Published in J Cell Sci on March 01, 2004
NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell (2008) 4.88
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell (2011) 3.83
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood (2007) 3.71
Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J (2007) 2.91
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci U S A (2006) 2.72
Extrinsic regulation of pluripotent stem cells. Nature (2010) 2.39
Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells (2006) 2.37
Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol (2012) 2.00
Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium. Proc Natl Acad Sci U S A (2008) 1.82
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell (2008) 1.79
Systematic identification of cis-regulatory sequences active in mouse and human embryonic stem cells. PLoS Genet (2007) 1.77
A continuum of cell states spans pluripotency and lineage commitment in human embryonic stem cells. PLoS One (2009) 1.74
FGF signalling inhibits neural induction in human embryonic stem cells. EMBO J (2011) 1.61
High-efficiency induction of neural conversion in human ESCs and human induced pluripotent stem cells with a single chemical inhibitor of transforming growth factor beta superfamily receptors. Stem Cells (2010) 1.61
Albumin-associated lipids regulate human embryonic stem cell self-renewal. PLoS One (2008) 1.54
Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A (2011) 1.52
Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell Mol Life Sci (2011) 1.40
Neural differentiation of human embryonic stem cells. J Cell Biochem (2008) 1.35
Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol (2009) 1.32
Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. Cell Stem Cell (2008) 1.32
Human pluripotent stem cells: applications and challenges in neurological diseases. Front Physiol (2012) 1.31
Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J Biol Chem (2008) 1.26
Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. BMC Dev Biol (2007) 1.21
Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech Dev (2011) 1.17
Inhibition of caspase-mediated anoikis is critical for basic fibroblast growth factor-sustained culture of human pluripotent stem cells. J Biol Chem (2009) 1.16
Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines. J Biomed Sci (2010) 1.16
Role of mechanical factors in fate decisions of stem cells. Regen Med (2011) 1.15
Single-cell gene expression profiles define self-renewing, pluripotent, and lineage primed states of human pluripotent stem cells. Stem Cell Reports (2014) 1.11
Label-free separation of human embryonic stem cells and their differentiating progenies by phasor fluorescence lifetime microscopy. J Biomed Opt (2012) 1.08
BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway. J Cell Biochem (2010) 1.08
Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming. J Cell Physiol (2010) 1.07
Sox3 expression is maintained by FGF signaling and restricted to the neural plate by Vent proteins in the Xenopus embryo. Dev Biol (2007) 1.04
Human embryonic stem cells for brain repair? Philos Trans R Soc Lond B Biol Sci (2008) 1.04
Efficient derivation of lateral plate and paraxial mesoderm subtypes from human embryonic stem cells through GSKi-mediated differentiation. Stem Cells Dev (2013) 1.03
The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling. Biomaterials (2013) 1.03
Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci (2010) 1.02
Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease. PLoS One (2012) 1.02
FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast. Stem Cells Dev (2012) 1.01
Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation. Front Cell Neurosci (2012) 1.01
Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction. PLoS One (2011) 0.99
Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction? Gut (2011) 0.98
Trophoblast stem cells: models for investigating trophectoderm differentiation and placental development. Endocr Rev (2009) 0.98
Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size. Integr Biol (Camb) (2012) 0.96
High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias. Nat Methods (2013) 0.94
Moving stem cells to the clinic: potential and limitations for brain repair. Neuron (2015) 0.94
Endogenous WNT signals mediate BMP-induced and spontaneous differentiation of epiblast stem cells and human embryonic stem cells. Stem Cell Reports (2014) 0.93
Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. Stem Cells (2012) 0.93
Pluripotent stem cells for the study of CNS development. Front Mol Neurosci (2011) 0.92
L1TD1 is a marker for undifferentiated human embryonic stem cells. PLoS One (2011) 0.92
Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells. Dev Biol (2013) 0.91
Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways. PLoS One (2012) 0.91
Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells. Stem Cells (2012) 0.91
Blockage of lysophosphatidic acid signaling improves spinal cord injury outcomes. Am J Pathol (2012) 0.90
Endothelial cells in co-culture enhance embryonic stem cell differentiation to pancreatic progenitors and insulin-producing cells through BMP signaling. Stem Cell Rev (2011) 0.88
Engineering the human pluripotent stem cell microenvironment to direct cell fate. Biotechnol Adv (2013) 0.87
Colorectal cancer stem cells and cell death. Cancers (Basel) (2011) 0.87
BMP induction of cardiogenesis in P19 cells requires prior cell-cell interaction(s). Dev Dyn (2006) 0.87
Proteomic analysis of stem cell differentiation and early development. Cold Spring Harb Perspect Biol (2012) 0.86
Aneuploidy in pluripotent stem cells and implications for cancerous transformation. Protein Cell (2014) 0.85
Gene expression in breastmilk cells is associated with maternal and infant characteristics. Sci Rep (2015) 0.84
Embryonic stem cell-derived trophoblast differentiation: a comparative review of the biology, function, and signaling mechanisms. J Endocrinol (2013) 0.84
Protein kinase C-induced early growth response protein-1 binding to SNAIL promoter in epithelial-mesenchymal transition of human embryonic stem cells. Stem Cells Dev (2014) 0.84
Manufacturing neurons from human embryonic stem cells: biological and regulatory aspects to develop a safe cellular product for stroke cell therapy. Regen Med (2009) 0.83
Review: Trophoblast differentiation from human embryonic stem cells. Placenta (2012) 0.82
Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid. J Lipid Res (2013) 0.82
Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dish. Psychopharmacology (Berl) (2014) 0.81
BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells. PLoS One (2010) 0.81
A hybrid computational method for the discovery of novel reproduction-related genes. PLoS One (2015) 0.81
Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis. PLoS One (2014) 0.81
WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate. Development (2016) 0.80
Biomedical and clinical promises of human pluripotent stem cells for neurological disorders. Biomed Res Int (2013) 0.80
IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations. FASEB J (2015) 0.80
Growth factors and feeder cells promote differentiation of human embryonic stem cells into dopaminergic neurons: a novel role for fibroblast growth factor-20. Front Neurosci (2008) 0.79
Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties. Stem Cells Dev (2014) 0.79
Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts. J Biol Chem (2015) 0.79
Synaptically-competent neurons derived from canine embryonic stem cells by lineage selection with EGF and Noggin. PLoS One (2011) 0.79
Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation. Stem Cells Dev (2013) 0.79
Rapid and efficient generation of neurons from human pluripotent stem cells in a multititre plate format. J Vis Exp (2013) 0.78
RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms. Sci Signal (2016) 0.78
Low Molecular Weight Fraction of Commercial Human Serum Albumin Induces Morphologic and Transcriptional Changes of Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Transl Med (2015) 0.77
Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation. Tissue Eng Part B Rev (2015) 0.77
Proteomics and pluripotency. Crit Rev Biochem Mol Biol (2011) 0.77
Human pluripotent embryonal carcinoma NTERA2 cl.D1 cells maintain their typical morphology in an angiomyogenic medium. J Negat Results Biomed (2007) 0.77
The response of early neural genes to FGF signaling or inhibition of BMP indicate the absence of a conserved neural induction module. BMC Dev Biol (2011) 0.77
Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients. Mol Brain (2015) 0.77
Human embryonic stem cell technology: large scale cell amplification and differentiation. Cytotechnology (2006) 0.77
Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling. Stem Cell Reports (2016) 0.76
Noggin maintains pluripotency of human embryonic stem cells grown on Matrigel. Cell Prolif (2009) 0.76
Culture adaptation alters transcriptional hierarchies among single human embryonic stem cells reflecting altered patterns of differentiation. PLoS One (2015) 0.75
Down-regulation of nestin in mesenchymal stem cells derived from peripheral blood through blocking bone morphogenesis pathway. J Cell Commun Signal (2016) 0.75
Triploid human embryonic stem cells derived from tripronuclear zygotes displayed pluripotency and trophoblast differentiation ability similar to the diploid human embryonic stem cells. J Reprod Dev (2016) 0.75
Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells. Stem Cells Int (2017) 0.75
Quantitative Raman spectral changes of the differentiation of mesenchymal stem cells into islet-like cells by biochemical component analysis and multiple peak fitting. J Biomed Opt (2015) 0.75
Translating Stem Cell Biology Into Drug Discovery. Drug Target Rev (2016) 0.75
Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases. Stem Cells Int (2016) 0.75
Top-Down Inhibition of BMP Signaling Enables Robust Induction of hPSCs Into Neural Crest in Fully Defined, Xeno-free Conditions. Stem Cell Reports (2017) 0.75
Regulated differentiation of WERI-Rb-1 cells into retinal neuron-like cells. Int J Mol Med (2017) 0.75
Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation (2003) 6.30
SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell (2003) 3.80
Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. Dev Cell (2006) 3.67
Recombinant vitronectin is a functionally defined substrate that supports human embryonic stem cell self-renewal via alphavbeta5 integrin. Stem Cells (2008) 3.33
Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J (2004) 3.17
Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. Cell Stem Cell (2009) 3.09
Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction. Stem Cell Res (2007) 3.04
SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. Nat Biotechnol (2011) 2.84
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
A method for genetic modification of human embryonic stem cells using electroporation. Nat Protoc (2007) 2.76
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell (2013) 2.74
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell (2013) 2.74
Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation. Blood (2005) 2.69
Origins and fates of cardiovascular progenitor cells. Cell (2008) 2.55
Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci U S A (2002) 2.53
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J Cell Biol (2003) 2.51
NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods (2011) 2.29
Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures. Stem Cells (2005) 2.23
A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies. Nat Protoc (2008) 1.95
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91
Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Am J Pathol (2009) 1.86
Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells. J Neurosci (2008) 1.81
Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension. Nat Biotechnol (2010) 1.73
Toward the development of a global induced pluripotent stem cell library. Cell Stem Cell (2013) 1.70
Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome. Hum Mol Genet (2007) 1.68
Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation (2007) 1.66
A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives. Stem Cells (2011) 1.60
Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development (2002) 1.59
CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nat Biotechnol (2006) 1.58
Characterization of mice lacking the tetraspanin superfamily member CD151. Mol Cell Biol (2004) 1.57
Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells. Differentiation (2008) 1.56
Genetic modification of human embryonic stem cells for derivation of target cells. Cell Stem Cell (2008) 1.56
Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity (2003) 1.55
Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes. Stem Cells (2006) 1.52
Human embryonic stem cells: research, ethics and policy. Hum Reprod (2003) 1.50
Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Mol Cell Biol (2004) 1.48
Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. Dev Biol (2006) 1.47
Testicular cell conditioned medium supports differentiation of embryonic stem cells into ovarian structures containing oocytes. Stem Cells (2005) 1.46
Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells. Stem Cells (2005) 1.45
Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines. Genome Res (2007) 1.41
Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis. PLoS One (2008) 1.39
Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells. Stem Cells (2007) 1.38
The early days of IVF outside the UK. Hum Reprod Update (2005) 1.38
Generation of peripheral sensory and sympathetic neurons and neural crest cells from human embryonic stem cells. Stem Cells (2005) 1.38
The hESC line Envy expresses high levels of GFP in all differentiated progeny. Nat Methods (2005) 1.35
Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Diabetes (2004) 1.33
Differentiation is coupled to changes in the cell cycle regulatory apparatus of human embryonic stem cells. Stem Cell Res (2007) 1.31
The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Development (2005) 1.31
Monitoring of cell therapy and assessment of cardiac function using magnetic resonance imaging in a mouse model of myocardial infarction. Nat Protoc (2007) 1.31
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. EMBO J (2013) 1.28
Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. EMBO J (2013) 1.24
Tolerance strategies for stem-cell-based therapies. Nature (2008) 1.18
The fine structure of human embryonic stem cells. Reprod Biomed Online (2002) 1.18
A novel compound heterozygous mutation of the aromatase gene in an adult man: reinforced evidence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome. Clin Endocrinol (Oxf) (2007) 1.15
A protocol for removal of antibiotic resistance cassettes from human embryonic stem cells genetically modified by homologous recombination or transgenesis. Nat Protoc (2008) 1.13
Differentiating embryonic stem cells pass through 'temporal windows' that mark responsiveness to exogenous and paracrine mesendoderm inducing signals. PLoS One (2010) 1.12
Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair. Am J Respir Crit Care Med (2010) 1.12
Identification of cell surface proteins for antibody-based selection of human embryonic stem cell-derived cardiomyocytes. J Proteome Res (2010) 1.11
CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J Cell Sci (2010) 1.08
Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. J Cell Sci (2007) 1.08
Functions of the TGFbeta superfamily in human embryonic stem cells. APMIS (2006) 1.07
Generating GABAergic cerebral cortical interneurons from mouse and human embryonic stem cells. Stem Cell Res (2011) 1.07
Sox2 transduction enhances cardiovascular repair capacity of blood-derived mesoangioblasts. Circ Res (2010) 1.04
Heart repair and stem cells. J Physiol (2006) 1.04
Selected genetic factors associated with male infertility. Hum Reprod Update (2002) 1.04
Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts. J Cell Physiol (2011) 1.03
Pluripotent stem cell models of human heart disease. Cold Spring Harb Perspect Med (2013) 1.01
Neural differentiation of patient specific iPS cells as a novel approach to study the pathophysiology of multiple sclerosis. Stem Cell Res (2011) 1.00
Improvement of mouse cardiac function by hESC-derived cardiomyocytes correlates with vascularity but not graft size. Stem Cell Res (2009) 1.00
Human embryonic stem cells suppress T cell responses via arginase I-dependent mechanism. J Immunol (2009) 0.99
ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells. DNA Repair (Amst) (2006) 0.99
Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J Cell Sci (2002) 0.99
Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Dev Biol (2007) 0.99
Lentiviral vector-mediated gene delivery into human embryonic stem cells. Methods Enzymol (2006) 0.98
Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation. Stem Cells (2009) 0.98
Inhibition of ROCK improves survival of human embryonic stem cell-derived cardiomyocytes after dissociation. Ann N Y Acad Sci (2010) 0.96
Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation. PLoS One (2012) 0.95
BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2. Stem Cells (2014) 0.94
Origin and use of embryonic and adult stem cells in differentiation and tissue repair. Cardiovasc Res (2003) 0.94
Cardiomyocyte differentiation from embryonic and adult stem cells. Curr Opin Biotechnol (2005) 0.94
WNT3A promotes hematopoietic or mesenchymal differentiation from hESCs depending on the time of exposure. Stem Cell Reports (2013) 0.94
Directed differentiation of human embryonic stem cells as spin embryoid bodies and a description of the hematopoietic blast colony forming assay. Curr Protoc Stem Cell Biol (2008) 0.94
Progenitor cells for cardiac repair. Semin Cell Dev Biol (2006) 0.93
Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair. PLoS One (2012) 0.93
Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile. Stem Cells (2008) 0.93
Stem cells in a new light. Nat Biotechnol (2008) 0.93
Stem cell therapies in clinical trials: workshop on best practices and the need for harmonization. Cell Stem Cell (2010) 0.93