Published in Antioxid Redox Signal on December 01, 2003
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 2.06
Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss. J Biol Chem (2010) 1.24
LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling. J Inflamm (Lond) (2012) 1.18
Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1. Am J Respir Cell Mol Biol (2005) 1.17
Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity. Nat Commun (2014) 0.91
Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. J Vasc Res (2010) 0.91
Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism. Arch Toxicol (2015) 0.88
Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cells. PLoS One (2013) 0.86
Hydrogen sulfide, an enhancer of vascular nitric oxide signalling: mechanisms and implications. Am J Physiol Cell Physiol (2016) 0.86
Regulation of cell survival and death signals induced by oxidative stress. J Clin Biochem Nutr (2008) 0.85
Melatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway. J Pineal Res (2015) 0.81
Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells. Redox Biol (2016) 0.81
Squamosamide derivative FLZ protects retinal pigment epithelium cells from oxidative stress through activation of epidermal growth factor receptor (EGFR)-AKT signaling. Int J Mol Sci (2014) 0.79
PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide. PLoS One (2016) 0.76
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 3.94
Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint. Free Radic Biol Med (2012) 1.58
Synthesis and characterization of a practically better DEPMPO-type spin trap, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO). Free Radic Res (2006) 1.31
Radiation tolerance in the tardigrade Milnesium tardigradum. Int J Radiat Biol (2006) 1.22
Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress. Mol Biol Cell (2005) 1.15
Sos-mediated activation of rac1 by p66shc. J Cell Biol (2006) 1.10
Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt. Biochem Biophys Res Commun (2004) 1.07
p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc. Circ Res (2008) 1.03
Involvement of adenosine in depression of synaptic transmission during hypercapnia in isolated spinal cord of neonatal rats. J Physiol (2006) 1.03
Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease. Gut (2009) 1.01
Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells. Free Radic Res (2002) 0.98
24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. J Biol Chem (2011) 0.97
Preconditioning prevents ischemia-induced neuronal death through persistent Akt activation in the penumbra region of the rat brain. J Vet Med Sci (2004) 0.97
Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells. Cancer Lett (2008) 0.97
Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography. J Magn Reson Imaging (2008) 0.96
Analysis of transient receptor potential ankyrin 1 (TRPA1) in frogs and lizards illuminates both nociceptive heat and chemical sensitivities and coexpression with TRP vanilloid 1 (TRPV1) in ancestral vertebrates. J Biol Chem (2012) 0.95
Purification and properties of a new Brevibacterium sterolicum cholesterol oxidase produced by E. coli MM294/pnH10. FEMS Microbiol Lett (2002) 0.93
Bone marrow stromal cells prepared using AB serum and bFGF for hematopoietic stem cells expansion. Transfusion (2002) 0.91
A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression. Hum Mol Genet (2010) 0.90
Activation of c-kit by stem cell factor induces radioresistance to apoptosis through ERK-dependent expression of survivin in HL60 cells. J Radiat Res (2004) 0.90
Lipopolysaccharides enhance the action of bradykinin in enteric neurons via secretion of interleukin-1beta from enteric glial cells. J Neurosci Res (2009) 0.89
Proinsulin C-peptide abrogates type-1 diabetes-induced increase of renal endothelial nitric oxide synthase in rats. Diabetes Metab Res Rev (2008) 0.89
Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase. Circ Res (2010) 0.89
Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison. Mol Biol Evol (2014) 0.88
Radiation-induced apoptosis of tumor cells is facilitated by inhibition of the interaction between Survivin and Smac/DIABLO. Cancer Lett (2007) 0.87
Tolerance of anhydrobiotic eggs of the Tardigrade Ramazzottius varieornatus to extreme environments. Astrobiology (2012) 0.87
Treatment combining X-irradiation and a ribonucleoside anticancer drug, TAS106, effectively suppresses the growth of tumor cells transplanted in mice. Int J Radiat Oncol Biol Phys (2007) 0.87
Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils. Free Radic Res (2006) 0.87
Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells. J Radiat Res (2003) 0.86
Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radic Res (2012) 0.85
Regulation of cell survival and death signals induced by oxidative stress. J Clin Biochem Nutr (2008) 0.85
Relationship between the activation of cyclic AMP responsive element binding protein and ischemic tolerance in the penumbra region of rat cerebral cortex. Neurosci Lett (2002) 0.85
ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51. FEBS Lett (2013) 0.85
Effects of overexpression and antisense RNA expression of Orf17, a MutT-type enzyme. Biol Pharm Bull (2006) 0.85
Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. PLoS One (2013) 0.85
Effects of amifostine on the proliferation and differentiation of megakaryocytic progenitor cells. Eur J Pharmacol (2002) 0.84
Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences. J Mol Neurosci (2013) 0.84
Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells. BMC Cancer (2012) 0.84
Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils. Biochem Biophys Res Commun (2002) 0.84
A novel anticancer ribonucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, enhances radiation-induced cell death in tumor cells. Radiat Res (2004) 0.83
Regeneration of megakaryocytopoiesis and thrombopoiesis in vitro from X-irradiated human hematopoietic stem cells. Radiat Res (2006) 0.82
Reactive oxygen species mediate shear stress-induced fluid-phase endocytosis in vascular endothelial cells. Free Radic Res (2006) 0.82
A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression. Mol Cancer (2011) 0.82
3-Methyl pyruvate enhances radiosensitivity through increasing mitochondria-derived reactive oxygen species in tumor cell lines. J Radiat Res (2014) 0.81
Canine neutrophil dysfunction caused by downregulation of beta2-integrin expression without mutation. Vet Immunol Immunopathol (2009) 0.81
In vivo tumour extracellular pH monitoring using electron paramagnetic resonance: the effect of X-ray irradiation. NMR Biomed (2014) 0.81
Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model. Biochem Biophys Res Commun (2013) 0.81
Magnetic resonance imaging and immunoblot analyses in rats with experimentally induced cerebral alveolar echinococcosis. Comp Med (2003) 0.81
Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT(2A) and 5-HT(3) receptors. Eur J Pharmacol (2013) 0.81
Inhibitory effects of opioids on voltage-dependent Ca(2+) channels and catecholamine secretion in cultured porcine adrenal chromaffin cells. Brain Res (2002) 0.80
X irradiation induces the proapoptotic state independent of the loss of clonogenic ability in Chinese hamster V79 cells. Radiat Res (2005) 0.80
Involvement of TRPA1 activation in acute pain induced by cadmium in mice. Mol Pain (2013) 0.80
Lipid raft disruption prevents apoptosis induced by 2-chloro-2'-deoxyadenosine (Cladribine) in leukemia cell lines. Leuk Res (2006) 0.80
Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists. J Radiat Res (2005) 0.80
Identification of pH-sensitive regions in the mouse prion by the cysteine-scanning spin-labeling ESR technique. Biochem Biophys Res Commun (2006) 0.79
Individual differences in the radiosensitivity of hematopoietic progenitor cells detected in steady-state human peripheral blood. J Radiat Res (2007) 0.79
Purvalanol A induces apoptosis and downregulation of antiapoptotic proteins through abrogation of phosphorylation of JAK2/STAT3 and RNA polymerase II. Anticancer Drugs (2008) 0.79
The antiproliferative effect of bovine lactoferrin on canine mammary gland tumor cells. J Vet Med Sci (2008) 0.79
The effects of (-)-epigallocatechin-3-gallate on the proliferation and differentiation of human megakaryocytic progenitor cells. J Radiat Res (2006) 0.79
The influence of gender- and age-related differences in the radiosensitivity of hematopoietic progenitor cells detected in steady-state human peripheral blood. J Radiat Res (2011) 0.79
Different radiosensitive megakaryocytic progenitor cells exist in steady-state human peripheral blood. Radiat Res (2005) 0.79
Radiation-chemical properties of the hypoxic cell radiosensitizer doranidazole (PR-350). J Radiat Res (2002) 0.79
Ca(2+)-dependent and caspase-3-independent apoptosis caused by damage in Golgi apparatus due to 2,4,5,7-tetrabromorhodamine 123 bromide-induced photodynamic effects. Photochem Photobiol (2003) 0.79