Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells.

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Published in Invest Ophthalmol Vis Sci on March 01, 2004

Authors

Ke-Ping Xu1, Yu Ding, Jianhua Ling, Zheng Dong, Fu-Shin X Yu

Author Affiliations

1: Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA.

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Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol (1960) 21.27

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