PubRank

Thomas Wirth

Author PubWeight™ 125.39‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004 5.06
2 MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Blood 2008 3.03
3 Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem 2003 1.91
4 IKK mediates ischemia-induced neuronal death. Nat Med 2005 1.83
5 NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett 2010 1.67
6 Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus. J Natl Cancer Inst 2006 1.63
7 NF-kappaB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program. Nucleic Acids Res 2005 1.57
8 TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway. Bone 2009 1.55
9 Advances in the understanding of MYC-induced lymphomagenesis. Br J Haematol 2010 1.41
10 Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Hepatology 2012 1.40
11 Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. Cancer Res 2010 1.40
12 Epithelial-mesenchymal transition: NF-kappaB takes center stage. Cell Cycle 2004 1.38
13 KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma. Blood 2010 1.38
14 Deficiency of innate and acquired immunity caused by an IKBKB mutation. N Engl J Med 2013 1.37
15 Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. Blood 2002 1.32
16 FOXO1 is a tumor suppressor in classical Hodgkin lymphoma. Blood 2012 1.31
17 Reduction of marginal zone B cells in CD22-deficient mice. Eur J Immunol 2002 1.31
18 The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells. J Immunol 2003 1.25
19 Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma. Blood 2005 1.24
20 Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo. J Clin Invest 2007 1.24
21 Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression. Blood 2004 1.23
22 Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells. J Biol Chem 2002 1.21
23 Identification of novel Myc target genes with a potential role in lymphomagenesis. Nucleic Acids Res 2004 1.20
24 Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure. Proc Natl Acad Sci U S A 2012 1.17
25 Iodoxolone-based hypervalent iodine reagents. Org Lett 2009 1.15
26 Dietary polyphenol quercetin targets pancreatic cancer stem cells. Int J Oncol 2010 1.14
27 A cellular model for Friedreich Ataxia reveals small-molecule glutathione peroxidase mimetics as novel treatment strategy. Hum Mol Genet 2002 1.14
28 Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct2, PU.1, and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas, and Hodgkin lymphomas. J Pathol 2004 1.12
29 The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis. Blood 2009 1.11
30 The IKK-2/Ikappa Balpha /NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha -deficient mice. J Biol Chem 2001 1.11
31 C-myc activation impairs the NF-kappaB and the interferon response: implications for the pathogenesis of Burkitt's lymphoma. Int J Cancer 2007 1.11
32 Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells. J Biotechnol 2007 1.10
33 BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. EMBO J 2007 1.10
34 Advanced organic synthesis using microreactor technology. Org Biomol Chem 2006 1.10
35 FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model. Cardiovasc Res 2011 1.09
36 IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling. J Neurosci 2012 1.08
37 Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses. Cancer Res 2009 1.06
38 Reversible lymphomagenesis in conditionally c-MYC expressing mice. Int J Cancer 2004 1.06
39 Iodine monochloride-amine complexes: an experimental and computational approach to new chiral electrophiles. Chemistry 2005 1.06
40 Reagent-controlled stereoselective iodolactonizations. Org Lett 2002 1.03
41 B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice. J Exp Med 2003 1.02
42 BOB.1/OBF.1 deficiency affects marginal-zone B-cell compartment. Mol Cell Biol 2002 1.01
43 Challenges in monoclonal antibody-based therapies. Ann Med 2009 1.00
44 Hypervalent iodine goes catalytic. Angew Chem Int Ed Engl 2006 1.00
45 Repressing the repressor: a new mode of MYC action in lymphomagenesis. Cell Cycle 2009 1.00
46 Adenovirus mediated herpes simplex virus-thymidine kinase/ganciclovir gene therapy for resectable malignant glioma. Curr Gene Ther 2009 0.99
47 Iodine electrophiles in stereoselective reactions: recent developments and synthetic applications. Chem Soc Rev 2004 0.99
48 Three-step tumor targeting of paclitaxel using biotinylated PLA-PEG nanoparticles and avidin-biotin technology: Formulation development and in vitro anticancer activity. Eur J Pharm Biopharm 2008 0.99
49 Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut 2006 0.98
50 Highly stereoselective metal-free oxyaminations using chiral hypervalent iodine reagents. Angew Chem Int Ed Engl 2012 0.94
51 Epithelial-mesenchymal transition in pancreatic carcinoma. Cancers (Basel) 2010 0.94
52 Improving safety of gene therapy. Curr Drug Saf 2008 0.94
53 Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques. Am J Pathol 2009 0.93
54 Determination of hip reduction in spica cast treatment for DDH: a comparison of radiography and ultrasound. J Child Orthop 2009 0.92
55 Controlling hazardous chemicals in microreactors: synthesis with iodine azide. Beilstein J Org Chem 2009 0.92
56 Selenium-containing naphthalimides as anticancer agents: design, synthesis and bioactivity. Bioorg Med Chem 2012 0.92
57 Long-term IKK2/NF-κB signaling in pancreatic β-cells induces immune-mediated diabetes. Diabetes 2013 0.90
58 Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells. J Neurochem 2005 0.88
59 Stereoselective rearrangements with chiral hypervalent iodine reagents. Angew Chem Int Ed Engl 2013 0.88
60 Myc regulates embryonic vascular permeability and remodeling. Circ Res 2009 0.88
61 Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release. J Biol Chem 2004 0.88
62 In vivo implantation of 2,2'-bis(oxazoline)-linked poly-epsilon-caprolactone: proof for enzyme sensitive surface erosion and biocompatibility. Eur J Pharm Sci 2008 0.88
63 Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging. Mol Neurodegener 2013 0.88
64 Nonunion of forearm shaft fractures in children after intramedullary nailing. J Pediatr Orthop B 2009 0.87
65 CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice. Eur J Immunol 2002 0.87
66 Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation. J Biol Chem 2003 0.87
67 A practical microreactor for electrochemistry in flow. Beilstein J Org Chem 2011 0.86
68 Nuclear factor κB activation impairs ependymal ciliogenesis and links neuroinflammation to hydrocephalus formation. J Neurosci 2012 0.86
69 Evaluation of cancer virotherapy with attenuated replicative Semliki forest virus in different rodent tumor models. Int J Cancer 2007 0.86
70 Tetrafluoro-IBA and-IBX: hypervalent iodine reagents. Angew Chem Int Ed Engl 2007 0.86
71 Flexible stereoselective functionalizations of ketones through umpolung with hypervalent iodine reagents. Angew Chem Int Ed Engl 2014 0.86
72 Diazo compounds in continuous-flow technology. ChemSusChem 2014 0.85
73 Pre-targeting and direct immunotargeting of liposomal drug carriers to ovarian carcinoma. PLoS One 2012 0.85
74 Selenocyclizations: control by coordination and by the counterion. Angew Chem Int Ed Engl 2004 0.85
75 Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-kappa B and extracellular signal-regulated protein kinase activation. Biochem Pharmacol 2002 0.85
76 Hypervalent iodine-mediated aziridination of alkenes: mechanistic insights and requirements for catalysis. Chemistry 2007 0.85
77 Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB. Nucleic Acids Res 2013 0.85
78 Hypervalent iodine-catalyzed oxidative functionalizations including stereoselective reactions. Chem Asian J 2014 0.85
79 Decitabine represses translocated MYC oncogene in Burkitt lymphoma. J Pathol 2013 0.85
80 B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice. J Immunol 2005 0.85
81 A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo. Nucleic Acids Res 2005 0.85
82 Doxycycline regulation in a single retroviral vector by an autoregulatory loop facilitates controlled gene expression in liver cells. Nucleic Acids Res 2004 0.84
83 Critical role of RelB serine 368 for dimerization and p100 stabilization. J Biol Chem 2003 0.84
84 Novel lactonization with phenonium ion participation induced by hypervalent iodine reagents. Org Lett 2003 0.84
85 Expression of the aldehyde dehydrogenase 2-like gene is controlled by BOB.1/OBF.1 in B lymphocytes. J Biol Chem 2003 0.84
86 15-Lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma. In Vivo 2012 0.83
87 Btk expression is controlled by Oct and BOB.1/OBF.1. Nucleic Acids Res 2006 0.83
88 Intelligent microflow: development of self-optimizing reaction systems. Angew Chem Int Ed Engl 2011 0.82
89 A versatile and highly reactive polyfluorinated hypervalent iodine(III) compound. Angew Chem Int Ed Engl 2010 0.82
90 Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors. FASEB J 2012 0.81
91 Tumor-specific adenoviral gene therapy: transcriptional repression of gene expression by utilizing p53-signal transduction pathways. Cancer Gene Ther 2004 0.81
92 Selenium-catalyzed regioselective cyclization of unsaturated carboxylic acids using hypervalent iodine oxidants. Org Lett 2011 0.81
93 Protein transduction domains fused to virus receptors improve cellular virus uptake and enhance oncolysis by tumor-specific replicating vectors. J Virol 2004 0.81
94 BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression. Genes Cancer 2010 0.80
95 Catalytic use of selenium electrophiles in cyclizations. Org Lett 2007 0.80
96 Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP. Neurobiol Dis 2012 0.80
97 Avidin fusion protein-expressing lentiviral vector for targeted drug delivery. Hum Gene Ther 2009 0.80
98 MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts. Carcinogenesis 2013 0.80
99 New and efficient chiral selenium electrophiles. Chemistry 2002 0.79
100 Enantioselective diamination with novel chiral hypervalent iodine catalysts. Chemistry 2014 0.79
101 Application of XPS and ToF-SIMS for surface chemical analysis of DNA microarrays and their substrates. Anal Bioanal Chem 2009 0.79
102 Initiation of dopaminergic differentiation of Nurr1(-) mesencephalic precursor cells depends on activation of multiple mitogen-activated protein kinase pathways. Stem Cells 2009 0.79
103 Organocatalytic stereoselective iodoamination of alkenes. Chemistry 2014 0.79
104 Ritter reactions in flow. ChemSusChem 2011 0.79
105 Green chemistry with selenium reagents: development of efficient catalytic reactions. Angew Chem Int Ed Engl 2009 0.79
106 [(18)F]6-fluoro-3,4-dihydroxy-L-phenylalanine--recent modern syntheses for an elusive radiotracer. J Labelled Comp Radiopharm 2015 0.78
107 The talar axis-first metatarsal base angle in CVT treatment: a comparison of idiopathic and non-idiopathic cases treated with the Dobbs method. J Child Orthop 2012 0.78
108 Subtalar extra-articular screw arthroereisis (SESA) for the treatment of flexible flatfoot in children. J Child Orthop 2014 0.78
109 Arthroscopic reduction and acetabuloplasty for the treatment of dislocated hips in children of walking age: a preliminary report. Arch Orthop Trauma Surg 2014 0.78
110 Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury. J Trauma Acute Care Surg 2013 0.77
111 Direct iodination of alkanes. Org Lett 2003 0.77
112 Adlayers of dimannoside thiols on gold: surface chemical analysis. Langmuir 2011 0.77
113 Inflammation, regeneration, and transformation in the pancreas: results of the Collaborative Research Center 518 (SFB 518) at the University of Ulm. Pancreas 2011 0.77
114 New roles for Bcl10 in B-cell development and LPS response. Trends Immunol 2004 0.77
115 Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line. J Pathol 2005 0.76
116 Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator. Nucleic Acids Res 2004 0.76
117 Synthesis of indene derivatives via electrophilic cyclization. Org Lett 2009 0.76
118 Fast synthesis of benzofluorenes by selenium-mediated carbocyclizations. Angew Chem Int Ed Engl 2009 0.76
119 Transgastrically placed endoscopic vacuum-assisted closure system as an addition to transgastric necrosectomy in necrotizing pancreatitis (with video). Gastrointest Endosc 2012 0.76
120 Flow chemistry: enabling technology in drug discovery and process research. ChemSusChem 2012 0.76
121 Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation. Beilstein J Org Chem 2013 0.75
122 Solvent-free reactions with hypervalent iodine reagents. Org Lett 2005 0.75
123 Intestinal carcinogenesis: IKK can go all the way. J Clin Invest 2011 0.75
124 Focussing of extracorporal shock wave therapy (ESWT) in the treatment of calcifying tendinitis. Joint Bone Spine 2002 0.75
125 Targeted delivery via avidin fusion protein: intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes. Eur J Pharm Sci 2012 0.75
126 Efficient synthesis of a small molecule, nonpeptide inhibitor of LFA-1. Org Lett 2010 0.75
127 Soluble vascular endothelial growth factor receptor-1 improves therapeutic efficacy of suicide gene therapy in an angiogenesis-independent manner. Hum Gene Ther 2014 0.75
128 Rapid Generation and Safe Use of Carbenes Enabled by a Novel Flow Protocol with In-line IR spectroscopy. Chemistry 2015 0.75
129 Therapeutic delivery using gene-delivery methods. Ther Deliv 2011 0.75
130 Selenium-mediated synthesis of biaryls through rearrangement. Org Lett 2010 0.75
131 Multiple metachronous osteosarcomas in a patient with Li-Fraumeni syndrome. Pediatr Hematol Oncol 2013 0.75
132 Clubfoot associated with preaxial polydactyly. J Pediatr Orthop B 2014 0.75
133 Organic synthesis in flow for medicinal chemistry. Bioorg Med Chem 2017 0.75
134 Hypervalent bromine compounds: smaller, more reactive analogues of hypervalent iodine compounds. Angew Chem Int Ed Engl 2009 0.75
135 Lack of correlation between NF-kappaB activation and induction of programmed cell death in PC12 pheochromocytoma cells treated with 6-hydroxydopamine or the cannabinoid receptor 1-agonist CP55,940. Biochem Pharmacol 2002 0.75
136 Reactivity, chemoselectivity, and diastereoselectivity of the oxyfunctionalization of chiral allylic alcohols and derivatives in microemulsions: comparison of the chemical oxidation by the hydrogen peroxide/sodium molybdate system with the photooxygenation. J Am Chem Soc 2004 0.75