Published in Nat Rev Mol Cell Biol on September 01, 2003
Nuclear transport of single molecules: dwell times at the nuclear pore complex. J Cell Biol (2005) 2.23
Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Proc Natl Acad Sci U S A (2004) 2.09
Tracking single Kinesin molecules in the cytoplasm of mammalian cells. Biophys J (2007) 1.98
Automatic detection of single fluorophores in live cells. Biophys J (2007) 1.96
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A (2006) 1.96
Single-molecule spectroscopy and imaging of biomolecules in living cells. Anal Chem (2010) 1.78
Analysis of protein-ligand interactions by fluorescence polarization. Nat Protoc (2011) 1.71
Vertical nanopillars for highly localized fluorescence imaging. Proc Natl Acad Sci U S A (2011) 1.70
A genetically encoded fluorescent amino acid. Proc Natl Acad Sci U S A (2006) 1.66
Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements. Nano Lett (2006) 1.63
Stochastic signal processing and transduction in chemotactic response of eukaryotic cells. Biophys J (2007) 1.58
Single-molecule analysis of epidermal growth factor binding on the surface of living cells. EMBO J (2006) 1.45
Imaging gene expression in single living cells. Nat Rev Mol Cell Biol (2004) 1.39
Visualizing single molecules interacting with nuclear pore complexes by narrow-field epifluorescence microscopy. Methods (2006) 1.30
High-speed AFM and nano-visualization of biomolecular processes. Pflugers Arch (2007) 1.14
Myosin-X induces filopodia by multiple elongation mechanism. J Biol Chem (2010) 1.10
Photophysical properties of acene DCDHF fluorophores: long-wavelength single-molecule emitters designed for cellular imaging. J Phys Chem A (2007) 1.10
Intranuclear binding kinetics and mobility of single native U1 snRNP particles in living cells. Mol Biol Cell (2006) 1.06
Location of biomarkers and reagents within agarose beads of a programmable bio-nano-chip. Small (2011) 1.03
Imaging single molecules in living cells for systems biology. Mol Syst Biol (2006) 1.02
Cell biology of mRNA decay. Methods Enzymol (2008) 1.02
Single-molecule analysis of epidermal growth factor signaling that leads to ultrasensitive calcium response. Biophys J (2005) 0.98
An RNA toolbox for single-molecule force spectroscopy studies. Nucleic Acids Res (2007) 0.96
Single-molecule tools elucidate H2A.Z nucleosome composition. J Cell Sci (2012) 0.94
High-speed atomic force microscopy combined with inverted optical microscopy for studying cellular events. Sci Rep (2013) 0.90
Single-molecule tracking in living cells using single quantum dot applications. Theranostics (2012) 0.88
Total internal reflection fluorescence quantification of receptor pharmacology. Biosensors (Basel) (2015) 0.88
A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition. Biophys J (2009) 0.86
Real-time dynamics of methyl-CpG-binding domain protein 3 and its role in DNA demethylation by fluorescence correlation spectroscopy. Epigenetics (2013) 0.86
Functional membrane diffusion of G-protein coupled receptors. Eur Biophys J (2007) 0.85
Classification of dynamical diffusion states in single molecule tracking microscopy. Biophys J (2014) 0.82
The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells. Sci Rep (2015) 0.78
Visualization of lipid raft membrane compartmentalization in living RN46A neuronal cells using single quantum dot tracking. ACS Chem Neurosci (2012) 0.78
Single-Molecule Imaging Reveals Dynamics of CREB Transcription Factor Bound to Its Target Sequence. Sci Rep (2015) 0.76
Single hepatitis-B virus core capsid binding to individual nuclear pore complexes in Hela cells. Biophys J (2006) 0.75
Distinct modulated pupil function system for real-time imaging of living cells. PLoS One (2012) 0.75
Time-resolved biophysical approaches to nucleocytoplasmic transport. Comput Struct Biotechnol J (2017) 0.75
Direct visualization of secondary structures of F-actin by electron cryomicroscopy. Nature (2010) 2.93
Chemomechanical coupling of the forward and backward steps of single kinesin molecules. Nat Cell Biol (2002) 2.56
The motor domain determines the large step of myosin-V. Nature (2002) 2.23
Class VI myosin moves processively along actin filaments backward with large steps. Biochem Biophys Res Commun (2002) 2.01
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A (2006) 1.96
Self-organization of the phosphatidylinositol lipids signaling system for random cell migration. Proc Natl Acad Sci U S A (2010) 1.45
Single-molecule analysis of epidermal growth factor binding on the surface of living cells. EMBO J (2006) 1.45
Entropy rectifies the Brownian steps of kinesin. Nat Chem Biol (2005) 1.41
Functional analysis of spontaneous cell movement under different physiological conditions. PLoS One (2008) 1.41
EGF signalling amplification induced by dynamic clustering of EGFR. Biochem Biophys Res Commun (2004) 1.39
Brownian search-and-catch mechanism for myosin-VI steps. Nat Chem Biol (2009) 1.39
Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration. J Biol Chem (2003) 1.34
Trafficking of a ligand-receptor complex on the growth cones as an essential step for the uptake of nerve growth factor at the distal end of the axon: a single-molecule analysis. J Neurosci (2005) 1.29
Cargo-binding makes a wild-type single-headed myosin-VI move processively. Biophys J (2006) 1.27
Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells. Chemphyschem (2003) 1.26
Unconstrained steps of myosin VI appear longest among known molecular motors. Biophys J (2004) 1.24
Dynamic polymorphism of single actin molecules in the actin filament. Nat Chem Biol (2006) 1.23
Switch between large hand-over-hand and small inchworm-like steps in myosin VI. Cell (2010) 1.22
Simple dark-field microscopy with nanometer spatial precision and microsecond temporal resolution. Biophys J (2010) 1.16
Input-output relationship in galvanotactic response of Dictyostelium cells. Biosystems (2006) 1.14
Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis. Proc Natl Acad Sci U S A (2007) 1.13
Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Proc Natl Acad Sci U S A (2009) 1.11
Telencephalin slows spine maturation. J Neurosci (2006) 1.09
mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1. EMBO J (2009) 1.01
Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10. Biochem J (2006) 1.00
Fluorescence microscopy for simultaneous observation of 3D orientation and movement and its application to quantum rod-tagged myosin V. Proc Natl Acad Sci U S A (2012) 0.99
Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein. J Cell Sci (2006) 0.99
Simultaneous optical and electrical recording of a single ion-channel. Jpn J Physiol (2002) 0.98
Role of multiple bonds between the single cell adhesion molecules, nectin and cadherin, revealed by high sensitive force measurements. J Mol Biol (2006) 0.98
Single-molecule analysis of epidermal growth factor signaling that leads to ultrasensitive calcium response. Biophys J (2005) 0.98
Monitoring molecular beacon DNA probe hybridization at the single-molecule level. Chemistry (2003) 0.97
Multiple mechanisms for accumulation of myosin II filaments at the equator during cytokinesis. Traffic (2008) 0.94
The diffusive search mechanism of processive myosin class-V motor involves directional steps along actin subunits. Biochem Biophys Res Commun (2007) 0.93
Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance. Dev Cell (2013) 0.93
Formation of signal transduction complexes during immobile phase of NGFR movements. Biochem Biophys Res Commun (2006) 0.93
Dynamic polymorphism of Ras observed by single molecule FRET is the basis for molecular recognition. Biochem Biophys Res Commun (2006) 0.92
Role of the KcsA channel cytoplasmic domain in pH-dependent gating. Biophys J (2011) 0.92
Myosin-V makes two brownian 90 degrees rotations per 36-nm step. Nat Struct Mol Biol (2007) 0.91
Circulatory basis of fMRI signals: relationship between changes in the hemodynamic parameters and BOLD signal intensity. Neuroimage (2004) 0.91
Rearrangements in the KcsA cytoplasmic domain underlie its gating. J Biol Chem (2009) 0.90
Nonlinearity of mechanochemical motions in motor proteins. PLoS Comput Biol (2010) 0.90
Discrete stochastic process underlying perceptual rivalry. Neuroreport (2003) 0.89
Rapid severing and motility of chloroplast-actin filaments are required for the chloroplast avoidance response in Arabidopsis. Plant Cell (2013) 0.89
Simultaneous measurement of nucleotide occupancy and mechanical displacement in myosin-V, a processive molecular motor. Biophys J (2009) 0.88
Activation kinetics of RAF protein in the ternary complex of RAF, RAS-GTP, and kinase on the plasma membrane of living cells: single-molecule imaging analysis. J Biol Chem (2011) 0.88
Simultaneous observation of the lever arm and head explains myosin VI dual function. Small (2012) 0.88
In vivo imaging of the rat cerebral microvessels with optical coherence tomography. Clin Hemorheol Microcirc (2004) 0.87
Switching of myosin-V motion between the lever-arm swing and brownian search-and-catch. Nat Commun (2012) 0.87
Covalent immobilization of epidermal growth factor molecules for single-molecule imaging analysis of intracellular signaling. Biomaterials (2006) 0.86
A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition. Biophys J (2009) 0.86
Velocity profiles in the rat cerebral microvessels measured by optical coherence tomography. Clin Hemorheol Microcirc (2006) 0.86
A one-headed class V myosin molecule develops multiple large (approximately 32-nm) steps successively. Proc Natl Acad Sci U S A (2004) 0.85
Regulation of oxygen transport during brain activation: stimulus-induced hemodynamic responses in human and animal cortices. Dyn Med (2003) 0.85
Real-time nanoscopy by using blinking enhanced quantum dots. Biophys J (2010) 0.84
Lysenin forms a voltage-dependent channel in artificial lipid bilayer membranes. Biochem Biophys Res Commun (2006) 0.84
A unique mechanism for the processive movement of single-headed myosin-IX. Biochem Biophys Res Commun (2006) 0.84
Optical bioimaging: from living tissue to a single molecule: single-molecule visualization of cell signaling processes of epidermal growth factor receptor. J Pharmacol Sci (2003) 0.84
Immobilizing single lipid and channel molecules in artificial lipid bilayers with annexin A5. Langmuir (2006) 0.84
From single molecule fluctuations to muscle contraction: a Brownian model of A.F. Huxley's hypotheses. PLoS One (2012) 0.84
Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods. Biophys J (2013) 0.83
Stochastic signal inputs for chemotactic response in Dictyostelium cells revealed by single molecule imaging techniques. Biosystems (2006) 0.83
Spectral heterogeneity in single light-harvesting chlorosomes from green sulfur photosynthetic bacterium chlorobium tepidum. Photochem Photobiol (2002) 0.82
Measurement system for simultaneous observation of myosin V chemical and mechanical events. Biosystems (2008) 0.82
Fluctuation analysis of mechanochemical coupling depending on the type of biomolecular motors. Phys Rev Lett (2008) 0.82
Spontaneous detachment of the leading head contributes to myosin VI backward steps. PLoS One (2013) 0.81
Single molecule processes on the stepwise movement of ATP-driven molecular motors. Biosystems (2003) 0.81
The sensorimotor transformation of cross-modal spatial information in the anterior intraparietal sulcus as revealed by functional MRI. Brain Res Cogn Brain Res (2004) 0.81
Myosin-V as a mechanical sensor: an elastic network study. Biophys J (2012) 0.80
Smooth muscle myosin phosphorylated at single head shows sustained mechanical activity. J Biol Chem (2008) 0.80
Complex intramolecular mechanics of G-actin--an elastic network study. PLoS One (2012) 0.80
Mechano-chemical coupling of molecular motors revealed by single molecule measurements. Curr Protein Pept Sci (2004) 0.80
DNA oligonucleotide-assisted genetic manipulation increases transformation and homologous recombination efficiencies: Evidence from gene targeting of Dictyostelium discoideum. J Biotechnol (2007) 0.80
Molecular motors and single-molecule enzymology. Methods Enzymol (2003) 0.80
Single molecule FRET for the study on structural dynamics of biomolecules. Biosystems (2006) 0.80
Molecular machines like myosin use randomness to behave predictably. Chem Rev (2014) 0.79
Direct manipulation of a single potassium channel gate with an atomic force microscope probe. Small (2011) 0.79
Single molecular observation of self-regulated kinesin motility. Biochemistry (2010) 0.79
Changes in regional cerebral blood volume in frontal cortex during mental work with and without caffeine intake: functional monitoring using near-infrared spectroscopy. J Biomed Opt (2004) 0.79
Glycine insertion makes yellow fluorescent protein sensitive to hydrostatic pressure. PLoS One (2013) 0.79
Cooperative actions between myosin heads bring effective functions. Biosystems (2006) 0.79
How single molecule detection measures the dynamic actions of life. HFSP J (2007) 0.79
Ischemic vasoconstriction and tissue energy metabolism during global cerebral ischemia in gerbils. J Neurotrauma (2007) 0.79
Preparation of an imaging chamber for visualizing single molecules in living Dictyostelium cells. Cold Spring Harb Protoc (2012) 0.78
A protein switch with tunable steepness reconstructed in Escherichia coli cells with eukaryotic signaling proteins. Biochem Biophys Res Commun (2012) 0.78
Single molecule thermodynamics in biological motors. Biosystems (2006) 0.78
Noncontact backscatter-mode near-infrared time-resolved imaging system: Preliminary study for functional brain mapping. J Biomed Opt (2006) 0.78
Characterization of chemoreceptive protein binding to an oviposition stimulant using a fluorescent micro-binding assay in a butterfly. FEBS Lett (2008) 0.77
Absorber's effect projected directly above improves spatial resolution in near infrared backscattered imaging. Jpn J Physiol (2004) 0.77
Single supramolecule spectroscopy of natural and alkaline-treated chlorosomes from green sulfur photosynthetic bacteria. J Nanosci Nanotechnol (2006) 0.77
Mechanical characterization of one-headed myosin-V using optical tweezers. PLoS One (2010) 0.77
Noncontact surface force microscopy of protein molecules. Chemphyschem (2003) 0.77
Current recordings of ion channel proteins immobilized on resin beads. Anal Chem (2009) 0.77
VEPs elicited by local correlations and global symmetry: characteristics and interactions. Vision Res (2007) 0.77
Attentional set for external information activates the right intraparietal area. Brain Res Cogn Brain Res (2003) 0.77
Optical coherence tomography reveals in vivo cortical plasticity of adult mice in response to peripheral neuropathic pain. Neurosci Lett (2006) 0.77
Single channel properties of lysenin measured in artificial lipid bilayers and their applications to biomolecule detection. Proc Jpn Acad Ser B Phys Biol Sci (2010) 0.76
G146V mutation at the hinge region of actin reveals a myosin class-specific requirement of actin conformations for motility. J Biol Chem (2012) 0.76
Single-molecule FRET imaging for enzymatic reactions at high ligand concentrations. Small (2010) 0.76
Dynamic polymorphism of actin as activation mechanism for cell motility. Biosystems (2006) 0.76
Single-molecule imaging of the dynamic interactions between macromolecules. J Nanosci Nanotechnol (2004) 0.76