Hiroshi Maegawa

Author PubWeight™ 118.92‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008 9.39
2 A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 2010 2.81
3 Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study. Diabetologia 2014 2.21
4 Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J Clin Endocrinol Metab 2008 1.91
5 Less subclinical atherosclerosis in Japanese men in Japan than in White men in the United States in the post-World War II birth cohort. Am J Epidemiol 2007 1.90
6 Much lower prevalence of coronary calcium detected by electron-beam computed tomography among men aged 40-49 in Japan than in the US, despite a less favorable profile of major risk factors. Int J Epidemiol 2004 1.86
7 Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol 2004 1.75
8 Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension. J Hypertens 2006 1.67
9 Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. Am J Physiol Endocrinol Metab 2002 1.46
10 A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and U.S. whites. Eur Heart J Cardiovasc Imaging 2013 1.45
11 Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. J Hum Genet 2009 1.38
12 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Diabetes 2013 1.36
13 Genome-wide association study identifies three novel loci for type 2 diabetes. Hum Mol Genet 2013 1.28
14 Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation. Am J Physiol Endocrinol Metab 2002 1.23
15 A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet 2012 1.23
16 Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. J Am Soc Nephrol 2013 1.23
17 Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J Hum Genet 2005 1.21
18 Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy. Diabetes Care 2012 1.19
19 Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. J Hum Genet 2007 1.19
20 Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis. Kidney Int 2011 1.15
21 Higher levels of adiponectin in American than in Japanese men despite obesity. Metabolism 2006 1.10
22 SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells. Free Radic Biol Med 2011 1.08
23 Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes 2002 1.08
24 Inactivation of TNF-α ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab 2011 1.08
25 Dapagliflozin as monotherapy or combination therapy in Japanese patients with type 2 diabetes: an open-label study. Diabetes Ther 2014 1.08
26 Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS One 2011 1.07
27 Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem 2004 1.05
28 Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes. Diabetes 2012 1.05
29 The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes. Endocrinology 2005 1.04
30 Intronic polymorphisms within TFAP2B regulate transcriptional activity and affect adipocytokine gene expression in differentiated adipocytes. Mol Endocrinol 2005 1.03
31 Visceral and subcutaneous adiposity and adiponectin in middle-aged Japanese men: the ERA JUMP study. Obesity (Silver Spring) 2009 1.02
32 Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: population based prospective cohort study. Heart 2013 1.02
33 Autophagy as a therapeutic target in diabetic nephropathy. Exp Diabetes Res 2011 1.02
34 MicroRNA-494 regulates mitochondrial biogenesis in skeletal muscle through mitochondrial transcription factor A and Forkhead box j3. Am J Physiol Endocrinol Metab 2012 1.00
35 Autophagy regulates inflammation in adipocytes. Biochem Biophys Res Commun 2011 1.00
36 Retracted Reduction of microalbuminuria in patients with type 2 diabetes: the Shiga Microalbuminuria Reduction Trial (SMART). Diabetes Care 2007 0.99
37 Alcohol consumption and coronary artery calcium in middle-aged Japanese men. Am J Cardiol 2006 0.98
38 Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression. J Biol Chem 2003 0.98
39 Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1. Biochem Biophys Res Commun 2004 0.98
40 Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells. Biochem Biophys Res Commun 2010 0.98
41 Association between urinary type IV collagen level and deterioration of renal function in type 2 diabetic patients without overt proteinuria. Diabetes Care 2010 0.97
42 Single nucleotide polymorphism (-468 Gly to A) at the promoter region of SREBP-1c associates with genetic defect of fructose-induced hepatic lipogenesis [corrected]. J Biol Chem 2004 0.96
43 Transcription factor activating enhancer-binding protein-2beta. A negative regulator of adiponectin gene expression. J Biol Chem 2006 0.96
44 Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2012 0.96
45 Association between urinary angiotensinogen levels and renal and cardiovascular prognoses in patients with type 2 diabetes mellitus. J Diabetes Investig 2011 0.95
46 Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes. Endocrinology 2002 0.95
47 Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. Clin Exp Nephrol 2011 0.94
48 Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell. Biochem Biophys Res Commun 2010 0.93
49 RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet. FEBS Lett 2006 0.92
50 Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population. PLoS One 2013 0.91
51 Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. J Biol Chem 2002 0.91
52 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. PLoS One 2013 0.91
53 Fructose induces tubulointerstitial injury in the kidney of mice. Biochem Biophys Res Commun 2012 0.90
54 Correlation between albuminuria and spontaneous platelet microaggregate formation in type 2 diabetic patients. Diabetes Care 2009 0.90
55 Evaluation of a minimally invasive system for measuring glucose area under the curve during oral glucose tolerance tests: usefulness of sweat monitoring for precise measurement. J Diabetes Sci Technol 2013 0.90
56 Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study. Metabolism 2008 0.90
57 GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice. PLoS One 2011 0.89
58 Carotid intima-media thickness and plaque in apparently healthy Japanese individuals with an estimated 10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) guidelines 2012: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). J Atheroscler Thromb 2013 0.89
59 Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria. Diabetes Res Clin Pract 2011 0.89
60 Population Pharmacokinetics and Therapeutic Efficacy of Febuxostat in Patients with Severe Renal Impairment. Pharmacology 2015 0.89
61 Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension. Biochem Biophys Res Commun 2012 0.88
62 MafA differentiates rat intestinal cells into insulin-producing cells. Biochem Biophys Res Commun 2006 0.87
63 Serum levels of marine-derived n-3 fatty acids in Icelanders, Japanese, Koreans, and Americans--a descriptive epidemiologic study. Prostaglandins Leukot Essent Fatty Acids 2012 0.87
64 High sodium intake is associated with masked hypertension in Japanese patients with type 2 diabetes and treated hypertension. Am J Hypertens 2012 0.85
65 Relation of the expression of transcriptional factor TFAP2B to that of adipokines in subcutaneous and omental adipose tissues. Obesity (Silver Spring) 2009 0.85
66 Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population. J Clin Endocrinol Metab 2013 0.85
67 Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells. Atherosclerosis 2009 0.85
68 Autophagy: emerging therapeutic target for diabetic nephropathy. Semin Nephrol 2013 0.85
69 A simple and sensitive method for glutamine:fructose-6-phosphate amidotransferase assay. J Biochem Biophys Methods 2004 0.85
70 Stiffness and impaired blood flow in lower-leg arteries are associated with severity of coronary artery calcification among asymptomatic type 2 diabetic patients. Diabetes Care 2004 0.84
71 A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population. PLoS One 2012 0.84
72 Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet. Am J Physiol Endocrinol Metab 2013 0.84
73 Retracted Impact of renin-angiotensin system inhibition on microalbuminuria in type 2 diabetes: a post hoc analysis of the Shiga Microalbuminuria Reduction Trial (SMART). Hypertens Res 2008 0.83
74 Ethnic difference in liver fat content: a cross-sectional observation among Japanese American in Hawaii, Japanese in Japan, and non-Hispanic whites in United States. Obes Res Clin Pract 2013 0.83
75 Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes. J Biol Chem 2002 0.83
76 Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy. Arch Pharm Res 2013 0.83
77 Protein-tyrosine phosphatase 1B associates with insulin receptor and negatively regulates insulin signaling without receptor internalization. J Biochem 2004 0.83
78 The effects of blood pressure control levels on the renoprotection of type 2 diabetic patients without overt proteinuria. J Am Soc Hypertens 2011 0.82
79 Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men. J Interferon Cytokine Res 2010 0.82
80 Higher arterial stiffness, greater peripheral vascular resistance and lower blood flow in lower-leg arteries are associated with long-term hyperglycaemia in type 2 diabetic patients with normal ankle-brachial index. Diabetes Metab Res Rev 2009 0.82
81 Effects of a fish-based diet on the serum adiponectin concentration in young, non-obese, healthy Japanese subjects. J Atheroscler Thromb 2010 0.82
82 Transcription factor AP-2beta: a negative regulator of IRS-1 gene expression. Biochem Biophys Res Commun 2010 0.81
83 Regulation of ATP-sensitive potassium channel subunit Kir6.2 expression in rat intestinal insulin-producing progenitor cells. J Biol Chem 2004 0.81
84 Glycated albumin predicts the risk of mortality in type 2 diabetic patients on hemodialysis: evaluation of a target level for improving survival. Ther Apher Dial 2013 0.81
85 Impaired peripheral circulation in lower-leg arteries caused by higher arterial stiffness and greater vascular resistance associates with nephropathy in type 2 diabetic patients with normal ankle-brachial indices. Diabetes Res Clin Pract 2008 0.81
86 Cholesteryl ester transfer protein, coronary calcium, and intima-media thickness of the carotid artery in middle-age Japanese men. Am J Cardiol 2009 0.81
87 Autophagy: a novel therapeutic target for kidney diseases. Clin Exp Nephrol 2012 0.80
88 Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol. Clin Exp Nephrol 2010 0.80
89 Influence of cigarette smoking on coronary artery and aortic calcium among random samples from populations of middle-aged Japanese and Korean men. J Epidemiol Community Health 2012 0.80
90 The influence of a single nucleotide polymorphism within CNDP1 on susceptibility to diabetic nephropathy in Japanese women with type 2 diabetes. PLoS One 2013 0.80
91 Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage. Am J Pathol 2013 0.79
92 Transcription factor activating protein-2beta: a positive regulator of monocyte chemoattractant protein-1 gene expression. Endocrinology 2008 0.79
93 Postprandial activation of protein kinase Cµ regulates the expression of adipocytokines via the transcription factor AP-2β. Int J Mol Med 2011 0.79
94 Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells. Am J Physiol Cell Physiol 2005 0.79
95 Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy. Jpn J Ophthalmol 2014 0.78
96 Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population. J Hum Genet 2013 0.78
97 Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression and consequent hypertriglyceridaemia. J Biochem 2009 0.78
98 Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules. Biochim Biophys Acta 2013 0.78
99 Postprandial hyperglycemia after a gastrectomy and the prediabetic state: a comparison between a distal and total gastrectomy. Surg Today 2008 0.77
100 CCDC3 is specifically upregulated in omental adipose tissue in subjects with abdominal obesity. Obesity (Silver Spring) 2013 0.77
101 LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men. Atherosclerosis 2013 0.77
102 Presence and functional role of the rapidly activating delayed rectifier K(+) current in left and right atria of adult mice. Eur J Pharmacol 2010 0.77
103 Low blood flow estimates in lower-leg arteries predict cardiovascular events in Japanese patients with type 2 diabetes with normal ankle-brachial indexes. Diabetes Care 2006 0.77
104 Enhanced Intestinal Motility during Oral Glucose Tolerance Test after Laparoscopic Sleeve Gastrectomy: Preliminary Results Using Cine Magnetic Resonance Imaging. PLoS One 2013 0.77
105 SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene. BMB Rep 2009 0.77
106 Effect of sleeve gastrectomy on body weight, food intake, glucose tolerance, and metabolic hormone level in two different rat models: Goto-Kakizaki and diet-induced obese rat. J Surg Res 2013 0.76
107 Diet high in lipid hydroperoxide by vitamin E deficiency induces insulin resistance and impaired insulin secretion in normal rats. Diabetes Res Clin Pract 2005 0.76
108 The onset of diabetes in three out of four sisters: a Japanese family with type 1 diabetes. A case report. Endocr J 2009 0.76
109 Abnormal peripheral circulation in type 2 diabetic patients with normal ankle-brachial index associates with coronary atherosclerosis, large artery stiffness, and peripheral vascular resistance. Diabetes Res Clin Pract 2005 0.76
110 Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus. Nat Commun 2013 0.76
111 Association of myeloperoxidase G-463A gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic subjects. Endocr J 2012 0.76
112 Stem cell factor-activated bone marrow ameliorates amyotrophic lateral sclerosis by promoting protective microglial migration. J Neurosci Res 2014 0.75
113 Replication study for the association of 3 SNP loci identified in a genome-wide association study for diabetic nephropathy in European type 1 diabetes with diabetic nephropathy in Japanese patients with type 2 diabetes. Clin Exp Nephrol 2013 0.75
114 Safety and efficacy of skin patches containing loxoprofen sodium in diabetic patients with overt nephropathy. Clin Exp Nephrol 2013 0.75
115 Cilostazol attenuates spontaneous microaggregation of platelets in type 2 diabetic patients with insufficient platelet response to aspirin. Diabetes Care 2013 0.75
116 Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42). Medicine (Baltimore) 2017 0.75
117 Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis. Intern Med 2015 0.75
118 Factors associated with progression of diabetic nephropathy in Japanese elderly patients with type 2 diabetes: sub-analysis of the Japanese Elderly Diabetes Intervention Trial. Geriatr Gerontol Int 2012 0.75
119 [Sirt1 in diabetic nephropathy]. Nihon Jinzo Gakkai Shi 2011 0.75
120 [Infection complicated with diabetes mellitus]. Nihon Rinsho 2015 0.75
121 [Management for diabetes mellitus to prevent its complications]. Nihon Rinsho 2016 0.75
122 Octreotide improves early dumping syndrome potentially through incretins: a case report. Endocr J 2013 0.75
123 [Role of TFAP2B and WntSB in adipose tissue]. Nihon Rinsho 2011 0.75
124 Massive pericardial effusion secondary to Hashimoto's disease. Eur J Intern Med 2007 0.75
125 Furosemide-associated nephrocalcinosis and renal cysts. Kidney Int 2011 0.75
126 Renal segmental hypoplasia, Ask-Upmark kidney, in a patient with microalbuminuric hypertensive type 2 diabetes mellitus. Diabetes Res Clin Pract 2008 0.75
127 Prevalence and major risk factors of reduced flow volume in lower extremities with normal ankle-brachial index in Japanese patients with type 2 diabetes. Diabetes Care 2003 0.75
128 [The cutting-edge of medicine; new therapeutic targets for renal senescence]. Nihon Naika Gakkai Zasshi 2013 0.75
129 [Sirt1-mediated autophagy in aging kidney]. Nihon Jinzo Gakkai Shi 2012 0.75
130 [Hypertension and diabetes mellitus]. Nihon Rinsho 2015 0.75
131 [Fixed dose of combination of pioglitazone/metformin]. Nihon Rinsho 2012 0.75