Published in Trends Pharmacol Sci on December 01, 2003
Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling. Am J Physiol Heart Circ Physiol (2008) 2.19
Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol (2004) 2.09
Gastroprotective effect of NaHS against mucosal lesions induced by ischemia-reperfusion injury in rat. Dig Dis Sci (2012) 1.89
Measurement of plasma hydrogen sulfide in vivo and in vitro. Free Radic Biol Med (2011) 1.74
Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide? Br J Pharmacol (2006) 1.68
A fluorescent probe for fast and quantitative detection of hydrogen sulfide in blood. Angew Chem Int Ed Engl (2011) 1.58
Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat. Br J Pharmacol (2005) 1.47
Hydrogen sulfide (H2S) stimulates capsaicin-sensitive primary afferent neurons in the rat urinary bladder. Br J Pharmacol (2004) 1.46
Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Br J Pharmacol (2005) 1.45
A critical review of pharmacological significance of Hydrogen Sulfide in hypertension. Indian J Pharmacol (2015) 1.42
Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice. Br J Pharmacol (2008) 1.40
Increased transsulfuration mediates longevity and dietary restriction in Drosophila. Proc Natl Acad Sci U S A (2011) 1.14
Thiol reactive probes and chemosensors. Sensors (Basel) (2012) 1.12
H2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G. Br J Pharmacol (2008) 1.05
The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome. Mol Pain (2009) 1.02
The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart. Br J Pharmacol (2007) 1.00
Hydrogen sulfide, the next potent preventive and therapeutic agent in aging and age-associated diseases. Mol Cell Biol (2013) 0.98
Ischemia/reperfusion reduces transcription factor Sp1-mediated cystathionine beta-synthase expression in the kidney. J Biol Chem (2010) 0.98
Inhibition of Hydrogen Sulfide-induced Angiogenesis and Inflammation in Vascular Endothelial Cells: Potential Mechanisms of Gastric Cancer Prevention by Korean Red Ginseng. J Ginseng Res (2012) 0.97
A critical appraisal of the hemodynamic signal driving liver regeneration. Langenbecks Arch Surg (2012) 0.94
Hydrogen sulfide attenuates cardiac hypertrophy and fibrosis induced by abdominal aortic coarctation in rats. Mol Med Rep (2012) 0.93
Antisecretory effect of hydrogen sulfide on gastric acid secretion and the involvement of nitric oxide. Biomed Res Int (2014) 0.91
Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. Br J Pharmacol (2006) 0.89
Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. J Cell Mol Med (2008) 0.89
Regulation of the T-type Ca(2+) channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2 S in nociception. J Physiol (2016) 0.88
Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis. J Inflamm (Lond) (2009) 0.87
Role of hydrogen sulfide in the pathology of inflammation. Scientifica (Cairo) (2012) 0.87
Expression of cystathionine β-synthase and cystathionine γ-lyase in human pregnant myometrium and their roles in the control of uterine contractility. PLoS One (2011) 0.85
NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain. Pharmacol Res Perspect (2015) 0.85
Hydrogen sulfide inhibits formaldehyde-induced endoplasmic reticulum stress in PC12 cells by upregulation of SIRT-1. PLoS One (2014) 0.84
Up Regulation of cystathione γ lyase and Hydrogen Sulphide in the Myocardium Inhibits the Progression of Isoproterenol-Caffeine Induced Left Ventricular Hypertrophy in Wistar Kyoto Rats. PLoS One (2016) 0.81
Measurement of H2S in vivo and in vitro by the monobromobimane method. Methods Enzymol (2015) 0.79
Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity by downregulation of NF-κB and MAP kinase activity in LPS-activated RAW 264.7 cells. Biomed Res Int (2014) 0.79
Mangiferin regulates interleukin-6 and cystathionine-b-synthase in lipopolysaccharide-induced brain injury. Cell Mol Neurobiol (2014) 0.79
Hydrogen sulfide plays a key role in the inhibitory neurotransmission to the pig intravesical ureter. PLoS One (2014) 0.78
H2S mitigates severe acute pancreatitis through the PI3K/AKT-NF-κB pathway in vivo. World J Gastroenterol (2015) 0.78
Hydrogen sulfide regulates the colonic motility by inhibiting both L-type calcium channels and BKCa channels in smooth muscle cells of rat colon. PLoS One (2015) 0.78
Role of hydrogen sulfide in the physiology of penile erection. J Androl (2011) 0.77
Superoxide Mediates Depressive Effects Induced by Hydrogen Sulfide in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats. Oxid Med Cell Longev (2015) 0.77
Hydrogen sulfide down-regulates the expression and release of osteoprotegerin (OPG) by vascular endothelial cells. Invest New Drugs (2011) 0.76
Cystathionine β-synthase-derived hydrogen sulfide regulates lipopolysaccharide-induced apoptosis of the BRL rat hepatic cell line in vitro. Exp Ther Med (2012) 0.76
Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia. Oxid Med Cell Longev (2015) 0.76
ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function. Med Gas Res (2011) 0.76
Effects of hydrogen sulfide on high glucose-induced glomerular podocyte injury in mice. Int J Clin Exp Pathol (2015) 0.76
Effects of hydrogen sulfide (H2S) on mesenteric perfusion in experimental induced intestinal ischemia in a porcine model. Heart Lung Vessel (2015) 0.75
Protective effects of vitamin B6 alone and in combination with L-cysteine and NaHS on ethanol and indomethacin-induced gastric lesions in mice. Iran J Basic Med Sci (2015) 0.75
Hydrogen sulfide attenuates gastric mucosal injury induced by restraint water-immersion stress via activation of KATP channel and NF-κB dependent pathway. World J Gastroenterol (2017) 0.75
Correlation of Lower Concentrations of Hydrogen Sulfide with Activation of Protein Kinase CβII in Uremic Accelerated Atherosclerosis Patients. Chin Med J (Engl) (2015) 0.75
Effect of tobacco smoke on hydrogen sulfide-induced rat thoracic aorta relaxation. Braz J Med Biol Res (2017) 0.75
Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs. Front Chem (2017) 0.75
The anti-inflammatory effect of hydrogen sulphide on acute necrotizing pancreatitis in rats. Turk J Surg (2017) 0.75
Novel phenanthridine (PHE-4i) derivative inhibits carrageenan-induced rat hind paw oedema through suppression of hydrogen sulfide. Inflammopharmacology (2016) 0.75
Interaction of messengers--endogenous NO and H2S gasotransmitters--in signaling and regulatory processes in bacterial cells. Dokl Biochem Biophys (2015) 0.75
Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol (2004) 3.65
Retracted SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Science (2010) 3.63
Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J (2005) 3.23
Chemokines in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol (2005) 2.21
Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol (2004) 2.09
Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochem Biophys Res Commun (2006) 1.82
Involvement of ROS in BBB dysfunction. Free Radic Res (2009) 1.73
Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Crit Care Med (2010) 1.67
Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Br J Pharmacol (2005) 1.45
Can by-products in country-made alcohols induce acute pancreatitis? Pancreas (2010) 1.44
Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. Am J Physiol Lung Cell Mol Physiol (2006) 1.42
Hydrogen sulphide--a novel mediator of inflammation? Curr Opin Pharmacol (2006) 1.38
Systemic inflammatory response following acute traumatic brain injury. Front Biosci (Landmark Ed) (2009) 1.32
Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis. Biochem Biophys Res Commun (2005) 1.32
Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway. J Leukoc Biol (2007) 1.30
Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG-TAT for drug delivery across the blood-brain barrier. Biomaterials (2007) 1.24
Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery. J Pharmacol Exp Ther (2007) 1.20
Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB. Am J Physiol Lung Cell Mol Physiol (2007) 1.19
Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. J Leukoc Biol (2007) 1.17
Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. Mol Med (2010) 1.14
Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis. J Immunol (2008) 1.14
Essential role of monocytes and macrophages in the progression of acute pancreatitis. World J Gastroenterol (2010) 1.11
Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide. Am J Physiol Cell Physiol (2006) 1.10
Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity. J Biol Chem (2006) 1.10
Hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells. J Cell Mol Med (2007) 1.09
In vitro and in vivo characterization of MEMS microneedles. Biomed Microdevices (2005) 1.07
Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways. Am J Physiol Cell Physiol (2008) 1.06
Role of MCP-1 in endotoxemia and sepsis. Int Immunopharmacol (2008) 1.05
Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury. Neurosci Lett (2006) 1.04
Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation. J Immunol (2011) 1.03
The neuropeptide substance P is a critical mediator of burn-induced acute lung injury. J Immunol (2008) 1.03
Effect of blast exposure on the brain structure and cognition in Macaca fascicularis. J Neurotrauma (2011) 1.01
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. Eur J Pharmacol (2007) 0.99
Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling. PLoS One (2011) 0.99
A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury. Biochem Biophys Res Commun (2005) 0.99
A novel MHCp binding prediction model. Hum Immunol (2003) 0.99
Blockade of neurokinin-1 receptor attenuates CC and CXC chemokine production in experimental acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol (2006) 0.98
Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury. Pancreas (2008) 0.98
Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury. J Immunol (2007) 0.97
Polymeric micelles anchored with TAT for delivery of antibiotics across the blood-brain barrier. Biopolymers (2008) 0.97
Alterations in spatial learning and memory after forced exercise. Brain Res (2006) 0.96
Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis. J Immunol (2006) 0.96
Expression of the chemokines MCP-1/JE and cytokine-induced neutrophil chemoattractant in early acute pancreatitis. Pancreas (2002) 0.96
Sepsis as a model of SIRS. Front Biosci (Landmark Ed) (2009) 0.95
Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells. J Pharmacol Exp Ther (2009) 0.93
Applications of microarrays in pathogen detection and biodefence. Trends Biotechnol (2008) 0.92
Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. Am J Pathol (2007) 0.92
Involvement of SRC family kinases in substance P-induced chemokine production in mouse pancreatic acinar cells and its significance in acute pancreatitis. J Pharmacol Exp Ther (2009) 0.92
Effect of mitogen-activated protein kinases on chemokine synthesis induced by substance P in mouse pancreatic acinar cells. J Cell Mol Med (2008) 0.92
Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils. Am J Physiol Cell Physiol (2007) 0.92
The role of pro-inflammatory molecules and pharmacological agents in acute pancreatitis and sepsis. Inflamm Allergy Drug Targets (2010) 0.91
Substance P treatment stimulates chemokine synthesis in pancreatic acinar cells via the activation of NF-kappaB. Am J Physiol Gastrointest Liver Physiol (2006) 0.91
Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. Am J Physiol Cell Physiol (2007) 0.90
Gases in the mitochondria. Mitochondrion (2009) 0.90
Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. Br J Pharmacol (2006) 0.89
Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds. Biomaterials (2010) 0.89
Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages. FASEB J (2008) 0.89
Identification of a novel family of proteins in snake venoms. Purification and structural characterization of nawaprin from Naja nigricollis snake venom. J Biol Chem (2003) 0.88
H2S-induced pancreatic acinar cell apoptosis is mediated via JNK and p38 MAP kinase. J Cell Mol Med (2008) 0.88
Hydrogen sulfide in inflammation: friend or foe? Inflamm Allergy Drug Targets (2011) 0.88
Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-kappaB in a mouse model of burn-induced remote acute lung injury. J Immunol (2010) 0.88
Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. J Leukoc Biol (2007) 0.88
Hydrogen sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kappaB and Src-family kinases pathway. Exp Cell Res (2010) 0.87
Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis. J Inflamm (Lond) (2009) 0.87
Hydrogen sulfide: a novel mediator of leukocyte activation. Immunopharmacol Immunotoxicol (2008) 0.86
Neurogenic inflammation in acute pancreatitis. JOP (2005) 0.86
Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. Am J Respir Crit Care Med (2009) 0.86
Preprotachykinin-A gene deletion regulates hydrogen sulfide-induced toll-like receptor 4 signaling pathway in cerulein-treated pancreatic acinar cells. Pancreas (2011) 0.85
Hippocampal theta state in relation to formalin nociception. Pain (2006) 0.85
Hydrogen sulfide as a therapeutic target for inflammation. Expert Opin Ther Targets (2012) 0.85
The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. J Pathol (2006) 0.85
Hydrogen sulfide: regulatory role on blood pressure in hyperhomocysteinemia. Vascul Pharmacol (2010) 0.84
Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. Am J Physiol Gastrointest Liver Physiol (2007) 0.84
Extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase, through nuclear factor-kappaB and activator protein-1, contribute to caerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells. J Pharmacol Exp Ther (2009) 0.84
Treatment with BX471, a nonpeptide CCR1 antagonist, protects mice against acute pancreatitis-associated lung injury by modulating neutrophil recruitment. Pancreas (2007) 0.84
In vivo evaluation of an ultra-thin polycaprolactone film as a wound dressing. J Biomater Sci Polym Ed (2007) 0.84
Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia. J Leukoc Biol (2007) 0.83
Neuroprotection by aminoguanidine after lateral fluid-percussive brain injury in rats: a combined magnetic resonance imaging, histopathologic and functional study. Neuropharmacology (2003) 0.83
Administration of exogenous fractalkine, a CX3C chemokine, is capable of modulating inflammatory response in cecal ligation and puncture-induced sepsis. Shock (2009) 0.83
The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse. Am J Physiol Gastrointest Liver Physiol (2013) 0.82
Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS One (2012) 0.82
Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways. Am J Physiol Cell Physiol (2008) 0.82
Association between an intronic apolipoprotein E polymorphism and bone mineral density in Singaporean Chinese females. Bone (2010) 0.81
Plasma cytokine profiles in preprotachykinin-A knockout mice subjected to polymicrobial sepsis. Mol Med (2009) 0.81
Substance P in polymicrobial sepsis: molecular fingerprint of lung injury in preprotachykinin-A-/- mice. Mol Med (2010) 0.81
PKC δ mediates pro-inflammatory responses in a mouse model of caerulein-induced acute pancreatitis. J Mol Med (Berl) (2010) 0.81
Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Appl Microbiol Biotechnol (2013) 0.79
2', 3'-Cyclic nucleotide 3'-phosphodiesterase cells derived from transplanted marrow stromal cells and host tissue contribute to perineurial compartment formation in injured rat spinal cord. J Neurosci Res (2007) 0.79
Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol (2007) 0.79
The role of neutral endopeptidase in caerulein-induced acute pancreatitis. J Immunol (2011) 0.78
Potential biomarker panel for predicting organ dysfunction and acute coagulopathy in a polytrauma porcine model. Shock (2015) 0.78
Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis: molecular insights. Int J Inflam (2010) 0.78
Expression of nitric oxide synthase isoforms and nitric oxide production in acute pancreatitis and associated lung injury. Pancreatology (2008) 0.78