Published in Faraday Discuss on January 01, 2004
Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes. Trends Pharmacol Sci (2007) 1.22
A two-photon excitation fluorescence cross-correlation assay for a model ligand-receptor binding system using quantum dots. Biophys J (2005) 1.15
Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB J (2014) 1.01
Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. J Med Chem (2011) 0.89
Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors. Biochim Biophys Acta (2013) 0.86
Biophysical Detection of Diversity and Bias in GPCR Function. Front Endocrinol (Lausanne) (2014) 0.82
Fluorescent ligands for adenosine receptors. Bioorg Med Chem Lett (2012) 0.80
Bodilisant-a novel fluorescent, highly affine histamine h3 receptor ligand. ACS Med Chem Lett (2012) 0.79
Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands. Neuropharmacology (2015) 0.76
Transgenic enrichment of cardiomyocytes from human embryonic stem cells. Mol Ther (2007) 2.50
Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling. Mol Pharmacol (2003) 1.67
A porous framework polymer based on a zinc(II) 4,4'-bipyridine-2,6,2',6'-tetracarboxylate: synthesis, structure, and "zeolite-like" behaviors. J Am Chem Soc (2006) 1.53
Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor. Mol Pharmacol (2003) 1.52
The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional enterobactin biosynthesis and uptake system. Infect Immun (2002) 1.29
Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates. Trends Pharmacol Sci (2007) 1.29
Fluorophore-tagged GPCR ligands. Curr Opin Chem Biol (2005) 1.29
Infrared micro-spectral imaging: distinction of tissue types in axillary lymph node histology. BMC Clin Pathol (2008) 1.26
Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes. Trends Pharmacol Sci (2007) 1.22
Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics. FASEB J (2011) 1.21
The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells. Mol Pharmacol (2010) 1.17
Development of a broadband picosecond infrared spectrometer and its incorporation into an existing ultrafast time-resolved resonance Raman, UV/visible, and fluorescence spectroscopic apparatus. Appl Spectrosc (2003) 1.11
Photoreactivity examined through incorporation in metal-organic frameworks. Nat Chem (2010) 1.10
Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation. Br J Pharmacol (2004) 1.09
Pharmacological characterization of CGP 12177 at the human beta(2)-adrenoceptor. Br J Pharmacol (2002) 1.08
Quantitative profiling of nucleotides and related phosphate-containing metabolites in cultured mammalian cells by liquid chromatography tandem electrospray mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 1.06
Quantitative measurement of sulforaphane, iberin and their mercapturic acid pathway metabolites in human plasma and urine using liquid chromatography-tandem electrospray ionisation mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2006) 1.06
New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells. J Med Chem (2007) 1.05
Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands. Br J Pharmacol (2010) 1.04
Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses. Mol Pharmacol (2003) 1.02
ULTRA: A Unique Instrument for Time-Resolved Spectroscopy. Appl Spectrosc (2010) 1.02
Pharmacology and direct visualisation of BODIPY-TMR-CGP: a long-acting fluorescent beta2-adrenoceptor agonist. Br J Pharmacol (2003) 1.00
The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs. Br J Pharmacol (2014) 0.99
Photochemistry and photophysics of a Pd(II) metalloporphyrin: Re(I) tricarbonyl bipyridine molecular dyad and its activity toward the photoreduction of CO2 to CO. Inorg Chem (2011) 0.98
Monitoring the direct and indirect damage of DNA bases and polynucleotides by using time-resolved infrared spectroscopy. Proc Natl Acad Sci U S A (2006) 0.98
Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol (2012) 0.98
Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. Trends Pharmacol Sci (2011) 0.97
New members of the [Ru(diimine)(CN)(4)](2-) family: structural, electrochemical and photophysical properties. Dalton Trans (2005) 0.97
Role of key transmembrane residues in agonist and antagonist actions at the two conformations of the human beta1-adrenoceptor. Mol Pharmacol (2008) 0.97
Characterization of isoprenaline- and salmeterol-stimulated interactions between beta2-adrenoceptors and beta-arrestin 2 using beta-galactosidase complementation in C2C12 cells. J Pharmacol Exp Ther (2005) 0.96
Time-resolved infrared (TRIR) study on the formation and reactivity of organometallic methane and ethane complexes in room temperature solution. Proc Natl Acad Sci U S A (2007) 0.96
GPCR signaling: understanding the pathway to successful drug discovery. Methods Mol Biol (2009) 0.95
Characterization of an organometallic xenon complex using NMR and IR spectroscopy. Proc Natl Acad Sci U S A (2005) 0.94
Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex. J Med Chem (2005) 0.94
Plasma membrane diffusion of G protein-coupled receptor oligomers. Biochim Biophys Acta (2008) 0.94
A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor. J Pharmacol Exp Ther (2006) 0.93
Cleaner continuous photo-oxidation using singlet oxygen in supercritical carbon dioxide. Angew Chem Int Ed Engl (2009) 0.92
A combined theoretical and experimental study on the role of spin states in the chemistry of Fe(CO)5 photoproducts. J Am Chem Soc (2009) 0.92
A delicate balance of complexation vs. activation of alkanes interacting with [Re(Cp)(CO)(PF3)] studied with NMR and time-resolved IR spectroscopy. Proc Natl Acad Sci U S A (2007) 0.91
Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization. Br J Pharmacol (2014) 0.89
Mechanisms of cross-talk between G-protein-coupled receptors. Neurosignals (2002) 0.89
Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. J Med Chem (2011) 0.89
Monitoring the effect of ultrafast deactivation of the electronic excited states of DNA bases and polynucleotides following 267 nm laser excitation using picosecond time-resolved infrared spectroscopy. Chem Commun (Camb) (2005) 0.89
Unraveling the photochemistry of Fe(CO)5 in solution: observation of Fe(CO)3 and the conversion between 3Fe(CO)4 and 1Fe(CO)4(Solvent). J Am Chem Soc (2004) 0.89
Temporal characteristics of cAMP response element-mediated gene transcription: requirement for sustained cAMP production. Mol Pharmacol (2004) 0.89
Real-time feedback control using online attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy for continuous flow optimization and process knowledge. Appl Spectrosc (2013) 0.88
The PXR is a drug target for chronic inflammatory liver disease. J Steroid Biochem Mol Biol (2010) 0.88
Infrared characterization of the guanine radical cation: finger printing DNA damage. J Phys Chem B (2010) 0.87
Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor. Bioorg Med Chem Lett (2005) 0.87
ERK phosphorylation: spatial and temporal regulation by G protein-coupled receptors. Int J Biochem Cell Biol (2008) 0.86
Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells. Methods Mol Biol (2011) 0.86
Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications. Soft Matter (2014) 0.86
Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone. J Med Chem (2011) 0.86
Irreversible network transformation in a dynamic porous host catalyzed by sulfur dioxide. J Am Chem Soc (2013) 0.86
Electrodeposition of metals from supercritical fluids. Proc Natl Acad Sci U S A (2009) 0.86
Direct observation of a hydrogen-bonded charge-transfer state of 4-dimethylaminobenzonitrile in methanol by time-resolved IR spectroscopy. Angew Chem Int Ed Engl (2003) 0.85
Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold. J Med Chem (2012) 0.85
Promoting charge-separation in p-type dye-sensitized solar cells using bodipy. Chem Commun (Camb) (2013) 0.85
Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells. Br J Pharmacol (2005) 0.85
Identification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human β1-adrenoceptor. Mol Pharmacol (2014) 0.85
Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment. MAbs (2014) 0.84
Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC). Chembiochem (2004) 0.84
Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J (2011) 0.84
Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO Rep (2013) 0.83
Picosecond transient infrared study of the ultrafast deactivation processes of electronically excited B-DNA and Z-DNA forms of [poly(dG-dC)]2. Angew Chem Int Ed Engl (2009) 0.83
Structural and photophysical properties of adducts of [Ru(bipy)(CN)4]2- with different metal cations: metallochromism and its use in switching photoinduced energy transfer. J Am Chem Soc (2007) 0.83
Accelerated formation of multicellular 3-D structures by cell-to-cell cross-linking. Biotechnol Bioeng (2007) 0.83
A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus. Br J Pharmacol (2003) 0.82
Influence of mammographic screening on trends in breast-conserving surgery in Ireland. Eur J Cancer Prev (2006) 0.82
ps-TRIR covers all the bases--recent advances in the use of transient IR for the detection of short-lived species in nucleic acids. Analyst (2009) 0.82
Manganese alkane complexes: an IR and NMR spectroscopic investigation. J Am Chem Soc (2011) 0.81
Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Org Biomol Chem (2013) 0.81
Probing organometallic reactions by time-resolved infrared spectroscopy in solution and in the solid state using quantum cascade lasers. Appl Spectrosc (2015) 0.81
Reversible 100% linkage isomerization in a single-crystal to single-crystal transformation: photocrystallographic identification of the metastable [Ni(dppe)(eta1-ONO)Cl] isomer. Angew Chem Int Ed Engl (2009) 0.81
2,5-Bis(p-R-arylethynyl)rhodacyclopentadienes show intense fluorescence: denying the presence of a heavy atom. Angew Chem Int Ed Engl (2010) 0.80
Cell-type-specific adhesion onto polymer surfaces from mixed cell populations. Biotechnol Bioeng (2003) 0.80
Recent progress in the design of selectin inhibitors. Mini Rev Med Chem (2003) 0.80
Measurement of spatial resolution and sensitivity in transmission and backscattering Raman spectroscopy of opaque samples: impact on pharmaceutical quality control and Raman tomography. Appl Spectrosc (2010) 0.80
Comparison of potassium currents in human decidua before and after the onset of labor. Biol Reprod (2003) 0.80
Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu. J Cell Sci (2012) 0.80
Inhibition of tissue transglutaminase 2 attenuates contractility of pregnant human myometrium. Biol Reprod (2010) 0.80
The electrodeposition of copper from supercritical CO(2)/acetonitrile mixtures and from supercritical trifluoromethane. Phys Chem Chem Phys (2010) 0.79
Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: a time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO)3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2. Photochem Photobiol Sci (2011) 0.79
Electrodeposition of germanium from supercritical fluids. Phys Chem Chem Phys (2011) 0.79
Phase behaviour and conductivity study on multi-component mixtures for electrodeposition in supercritical fluids. Phys Chem Chem Phys (2009) 0.79
Phase behaviour and conductivity study of electrolytes in supercritical hydrofluorocarbons. Phys Chem Chem Phys (2010) 0.79
Picosecond time-resolved infrared spectroscopic investigation of excited state dynamics in a PtII diimine chromophore. Chem Commun (Camb) (2002) 0.79