Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMID 14623056)

Published in Bone on November 01, 2003

Authors

E R van Beek1, L H Cohen, I M Leroy, F H Ebetino, C W G M Löwik, S E Papapoulos

Author Affiliations

1: Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. E.R.van_Beek@lumc.nl

Articles citing this

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int (2008) 4.73

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds. J R Soc Interface (2009) 1.39

The science and practice of bone health in oncology: managing bone loss and metastasis in patients with solid tumors. J Natl Compr Canc Netw (2009) 1.03

How do bisphosphonates inhibit bone metastasis in vivo? Neoplasia (2010) 1.03

The effect of bisphosphonates on gene expression: GAPDH as a housekeeping or a new target gene? BMC Cancer (2006) 1.00

Skeletal effects of short-term exposure to dexamethasone and response to risedronate treatment studied in vivo in rabbits by magnetic resonance micro-imaging and spectroscopy. J Bone Miner Metab (2006) 0.93

Statins and hip fracture prevention--a population based cohort study in women. PLoS One (2012) 0.90

The volatome of Aspergillus fumigatus. Eukaryot Cell (2014) 0.90

Bisphosphonates' antiangiogenic potency in the development of bisphosphonate-associated osteonecrosis of the jaws: influence on microvessel sprouting in an in vivo 3D Matrigel assay. Clin Oral Investig (2013) 0.89

The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro. Head Face Med (2010) 0.88

Bisphosphonate treatment in the oim mouse model alters bone modeling during growth. J Biomech (2008) 0.87

Alendronate affects osteoblast functions by crosstalk through EphrinB1-EphB. J Dent Res (2011) 0.87

Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells. J Cell Mol Med (2008) 0.86

Effects of pamidronate on human alveolar osteoblasts in vitro. J Oral Maxillofac Surg (2012) 0.86

Bisphosphonate-associated osteonecrosis of the mandible: reliable soft tissue reconstruction using a local myofascial flap. Clin Oral Investig (2011) 0.85

Immobilization of pamidronic acids on the nanotube surface of titanium discs and their interaction with bone cells. Nanoscale Res Lett (2013) 0.85

Alendronate inhibits VEGF expression in growth plate chondrocytes by acting on the mevalonate pathway. Open Orthop J (2009) 0.84

New methodology for evaluating osteoclastic activity induced by orthodontic load. J Appl Oral Sci (2015) 0.83

Zoledronic acid enhances lipopolysaccharide-stimulated proinflammatory reactions through controlled expression of SOCS1 in macrophages. PLoS One (2013) 0.81

Clinical experience with intravenous zoledronic acid in the treatment of male osteoporosis: evidence and opinions. Ther Adv Musculoskelet Dis (2013) 0.81

Surface immobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants. J Mater Sci Mater Med (2010) 0.79

A population-based 2-year follow-up study on the relationship between bisphosphonates and the risk of stroke. Osteoporos Int (2012) 0.78

Technical advance: liposomal alendronate depletes monocytes and macrophages in the nonhuman primate model of human disease. J Leukoc Biol (2014) 0.78

Measurement of Ototoxicity Following Intracochlear Bisphosphonate Delivery. Otol Neurotol (2016) 0.78

Collapsing focal segmental glomerulosclerosis resulting from a single dose of zoledronate. Nephron Extra (2014) 0.76

Effect of bisphosphonates on the mandibular bone and gingival epithelium of rats without tooth extraction. Exp Ther Med (2016) 0.75

Optimizing bone health and minimizing skeletal morbidity in men with prostate cancer. Hematol Oncol Clin North Am (2013) 0.75

Life-threatening hyperkalemia following zoledronic acid infusion for Paget's disease: a case report. J Med Case Rep (2011) 0.75

Long-term treatment of osteoporotic women with bisphosphonates does not impair the response to subsequently administered intravenous pamidronate. Osteoporos Int (2013) 0.75

Articles by these authors

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int (2008) 4.73

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther (2001) 3.59

Influence of single amino acid substitutions on electrophoretic mobility of sodium dodecyl sulfate-protein complexes. Biochem Biophys Res Commun (1978) 3.26

Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone (2005) 3.13

Histones of Drosophila embryos. Electrophoretic isolation and structural studies. J Biol Chem (1974) 3.00

Large-scale isolation and fractionation of organs of Drosophila melanogaster larvae. J Cell Biol (1971) 2.56

The structure of the gene coding for the phosphorylated ribosomal protein S10 in yeast. Nucleic Acids Res (1982) 2.54

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts. J Biol Chem (1991) 2.52

Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation. Endocrinology (2000) 2.51

Interpretation and use of FRAX in clinical practice. Osteoporos Int (2011) 2.43

Assessment and prediction of stress-related growth. J Pers (1996) 2.37

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2. J Biol Chem (1994) 2.34

Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer Res (2000) 2.32

Parathyroid venous sampling: anatomic considerations and results in 95 patients with primary hyperparathyroidism. Br J Radiol (1980) 2.29

Stage-specific mRNAs coding for subtypes of H2A and H2B histones in the sea urchin embryo. Cell (1978) 1.99

Histones of polytene and nonpolytene nuclei of Drosophila melanogaster. J Biol Chem (1971) 1.97

Isolation of cloned ribosomal protein genes from the yeast Saccharomyces carlsbergensis. Gene (1981) 1.90

Histone changes during chromatin remodeling in embryogenesis. Cold Spring Harb Symp Quant Biol (1978) 1.73

Clinical risk factors as predictors of postmenopausal osteoporosis in general practice. Br J Gen Pract (2001) 1.73

Sclerostin: current knowledge and future perspectives. Calcif Tissue Int (2010) 1.71

1, 25-dihydroxycholecalciferol in the pathogenesis of the hypercalcaemia of sarcoidosis. Lancet (1979) 1.71

Isolation, properties and cellular distribution of D1, a chromosomal protein of Drosophila. Chromosoma (1980) 1.70

Ribosomal protein genes of yeast contain intervening sequences. Gene (1982) 1.65

Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis. Biochem Biophys Res Commun (1989) 1.64

The histone H1 complements of dividing and nondividing cells of the mouse. J Biol Chem (1983) 1.58

Locations of chromosomal proteins in polytene chromosomes. Proc Natl Acad Sci U S A (1976) 1.55

Yeast ribosomal protein S33 is encoded by an unsplit gene. Nucleic Acids Res (1983) 1.53

Use of psychotherapy research by professional psychologists. Am Psychol (1986) 1.49

Stage-specific switches in histone synthesis during embryogenesis of the sea urchin. Science (1975) 1.49

Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J Bone Miner Res (2002) 1.49

The role of neuroticism in daily stress and coping. J Pers Soc Psychol (1999) 1.46

Analysis of histone subtypes and their modified forms by polyacrylamide gel electrophoresis. Methods Enzymol (1989) 1.41

[Prevalence of osteoporosis in postmenopausal women in family practice]. Ned Tijdschr Geneeskd (1999) 1.41

Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices. Cancer Res (1997) 1.39

Cholesterol content of the rat lens is lowered by administration of simvastatin, but not by pravastatin. Exp Eye Res (1993) 1.38

Epi- and metaphyseal changes in children caused by administration of bisphosphonates. Radiology (1992) 1.37

Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages. Curr Pharm Des (2010) 1.37

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages. J Bone Miner Res (1998) 1.36

Paget's disease of bone: early and late responses to three different modes of treatment with aminohydroxypropylidene bisphosphonate (APD). Br Med J (Clin Res Ed) (1987) 1.33

Palliative pamidronate treatment in patients with bone metastases from breast cancer. J Clin Oncol (1993) 1.32

Studies of circulating parathyroid hormone in man using a homologous amino-terminal specific immunoradiometric assay. Clin Endocrinol (Oxf) (1980) 1.29

Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro. Ann Rheum Dis (2002) 1.24

The fate of the small micromeres in sea urchin development. Dev Biol (1986) 1.22

Image-guided surgery in head and neck cancer: current practice and future directions of optical imaging. Head Neck (2011) 1.22

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem (2001) 1.22

Fluorescently labeled risedronate and related analogues: "magic linker" synthesis. Bioconjug Chem (2008) 1.22

Transient vasopressin-resistant diabetes insipidus of pregnancy. N Engl J Med (1984) 1.21

Photoaffinity labeling of the Ah receptor. J Biol Chem (1986) 1.21

Interleukin-17: A new bone acting cytokine in vitro. J Bone Miner Res (1999) 1.20

Increased bone mass with pamidronate treatment in rheumatoid arthritis. Results of a three-year randomized, double-blind trial. Arthritis Rheum (1996) 1.19

Patients with primary hyperparathyroidism have lower circulating sclerostin levels than euparathyroid controls. Eur J Endocrinol (2010) 1.19

Long-term effects of bisphosphonates on the growing skeleton. Studies of young patients with severe osteoporosis. Medicine (Baltimore) (1997) 1.17

Maintained improvement in calcium balance and bone mineral content in patients with osteoporosis treated with the bisphosphonate APD. Bone Miner (1989) 1.15

Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types. Biochim Biophys Acta (1997) 1.15

Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype. J Clin Invest (1994) 1.13

Differentiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation. Bone (2002) 1.12

Characteristics and bisphosphonate treatment of a patient with juvenile osteoporosis. J Clin Endocrinol Metab (1985) 1.12

Acute renal failure from ticrynafen. N Engl J Med (1979) 1.11

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships. Bone (1998) 1.11

Sclerostin in mineralized matrices and van Buchem disease. J Dent Res (2009) 1.11

End-organ resistance to 1,25-dihydroxycholecalciferol. Lancet (1980) 1.09

Rat alpha-crystallin A chain with an insertion of 22 residues. Eur J Biochem (1978) 1.09

Reversible resistance to the renal action of parathyroid hormone in human vitamin D deficiency. Clin Sci (Lond) (1982) 1.09

Effects of DNA looping on pyrimidine dimer formation. Nucleic Acids Res (1992) 1.09

The alterations in H1 histone complement during mouse spermatogenesis and their significance for H1 subtype function. Dev Biol (1984) 1.07

Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors. Bone (2002) 1.07

Antiresorptive dose-response relationships across three generations of bisphosphonates. Drugs Exp Clin Res (1989) 1.06

Crystal agglomeration is a major element in calcium oxalate urinary stone formation. Kidney Int (1990) 1.06

Measurement of adolescents' life events: the junior high life experiences survey. Am J Community Psychol (1985) 1.06

The H1 histones and their interphase phosphorylated states in differentiated and undifferentiated cell lines derived from murine teratocarcinomas. J Biol Chem (1982) 1.05

Measurement of 1,25-dihydroxycholecalciferol in man by radioimmunoassay. Clin Endocrinol (Oxf) (1979) 1.05

Phosphorylation states of different histone 1 subtypes and their relationship to chromatin functions during the HeLa S-3 cell cycle. Biochemistry (1981) 1.04

Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J Clin Invest (1994) 1.04

Near-infrared fluorescence imaging in patients undergoing pancreaticoduodenectomy. Eur Surg Res (2011) 1.03

Mutations in the human Ca(2+)-sensing-receptor gene that cause familial hypocalciuric hypercalcemia. Am J Hum Genet (1995) 1.03

New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Curr Med Res Opin (2008) 1.02

Stimulation of the LDL receptor activity in the human hepatoma cell line Hep G2 by high-density serum fractions. Biochim Biophys Acta (1986) 1.01

Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate. J Bone Miner Res (1995) 1.00

Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study. J Rheumatol (1994) 1.00

The effects of dietary excesses in animal protein and in sodium on the composition and the crystallization kinetics of calcium oxalate monohydrate in urines of healthy men. J Clin Endocrinol Metab (1990) 1.00

A frame-shift mutation in the type I parathyroid hormone (PTH)/PTH-related peptide receptor causing Blomstrand lethal osteochondrodysplasia. J Clin Endocrinol Metab (1999) 1.00

Fumarase: demonstration, separation, and hybridization of different subunit types. J Biol Chem (1971) 1.00

Excessive crystal agglomeration with low citrate excretion in recurrent stone-formers. Lancet (1986) 1.00

Comparison of the structures of human histone 1A and 1B and their intramolecular phosphorylation sites during the HeLa S-3 cell cycle. Biochemistry (1981) 0.98

Report on osteoporosis in the European Community: current status and recommendations for the future. Working Party from European Union Member States. Osteoporos Int (1998) 0.98

Intraoperative near-infrared fluorescence imaging of colorectal metastases targeting integrin α(v)β(3) expression in a syngeneic rat model. Eur J Surg Oncol (2011) 0.97

Studies of hypoparathyroidism and pseudohypoparathyroidism. Q J Med (1978) 0.97

A potential role for the mast cell in the pathogenesis of idiopathic osteoporosis in men. Bone (2002) 0.97

Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle. Biochem Pharmacol (1996) 0.97

Optical advances in skeletal imaging applied to bone metastases. Bone (2010) 0.97

Inhibition of the bicarbonate exit step in urinary acidification by a disulfonic stilbene. J Clin Invest (1978) 0.96

Differences between bisphosphonates in binding affinities for hydroxyapatite. J Biomed Mater Res B Appl Biomater (2010) 0.96

CITED2 and NCOR2 in anti-oestrogen resistance and progression of breast cancer. Br J Cancer (2009) 0.95

The prevalence of low bone mineral density in Dutch perimenopausal women: the Eindhoven perimenopausal osteoporosis study. Osteoporos Int (1998) 0.95