Published in Org Lett on March 18, 2004
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58
Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol (2005) 1.73
Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol (2004) 1.58
Amino acid promoted CuI-catalyzed C-N bond formation between aryl halides and amines or N-containing heterocycles. J Org Chem (2005) 1.56
Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy (2010) 1.51
Enantioselective arylation of 2-methylacetoacetates catalyzed by CuI/trans-4-hydroxy-L-proline at low reaction temperatures. J Am Chem Soc (2006) 1.16
Asymmetric, protecting-group-free total synthesis of (-)-englerin A. Angew Chem Int Ed Engl (2010) 1.15
CuI/N,N-dimethylglycine-catalyzed coupling of vinyl halides with amides or carbamates. Org Lett (2004) 1.10
Synthesis of aryl azides and vinyl azides via proline-promoted CuI-catalyzed coupling reactions. Chem Commun (Camb) (2004) 1.10
Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy. J Cell Biol (2009) 1.09
Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network. Identification of DKV582 as a recycling signal. J Biol Chem (2003) 1.06
Total synthesis and absolute stereochemical assignment of (-)-communesin F. J Am Chem Soc (2010) 1.03
Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases. Org Lett (2005) 1.02
Total synthesis of the monoterpenoid indole alkaloid (±)-aspidophylline A. Angew Chem Int Ed Engl (2014) 1.01
A novel small molecule regulator of guanine nucleotide exchange activity of the ADP-ribosylation factor and golgi membrane trafficking. J Biol Chem (2008) 1.00
Total synthesis of Akuammiline alkaloid (-)-vincorine via intramolecular oxidative coupling. J Am Chem Soc (2012) 1.00
Elaboration of 2-(trifluoromethyl)indoles via a cascade coupling/condensation/deacylation process. Org Lett (2008) 0.98
CuI/L-proline-catalyzed coupling reactions of aryl halides with activated methylene compounds. Org Lett (2005) 0.97
Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis. Arthritis Res Ther (2011) 0.96
Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. J Med Chem (2009) 0.96
Total synthesis and structure assignment of papuamide B, a potent marine cyclodepsipeptide with anti-HIV properties. Angew Chem Int Ed Engl (2008) 0.95
Enantioselective total syntheses of communesins A and B. Angew Chem Int Ed Engl (2011) 0.94
Total synthesis of microsclerodermin E. Angew Chem Int Ed Engl (2003) 0.94
Enantioselective addition of activated terminal alkynes to 1-acylpyridinium salts catalyzed by Cu-Bis(oxazoline) complexes. J Am Chem Soc (2007) 0.93
Highly enantioselective bromocyclization of tryptamines and its application in the synthesis of (-)-chimonanthine. Angew Chem Int Ed Engl (2013) 0.92
Assembly of isoquinolines via CuI-catalyzed coupling of beta-keto esters and 2-halobenzylamines. Org Lett (2008) 0.92
PIM kinase inhibitors downregulate STAT3(Tyr705) phosphorylation. Mol Cancer Ther (2010) 0.92
Total synthesis of lepadins B, d, e, and h; determination of the configuration of the latter three alkaloids. Angew Chem Int Ed Engl (2004) 0.91
Facile entry to substituted decahydroquinoline alkaloids. Total synthesis of lepadins A-E and H. J Org Chem (2006) 0.91
Total synthesis of salinamide A: a potent anti-inflammatory bicyclic depsipeptide. Angew Chem Int Ed Engl (2008) 0.89
A class of novel carboline intercalators: Their synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and 3D QSAR analysis. Bioorg Med Chem (2010) 0.88
Nanosized aspirin-Arg-Gly-Asp-Val: delivery of aspirin to thrombus by the target carrier Arg-Gly-Asp-Val tetrapeptide. ACS Nano (2013) 0.87
Synthesis of 3-substituted and 2,3-disubstituted quinazolinones via Cu-catalyzed aryl amidation. Org Lett (2012) 0.87
Mild Ullmann-type biaryl ether formation reaction by combination of ortho-substituent and ligand effects. Angew Chem Int Ed Engl (2006) 0.86
Synthesis of 1,2-disubstituted benzimidazoles by a Cu-catalyzed cascade aryl amination/condensation process. Angew Chem Int Ed Engl (2007) 0.86
Palladium-catalyzed direct functionalization of 2-aminobutanoic acid derivatives: application of a convenient and versatile auxiliary. Angew Chem Int Ed Engl (2013) 0.86
Synthesis of an oxazoline analogue of apratoxin A. Org Lett (2003) 0.85
Organocatalytic approach to polysubstituted piperidines and tetrahydropyrans. Org Lett (2011) 0.84
Formation of arylboronates by a CuI-catalyzed coupling reaction of pinacolborane with aryl iodides at room temperature. Org Lett (2006) 0.84
Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor. J Med Chem (2011) 0.84
A one-pot coupling/hydrolysis/condensation process to pyrrolo[1,2-a]quinoxaline. J Org Chem (2008) 0.84
Facile benzo-ring construction via palladium-catalyzed functionalization of unactivated sp3 C-H bonds under mild reaction conditions. Org Lett (2010) 0.83
Organocatalytic approach for the syntheses of corynantheidol, dihydrocorynantheol, protoemetinol, protoemetine, and mitragynine. Chem Asian J (2011) 0.83
Asymmetric total syntheses of marine cyclic depsipeptide halipeptins A-D. Chemistry (2006) 0.82
Assembly of substituted 1H-benzimidazoles and 1,3-dihydrobenzimidazol-2-ones via CuI/L-proline catalyzed coupling of aqueous ammonia with 2-iodoacetanilides and 2-iodophenylcarbamates. J Org Chem (2009) 0.82
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM): its anti-cancer efficacy and intercalation mechanism identified via multi-model systems. Mol Biosyst (2010) 0.82
Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg Med Chem Lett (2005) 0.82
Asymmetric total synthesis of (-)-alkaloid 223A and its 6-epimer. J Org Chem (2003) 0.81
Synthesis of aryl sulfones via L-proline-promoted CuI-catalyzed coupling reaction of aryl halides with sulfinic acid salts. J Org Chem (2005) 0.81
An efficient sequential reaction process to polysubstituted indolizidines and quinolizidines and its application to the total synthesis of indolizidine 223A. Org Lett (2005) 0.81
CuI/DMPAO-catalyzed N-arylation of acyclic secondary amines. Org Lett (2012) 0.80
Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J Med Chem (2013) 0.80
Synthetic studies toward galbulimima alkaloid (-)-GB 13 and (+)-GB 16 and (-)-himgaline. Chem Asian J (2010) 0.80
Organocatalytic Michael addition of aldehydes to protected 2-amino-1-nitroethenes: the practical syntheses of oseltamivir (Tamiflu) and substituted 3-aminopyrrolidines. Angew Chem Int Ed Engl (2010) 0.80
Assembly of substituted 3-methyleneisoindolin-1-ones via a CuI/l-proline-catalyzed domino reaction process of 2-bromobenzamides and terminal alkynes. Org Lett (2009) 0.80
Identification of a small molecule activator of novel PKCs for promoting glucose-dependent insulin secretion. Cell Res (2010) 0.79
Transition-metal and organocatalysis in natural product synthesis. Beilstein J Org Chem (2013) 0.79
Structural basis of RasGRP binding to high-affinity PKC ligands. J Med Chem (2002) 0.79
Enantioselective synthesis of polysubstituted cyclopentanones by organocatalytic double Michael addition reactions. Org Lett (2010) 0.79
CuI/4-hydro-L-proline as a more effective catalytic system for coupling of aryl bromides with N-boc hydrazine and aqueous ammonia. J Org Chem (2009) 0.79
Retracted The N-aryl aminocarbonyl ortho-substituent effect in Cu-catalyzed aryl amination and its application in the synthesis of 5-substituted 11-oxo-dibenzodiazepines. Org Lett (2011) 0.79
Synthesis of symmetrical and unsymmetrical N,N'-diaryl guanidines via copper/N-methylglycine-catalyzed arylation of guanidine nitrate. J Org Chem (2012) 0.79
A concise route to the proposed structure of lydiamycin B, an antimycobacterial depsipeptide. Org Lett (2009) 0.79
The application of tetrahydroisoquinoline-3-carbonyl-TARGD(F)F as an anti-thrombotic agent having dual mechanisms of action. Mol Biosyst (2012) 0.79
A general and efficient approach to aryl thiols: CuI-catalyzed coupling of aryl iodides with sulfur and subsequent reduction. Org Lett (2009) 0.79
Mild and nonracemizing conditions for Ullmann-type diaryl ether formation between aryl iodides and tyrosine derivatives. J Org Chem (2006) 0.78
[Resurfacing arthroplasty for treatment of avascular necrosis of femoral head in young and middle-aged patients]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2005) 0.78
Total synthesis of the indole alkaloid (±)- and (+)-methyl N-decarbomethoxychanofruticosinate. Angew Chem Int Ed Engl (2013) 0.78
Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases. J Med Chem (2013) 0.78
One single HPLC-PDA/(-)ESI-MS/MS analysis to simultaneously determine 30 components of the aqueous extract of Rabdosia rubescens. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.78
Cascade coupling/cyclization process to N-substituted 1,3-dihydrobenzimidazol-2-ones. Org Lett (2007) 0.78
Cu(I)/L-proline-catalyzed coupling of substituted 3-iodoprop-2-en-1-ols with 1-alkynes and subsequent cyclization: a convenient approach for synthesizing polysubstituted furans. Chem Asian J (2010) 0.78
A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines: aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. Eur J Med Chem (2011) 0.78
CuI-catalyzed domino process to 2,3-disubstituted benzofurans from 1-bromo-2-iodobenzenes and beta-keto esters. J Org Chem (2007) 0.78
Total synthesis of clavepictines A and B and pictamine. Org Lett (2006) 0.78
MDM4 overexpression contributes to synoviocyte proliferation in patients with rheumatoid arthritis. Biochem Biophys Res Commun (2010) 0.78
Facile access to polysubstituted indoles via a cascade Cu-catalyzed arylation-condensation process. J Org Chem (2007) 0.78
Poly-α,β-DL-aspartyl-L-cysteine: a novel nanomaterial having a porous structure, special complexation capability for Pb(II), and selectivity of removing Pb(II). Chem Res Toxicol (2012) 0.78
Preparation and Characterization of RGDS/Nanodiamond as a Vector for VEGF-siRNA Delivery. J Biomed Nanotechnol (2015) 0.77
A convergent route to the Galbulimima alkaloids (-)-GB 13 and (+)-GB 16. Angew Chem Int Ed Engl (2010) 0.77
Total synthesis of piperazimycin A: a cytotoxic cyclic hexadepsipeptide. Angew Chem Int Ed Engl (2009) 0.77
Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents. Bioorg Med Chem Lett (2010) 0.77
Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. J Anal Methods Chem (2013) 0.77
Organocatalytic Michael addition of aldehydes to gamma-keto-alpha,beta-unsaturated esters. an efficient entry to versatile chiral building blocks. Org Lett (2008) 0.77
A one-pot formal [4 + 2] cycloaddition approach to substituted piperidines, indolizidines, and quinolizidines. total synthesis of indolizidine (-)-209I. J Org Chem (2005) 0.77
Total synthesis and cytotoxicity studies of a cyclic depsipeptide with proposed structure of palau'amide. Org Lett (2005) 0.77
Assembly of conjugated enynes and substituted indoles via CuI/amino acid-catalyzed coupling of 1-alkynes with vinyl iodides and 2-bromotrifluoroacetanilides. J Org Chem (2007) 0.77
Assembly of N,N-disubstituted hydrazines and 1-aryl-1H-indazoles via copper-catalyzed coupling reactions. Org Lett (2012) 0.77
Lead detoxification activities and ADMET hepatotoxicities of a class of novel 5-(1-carbonyl-L-amino-acid)-2,2-dimethyl-[1,3]dithiolane-4-carboxylic acids. Bioorg Med Chem Lett (2011) 0.77
A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carbonyl]- N'-(amino-acid-acyl)hydrazine: discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. Eur J Med Chem (2011) 0.77
Metal-catalyzed derivatization of C(alpha)-tetrasubstituted amino acids and their use in the synthesis of cyclic peptides. Chem Asian J (2009) 0.77
Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem (2013) 0.77
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem (2013) 0.77
A class of novel N-isoquinoline-3-carbonyl-L-amino acid benzylesters: synthesis, anti-tumor evaluation and 3D QSAR analysis. Eur J Med Chem (2011) 0.77