellar, midbrain and eye development. Mech Dev (1998) 0.92

Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder. Neuroreport (1999) 0.92

Localized deposition of M-cadherin in the glomeruli of the granular layer during the postnatal development of mouse cerebellum. J Comp Neurol (1997) 0.91

Update on dopamine receptors. Ann Clin Psychiatry (1994) 0.90

cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors. Genomics (1997) 0.90

Developmental regulation of somatostatin gene expression in the brain is region specific. Mol Endocrinol (1987) 0.86

Astrocytes express specific variants of CaM KII delta and gamma, but not alpha and beta, that determine their cellular localizations. Glia (2000) 0.86

GABAA-receptors: structural requirements and sites of gene expression in mammalian brain. Neurochem Res (1990) 0.85

Proopiomelanocortin peptide immunocytochemistry in rhesus monkey brain. Brain Res Bull (1984) 0.85

Elevation of CSF somatostatin concentrations in mania. Am J Psychiatry (1995) 0.82

Is T-cadherin (CDH13, H-cadherin) expression related to lung metastasis of osteosarcoma? Histopathology (2000) 0.79

Cholecystokinin in CSF from depressed patients: possible relations to severity of depression and suicidal behaviour. Eur Neuropsychopharmacol (1998) 0.78

Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment. Schizophr Res (1994) 0.78

Regional distribution of neuropeptide Y mRNA in postmortem human brain. Brain Res Mol Brain Res (1989) 0.77

Somatostatin and neuropeptide Y in cerebrospinal fluid: correlations with severity of disease and clinical signs in Alzheimer's disease and frontotemporal dementia. Dement Geriatr Cogn Disord (1997) 0.77

Articles by these authors

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

The sequence of the human genome. Science (2001) 101.55

The genome sequence of Drosophila melanogaster. Science (2000) 74.32

TM4: a free, open-source system for microarray data management and analysis. Biotechniques (2003) 38.02

Comparative genomics of the eukaryotes. Science (2000) 26.62

Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast (1998) 23.00

A gene map of the human genome. Science (1996) 14.32

Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes. Proc Natl Acad Sci U S A (1989) 13.66

A physical map of 30,000 human genes. Science (1998) 12.43

A physical map of the human genome. Nature (2001) 12.39

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy (2008) 12.35

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science (1997) 11.89

Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet (1999) 11.10

Detection and localization of single base changes by denaturing gradient gel electrophoresis. Methods Enzymol (1987) 10.90

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet (1997) 10.71

Ubiquitous, interspersed repeated sequences in mammalian genomes. Proc Natl Acad Sci U S A (1980) 9.48

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med (2013) 8.89

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature (1999) 8.23

Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science (1996) 8.06

Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding. J Virol (1990) 7.85

Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol (1998) 7.76

Reimmunization Against Diphtheria of Previously Immunized Children. Am J Public Health Nations Health (1942) 7.70

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nature (1990) 7.32

Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry (1995) 7.19

Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication. Proc Natl Acad Sci U S A (1980) 7.04

IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity (2001) 6.56

Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 6.52

Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol (1996) 6.43

Fine structure genetic analysis of a beta-globin promoter. Science (1986) 6.36

Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Science (1985) 6.35

Structure and variability of human chromosome ends. Mol Cell Biol (1990) 6.18

Detection of single base substitutions in total genomic DNA. Nature (1985) 5.99

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature (1990) 5.86

Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease. Neurology (2006) 5.67

Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58

Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science (1990) 5.35

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A (1997) 5.32

Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science (1999) 5.22

Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates. J Virol (1995) 5.01

A genomic screen of autism: evidence for a multilocus etiology. Am J Hum Genet (1999) 4.96

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature (1990) 4.87

SV40 gene expression is modulated by the cooperative binding of T antigen to DNA. Cell (1981) 4.64

Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. Cell (1999) 4.57

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell (2000) 4.53

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature (1990) 4.46

Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A (1998) 4.35

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res (1997) 4.32

Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J (2001) 4.23

Genetic diversity within Cryptosporidium parvum and related Cryptosporidium species. Appl Environ Microbiol (1999) 4.22

A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell (1998) 4.21

Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients. Antimicrob Agents Chemother (2011) 4.21

Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial. Gut (2007) 4.21

Dominance is the major genetic basis of heterosis in rice as revealed by QTL analysis using molecular markers. Genetics (1995) 4.18

Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science (1997) 4.03

Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest (1997) 4.00

Diphtheria Immunization with Fluid Toxoid and Alum-Precipitated Toxoid. Am J Public Health Nations Health (1942) 3.95

A general method for saturation mutagenesis of cloned DNA fragments. Science (1985) 3.94

Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test-retest reproducibility. Skeletal Radiol (2003) 3.93

Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo. Gene Ther (2003) 3.85

Prophylactic atenolol reduces postoperative myocardial ischemia. McSPI Research Group. Anesthesiology (1998) 3.79

RNA polymerase III transcriptional units are interspersed among human non-alpha-globin genes. Proc Natl Acad Sci U S A (1979) 3.78

THE GERMINATION OF LETTUCE SEED STIMULATED BY CHEMICAL TREATMENT. Science (1938) 3.77

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science (1991) 3.73

Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant Physiol (2000) 3.73

Conformation and function of the N-linked glycan in the adhesion domain of human CD2. Science (1995) 3.62

Evidence for a partially folded intermediate in alpha-synuclein fibril formation. J Biol Chem (2001) 3.60

Light control of Arabidopsis development entails coordinated regulation of genome expression and cellular pathways. Plant Cell (2001) 3.60

The 5'-terminal leader sequence of late 16 S mRNA from cells infected with simian virus 40. J Biol Chem (1978) 3.60

An STS-based radiation hybrid map of the human genome. Genome Res (1997) 3.57

An anatomical study of converging sensory pathways within the cerebral cortex of the monkey. Brain (1970) 3.48

Reliability and validity of the CMT neuropathy score as a measure of disability. Neurology (2005) 3.44

LifeLines: using visualization to enhance navigation and analysis of patient records. Proc AMIA Symp (1998) 3.35

Tenofovir is superior to entecavir for achieving complete viral suppression in HBeAg-positive chronic hepatitis B patients with high HBV DNA. Aliment Pharmacol Ther (2014) 3.32

Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27

Molecular characterization of Cryptosporidium isolates from humans and other animals using random amplified polymorphic DNA analysis. Am J Trop Med Hyg (1995) 3.21

Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron (2001) 3.20

Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res (1997) 3.17

Extracellular labeling of nascent polypeptides traversing the membrane of Escherichia coli. Proc Natl Acad Sci U S A (1977) 3.16

Plasmodium malariae infection in an asymptomatic 74-year-old Greek woman with splenomegaly. N Engl J Med (1998) 3.13

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure. J Biol Chem (2001) 3.13

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity. J Virol (1991) 3.09

Is guided self-help as effective as face-to-face psychotherapy for depression and anxiety disorders? A systematic review and meta-analysis of comparative outcome studies. Psychol Med (2010) 3.08

Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1. Science (2000) 3.07

Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res (1996) 3.03

Coping skills training for youth with diabetes mellitus has long-lasting effects on metabolic control and quality of life. J Pediatr (2000) 3.02

Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci (1995) 3.00

Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging (2005) 3.00

The Arabidopsis deetiolated2 mutant is blocked early in brassinosteroid biosynthesis. Plant Cell (1997) 3.00

Artificial 'spin ice' in a geometrically frustrated lattice of nanoscale ferromagnetic islands. Nature (2006) 2.96

Positioning of the mitotic spindle by a cortical-microtubule capture mechanism. Science (2000) 2.92

Identification of trait-improving quantitative trait loci alleles from a wild rice relative, Oryza rufipogon. Genetics (1998) 2.91

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today (1991) 2.91

Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 2.90

The completeness, validity, and timeliness of AIDS surveillance data. Ann Epidemiol (2001) 2.89

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem (2001) 2.89

Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis. J Clin Invest (1990) 2.86

Adeno-associated virus vector carrying human minidystrophin genes effectively ameliorates muscular dystrophy in mdx mouse model. Proc Natl Acad Sci U S A (2000) 2.83

Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist. J Clin Invest (1990) 2.83