Published in Pain on December 01, 2003
ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J (2008) 2.18
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. EMBO J (2004) 2.07
ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons. Mol Pain (2005) 1.95
ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain (2006) 1.79
Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases. Curr Opin Pharmacol (2007) 1.68
Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. Neuron (2010) 1.53
ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury. J Pain (2009) 1.50
Dry needling - peripheral and central considerations. J Man Manip Ther (2011) 1.45
Acid-sensitive ion channels and receptors. Handb Exp Pharmacol (2009) 1.43
Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J Neurosci (2004) 1.40
Spinal antinociceptive action of amiloride and its interaction with tizanidine in the rat formalin test. Pain Res Manag (2015) 1.39
Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis. Hypertension (2008) 1.37
Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice. Pain (2008) 1.36
Acid-sensing ion channels: A new target for pain and CNS diseases. Curr Opin Drug Discov Devel (2009) 1.36
Comprehensive phenotyping of group III and IV muscle afferents in mouse. J Neurophysiol (2013) 1.27
Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain. Curr Pain Headache Rep (2008) 1.26
Structure and activity of the acid-sensing ion channels. Am J Physiol Cell Physiol (2012) 1.25
Descending facilitatory pathways from the RVM initiate and maintain bilateral hyperalgesia after muscle insult. Pain (2007) 1.24
Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome. J Intern Med (2011) 1.21
Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans. Pain (2008) 1.20
Ca2+ -permeable acid-sensing ion channels and ischemic brain injury. J Membr Biol (2006) 1.19
A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a. J Biol Chem (2010) 1.17
Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2. Br J Pharmacol (2010) 1.15
Muscle fatigue increases the probability of developing hyperalgesia in mice. J Pain (2007) 1.14
Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache. Pain (2010) 1.13
Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line. J Physiol (2004) 1.12
Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism. J Gen Physiol (2006) 1.12
Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury. J Physiol (2006) 1.10
Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis. J Pain (2009) 1.10
Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits. FASEB J (2012) 1.09
Pain channelopathies. J Physiol (2010) 1.09
Conformational changes associated with proton-dependent gating of ASIC1a. J Biol Chem (2009) 1.09
Blockade of acid sensing ion channels attenuates the exercise pressor reflex in cats. J Physiol (2007) 1.08
Femoral artery occlusion increases expression of ASIC3 in dorsal root ganglion neurons. Am J Physiol Heart Circ Physiol (2010) 1.08
Peripheral pain mechanisms in chronic widespread pain. Best Pract Res Clin Rheumatol (2011) 1.05
Diarylamidines: high potency inhibitors of acid-sensing ion channels. Neuropharmacology (2010) 1.05
Calcitonin gene-related peptide promotes cellular changes in trigeminal neurons and glia implicated in peripheral and central sensitization. Mol Pain (2011) 1.04
A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans. EMBO J (2008) 1.01
An antinociceptive role for substance P in acid-induced chronic muscle pain. Proc Natl Acad Sci U S A (2011) 0.99
Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation. Pain (2011) 0.99
"Intensity-response" effects of electroacupuncture on gastric motility and its underlying peripheral neural mechanism. Evid Based Complement Alternat Med (2013) 0.98
Contrasting phenotypes of putative proprioceptive and nociceptive trigeminal neurons innervating jaw muscle in rat. Mol Pain (2005) 0.98
Enhanced muscle fatigue occurs in male but not female ASIC3-/- mice. Am J Physiol Regul Integr Comp Physiol (2008) 0.98
Expression and function of proton-sensing G-protein-coupled receptors in inflammatory pain. Mol Pain (2009) 0.97
Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts. Am J Physiol Cell Physiol (2008) 0.97
Neurosensory mechanotransduction through acid-sensing ion channels. J Cell Mol Med (2013) 0.97
Role played by acid-sensitive ion channels in evoking the exercise pressor reflex. Am J Physiol Heart Circ Physiol (2008) 0.96
Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke? Prog Neurobiol (2014) 0.96
Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential. Int J Physiol Pathophysiol Pharmacol (2011) 0.96
Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2. Br J Pharmacol (2012) 0.95
ASIC3 channels in multimodal sensory perception. ACS Chem Neurosci (2010) 0.95
Basic aspects of musculoskeletal pain: from acute to chronic pain. J Man Manip Ther (2011) 0.95
Physiological and pathological functions of acid-sensing ion channels in the central nervous system. Curr Drug Targets (2012) 0.94
Algesic agents exciting muscle nociceptors. Exp Brain Res (2009) 0.94
Assessment of the potential role of muscle spindle mechanoreceptor afferents in chronic muscle pain in the rat masseter muscle. PLoS One (2010) 0.94
Cutaneous tactile allodynia associated with microvascular dysfunction in muscle. Mol Pain (2008) 0.93
Two mechanisms involved in trigeminal CGRP release: implications for migraine treatment. Headache (2012) 0.92
Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain. Neurosci Lett (2009) 0.92
Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience (2016) 0.92
Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia. Mol Pain (2014) 0.92
Blockade of acid sensing ion channels attenuates the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. J Physiol (2011) 0.91
SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res (2008) 0.91
Acidic saline-induced primary and secondary mechanical hyperalgesia in mice. J Pain (2009) 0.91
Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride. J Biol Chem (2011) 0.91
ENaCs and ASICs as therapeutic targets. Am J Physiol Cell Physiol (2012) 0.91
Aerobic exercise alters analgesia and neurotrophin-3 synthesis in an animal model of chronic widespread pain. Phys Ther (2010) 0.90
Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release. Ann Rheum Dis (2009) 0.90
ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections. Pain Res Treat (2011) 0.89
Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. J Biol Chem (2010) 0.88
Acid-sensing ion channel 3 mediates peripheral anti-hyperalgesia effects of acupuncture in mice inflammatory pain. J Biomed Sci (2011) 0.88
Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis. Arthritis Rheum (2013) 0.88
Contribution of transient receptor potential ankyrin 1 to chronic pain in aged mice with complete Freund's adjuvant-induced arthritis. Arthritis Rheumatol (2014) 0.88
Acid-sensing ion channels in pathological conditions. Adv Exp Med Biol (2013) 0.87
Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression. Neuroscience (2007) 0.87
Effect of a temperature increase in the non-noxious range on proton-evoked ASIC and TRPV1 activity. Pflugers Arch (2010) 0.87
The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function. J Biol Chem (2010) 0.87
Animal models of fibromyalgia. Arthritis Res Ther (2013) 0.87
Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis. J Biomed Sci (2012) 0.87
Analgesic Effect of Electroacupuncture in a Mouse Fibromyalgia Model: Roles of TRPV1, TRPV4, and pERK. PLoS One (2015) 0.86
Subunit and frequency-dependent inhibition of acid sensing ion channels by local anesthetic tetracaine. Mol Pain (2013) 0.85
Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition. Neuroscience (2011) 0.85
Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels. Protein Sci (2005) 0.85
Highly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels. J Biol Chem (2012) 0.85
Acid-sensing ion channels under hypoxia. Channels (Austin) (2013) 0.84
ASIC2 subunits facilitate expression at the cell surface and confer regulation by PSD-95. PLoS One (2014) 0.84
Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats. Auton Neurosci (2012) 0.84
Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome. Pain Res Treat (2011) 0.84
Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing interleukin-10 in mice. Pain (2016) 0.83
Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain. Mol Pain (2014) 0.83
Chronic hypoxia-induced acid-sensitive ion channel expression in chemoafferent neurons contributes to chemoreceptor hypersensitivity. Am J Physiol Lung Cell Mol Physiol (2011) 0.83
Use of Animal Models in Understanding Cancer-induced Bone Pain. Cancer Growth Metastasis (2015) 0.83
ASICs as therapeutic targets for migraine. Neuropharmacology (2015) 0.83
Age-dependent sensitization of cutaneous nociceptors during developmental inflammation. Mol Pain (2014) 0.82
Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium. Arthritis Res Ther (2014) 0.82
Linalool and linalool complexed in β-cyclodextrin produce anti-hyperalgesic activity and increase Fos protein expression in animal model for fibromyalgia. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.82
The pharmacology and therapeutic potential of small molecule inhibitors of acid-sensing ion channels in stroke intervention. Acta Pharmacol Sin (2012) 0.81
Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels. Respir Res (2006) 0.81
Assessment of avoidance behaviors in mouse models of muscle pain. Neuroscience (2013) 0.81
TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation. Pain (2012) 0.81
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28
The menthol receptor TRPM8 is the principal detector of environmental cold. Nature (2007) 6.16
Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell (2004) 6.15
A component of innate immunity prevents bacterial biofilm development. Nature (2002) 4.73
Motile cilia of human airway epithelia are chemosensory. Science (2009) 4.40
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron (2002) 4.11
Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci (2006) 3.95
Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. Nature (2003) 3.61
Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape. Cell (2002) 3.53
An in vitro model of differentiated human airway epithelia. Methods for establishing primary cultures. Methods Mol Biol (2002) 3.48
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36
Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer. J Clin Invest (2008) 3.33
Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A (2002) 3.05
Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci (2003) 3.05
The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell (2009) 3.03
Origins of cystic fibrosis lung disease. N Engl J Med (2015) 2.97
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94
Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A (2002) 2.56
Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a. Proc Natl Acad Sci U S A (2004) 2.56
The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol (2004) 2.48
Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Med (2007) 2.28
Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1. Curr Biol (2003) 2.25
Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia. Cell (2010) 2.24
Identification and function of thermosensory neurons in Drosophila larvae. Nat Neurosci (2003) 2.20
Seizure termination by acidosis depends on ASIC1a. Nat Neurosci (2008) 2.18
Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons. J Biol Chem (2004) 2.15
TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci (2009) 2.07
The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med (2011) 2.01
The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron (2009) 1.97
Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am J Respir Crit Care Med (2010) 1.94
Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses. J Neurosci (2008) 1.90
The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci (2002) 1.82
ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain (2006) 1.79
Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci U S A (2004) 1.77
Drosophila hygrosensation requires the TRP channels water witch and nanchung. Nature (2007) 1.73
Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines. Proc Natl Acad Sci U S A (2006) 1.73
Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia. Proc Natl Acad Sci U S A (2004) 1.66
Species and strain differences in rodent sciatic nerve anatomy: implications for studies of neuropathic pain. Pain (2008) 1.65
Contribution of Drosophila DEG/ENaC genes to salt taste. Neuron (2003) 1.65
Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. J Clin Invest (2008) 1.64
Processing and function of CFTR-DeltaF508 are species-dependent. Proc Natl Acad Sci U S A (2007) 1.62
Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts. Toxicol Sci (2004) 1.60
Pathology of gastrointestinal organs in a porcine model of cystic fibrosis. Am J Pathol (2010) 1.60
Differential response properties of IB(4)-positive and -negative unmyelinated sensory neurons to protons and capsaicin. J Neurophysiol (2003) 1.56
Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors. J Neurosci (2005) 1.56
ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury. J Pain (2009) 1.50
Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit. Biol Psychiatry (2007) 1.50
Lysozyme secretion by submucosal glands protects the airway from bacterial infection. Am J Respir Cell Mol Biol (2005) 1.49
Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia. Proc Natl Acad Sci U S A (2008) 1.49
Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain (2005) 1.46
Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). Biochem J (2002) 1.46
TRPA channels distinguish gravity sensing from hearing in Johnston's organ. Proc Natl Acad Sci U S A (2009) 1.45
Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain (2009) 1.42
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. Blood (2011) 1.42
Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. J Neurosci (2005) 1.40
Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Mol Pharmacol (2004) 1.40
Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse. Pain (2005) 1.40
Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J Neurosci (2004) 1.40
Patients with sickle cell disease have increased sensitivity to cold and heat. Am J Hematol (2012) 1.38
The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology (2004) 1.36
Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance. Proc Natl Acad Sci U S A (2011) 1.36
Acid-sensing ion channels: A new target for pain and CNS diseases. Curr Opin Drug Discov Devel (2009) 1.36
Biochemical basis of touch perception: mechanosensory function of degenerin/epithelial Na+ channels. J Biol Chem (2001) 1.34
ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J Neurosci (2009) 1.33
Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Proc Natl Acad Sci U S A (2003) 1.33
Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine. J Neurosci (2009) 1.30
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest (2013) 1.30
Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits. Proc Natl Acad Sci U S A (2009) 1.29
Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior. J Neurosci (2009) 1.29
TRPA1 mediates mechanical sensitization in nociceptors during inflammation. PLoS One (2012) 1.29
ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster. PLoS Genet (2012) 1.27
Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain. Proc Natl Acad Sci U S A (2004) 1.26
TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons. PLoS One (2010) 1.25
Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR. Am J Physiol Lung Cell Mol Physiol (2005) 1.25
Stomatin modulates gating of acid-sensing ion channels. J Biol Chem (2004) 1.24
Fear and panic in humans with bilateral amygdala damage. Nat Neurosci (2013) 1.22
Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse. Gastroenterology (2007) 1.21
Eukaryotic operon-like transcription of functionally related genes in Drosophila. Proc Natl Acad Sci U S A (2006) 1.20