Published in Antiviral Res on October 01, 2003
Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion. J Virol (2007) 3.57
Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. Proc Natl Acad Sci U S A (2009) 3.49
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes. J Virol (2004) 3.39
Human apolipoprotein e is required for infectivity and production of hepatitis C virus in cell culture. J Virol (2007) 3.18
Quantitative analysis of the hepatitis C virus replication complex. J Virol (2005) 2.91
Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus. J Virol (2006) 1.99
A dynamic view of hepatitis C virus replication complexes. J Virol (2008) 1.66
Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication. J Virol (2011) 1.58
Dissecting the interferon-induced inhibition of hepatitis C virus replication by using a novel host cell line. J Virol (2005) 1.41
SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication. PLoS Pathog (2011) 1.32
Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection. Virology (2010) 1.31
Cell culture-adaptive mutations promote viral protein-protein interactions and morphogenesis of infectious hepatitis C virus. J Virol (2012) 1.24
Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J Virol (2007) 1.19
Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A. J Virol (2010) 1.09
Hepatitis C virus and natural compounds: a new antiviral approach? Viruses (2012) 1.03
Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions. J Virol (2010) 1.01
Hepatitis C Virus entry: the early steps in the viral replication cycle. Virol J (2009) 1.01
Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication. J Virol (2010) 0.97
Activation and evasion of antiviral innate immunity by hepatitis C virus. J Mol Biol (2013) 0.96
Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity. PLoS One (2010) 0.96
Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol. Biochemistry (2007) 0.96
Binding dynamics of hepatitis C virus' NS5A amphipathic peptide to cell and model membranes. J Virol (2007) 0.94
Coevolution of the hepatitis C virus polyprotein sites in patients on combined pegylated interferon and ribavirin therapy. J Virol (2011) 0.92
Nanomedicine as an emerging approach against intracellular pathogens. Int J Nanomedicine (2011) 0.91
Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain. Virol J (2009) 0.89
Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection. Virol J (2006) 0.89
Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein. Antimicrob Agents Chemother (2013) 0.85
Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion. Virol J (2011) 0.85
Cytosolic phospholipase A2 gamma is involved in hepatitis C virus replication and assembly. J Virol (2012) 0.85
Spatiotemporal analysis of hepatitis C virus infection. PLoS Pathog (2015) 0.85
Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2), a host membrane-deforming protein, is critical for membranous web formation in hepatitis C virus replication. J Virol (2011) 0.83
Encoded library technology screening of hepatitis C virus NS4B yields a small-molecule compound series with in vitro replicon activity. Antimicrob Agents Chemother (2015) 0.83
Characterization of nonstructural protein membrane anchor deletion mutants expressed in the context of the hepatitis C virus polyprotein. J Virol (2005) 0.83
Removal of hepatitis C virus-infected cells by a zymogenized bacterial toxin. PLoS One (2012) 0.82
Characterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase. Virol J (2011) 0.82
The C-terminal hydrophobic domain of hepatitis C virus RNA polymerase NS5B can be replaced with a heterologous domain of poliovirus protein 3A. J Virol (2006) 0.81
The Autophagosomal SNARE Protein Syntaxin 17 Is an Essential Factor for the Hepatitis C Virus Life Cycle. J Virol (2016) 0.79
Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus. J Virol (2014) 0.78
Determinants in the maturation of rubella virus p200 replicase polyprotein precursor. J Virol (2012) 0.78
Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection. J Virol (2013) 0.78
Engineered toxins "zymoxins" are activated by the HCV NS3 protease by removal of an inhibitory protein domain. PLoS One (2011) 0.76
The hepatitis C virus core protein can modulate RNA-dependent RNA synthesis by the 2a polymerase. Virus Res (2014) 0.76
Inhibition effect of Chinese herbal medicine on transcription of hepatitis C virus structural gene in vitro. World J Gastroenterol (2005) 0.75
Hepatitis C virus promotes virion secretion through cleavage of the Rab7 adaptor protein RILP. Proc Natl Acad Sci U S A (2016) 0.75
PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally. Antimicrob Agents Chemother (2016) 0.75
Lipid Binding of the Amphipathic Helix Serving as Membrane Anchor of Pestivirus Glycoprotein Erns. PLoS One (2015) 0.75
Last stop before exit - hepatitis C assembly and release as antiviral drug targets. Viruses (2010) 0.75
Hepatitis C-like viruses are produced in cells from rabbit and hare DNA. Sci Rep (2015) 0.75
Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2. J Biol Chem (2016) 0.75
HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis. Oxid Med Cell Longev (2016) 0.75
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology (2005) 9.39
Replication of hepatitis C virus. Nat Rev Microbiol (2007) 8.31
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J Virol (2002) 6.69
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol (2003) 5.41
Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection. Radiology (2003) 4.13
An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A. J Biol Chem (2001) 3.91
RNA replication of mouse hepatitis virus takes place at double-membrane vesicles. J Virol (2002) 3.69
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes. J Virol (2004) 3.39
Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors. J Infect Dis (2009) 3.23
Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proc Natl Acad Sci U S A (2007) 3.13
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology (2002) 3.02
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate. J Biol Chem (2003) 2.94
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog (2010) 2.91
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J Biol Chem (2004) 2.71
T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol (2005) 2.58
euHCVdb: the European hepatitis C virus database. Nucleic Acids Res (2006) 2.41
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81. Hepatology (2007) 2.25
Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc Natl Acad Sci U S A (2010) 2.19
Visualization and functional analysis of RNA-dependent RNA polymerase lattices. Science (2002) 2.14
Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution. Hepatology (2006) 1.96
Subcellular localization and topology of the p7 polypeptide of hepatitis C virus. J Virol (2002) 1.89
MAVS dimer is a crucial signaling component of innate immunity and the target of hepatitis C virus NS3/4A protease. J Virol (2008) 1.86
Binding of hepatitis C virus-like particles derived from infectious clone H77C to defined human cell lines. J Virol (2002) 1.84
APOBEC-mediated interference with hepadnavirus production. Hepatology (2005) 1.82
Malignant ascites: systematic review and guideline for treatment. Eur J Cancer (2006) 1.78
Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma. Hepatology (2014) 1.76
Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J Virol (2005) 1.74
Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction. J Virol (2006) 1.71
Interaction of hepatitis C virus proteins with host cell membranes and lipids. Trends Cell Biol (2002) 1.71
Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis. Am J Gastroenterol (2002) 1.70
The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein. J Virol (2007) 1.69
Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology (2003) 1.66
End-of-life care in hospital: current practice and potentials for improvement. J Pain Symptom Manage (2007) 1.65
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex. Proc Natl Acad Sci U S A (2008) 1.62
Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection. Hepatology (2005) 1.61
Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. J Biol Chem (2009) 1.61
Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus. J Virol (2007) 1.59
Evidence of viral replication in circulating dendritic cells during hepatitis C virus infection. J Infect Dis (2003) 1.59
Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation. Transplantation (2007) 1.56
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment. J Virol (2002) 1.56
NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly. PLoS Pathog (2011) 1.52
Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol (2006) 1.52
Topological changes in the transmembrane domains of hepatitis C virus envelope glycoproteins. EMBO J (2002) 1.52
Regulation of hepatitis C virus polyprotein processing by signal peptidase involves structural determinants at the p7 sequence junctions. J Biol Chem (2004) 1.49
Hepatitis C virus proteins: from structure to function. Curr Top Microbiol Immunol (2013) 1.47
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest (2009) 1.46
Intracellular location and translocation of silent and active poliovirus replication complexes. J Gen Virol (2005) 1.44
Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores. J Virol (2004) 1.43
Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis. Cancer (2005) 1.42
Hepatitis C virus glycoproteins mediate low pH-dependent membrane fusion with liposomes. J Biol Chem (2005) 1.41
Frequent compartmentalization of hepatitis C virus variants in circulating B cells and monocytes. Hepatology (2004) 1.41
Comment on "Inhibition of hepatitis B virus replication by APOBEC3G". Science (2004) 1.41
Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology (2008) 1.40
Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B. J Virol (2009) 1.37
Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner. J Immunol (2008) 1.36
Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA. J Virol (2004) 1.36
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication. J Virol (2004) 1.36
Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded. Biochem Biophys Res Commun (2009) 1.34
Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features. J Virol (2005) 1.34
Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory. Rev Med Virol (2010) 1.32
The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication. J Virol (2007) 1.32
Pathogenesis of hepatocellular carcinoma. Eur J Gastroenterol Hepatol (2005) 1.30
Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C. J Virol (2004) 1.29
Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency. J Virol (2011) 1.28
Targeted therapy for hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol (2009) 1.27
Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H. J Gen Virol (2008) 1.25
Transmembrane domains of hepatitis C virus envelope glycoproteins: residues involved in E1E2 heterodimerization and involvement of these domains in virus entry. J Virol (2006) 1.25
Molecular virology of hepatitis C virus (HCV): 2006 update. Int J Med Sci (2006) 1.24
Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection. Hepatology (2008) 1.24
Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference. Hepatology (2009) 1.24
Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B. J Virol (2010) 1.23
Unusual multiple recoding events leading to alternative forms of hepatitis C virus core protein from genotype 1b. J Biol Chem (2003) 1.22
Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia. Am J Gastroenterol (2002) 1.22
The hepatitis C virus Core protein is a potent nucleic acid chaperone that directs dimerization of the viral (+) strand RNA in vitro. Nucleic Acids Res (2004) 1.22
NMR structure and ion channel activity of the p7 protein from hepatitis C virus. J Biol Chem (2010) 1.21
HCVDB: hepatitis C virus sequences database. Appl Bioinformatics (2004) 1.21
Solid state NMR sequential resonance assignments and conformational analysis of the 2x10.4 kDa dimeric form of the Bacillus subtilis protein Crh. J Biomol NMR (2003) 1.21
Basic residues in hypervariable region 1 of hepatitis C virus envelope glycoprotein e2 contribute to virus entry. J Virol (2005) 1.21
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem (2001) 1.19
Hepatitis C: molecular virology and antiviral targets. Trends Mol Med (2002) 1.17
A region of the Epstein-Barr virus (EBV) mRNA export factor EB2 containing an arginine-rich motif mediates direct binding to RNA. J Biol Chem (2003) 1.17
Hepatitis C virus-induced hepatocarcinogenesis. J Hepatol (2009) 1.17
An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association. J Virol (2009) 1.16
Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion. Gastroenterology (2008) 1.16