Published in Biol Proced Online on October 24, 2003
Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance. Proc Natl Acad Sci U S A (2005) 2.85
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci U S A (2006) 1.30
MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell context. Haematologica (2010) 1.16
Ten things you should know about protein kinases: IUPHAR Review 14. Br J Pharmacol (2015) 1.06
A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation. J Biol Chem (2009) 1.03
ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines. Blood (2009) 0.84
Farnesyl transferase inhibitor resistance probed by target mutagenesis. Blood (2007) 0.79
Refining targeted therapies in chronic myeloid leukemia: development and application of nilotinib, a step beyond imatinib. Onco Targets Ther (2008) 0.77
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science (2001) 20.30
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med (2003) 17.23
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med (1996) 13.49
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell (2002) 13.03
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med (2001) 11.88
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell (2003) 5.71
Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci U S A (1988) 3.74
Issues and progress with protein kinase inhibitors for cancer treatment. Nat Rev Drug Discov (2003) 2.32
Novel retroviral vectors to facilitate expression screens in mammalian cells. Nucleic Acids Res (2002) 1.51
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature (2009) 4.14
Quantification of the yeast transcriptome by single-molecule sequencing. Nat Biotechnol (2009) 3.86
Case records of the Massachusetts General Hospital. Case 28-2014. A 39-year-old man with a rash, headache, fever, nausea, and photophobia. N Engl J Med (2014) 2.62
The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA. BMC Biol (2010) 2.59
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov (2014) 1.99
A comparison of single molecule and amplification based sequencing of cancer transcriptomes. PLoS One (2011) 1.44
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci U S A (2006) 1.30
Single-molecule sequencing: sequence methods to enable accurate quantitation. Methods Enzymol (2010) 1.01
Merkel cell carcinoma: 30-year experience from a single institution. Ann Surg Oncol (2012) 0.97
FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells. Am J Hematol (2009) 0.91
Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation. Am J Surg Pathol (2017) 0.90
Unique in utero identification of fetuses in multifetal mouse pregnancies by placental bidirectional arterial spin labeling MRI. Magn Reson Med (2011) 0.88
Parasitic infection by larval helminths in Antarctic fishes: pathological changes and impact on the host body condition index. Dis Aquat Organ (2013) 0.87
Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients. Clin Cancer Res (2012) 0.86
Farnesyl transferase inhibitor resistance probed by target mutagenesis. Blood (2007) 0.79
Ovarian dendritic cells act as a double-edged pro-ovulatory and anti-inflammatory sword. Mol Endocrinol (2014) 0.79
Multifactorial context effects on visual recognition memory. Q J Exp Psychol (Hove) (2007) 0.78
Administration of vincristine in a patient with Machado-Joseph disease. Oncology (2012) 0.77
Case records of the Massachusetts General Hospital. Case 24-2013. A 53-year-old woman with erythroderma, pruritus, and lymphadenopathy. N Engl J Med (2013) 0.75
Case records of the Massachusetts General Hospital. Case 40-2014. A 57-year-old man with inguinal pain, lymphadenopathy, and HIV infection. N Engl J Med (2014) 0.75
Probing the brain substrates of cognitive processes responsible for context effects on recognition memory. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn (2010) 0.75
Primary Endometrial Marginal Zone Lymphoma (MALT Lymphoma): A Unique Clinicopathologic Entity. Am J Surg Pathol (2016) 0.75
Chronic Akt1 deficiency attenuates adverse remodeling and enhances angiogenesis after myocardial infarction. Circ Cardiovasc Imaging (2013) 0.75