Published in Curr Biol on February 03, 2004
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Cell (2011) 2.71
Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates. Mol Cell (2009) 2.45
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity. Proc Natl Acad Sci U S A (2005) 2.08
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite. J Cell Biol (2006) 1.84
Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res (2007) 1.79
Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. EMBO J (2004) 1.77
Thrombomodulin and its role in inflammation. Semin Immunopathol (2011) 1.30
Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep (2011) 1.21
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Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response. Blood (2008) 1.11
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How intramembrane proteases bury hydrolytic reactions in the membrane. Nature (2009) 1.08
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Functional characterization of Escherichia coli GlpG and additional rhomboid proteins using an aarA mutant of Providencia stuartii. J Bacteriol (2006) 1.04
The PARL family of mitochondrial rhomboid proteases. Semin Cell Dev Biol (2010) 1.01
Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila. PLoS Genet (2010) 0.93
Vascular lesions and s-thrombomodulin concentrations from auricular arteries of rabbits infused with microbubble contrast agent and exposed to pulsed ultrasound. Ultrasound Med Biol (2006) 0.92
Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A (2014) 0.84
Structure and mechanism of rhomboid protease. J Biol Chem (2013) 0.83
Regulation of receptor tyrosine kinase ligand processing. Cold Spring Harb Perspect Biol (2014) 0.83
GC-1 mRHBDD1 knockdown spermatogonia cells lose their spermatogenic capacity in mouse seminiferous tubules. BMC Cell Biol (2009) 0.82
Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway. Nat Commun (2015) 0.82
Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation. Blood (2015) 0.81
Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. PLoS One (2012) 0.81
Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα. Sci Rep (2016) 0.78
Thrombomodulin gene polymorphisms in brain infarction and mortality after stroke. J Neurol (2008) 0.78
Histones Induce the Procoagulant Phenotype of Endothelial Cells through Tissue Factor Up-Regulation and Thrombomodulin Down-Regulation. PLoS One (2016) 0.76
RHBDL2 is a critical membrane protease for anoikis resistance in human malignant epithelial cells. ScientificWorldJournal (2014) 0.76
Intriguing parasites and intramembrane proteases. Genes Dev (2008) 0.75
Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain. PLoS One (2014) 0.75
Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development. Front Microbiol (2017) 0.75
Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis. Sci Rep (2017) 0.75
Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature (2003) 3.20
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol (2006) 3.00
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Cell (2011) 2.71
Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science (2012) 2.57
Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol Cell (2003) 2.48
Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates. Mol Cell (2009) 2.45
A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. EMBO J (2002) 2.20
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. Proc Natl Acad Sci U S A (2005) 1.99
Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria. PLoS Pathog (2006) 1.95
Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids. Curr Biol (2002) 1.88
Intramembrane proteolysis controls diverse signalling pathways throughout evolution. Curr Opin Genet Dev (2002) 1.83
Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res (2007) 1.79
Control of cell proliferation in the Drosophila eye by Notch signaling. Dev Cell (2005) 1.79
Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. EMBO J (2004) 1.77
Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase. Proc Natl Acad Sci U S A (2007) 1.70
Myosin II regulates complex cellular arrangement and epithelial architecture in Drosophila. Dev Cell (2007) 1.63
New lives for old: evolution of pseudoenzyme function illustrated by iRhoms. Nat Rev Mol Cell Biol (2012) 1.58
Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate. Proc Natl Acad Sci U S A (2007) 1.56
Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. Curr Biol (2006) 1.47
Live imaging of Drosophila imaginal disc development. Proc Natl Acad Sci U S A (2010) 1.27
Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis. Nat Cell Biol (2002) 1.24
Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep (2011) 1.21
The structural basis for catalysis and substrate specificity of a rhomboid protease. EMBO J (2010) 1.20
The role of protease activity in ErbB biology. Exp Cell Res (2008) 1.20
Control of Drosophila eye specification by Wingless signalling. Development (2002) 1.16
An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion. Genes Dev (2008) 1.15
Architectural and thermodynamic principles underlying intramembrane protease function. Nat Chem Biol (2012) 1.15
Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics. Elife (2012) 1.10
Cutting proteins within lipid bilayers: rhomboid structure and mechanism. Mol Cell (2007) 1.04
Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation. EMBO Rep (2013) 1.00
Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway. Dev Biol (2006) 1.00
Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila. Dev Biol (2006) 0.99
An Arabidopsis Rhomboid homolog is an intramembrane protease in plants. FEBS Lett (2005) 0.98
Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye. Development (2003) 0.97
EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development (2004) 0.96
Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases. ACS Chem Biol (2011) 0.95
Epithelial organisation revealed by a network of cellular contacts. Nat Commun (2011) 0.95
Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication. Proc Natl Acad Sci U S A (2012) 0.92
Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling. Development (2009) 0.92
An internal water-retention site in the rhomboid intramembrane protease GlpG ensures catalytic efficiency. Structure (2012) 0.89
Mechanism of G1 arrest in the Drosophila eye imaginal disc. BMC Dev Biol (2007) 0.89
Dual role of myosin II during Drosophila imaginal disc metamorphosis. Nat Commun (2013) 0.85
Modulation of Drosophila retinal epithelial integrity by the adhesion proteins capricious and tartan. PLoS One (2008) 0.85
Regulation of receptor tyrosine kinase ligand processing. Cold Spring Harb Perspect Biol (2014) 0.83
Structural biology: enzyme theory holds water. Nature (2006) 0.82
Structure of rhomboid protease in complex with β-lactam inhibitors defines the S2' cavity. Structure (2013) 0.80
Complexities during transitions to adulthood for youth with disabilities: person-environment interactions. Disabil Rehabil (2014) 0.80
Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory. J Membr Biol (2015) 0.79
The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye. Dev Biol (2007) 0.78
Intramembrane proteolysis by rhomboids: catalytic mechanisms and regulatory principles. Curr Opin Struct Biol (2013) 0.78
Smoking cessation for high school students. Impact evaluation of a novel program. Behav Modif (2004) 0.76
Developmental biology: partners united. Nature (2003) 0.75
Matthew Freeman: the sharp end of rhomboids. J Cell Biol (2014) 0.75
Social participation of adolescents with cerebral palsy: trade-offs and choices. Phys Occup Ther Pediatr (2011) 0.75
Erratum: Control of ADAM17 activity by regulation of its cellular localisation. Sci Rep (2016) 0.75
Clinical, Biomechanical, and Anatomic Investigation of Colles Fascia and Pubic Ramus Periosteum for Use During Medial Thighplasty. Ann Plast Surg (2017) 0.75