| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells.
|
Circulation
|
2002
|
2.02
|
|
2
|
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
|
J Clin Invest
|
2005
|
1.76
|
|
3
|
Ghrelin restores the endothelin 1/nitric oxide balance in patients with obesity-related metabolic syndrome.
|
Hypertension
|
2009
|
1.62
|
|
4
|
Generalized impairment of vasodilator reactivity during hyperinsulinemia in patients with obesity-related metabolic syndrome.
|
Am J Physiol Endocrinol Metab
|
2010
|
1.60
|
|
5
|
Adiponectin isoforms in elderly patients with or without coronary artery disease.
|
J Am Geriatr Soc
|
2010
|
1.52
|
|
6
|
Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes.
|
Diabetes
|
2007
|
1.42
|
|
7
|
An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment.
|
Regul Pept
|
2007
|
1.34
|
|
8
|
Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects.
|
Intern Emerg Med
|
2011
|
1.30
|
|
9
|
Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis.
|
Circulation
|
2005
|
1.22
|
|
10
|
Ghrelin improves endothelial function in patients with metabolic syndrome.
|
Circulation
|
2005
|
1.18
|
|
11
|
Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling.
|
Diabetes
|
2006
|
1.18
|
|
12
|
Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation.
|
PLoS One
|
2010
|
1.14
|
|
13
|
G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.
|
Circulation
|
2004
|
1.09
|
|
14
|
A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects.
|
Diabetes
|
2003
|
1.08
|
|
15
|
Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes.
|
Atherosclerosis
|
2009
|
1.08
|
|
16
|
Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.
|
FASEB J
|
2004
|
1.07
|
|
17
|
Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.
|
J Clin Endocrinol Metab
|
2011
|
1.06
|
|
18
|
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.
|
Diabetes
|
2004
|
1.05
|
|
19
|
The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients.
|
Diabetes
|
2011
|
1.05
|
|
20
|
Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus.
|
Metabolism
|
2007
|
1.03
|
|
21
|
Endothelial function and arterial stiffness in normotensive normoglycemic first-degree relatives of diabetic patients are independent of the metabolic syndrome.
|
Nutr Metab Cardiovasc Dis
|
2007
|
1.01
|
|
22
|
Effects of GLP-1 on forearm vasodilator function and glucose disposal during hyperinsulinemia in the metabolic syndrome.
|
Diabetes Care
|
2012
|
0.99
|
|
23
|
Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells.
|
Am J Physiol Endocrinol Metab
|
2006
|
0.99
|
|
24
|
Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients.
|
Am J Physiol Endocrinol Metab
|
2006
|
0.99
|
|
25
|
Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.
|
FASEB J
|
2003
|
0.98
|
|
26
|
Metabolic syndrome, chronic kidney, and cardiovascular diseases: role of adipokines.
|
Cardiol Res Pract
|
2011
|
0.96
|
|
27
|
TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice.
|
Diabetes
|
2012
|
0.94
|
|
28
|
Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice.
|
Arterioscler Thromb Vasc Biol
|
2011
|
0.94
|
|
29
|
The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.
|
Diabetes Care
|
2004
|
0.93
|
|
30
|
The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.
|
J Clin Endocrinol Metab
|
2003
|
0.93
|
|
31
|
Aortic stiffness and hypotension episodes are associated with impaired cognitive function in older subjects with subjective complaints of memory loss.
|
Int J Cardiol
|
2013
|
0.92
|
|
32
|
Pioglitazone improves endothelial and adipose tissue dysfunction in pre-diabetic CAD subjects.
|
Atherosclerosis
|
2010
|
0.90
|
|
33
|
High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway.
|
Am J Respir Cell Mol Biol
|
2012
|
0.90
|
|
34
|
Insulin receptor β-subunit haploinsufficiency impairs hippocampal late-phase LTP and recognition memory.
|
Neuromolecular Med
|
2012
|
0.89
|
|
35
|
Type 2 diabetes mellitus impairs the maturation of endothelial progenitor cells and increases the number of circulating endothelial cells in peripheral blood.
|
Cytometry A
|
2012
|
0.89
|
|
36
|
Identification of multipotent cytotrophoblast cells from human first trimester chorionic villi.
|
Cloning Stem Cells
|
2009
|
0.87
|
|
37
|
Hypoglycemia assessed by continuous glucose monitoring is associated with preclinical atherosclerosis in individuals with impaired glucose tolerance.
|
PLoS One
|
2011
|
0.86
|
|
38
|
Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes.
|
J Clin Endocrinol Metab
|
2003
|
0.86
|
|
39
|
Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness.
|
Diabetes
|
2011
|
0.86
|
|
40
|
Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.
|
EMBO Mol Med
|
2013
|
0.85
|
|
41
|
Pharmacogenomics and pharmacogenetics of thiazolidinediones: role in diabetes and cardiovascular risk factors.
|
Pharmacogenomics
|
2014
|
0.85
|
|
42
|
Platelet isoprostane overproduction in diabetic patients treated with aspirin.
|
Diabetes
|
2012
|
0.85
|
|
43
|
Sildenafil reduces insulin-resistance in human endothelial cells.
|
PLoS One
|
2011
|
0.85
|
|
44
|
Early vascular and metabolic effects of rosuvastatin compared with simvastatin in patients with type 2 diabetes.
|
Atherosclerosis
|
2009
|
0.84
|
|
45
|
Atherosclerosis severity but not undiagnosed diabetes predicts new cardiovascular events of subjects in secondary cardiovascular prevention.
|
Atherosclerosis
|
2012
|
0.83
|
|
46
|
Asthma and COPD in an Italian adult population: role of BMI considering the smoking habit.
|
Respir Med
|
2013
|
0.83
|
|
47
|
The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy.
|
Diabetes
|
2003
|
0.83
|
|
48
|
Metabolic syndrome and risk of pulmonary involvement.
|
Respir Med
|
2009
|
0.83
|
|
49
|
Deterioration of glucose homeostasis in type 2 diabetic patients one year after beginning of statins therapy.
|
Atherosclerosis
|
2012
|
0.82
|
|
50
|
Tumor necrosis factor-alpha antagonism improves vasodilation during hyperinsulinemia in metabolic syndrome.
|
Diabetes Care
|
2008
|
0.81
|
|
51
|
Elbow deformities in a patient with mandibuloacral dysplasia type A.
|
Am J Med Genet A
|
2010
|
0.80
|
|
52
|
Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation.
|
Atherosclerosis
|
2010
|
0.80
|
|
53
|
Relationship between plasma free fatty acids and uncoupling protein-3 gene expression in skeletal muscle of obese subjects: in vitro evidence of a causal link.
|
Clin Endocrinol (Oxf)
|
2002
|
0.79
|
|
54
|
Serum glucocorticoid inducible kinase (SGK)-1 protects endothelial cells against oxidative stress and apoptosis induced by hyperglycaemia.
|
Acta Diabetol
|
2014
|
0.78
|
|
55
|
A systems medicine clinical platform for understanding and managing non- communicable diseases.
|
Curr Pharm Des
|
2014
|
0.77
|
|
56
|
Effects of switching from NPH insulin to insulin glargine in patients with type 2 diabetes: the retrospective, observational LAUREL study in Italy.
|
Acta Diabetol
|
2013
|
0.77
|
|
57
|
Impact of VEGF gene polymorphisms in elderly cancer patients: clinical outcome and toxicity.
|
Pharmacogenomics
|
2015
|
0.77
|
|
58
|
Acute hyperglycemia reduces cerebrovascular reactivity: the role of glycemic variability.
|
J Clin Endocrinol Metab
|
2014
|
0.76
|
|
59
|
Human placental lactogen (hPL-A) activates signaling pathways linked to cell survival and improves insulin secretion in human pancreatic islets.
|
Islets
|
2011
|
0.76
|
|
60
|
Post-traumatic stress disorder, coping strategies and type 2 diabetes: psychometric assessment after L'Aquila earthquake.
|
Acta Diabetol
|
2014
|
0.76
|
|
61
|
Parathyroid hormone and insulin resistance in distinct phenotypes of severe obesity: a cross-sectional analysis in middle-aged men and premenopausal women.
|
J Clin Endocrinol Metab
|
2012
|
0.75
|
|
62
|
The mitochondrial Italian Human Proteome Project initiative (mt-HPP).
|
Mol Biosyst
|
2013
|
0.75
|
|
63
|
HLA-DRB1*13:01 allele in the genetic susceptibility to colorectal carcinoma.
|
Int J Cancer
|
2014
|
0.75
|
|
64
|
Insulin resistance and increased intimal medial thickness in glucose tolerant offspring of type 2 diabetic subjects carrying the D298D genotype of endothelial nitric oxide synthase.
|
Arterioscler Thromb Vasc Biol
|
2006
|
0.75
|