| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
|
Proc Natl Acad Sci U S A
|
2002
|
8.01
|
|
2
|
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
|
Proc Natl Acad Sci U S A
|
2004
|
5.54
|
|
3
|
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.
|
Proc Natl Acad Sci U S A
|
2002
|
3.18
|
|
4
|
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
|
Proc Natl Acad Sci U S A
|
2005
|
3.08
|
|
5
|
Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.
|
Cancer Epidemiol Biomarkers Prev
|
2005
|
2.45
|
|
6
|
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.
|
Arch Biochem Biophys
|
2010
|
2.27
|
|
7
|
Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.
|
Nutr Cancer
|
2006
|
2.10
|
|
8
|
Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans.
|
Clin Chim Acta
|
2002
|
2.09
|
|
9
|
Direct and indirect antioxidant properties of inducers of cytoprotective proteins.
|
Mol Nutr Food Res
|
2008
|
1.96
|
|
10
|
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.
|
Carcinogenesis
|
2007
|
1.91
|
|
11
|
Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations.
|
Proc Natl Acad Sci U S A
|
2003
|
1.66
|
|
12
|
Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage.
|
Proc Natl Acad Sci U S A
|
2004
|
1.64
|
|
13
|
Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.
|
Adv Enzyme Regul
|
2004
|
1.60
|
|
14
|
Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.
|
Cancer Lett
|
2005
|
1.52
|
|
15
|
Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.
|
Cancer Epidemiol Biomarkers Prev
|
2007
|
1.52
|
|
16
|
The "Prochaska" microtiter plate bioassay for inducers of NQO1.
|
Methods Enzymol
|
2004
|
1.44
|
|
17
|
Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China.
|
Cancer Prev Res (Phila)
|
2011
|
1.37
|
|
18
|
Electrophilic tuning of the chemoprotective natural product sulforaphane.
|
Proc Natl Acad Sci U S A
|
2010
|
1.37
|
|
19
|
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex.
|
Proc Natl Acad Sci U S A
|
2007
|
1.34
|
|
20
|
An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.
|
J Biol Chem
|
2010
|
1.32
|
|
21
|
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.
|
Top Curr Chem
|
2013
|
1.31
|
|
22
|
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.
|
Carcinogenesis
|
2005
|
1.28
|
|
23
|
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
|
Proc Natl Acad Sci U S A
|
2005
|
1.28
|
|
24
|
Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.
|
Proc Natl Acad Sci U S A
|
2008
|
1.21
|
|
25
|
Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).
|
Methods Enzymol
|
2004
|
1.21
|
|
26
|
Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.
|
Carcinogenesis
|
2011
|
1.12
|
|
27
|
Notes from the field: "green" chemoprevention as frugal medicine.
|
Cancer Prev Res (Phila)
|
2012
|
1.11
|
|
28
|
Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.
|
Cancer Prev Res (Phila)
|
2012
|
0.96
|
|
29
|
Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.
|
Chem Res Toxicol
|
2008
|
0.93
|
|
30
|
Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.
|
Mol Cancer Ther
|
2007
|
0.90
|
|
31
|
Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention.
|
Proc Natl Acad Sci U S A
|
2013
|
0.88
|
|
32
|
Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
|
Photochem Photobiol Sci
|
2010
|
0.88
|
|
33
|
Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.
|
Cancer Epidemiol Biomarkers Prev
|
2011
|
0.87
|
|
34
|
Neuroprotective effects of sulforaphane after contusive spinal cord injury.
|
J Neurotrauma
|
2012
|
0.87
|
|
35
|
Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates.
|
Biochem Biophys Res Commun
|
2013
|
0.85
|
|
36
|
Stimulation of phagocytosis by sulforaphane.
|
Biochem Biophys Res Commun
|
2011
|
0.84
|
|
37
|
Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
|
Nutr Res
|
2008
|
0.83
|
|
38
|
Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance.
|
Alcohol Alcohol
|
2013
|
0.82
|
|
39
|
A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.
|
Biochem Biophys Res Commun
|
2008
|
0.80
|
|
40
|
Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors.
|
Photodermatol Photoimmunol Photomed
|
2009
|
0.80
|
|
41
|
Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital.
|
Free Radic Biol Med
|
2004
|
0.79
|
|
42
|
Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.
|
Chem Biol Interact
|
2010
|
0.78
|
|
43
|
Dietary amelioration of Helicobacter pylori infection: design criteria for a clinical trial.
|
Cancer Epidemiol Biomarkers Prev
|
2004
|
0.76
|
|
44
|
Correction: Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial.
|
PLoS One
|
2017
|
0.75
|
|
45
|
Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD).
|
CNS Neurol Disord Drug Targets
|
2016
|
0.75
|