Published in Nat Struct Biol on October 26, 2003
The chemical biology of protein phosphorylation. Annu Rev Biochem (2009) 1.59
Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A (2005) 1.49
Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production. Genes Dev (2007) 1.13
The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction. Chem Biol (2009) 1.08
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125. J Am Chem Soc (2012) 1.06
Preparation of orthogonally protected (2S, 3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of Polo-box domain-binding peptides. Tetrahedron (2009) 0.99
An efficient on-column expressed protein ligation strategy: application to segmental triple labeling of human apolipoprotein E3. Protein Sci (2008) 0.89
Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis. Biochemistry (2008) 0.89
Synthetic approaches to protein phosphorylation. Curr Opin Chem Biol (2015) 0.88
Protein phosphorylation by semisynthesis: from paper to practice. Methods Enzymol (2009) 0.87
Expressed protein ligation using an N-terminal cysteine containing fragment generated in vivo from a pelB fusion protein. Protein Expr Purif (2007) 0.86
Semisynthesis and segmental isotope labeling of the apoE3 N-terminal domain using expressed protein ligation. J Lipid Res (2008) 0.78
Mechanistic and structural analysis of Drosophila melanogaster arylalkylamine N-acetyltransferases. Biochemistry (2014) 0.78
Expressed protein ligation-mediated template protein extension. Protein Expr Purif (2012) 0.75
Systematic identification of phosphorylation-mediated protein interaction switches. PLoS Comput Biol (2017) 0.75
Room-temperature alternative to the Arbuzov reaction: the reductive deoxygenation of acyl phosphonates. Org Lett (2010) 0.75
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell (2006) 10.28
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol (2004) 3.70
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53
A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol (2006) 3.40
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38
Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron (2010) 3.15
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature (2008) 2.83
Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (2008) 2.79
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature (2007) 2.78
Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A (2006) 2.30
DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell (2002) 2.29
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12
Chemical rescue of a mutant enzyme in living cells. Science (2006) 1.95
Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nat Struct Mol Biol (2008) 1.89
Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr Opin Struct Biol (2008) 1.72
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science (2011) 1.70
Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog Retin Eye Res (2005) 1.68
Structural basis for the recognition of c-Src by its inactivator Csk. Cell (2008) 1.66
A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription. EMBO J (2003) 1.65
The chemical biology of protein phosphorylation. Annu Rev Biochem (2009) 1.59
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol (2007) 1.59
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol (2007) 1.58
Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J (2010) 1.58
Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant. Endocrinology (2007) 1.55
Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes. Cancer Res (2002) 1.53
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol (2005) 1.52
LSD1 and the chemistry of histone demethylation. Curr Opin Chem Biol (2007) 1.52
Reading and function of a histone code involved in targeting corepressor complexes for repression. Mol Cell Biol (2005) 1.52
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science (2011) 1.49
Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A (2005) 1.49
Evolution of cell-cell signaling in animals: did late horizontal gene transfer from bacteria have a role? Trends Genet (2004) 1.45
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry (2007) 1.44
A mechanism-based inactivator for histone demethylase LSD1. J Am Chem Soc (2006) 1.43
Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell (2003) 1.42
Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell (2013) 1.40
Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines. Mol Cancer Ther (2011) 1.39
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci U S A (2007) 1.39
Electrophilic tuning of the chemoprotective natural product sulforaphane. Proc Natl Acad Sci U S A (2010) 1.37
Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell Tissue Res (2002) 1.35
The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation. J Biol Chem (2002) 1.34
Csk, a critical link of g protein signals to actin cytoskeletal reorganization. Dev Cell (2002) 1.30
Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A (2011) 1.30
Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J Am Chem Soc (2010) 1.29
Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. J Biol Chem (2008) 1.27
Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. J Biol Chem (2006) 1.26
p300/CBP-associated factor drives DEK into interchromatin granule clusters. J Biol Chem (2005) 1.24
Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nat Chem Biol (2012) 1.24
MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms. FASEB J (2012) 1.24
Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proc Natl Acad Sci U S A (2002) 1.22
Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nat Struct Mol Biol (2011) 1.21
Investigation of the roles of catalytic residues in serotonin N-acetyltransferase. J Biol Chem (2002) 1.20
Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry (2007) 1.20
Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205. J Biol Chem (2005) 1.17
Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Chem Biol (2011) 1.16
In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry (2009) 1.16
Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. J Am Chem Soc (2010) 1.15
Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor. J Am Chem Soc (2005) 1.14
The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. J Biol Chem (2006) 1.14
Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template. Mol Cell Biol (2002) 1.14
Protein semisynthesis and expressed protein ligation: chasing a protein's tail. Curr Opin Chem Biol (2005) 1.11
Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat. Exp Eye Res (2007) 1.10
Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent. Mol Cell Biol (2003) 1.09
X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition. J Mol Biol (2002) 1.09
Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation. Structure (2011) 1.07
Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms. Cancer Res (2002) 1.07
Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1. Proc Natl Acad Sci U S A (2005) 1.05
Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. Biochemistry (2007) 1.05
Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. J Neurosci (2011) 1.05
Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. J Neurochem (2006) 1.05
A selective chemical probe for coenzyme A-requiring enzymes. Angew Chem Int Ed Engl (2007) 1.04
The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity. Nucleic Acids Res (2009) 1.04
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity. Nat Med (2013) 1.02
Protein tyrosine kinase-substrate interactions. Curr Opin Struct Biol (2006) 1.02
Circadian changes in long noncoding RNAs in the pineal gland. Proc Natl Acad Sci U S A (2012) 1.02
Chemical dissection of the effects of tyrosine phosphorylation of SHP-2. Biochemistry (2003) 1.01
Designing bisubstrate analog inhibitors for protein kinases. Pharmacol Ther (2002) 0.99
Serotonin N-acetyltransferase: mechanism and inhibition. Curr Med Chem (2002) 0.99
Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells. J Neurochem (2008) 0.99
Starting the zebrafish pineal circadian clock with a single photic transition. Endocrinology (2006) 0.98
Development of photo-crosslinking reagents for protein kinase-substrate interactions. FEBS Lett (2002) 0.97
Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina. Exp Eye Res (2008) 0.97
Transcriptome analysis of the zebrafish pineal gland. Dev Dyn (2009) 0.97
Pineal function: impact of microarray analysis. Mol Cell Endocrinol (2009) 0.97
Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells. J Invest Dermatol (2013) 0.96
HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Chem Biol (2011) 0.96
Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity. FASEB J (2009) 0.96
Neurochemical and molecular characterization of ketamine-induced experimental psychosis model in mice. Neuropharmacology (2012) 0.96
Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling. Endocrinology (2008) 0.95
Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation. Mol Endocrinol (2009) 0.95
Pineal-specific expression of green fluorescent protein under the control of the serotonin-N-acetyltransferase gene regulatory regions in transgenic zebrafish. Dev Dyn (2002) 0.94