Published in Biochem J on February 01, 2004
Structure, evolution, and biology of the MUC4 mucin. FASEB J (2007) 1.75
The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family. Oncogene (2012) 1.11
Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma. World J Gastroenterol (2008) 1.07
Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction. Cancer Biol Ther (2013) 0.96
Muc4/MUC4 functions and regulation in cancer. Future Oncol (2009) 0.95
Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha. Biochem J (2007) 0.94
The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. PLoS One (2012) 0.91
Deoxycholic acid induces the overexpression of intestinal mucin, MUC2, via NF-kB signaling pathway in human esophageal adenocarcinoma cells. BMC Cancer (2008) 0.91
IL-4 induced MUC4 enhancement in respiratory epithelial cells in vitro is mediated through JAK-3 selective signaling. Respir Res (2006) 0.88
MUC4 is increased in high grade intraepithelial neoplasia in Barrett's oesophagus and is associated with a proapoptotic Bax to Bcl-2 ratio. J Clin Pathol (2004) 0.87
The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells. Biochem J (2005) 0.85
Genetic variants in MUC4 gene are associated with lung cancer risk in a Chinese population. PLoS One (2013) 0.78
Induction of MUC5AC mucin by conjugated bile acids in the esophagus involves the phosphatidylinositol 3-kinase/protein kinase C/activator protein-1 pathway. Cancer (2010) 0.78
Shigella dysenteriae modulates BMP pathway to induce mucin gene expression in vivo and in vitro. PLoS One (2014) 0.77
Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer. Mol Oncol (2016) 0.75
Nuclear receptors and lipid physiology: opening the X-files. Science (2001) 8.76
Barrett's esophagus. Gastroenterology (2002) 3.27
Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. Am J Pathol (1999) 2.88
Barrett's metaplasia. Lancet (2000) 2.47
Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease. Cancer (2003) 2.23
MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. Am J Clin Pathol (2002) 2.18
Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut (2000) 1.99
The MUC family: an obituary. Trends Biochem Sci (2002) 1.80
Implication of duodenogastric reflux in the pathogenesis of Barrett's oesophagus. Br J Surg (1988) 1.79
Model bile and bile salts accelerate mucin secretion by cultured dog gallbladder epithelial cells. Gastroenterology (1995) 1.61
Five newly established oesophageal carcinoma cell lines: phenotypic and immunological characterization. Br J Cancer (1997) 1.61
Cell signaling through membrane mucins. Bioessays (2003) 1.51
Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1. J Biol Chem (2002) 1.49
Expression of sulfated carbohydrate chain and core peptides of mucin detected by monoclonal antibodies in Barrett's esophagus and esophageal adenocarcinoma. J Gastroenterol (1998) 1.45
Reflux of duodenal or gastro-duodenal contents induces esophageal carcinoma in rats. Int J Cancer (1996) 1.43
Genetic pathways involved in the progression of Barrett's metaplasia to adenocarcinoma. Br J Surg (2002) 1.40
Surgical management of and long-term survival after adenocarcinoma of the cardia. Br J Surg (2002) 1.27
The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem (2000) 1.24
Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis. Carcinogenesis (2001) 1.19
The role of bile acids in carcinogenesis. Mutat Res (2001) 1.17
Molecular biology of Barrett's adenocarcinoma. Ann Surg (2001) 1.17
Mucin gene expression and cell differentiation in human normal, premalignant and malignant esophagus. Int J Cancer (2000) 1.14
Characterization of human mucin gene MUC4 promoter: importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells. J Biol Chem (2001) 1.09
Expression of mucin 1 (MUC1) in esophageal squamous-cell carcinoma: its relationship with prognosis. Int J Cancer (1999) 1.08
Mucin gene expression in Barrett's oesophagus: an in situ hybridisation and immunohistochemical study. Gut (2000) 1.06
Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells. Biochem J (2000) 1.05
Nuclear receptors. I. Nuclear receptors and bile acid homeostasis. Am J Physiol Gastrointest Liver Physiol (2002) 1.02
The sequential model of Barrett's esophagus and adenocarcinoma induced by duodeno-esophageal reflux without exogenous carcinogens. Anticancer Res (2002) 1.00
Bile acid stimulation of early growth response gene and mitogen-activated protein kinase is protein kinase C-dependent. Biochem J (1996) 1.00
From normal respiratory mucosa to epidermoid carcinoma: expression of human mucin genes. Int J Cancer (2000) 0.99
Differential expression of mucins and trefoil peptides in native epithelium, Barrett's metaplasia and squamous cell carcinoma of the oesophagus. J Cancer Res Clin Oncol (1999) 0.99
Regulation of mucin secretion in human gallbladder epithelial cells: predominant role of calcium and protein kinase C. Gastroenterology (1997) 0.90
Gene expression in Barrett's mucosa: acute and chronic adaptive responses in the oesophagus. Gut (1993) 0.89
Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines. Int J Biochem Cell Biol (1996) 0.88
Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect. Biochem J (1998) 0.86
The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes. Gastroenterology (2001) 0.86
Mucin secretion by the human colon cell line LS174T is regulated by bile salts. Glycobiology (1999) 0.86
Effect of bile salts on colonic mucus secretion in isolated vascularly perfused rat colon. Dig Dis Sci (2001) 0.84
Effects of bile acids on hepatocellular signaling and secretion. Yale J Biol Med (1998) 0.78
Recent developments in Barrett's esophagus. Curr Oncol Rep (2000) 0.78
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology (2006) 6.55
Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology (2006) 5.46
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet (2005) 2.85
Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene. JAMA (2005) 2.69
Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease. Cancer (2003) 2.23
Therapeutic strategies in oesophageal carcinoma: role of surgery and other modalities. Lancet Oncol (2007) 2.07
Primary graft function, metabolic control, and graft survival after islet transplantation. Diabetes Care (2009) 2.06
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev (2008) 1.93
Aldosterone, mortality, and acute ischaemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure. Eur Heart J (2011) 1.93
Signet ring cell histology is an independent predictor of poor prognosis in gastric adenocarcinoma regardless of tumoral clinical presentation. Ann Surg (2009) 1.70
Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease. Gastroenterology (2009) 1.67
Weiss system revisited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors. Am J Surg Pathol (2002) 1.60
Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans. J Histochem Cytochem (2004) 1.58
Mortality and morbidity after resection for adenocarcinoma of the gastroesophageal junction: predictive factors. J Am Coll Surg (2005) 1.54
Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out. Cancer Res (2009) 1.53
Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1. J Biol Chem (2002) 1.49
An analysis of the biochemical diagnosis of 66 pheochromocytomas. Eur J Endocrinol (2007) 1.47
Experience of gemcitabine plus oxaliplatin chemotherapy in patients with advanced biliary tract carcinoma. Chemotherapy (2010) 1.43
Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells. J Cell Biol (2005) 1.43
Life-threatening postoperative pancreatic fistula (grade C) after pancreaticoduodenectomy: incidence, prognosis, and risk factors. Am J Surg (2008) 1.41
Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis. Gut (2011) 1.33
Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem (2003) 1.29
The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers. Biochimie (2009) 1.28
Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions. J Pathol (2002) 1.27
Increased circulating miR-21 levels are associated with kidney fibrosis. PLoS One (2013) 1.27
Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells. Cancer Res (2010) 1.27
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors. Hum Genet (2008) 1.26
MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Cancer Res (2009) 1.24
Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer. Anticancer Drugs (2006) 1.19
Oligoanovulation with polycystic ovaries but not overt hyperandrogenism. J Clin Endocrinol Metab (2006) 1.19
Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis. Clin Cancer Res (2013) 1.18
Factors affecting postoperative course and survival after en bloc resection for esophageal carcinoma. Ann Thorac Surg (2004) 1.18
Anti-Müllerian hormone follow-up in young women treated by chemotherapy for lymphoma: preliminary results. Reprod Biomed Online (2009) 1.18
Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon. Hum Pathol (2012) 1.13
Signal pathway of 17beta-estradiol-induced MUC5B expression in human airway epithelial cells. Am J Respir Cell Mol Biol (2008) 1.11
GOSPEL: prospective survey of gout in France. Part I: design and patient characteristics (n = 1003). Joint Bone Spine (2012) 1.11
The evolution of severe steatosis after bariatric surgery is related to insulin resistance. Gastroenterology (2006) 1.09
Specific clinical and biological features characterize inflammatory bowel disease associated colorectal cancers showing microsatellite instability. J Clin Oncol (2007) 1.08
Open versus laparoscopically-assisted oesophagectomy for cancer: a multicentre randomised controlled phase III trial - the MIRO trial. BMC Cancer (2011) 1.08
Suitability of surgically induced chronic reflux in rats for studying esophageal carcinogenesis. Ann Surg (2015) 1.07
Esophageal carcinoma: prognostic differences between squamous cell carcinoma and adenocarcinoma. World J Surg (2005) 1.07
The mouse secreted gel-forming mucin gene cluster. Biochim Biophys Acta (2004) 1.07
OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells. J Pathol (2005) 1.06
Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells. Traffic (2009) 1.05
CD30 and CD117 (c-kit) used in combination are useful for distinguishing embryonal carcinoma from seminoma. J Histochem Cytochem (2002) 1.04
Resistin-like molecule beta regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice. Inflamm Bowel Dis (2008) 1.04
Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4. PLoS One (2012) 1.04
The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem (2007) 1.03
TTC7A mutations disrupt intestinal epithelial apicobasal polarity. J Clin Invest (2014) 1.02
Etilefrine use in the management of post-operative chyle leaks in thoracic surgery. Interact Cardiovasc Thorac Surg (2004) 1.01
A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis. Oncogene (2004) 1.00
IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosa. Biochem J (2008) 1.00
Diagnostic value of MUC4 immunostaining in distinguishing epithelial mesothelioma and lung adenocarcinoma. Mod Pathol (2004) 1.00
IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines. Biochim Biophys Acta (2008) 1.00
mRNA expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch. PLoS One (2012) 0.99
Obesity and serum luteinizing hormone level have an independent and opposite effect on the serum inhibin B level in patients with polycystic ovary syndrome. Fertil Steril (2002) 0.99
Morphometric analysis of ultrastructural vascular changes in CADASIL: analysis of 50 skin biopsy specimens and pathogenic implications. Acta Neuropathol (2002) 0.97
The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. Biochem Biophys Res Commun (2004) 0.97
Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways. Oncogene (2005) 0.97
Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testis. Appl Immunohistochem Mol Morphol (2002) 0.97
Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1. Biochem J (2004) 0.96
Reconciling the definitions of polycystic ovary syndrome: the ovarian follicle number and serum anti-Müllerian hormone concentrations aggregate with the markers of hyperandrogenism. J Clin Endocrinol Metab (2010) 0.96
Metabolic syndrome and collateral vessel formation in patients with documented occluded coronary arteries: association with hyperglycaemia, insulin-resistance, adiponectin and plasminogen activator inhibitor-1. Eur Heart J (2009) 0.96
Genomic organization of MUC4 mucin gene. Towards the characterization of splice variants. Eur J Biochem (2002) 0.95
Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice. Lab Invest (2008) 0.95
Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha. Biochem J (2007) 0.94
MUC1 expression is correlated with nuclear grade and tumor progression in pT1 renal clear cell carcinoma. Am J Clin Pathol (2002) 0.93
Viral protein VP4 is a target of human antibodies enhancing coxsackievirus B4- and B3-induced synthesis of alpha interferon. J Virol (2005) 0.93
Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. Hum Mutat (2006) 0.93
Central extracorporeal life support in pheochromocytoma crisis. Ann Thorac Surg (2012) 0.93
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice. Diabetes (2012) 0.93
Transcription factor AP-2alpha represses both the mucin MUC4 expression and pancreatic cancer cell proliferation. Carcinogenesis (2007) 0.93
Morphologic subtyping of papillary renal cell carcinoma: correlation with prognosis and differential expression of MUC1 between the two subtypes. Mod Pathol (2002) 0.92