Published in Biorheology on January 01, 2003
Osteocytes: master orchestrators of bone. Calcif Tissue Int (2013) 2.48
Mechanotransduction and strain amplification in osteocyte cell processes. Proc Natl Acad Sci U S A (2004) 2.16
Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci U S A (2007) 2.10
Hyaluronan-dependent pericellular matrix. Adv Drug Deliv Rev (2007) 1.73
A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Natl Acad Sci U S A (2007) 1.61
Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction. Annu Rev Fluid Mech (2009) 1.49
Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress. Front Biosci (2007) 1.34
Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels. Proc Natl Acad Sci U S A (2010) 1.30
Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice. Biotechniques (2012) 1.26
Beta1 integrins mediate mechanosensitive signaling pathways in osteocytes. Calcif Tissue Int (2010) 1.09
Mesenchymal stem cell responses to mechanical stimuli. Muscles Ligaments Tendons J (2012) 1.03
Finite-element stress analysis of a multicomponent model of sheared and focally-adhered endothelial cells. Ann Biomed Eng (2006) 1.02
Mechanical loading stimulates expression of connexin 43 in alveolar bone cells in the tooth movement model. Cell Commun Adhes (2006) 0.99
Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone. J Bone Miner Res (2011) 0.98
Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts. FASEB J (2013) 0.95
Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system. J Bone Miner Res (2014) 0.89
Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require αVβ3 integrin. Proc Natl Acad Sci U S A (2013) 0.89
An experimental and computational analysis of primary cilia deflection under fluid flow. Comput Methods Biomech Biomed Engin (2012) 0.88
Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow. J Biomech (2010) 0.87
An Integrative Review of Mechanotransduction in Endothelial, Epithelial (Renal) and Dendritic Cells (Osteocytes). Cell Mol Bioeng (2011) 0.87
Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process. Proc Natl Acad Sci U S A (2013) 0.87
An in-vitro traumatic model to evaluate the response of myelinated cultures to sustained hydrostatic compression injury. J Neurotrauma (2009) 0.86
Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes. J R Soc Interface (2012) 0.85
Preclinical models for in vitro mechanical loading of bone-derived cells. Bonekey Rep (2015) 0.81
Novel early response genes in osteoblasts exposed to dynamic fluid flow. Philos Trans A Math Phys Eng Sci (2010) 0.78
Dark horse in osteocyte biology: Glycocalyx around the dendrites is critical for osteocyte mechanosensing. Commun Integr Biol (2011) 0.76
P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PLoS One (2016) 0.76
The molecular basis of bone mechanotransduction. J Musculoskelet Neuronal Interact (2016) 0.75
A new perspective on mechanisms governing skeletal complications in type 1 diabetes. Ann N Y Acad Sci (2016) 0.75
In Vitro Bone Cell Models: Impact of Fluid Shear Stress on Bone Formation. Front Bioeng Biotechnol (2016) 0.75
Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol (2007) 2.24
Cell sensing and response to micro- and nanostructured surfaces produced by chemical and topographic patterning. Tissue Eng (2007) 2.14
Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci U S A (2007) 2.10
A finite element model of the human knee joint for the study of tibio-femoral contact. J Biomech Eng (2002) 1.98
Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Eng Part C Methods (2009) 1.79
Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone (2007) 1.79
Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res (2004) 1.69
Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. Exp Cell Res (2002) 1.68
Mechanically induced osteogenic differentiation--the role of RhoA, ROCKII and cytoskeletal dynamics. J Cell Sci (2009) 1.66
Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res (2004) 1.62
Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair. J Orthop Res (2012) 1.56
Serum markers of bone metabolism show bone loss in hibernating bears. Clin Orthop Relat Res (2003) 1.47
Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. PLoS One (2011) 1.45
Mobilization of endogenous stem cell populations enhances fracture healing in a murine femoral fracture model. Cytotherapy (2013) 1.44
Effect of COX-2-specific inhibition on fracture-healing in the rat femur. J Bone Joint Surg Am (2004) 1.43
Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro. Biomaterials (2007) 1.38
Human foetal osteoblastic cell response to polymer-demixed nanotopographic interfaces. J R Soc Interface (2005) 1.34
The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells. Birth Defects Res C Embryo Today (2010) 1.34
The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography. Biomaterials (2006) 1.33
Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood, and umbilical cord tissue. Am J Vet Res (2010) 1.28
Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS One (2009) 1.26
Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J Biomech (2005) 1.26
How the stiffness of meniscal attachments and meniscal material properties affect tibio-femoral contact pressure computed using a validated finite element model of the human knee joint. J Biomech (2003) 1.24
MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation. Am J Physiol Cell Physiol (2005) 1.23
A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis. Clin Exp Metastasis (2004) 1.23
Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity. J Bone Miner Res (2004) 1.22
The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation. Bone (2008) 1.21
Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells. FASEB J (2010) 1.20
From streaming-potentials to shear stress: 25 years of bone cell mechanotransduction. J Orthop Res (2009) 1.18
Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts. J Cell Biochem (2010) 1.17
The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts. Am J Physiol Cell Physiol (2007) 1.13
Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs. Clin Exp Metastasis (2008) 1.12
Osteoblast adhesion on poly(L-lactic acid)/polystyrene demixed thin film blends: effect of nanotopography, surface chemistry, and wettability. Biomacromolecules (2005) 1.12
Primary cilia-mediated mechanotransduction in human mesenchymal stem cells. Stem Cells (2012) 1.11
Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling. Bone (2013) 1.11
The Role of Primary Cilia in Mesenchymal Stem Cell Differentiation: A Pivotal Switch in Guiding Lineage Commitment. Cell Mol Bioeng (2010) 1.10
The sensitivity of tibiofemoral contact pressure to the size and shape of the lateral and medial menisci. J Orthop Res (2004) 1.09
Modulation of connexin43 alters expression of osteoblastic differentiation markers. Am J Physiol Cell Physiol (2005) 1.09
Osteoblastic cells have refractory periods for fluid-flow-induced intracellular calcium oscillations for short bouts of flow and display multiple low-magnitude oscillations during long-term flow. J Biomech (2003) 1.09
Beta1 integrins mediate mechanosensitive signaling pathways in osteocytes. Calcif Tissue Int (2010) 1.09
The epigenetic mechanism of mechanically induced osteogenic differentiation. J Biomech (2010) 1.07
Breast cancer metastatic potential: correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells. Int J Cancer (2004) 1.07
Surface energy effects on osteoblast spatial growth and mineralization. Biomaterials (2008) 1.07
P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J Biol Chem (2002) 1.05
ATP release mediates fluid flow-induced proliferation of human bone marrow stromal cells. J Bone Miner Res (2007) 1.05
Primary cilia: cellular sensors for the skeleton. Anat Rec (Hoboken) (2008) 1.05
Gap junction and hemichannel functions in osteocytes. Bone (2012) 1.04
A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. Biochem Biophys Res Commun (2011) 1.03
Oxygen tension differentially influences osteogenic differentiation of human adipose stem cells in 2D and 3D cultures. J Cell Biochem (2010) 1.03
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. Res Vet Sci (2010) 1.02
Effects of cell swelling on intracellular calcium and membrane currents in bovine articular chondrocytes. J Cell Biochem (2002) 1.02
Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential. Clin Exp Metastasis (2008) 1.01
Integrin expression and osteopontin regulation in human fetal osteoblastic cells mediated by substratum surface characteristics. Tissue Eng (2005) 1.01
Mechanically induced osteogenic lineage commitment of stem cells. Stem Cell Res Ther (2013) 1.00
Mechanosensing by the primary cilium: deletion of Kif3A reduces bone formation due to loading. PLoS One (2012) 0.99
The periosteum as a cellular source for functional tissue engineering. Tissue Eng Part A (2009) 0.99
Effect of surface nanoscale topography on elastic modulus of individual osteoblastic cells as determined by atomic force microscopy. J Biomech (2007) 0.99
Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading. J Bone Miner Res (2012) 0.98
Breast cancer cells induce osteoblast apoptosis: a possible contributor to bone degradation. J Cell Biochem (2004) 0.97
The mechanics of the primary cilium: an intricate structure with complex function. J Biomech (2011) 0.97
Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing. J Orthop Res (2012) 0.96
Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone (2009) 0.95
A substance P receptor (NK1) antagonist enhances the widespread osteoporotic effects of sciatic nerve section. Bone (2003) 0.95
Optimizing the osteogenic potential of adult stem cells for skeletal regeneration. J Orthop Res (2011) 0.95
Osteocyte primary cilium and its role in bone mechanotransduction. Ann N Y Acad Sci (2010) 0.95
Mesenchymal stem cell mechanobiology. Curr Osteoporos Rep (2010) 0.95
Systematic variation in osteoblast adhesion and phenotype with substratum surface characteristics. J Biomed Mater Res A (2004) 0.92
The effect of oxygen tension on the long-term osteogenic differentiation and MMP/TIMP expression of human mesenchymal stem cells. Cells Tissues Organs (2009) 0.92
Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression. PLoS One (2011) 0.92
Hypoxic regulation of mesenchymal stem cell migration: the role of RhoA and HIF-1α. Cell Biol Int (2011) 0.92
Chemotransport contributes to the effect of oscillatory fluid flow on human bone marrow stromal cell proliferation. J Orthop Res (2008) 0.91
Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan. Bone (2007) 0.90
Hypoxia increases Annexin A2 expression in osteoblastic cells via VEGF and ERK. Bone (2010) 0.90
Porous thermoresponsive-co-biodegradable hydrogels as tissue-engineering scaffolds for 3-dimensional in vitro culture of chondrocytes. Tissue Eng (2007) 0.89
Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling. J Biomech (2007) 0.89
Mechanically induced intracellular calcium waves in osteoblasts demonstrate calcium fingerprints in bone cell mechanotransduction. Biomech Model Mechanobiol (2006) 0.89
Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load. J Bone Miner Res (2014) 0.89
Intracellular calcium changes in rat aortic smooth muscle cells in response to fluid flow. Ann Biomed Eng (2002) 0.88
An experimental and computational analysis of primary cilia deflection under fluid flow. Comput Methods Biomech Biomed Engin (2012) 0.88
Hypoxic osteocytes recruit human MSCs through an OPN/CD44-mediated pathway. Biochem Biophys Res Commun (2007) 0.88
Cancer interaction with the bone microenvironment: a workshop of the National Institutes of Health Tumor Microenvironment Study Section. Am J Pathol (2006) 0.87
Interdependence of muscle atrophy and bone loss induced by mechanical unloading. J Bone Miner Res (2014) 0.87
Osteoprotegrin and the bone homing and colonization potential of breast cancer cells. J Cell Biochem (2008) 0.86
Emerging role of primary cilia as mechanosensors in osteocytes. Bone (2012) 0.86
Inhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice. PLoS One (2013) 0.86
Effects of membrane cholesterol depletion and GPI-anchored protein reduction on osteoblastic mechanotransduction. J Cell Physiol (2011) 0.86
Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells. Biomaterials (2011) 0.85
Hypoxia regulates PGE(2) release and EP1 receptor expression in osteoblastic cells. J Cell Physiol (2007) 0.84
HIF-1alpha regulates hypoxia-induced EP1 expression in osteoblastic cells. J Cell Biochem (2009) 0.84
Age-related changes in gap junctional intercellular communication in osteoblastic cells. J Orthop Res (2012) 0.84
Increased mechanosensitivity of cells cultured on nanotopographies. J Biomech (2010) 0.84