Edward N Pugh

Author PubWeight™ 81.74‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med 2008 17.21
2 G proteins and phototransduction. Annu Rev Physiol 2002 3.74
3 The proteome of the mouse photoreceptor sensory cilium complex. Mol Cell Proteomics 2007 3.53
4 Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation. Neuron 2002 3.09
5 Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings. J Gen Physiol 2006 3.00
6 In utero gene therapy rescues vision in a murine model of congenital blindness. Mol Ther 2004 2.56
7 Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse. Invest Ophthalmol Vis Sci 2005 2.51
8 From candelas to photoisomerizations in the mouse eye by rhodopsin bleaching in situ and the light-rearing dependence of the major components of the mouse ERG. Vision Res 2004 2.44
9 Light-driven translocation of signaling proteins in vertebrate photoreceptors. Trends Cell Biol 2006 2.36
10 Phototransduction, dark adaptation, and rhodopsin regeneration the proctor lecture. Invest Ophthalmol Vis Sci 2006 2.17
11 Photoreceptors of Nrl -/- mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms. J Gen Physiol 2005 1.99
12 Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nat Rev Neurosci 2007 1.89
13 Mouse cones require an arrestin for normal inactivation of phototransduction. Neuron 2008 1.66
14 Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone vision. J Neurosci 2010 1.50
15 Quantification of the cytoplasmic spaces of living cells with EGFP reveals arrestin-EGFP to be in disequilibrium in dark adapted rod photoreceptors. J Cell Sci 2004 1.47
16 Diffusion of a soluble protein, photoactivatable GFP, through a sensory cilium. J Gen Physiol 2010 1.47
17 Models and mechanistic insight. J Gen Physiol 2008 1.44
18 RP1 is required for the correct stacking of outer segment discs. Invest Ophthalmol Vis Sci 2003 1.42
19 Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye. Biochemistry 2005 1.39
20 Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments. Invest Ophthalmol Vis Sci 2008 1.31
21 Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors. J Neurosci 2010 1.26
22 The retinal G protein-coupled receptor (RGR) enhances isomerohydrolase activity independent of light. J Biol Chem 2005 1.22
23 Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda) 2010 1.20
24 Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. Am J Hum Genet 2009 1.16
25 RGS9 concentration matters in rod phototransduction. Biophys J 2009 1.12
26 Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epithelium. J Comp Neurol 2007 1.03
27 A mouse M-opsin monochromat: retinal cone photoreceptors have increased M-opsin expression when S-opsin is knocked out. Vision Res 2011 1.03
28 Delivery of adeno-associated virus vectors to the fetal retina: impact of viral capsid proteins on retinal neuronal progenitor transduction. J Virol 2003 1.02
29 Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes. Neuron 2012 1.02
30 Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice. Am J Physiol Cell Physiol 2008 1.01
31 Scanning laser ophthalmoscope measurement of local fundus reflectance and autofluorescence changes arising from rhodopsin bleaching and regeneration. Invest Ophthalmol Vis Sci 2013 0.97
32 An S-opsin knock-in mouse (F81Y) reveals a role for the native ligand 11-cis-retinal in cone opsin biosynthesis. J Neurosci 2012 0.91
33 Spatiotemporal cGMP dynamics in living mouse rods. Biophys J 2012 0.90
34 Cones respond to light in the absence of transducin β subunit. J Neurosci 2013 0.89
35 The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine. J Gen Physiol 2011 0.85
36 Connexin36 forms synapses essential for night vision. Neuron 2002 0.84
37 Regulation of rhodopsin-eGFP distribution in transgenic xenopus rod outer segments by light. PLoS One 2013 0.81
38 Adaptive algorithms for two-channel polarization sensing under various polarization statistics with nonuniform distributions. Appl Opt 2006 0.81
39 Wavefront correction and high-resolution in vivo OCT imaging with an objective integrated multi-actuator adaptive lens. Opt Express 2015 0.80
40 Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage. J Gen Physiol 2012 0.79
41 Effect of scanning beam size on the lateral resolution of mouse retinal imaging with SLO. Opt Lett 2015 0.79
42 Good scientists do reach and hold divergent views on important issues. J Gen Physiol 2011 0.75
43 The 64th Symposium of the Society for General Physiologists: optogenetics and superresolution microscopy take center stage. J Gen Physiol 2011 0.75
44 Kudos to reviewers for the JGP: you make our science better. J Gen Physiol 2009 0.75
45 Embracing the principles of the San Francisco Declaration of Research Assessment: Robert Balaban's editorial. J Gen Physiol 2013 0.75
46 Spotlight summary: quantitative fundus autofluorescence and A2E increase with aging in wild-type and "Stargardt" mice. Invest Ophthalmol Vis Sci 2013 0.75
47 Redefining our menu: communications and reviews. J Gen Physiol 2011 0.75
48 Emerging questions about the macromolecular machines of muscle. J Gen Physiol 2010 0.75
49 Polarization-based and specular-reflection-based noncontact latent fingerprint imaging and lifting. J Opt Soc Am A Opt Image Sci Vis 2006 0.75
50 Separation and contrast enhancement of overlapping cast shadow components using polarization. Opt Express 2006 0.75
51 Enlisting young physiologists. J Gen Physiol 2009 0.75
52 Introducing the viewpoint. J Gen Physiol 2012 0.75
53 We were there... J Gen Physiol 2010 0.75
54 Neuroimaging the retina. Vision Res 2005 0.75