Published in Biol Pharm Bull on February 01, 2004
Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics. ACS Med Chem Lett (2015) 0.75
2',6'-dimethylphenylalanine: a useful aromatic amino Acid surrogate for tyr or phe residue in opioid peptides. Int J Med Chem (2012) 0.75
Effect of acute hypoxia on blood flow in vertebral and internal carotid arteries. Exp Physiol (2012) 1.56
Central command contributes to increased blood flow in the noncontracting muscle at the start of one-legged dynamic exercise in humans. J Appl Physiol (1985) (2012) 1.46
Sporadic heterozygous frameshift mutation of HESX1 causing pituitary and optic nerve hypoplasia and combined pituitary hormone deficiency in a Japanese patient. J Clin Endocrinol Metab (2003) 1.34
Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2. J Med Chem (2005) 1.02
The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects. Clin Physiol Funct Imaging (2011) 1.00
Five-year follow-up study of mother-to-child transmission of Helicobacter pylori infection detected by a random amplified polymorphic DNA fingerprinting method. J Clin Microbiol (2005) 0.98
Endomorphin 2 analogues containing Dmp residue as an aromatic amino acid surrogate with high mu-opioid receptor affinity and selectivity. Bioorg Med Chem (2003) 0.97
Effect of intermittent hypoxia on oxygen uptake during submaximal exercise in endurance athletes. Eur J Appl Physiol (2004) 0.97
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem (2006) 0.97
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice. J Pharmacol Exp Ther (2004) 0.96
Structural studies of [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond. Bioorg Med Chem (2003) 0.94
Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties. J Med Chem (2004) 0.91
Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse. Eur J Pharmacol (2005) 0.90
Enhanced Fe ion-uptake activity in Helicobacter pylori strains isolated from patients with iron-deficiency anemia. Clin Infect Dis (2008) 0.90
Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia. J Med Chem (2003) 0.89
Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia. J Med Chem (2004) 0.89
Perceived exertion is not necessarily associated with altered brain activity during exercise. J Physiol Anthropol (2009) 0.87
Blood flow distribution during heat stress: cerebral and systemic blood flow. J Cereb Blood Flow Metab (2013) 0.87
Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists. Bioorg Med Chem (2006) 0.87
Ventilatory and circulatory responses at the onset of exercise after eccentric exercise. Eur J Appl Physiol (2006) 0.85
Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3). Bioorg Med Chem Lett (2005) 0.85
Possible involvement of β-endorphin in docosahexaenoic acid-induced antinociception. Eur J Pharmacol (2011) 0.84
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore. J Med Chem (2009) 0.84
A decrease in spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation by phenylephrine reflects reduced skin blood flow. Anesth Analg (2014) 0.84
Quantification of delayed oxygenation in ipsilateral primary motor cortex compared with contralateral side during a unimanual dominant-hand motor task using near-infrared spectroscopy. Brain Res (2008) 0.83
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem (2007) 0.83
Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1. Pharmacol Biochem Behav (2006) 0.83
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem (2005) 0.83
Acceleration with exercise during head-down bed rest preserves upright exercise responses. Aviat Space Environ Med (2004) 0.82
Intensive cycle training with artificial gravity maintains muscle size during bed rest. Aviat Space Environ Med (2005) 0.82
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore. Bioorg Med Chem (2007) 0.82
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem (2008) 0.82
Photo-triggered fluorescent labelling of recombinant proteins in live cells. Chem Commun (Camb) (2015) 0.81
Dynamic cerebral autoregulation during and after handgrip exercise in humans. J Appl Physiol (1985) (2010) 0.81
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor. Bioorg Med Chem Lett (2010) 0.80
Predominance of mother-to-child transmission of Helicobacter pylori infection detected by random amplified polymorphic DNA fingerprinting analysis in Japanese families. Pediatr Infect Dis J (2008) 0.80
Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. Bioorg Med Chem (2010) 0.80
Kinetics of exercise-induced neural activation; interpretive dilemma of altered cerebral perfusion. Exp Physiol (2011) 0.80
Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform. Bioorg Med Chem Lett (2007) 0.80
Dual kinetically controlled native chemical ligation using a combination of sulfanylproline and sulfanylethylanilide peptide. Org Lett (2011) 0.79
Cell-penetrating peptide-conjugated XIAP-inhibitory cyclic hexapeptides enter into Jurkat cells and inhibit cell proliferation. FEBS J (2008) 0.79
Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities. Bioorg Med Chem Lett (2003) 0.79
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging. J Med Chem (2008) 0.79
Ventilatory and heart rate responses at the onset of chair rotation in man. Jpn J Physiol (2004) 0.78
Ventilatory and circulatory responses at the onset of dominant and non-dominant limb exercise. Eur J Appl Physiol (2007) 0.78
Blood flow in internal carotid and vertebral arteries during graded lower body negative pressure in humans. Exp Physiol (2015) 0.78
Tendon vibration attenuates superficial venous vessel response of the resting limb during static arm exercise. J Physiol Anthropol (2012) 0.78
New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. Bioorg Med Chem Lett (2005) 0.78
ORL1 and opioid receptor preferences of nociceptin and dynorphin A analogues with Dmp substituted for N-terminal aromatic residues. Bioorg Med Chem (2006) 0.78
Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity. Bioorg Med Chem Lett (2002) 0.78
Superficial venous vascular response of the resting limb during static exercise and postexercise muscle ischemia. Appl Physiol Nutr Metab (2013) 0.78
Changes in ventilatory responses to hypercapnia and hypoxia after intermittent hypoxia in humans. Respir Physiol Neurobiol (2005) 0.78
Synthesis and antinociceptive activity of cyclic endomorphin-2 and morphiceptin analogs. Biochem Pharmacol (2005) 0.77
Receptor binding properties and antinociceptive effects of chimeric peptides consisting of a micro-opioid receptor agonist and an ORL1 receptor antagonist. Biol Pharm Bull (2007) 0.77
Occupational liver injury due to N,N-dimethylformamide in the synthetics industry. Intern Med (2009) 0.77
Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model. J Clin Invest (2016) 0.77
Blood flow and arterial vessel diameter change during graded handgrip exercise in dominant and non-dominant forearms of tennis players. Adv Exp Med Biol (2010) 0.77
Cycle ergometer exercise to counteract muscle atrophy during unilateral lower limb suspension. Aviat Space Environ Med (2009) 0.77
Examination of native chemical ligation using peptidyl prolyl thioesters. Chem Commun (Camb) (2013) 0.76
Effect of a repeated series of intermittent hypoxic exposures on ventilatory response in humans. High Alt Med Biol (2005) 0.76
One-pot/sequential native chemical ligation using N-sulfanylethylanilide peptide. Chem Rec (2012) 0.76
Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-amide. Bioorg Med Chem Lett (2006) 0.76
Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity. Bioorg Med Chem Lett (2006) 0.75
Labelling of endogenous target protein via N-S acyl transfer-mediated activation of N-sulfanylethylanilide. Org Biomol Chem (2016) 0.75
[The Present Conditions of a Provincial City]. Gan To Kagaku Ryoho (2015) 0.75
The effect of intense interval cycle-training on unloading-induced dysfunction and atrophy in the human calf muscle. J Physiol Anthropol (2011) 0.75
Ventilatory and cardiovascular responses to hypercapnia after 20 days of head-down bed rest. Aviat Space Environ Med (2004) 0.75
Programmable Assembly of Peptide Amphiphile via Noncovalent-to-Covalent Bond Conversion. J Am Chem Soc (2017) 0.75
Application of N-C- or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation. Bioorg Med Chem (2011) 0.75
Effects of intermittent hypoxic training and detraining on ventilatory chemosensitive adaptations in endurance athletes. Adv Exp Med Biol (2004) 0.75
Cardiorespiratory responses to hypoxia and hypercapnia at rest in vocalists. Jpn J Physiol (2003) 0.75
Calcium induced morphological transitions in Peptide Amphiphiles detected by (19)F-Magnetic Resonance Imaging. ACS Appl Mater Interfaces (2017) 0.75
Extra-cerebral oxygenation influence on near-infrared-spectroscopy-determined frontal lobe oxygenation in healthy volunteers: a comparison between INVOS-4100 and NIRO-200NX. Clin Physiol Funct Imaging (2014) 0.75
Thermodilution-determined Internal Jugular Venous Flow. Med Sci Sports Exerc (2016) 0.75
[An examination of home care for patients over age 85 after surgery]. Gan To Kagaku Ryoho (2014) 0.75
[Comparison of home-care and welfare facilities]. Gan To Kagaku Ryoho (2012) 0.75
Chemical synthesis of proteins using N-sulfanylethylanilide peptides, based on N-S acyl transfer chemistry. Top Curr Chem (2015) 0.75
[Home should be "a place for cancer patient to live a better life"]. Gan To Kagaku Ryoho (2011) 0.75
Oxygen uptake kinetics following 20 days of unilateral lower limb suspension. J Physiol Sci (2006) 0.75
Synthetic procedure for N-Fmoc amino acyl-N-sulfanylethylaniline linker as crypto-peptide thioester precursor with application to native chemical ligation. J Org Chem (2012) 0.75
Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH(2))(m)]-6-[H-Dmt-NH(CH(2))(n)]-2(1H)-pyrazinones, and studies on structure-activity relationships. Med Chem (2007) 0.75
[Medical cooperation for enabling a smooth shift to remote medical treatment]. Gan To Kagaku Ryoho (2012) 0.75
[A case of a patient with rheumatoid vasculitis who was successfully transferred to home-care services through regional cooperation]. Gan To Kagaku Ryoho (2012) 0.75
[Evaluation of efficacy and safety of manidipine hydrochloride among essential hypertensive patients: Substitution from branded product (Calslot) to Generic Product (Manidip)]. Yakugaku Zasshi (2007) 0.75
Heterogeneous Regulation of Brain Blood Flow during Low-Intensity Resistance Exercise. Med Sci Sports Exerc (2016) 0.75