Published in Glia on December 01, 2003
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci (2009) 2.69
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol (2010) 2.25
Regulation of tau pathology by the microglial fractalkine receptor. Neuron (2010) 2.24
Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J Neurosci (2009) 2.20
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci U S A (2007) 2.06
Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J Neurosci (2012) 1.71
Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin. Nature (2012) 1.69
Microglial cells in astroglial cultures: a cautionary note. J Neuroinflammation (2007) 1.66
The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β. Neurobiol Aging (2010) 1.62
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis (2009) 1.60
Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia. J Neuroinflammation (2013) 1.26
Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels. J Biol Chem (2011) 1.23
CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice. J Neurosci (2011) 1.22
IGF-1 receptor-mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus. Glia (2008) 1.21
Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia (2013) 1.15
Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain (2011) 1.11
Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicity. Neurobiol Dis (2007) 1.09
The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. J Neuroinflammation (2008) 1.06
IL-10 deficiency exacerbates the brain inflammatory response to permanent ischemia without preventing resolution of the lesion. J Cereb Blood Flow Metab (2013) 1.02
Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis (2013) 1.02
Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. J Cereb Blood Flow Metab (2012) 1.01
CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality. PLoS Pathog (2012) 1.00
Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes. J Biol Chem (2012) 1.00
Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation. Br J Pharmacol (2010) 0.99
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease. J Neurosci (2015) 0.99
The microglial α7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2. Antioxid Redox Signal (2013) 0.98
Microglia change from a reactive to an age-like phenotype with the time in culture. Front Cell Neurosci (2014) 0.97
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells. Brain Pathol (2008) 0.97
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain (2015) 0.96
A simple magnetic separation method for high-yield isolation of pure primary microglia. J Neurosci Methods (2010) 0.96
Dual role of CD38 in microglial activation and activation-induced cell death. J Immunol (2008) 0.96
Notch-1 signaling regulates microglia activation via NF-κB pathway after hypoxic exposure in vivo and in vitro. PLoS One (2013) 0.96
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants. PLoS One (2010) 0.96
Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice. PLoS One (2013) 0.93
Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis. J Neuroinflammation (2011) 0.92
Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity. J Neuroinflammation (2012) 0.91
IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain (2016) 0.91
Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects. J Biol Chem (2012) 0.91
Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β. J Neuroinflammation (2011) 0.90
Microglia are the major source of TNF-α and TGF-β1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin. Neurochem Int (2013) 0.89
ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing. J Biol Chem (2015) 0.88
Absence of glial α-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema. J Biol Chem (2012) 0.86
Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1. Neuroreport (2009) 0.86
Histamine: a new immunomodulatory player in the neuron-glia crosstalk. Front Cell Neurosci (2014) 0.86
Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. Cell Death Dis (2014) 0.85
Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents. PLoS One (2012) 0.85
A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function. BMC Neurosci (2011) 0.85
2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res (2014) 0.83
Thrombin-processed Ecrg4 recruits myeloid cells and induces antitumorigenic inflammation. Neuro Oncol (2014) 0.83
Histamine modulates microglia function. J Neuroinflammation (2012) 0.83
Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia. Glia (2012) 0.83
Loss of tau rescues inflammation-mediated neurodegeneration. Front Neurosci (2015) 0.83
SCM-198 inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-кB pathways. J Neuroinflammation (2014) 0.83
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. Nat Commun (2016) 0.82
Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease. J Neuroinflammation (2014) 0.82
Inhibition of CD200R1 expression by C/EBP β in reactive microglial cells. J Neuroinflammation (2012) 0.82
Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases. J Neuroinflammation (2012) 0.82
Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study. J Neuroinflammation (2016) 0.82
A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation. J Neuroinflammation (2016) 0.82
Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function. Antioxid Redox Signal (2015) 0.81
Mechanisms of action of naturally occurring antibodies against β-amyloid on microglia. J Neuroinflammation (2013) 0.81
Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. PLoS One (2011) 0.81
Statin treatment affects cytokine release and phagocytic activity in primary cultured microglia through two separable mechanisms. Mol Brain (2014) 0.81
Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis. J Neuroinflammation (2015) 0.81
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1. Glia (2015) 0.81
Macrophage-Microglia Networks Drive M1 Microglia Polarization After Mycobacterium Infection. Inflammation (2015) 0.80
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease. PLoS One (2012) 0.80
Time-dependent effects of hypothermia on microglial activation and migration. J Neuroinflammation (2012) 0.80
Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury. J Neurosci (2015) 0.80
beta-Glucan attenuates TLR2- and TLR4-mediated cytokine production by microglia. Neurosci Lett (2009) 0.80
Light-controlled inhibition of malignant glioma by opsin gene transfer. Cell Death Dis (2013) 0.80
Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling. Front Cell Neurosci (2014) 0.80
Reduced inflammatory phenotype in microglia derived from neonatal rat spinal cord versus brain. PLoS One (2014) 0.79
CCL5, CCR1 and CCR5 in murine glioblastoma: immune cell infiltration and survival rates are not dependent on individual expression of either CCR1 or CCR5. J Neuroimmunol (2012) 0.79
Activated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar β-amyloid by up-regulating lipoprotein lipase expression. Mol Cell Proteomics (2013) 0.79
Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance. Curr Transl Geriatr Exp Gerontol Rep (2012) 0.78
Runx1t1 (Runt-related transcription factor 1; translocated to, 1) epigenetically regulates the proliferation and nitric oxide production of microglia. PLoS One (2014) 0.78
Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice. Acta Pharmacol Sin (2016) 0.78
Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis. Front Cell Neurosci (2015) 0.78
Prion peptide uptake in microglial cells--the effect of naturally occurring autoantibodies against prion protein. PLoS One (2013) 0.78
Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance. J Neurosci (2014) 0.78
MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis. Oncogene (2016) 0.78
25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome. Nat Commun (2016) 0.77
Expression of sphingosine kinase 1 in amoeboid microglial cells in the corpus callosum of postnatal rats. J Neuroinflammation (2011) 0.77
Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and its roles in activated microglia in vivo and in vitro. J Neuroinflammation (2014) 0.77
N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. J Biol Chem (2010) 0.77
Neurons are host cells for Mycobacterium tuberculosis. Infect Immun (2014) 0.77
Mutant SOD1 microglia-generated nitroxidative stress promotes toxicity to human fetal neural stem cell-derived motor neurons through direct damage and noxious interactions with astrocytes. Am J Stem Cells (2011) 0.76
β-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia. Cell Death Differ (2013) 0.76
ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme. Mol Cancer Ther (2016) 0.76
Culture and characterization of microglia from the adult murine retina. ScientificWorldJournal (2014) 0.76
A much convenient and economical method to harvest a great number of microglia. Cell Mol Neurobiol (2011) 0.76
Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia. Cell Death Differ (2016) 0.75
Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice. J Neuroimmunol (2016) 0.75
NG2 expression in microglial cells affects the expression of neurotrophic and proinflammatory factors by regulating FAK phosphorylation. Sci Rep (2016) 0.75
Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide. J Neuroinflammation (2017) 0.75
Effective suppression of nitric oxide production by HX106N through transcriptional control of heme oxygenase-1. Exp Biol Med (Maywood) (2015) 0.75
Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation. Exp Neurobiol (2016) 0.75
In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis. Proc Natl Acad Sci U S A (2016) 0.75
Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. J Neurochem (2005) 1.10
Upregulation of CCAAT/enhancer binding protein beta in activated astrocytes and microglia. Glia (2007) 1.04
Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase is regulated by acetylation. Int J Biochem Cell Biol (2010) 1.02
Relationship between beta-AP peptide aggregation and microglial activation. Brain Res (2002) 0.92
Astrocytes enhance lipopolysaccharide-induced nitric oxide production by microglial cells. Eur J Neurosci (2002) 0.91
Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β. J Neuroinflammation (2011) 0.90
Concanavalin-A-induced liver injury is severely impaired in mice deficient in P-selectin. J Leukoc Biol (2002) 0.89
Distribution of Clostridium perfringens epsilon toxin in the brains of acutely intoxicated mice and its effect upon glial cells. Toxicon (2007) 0.88
The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers. Hepatology (2002) 0.88
CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression. Neurobiol Aging (2013) 0.86
CCAAT/enhancer binding protein delta in microglial activation. J Neurosci Res (2010) 0.86
C/EBPβ expression in activated microglia in amyotrophic lateral sclerosis. Neurobiol Aging (2011) 0.86
Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents. PLoS One (2012) 0.85
Effects of beta-AP peptides on activation of the transcription factor NF-kappaB and in cell proliferation in glial cell cultures. Neurosci Res (2004) 0.83
Inhibition of CCAAT/enhancer binding protein δ expression by chrysin in microglial cells results in anti-inflammatory and neuroprotective effects. J Neurochem (2010) 0.83
Inhibition of CD200R1 expression by C/EBP β in reactive microglial cells. J Neuroinflammation (2012) 0.82
Expression of C/EBPalpha and C/EBPbeta in glial cells in vitro after inducing glial activation by different stimuli. Neurosci Lett (2006) 0.81
CCAAT/enhancer binding protein-alpha is down-regulated by toll-like receptor agonists in microglial cells. J Neurosci Res (2007) 0.79
CD200R1 and CD200 expression are regulated by PPAR-γ in activated glial cells. Glia (2014) 0.78
Absence of the cell cycle inhibitor p21Cip1 reduces LPS-induced NO release and activation of the transcription factor NF-kappaB in mixed glial cultures. Glia (2005) 0.78
Structural, kinetic and cytotoxicity aspects of 12-28 beta-amyloid protein fragment: a reappraisal. J Pept Sci (2002) 0.78
PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27 Kip1. Nucleic Acids Res (2012) 0.78
The proteasome inhibitor bortezomib reduced cholesterol accumulation in fibroblasts from Niemann-Pick type C patients carrying missense mutations. FEBS J (2014) 0.77
Upregulation of p21Cip1 in activated glial cells. Glia (2009) 0.77
Excitotoxic and apoptotic neuronal death induce different patterns of glial activation in vitro. J Neurochem (2005) 0.75
Glial activation modulates glutamate neurotoxicity in cerebellar granule cell cultures. Glia (2004) 0.75